Aarno Palotie

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc From genetic discovery to future personalized health research
    Aarno Palotie
    The Wellcome Trust Sanger Institute, Cambridge, UK
    N Biotechnol 30:291-5. 2013
  2. ncbi request reprint [Do we need a Finnish biobank? Availability of epidemiologic data should benefit everybody]
    Aarno Palotie
    Suomen genomikeskus, Helsingin yliopisto
    Duodecim 120:1710-2. 2004
  3. pmc Pubertal timing and growth influences cardiometabolic risk factors in adult males and females
    Elisabeth Widen
    Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    Diabetes Care 35:850-6. 2012
  4. pmc Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits
    Kati Kristiansson
    National Institute for Health and Welfare, University of Helsinki, Biomedicum, Helsinki, Finland
    Circ Cardiovasc Genet 5:242-9. 2012
  5. pmc A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol
    Ida Surakka
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    PLoS Genet 7:e1002333. 2011
  6. doi request reprint Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy
    Annukka M Lahtinen
    Research Program for Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Heart Rhythm 8:1214-21. 2011
  7. pmc Distinct variants at LIN28B influence growth in height from birth to adulthood
    Elisabeth Widen
    Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    Am J Hum Genet 86:773-82. 2010
  8. pmc Finding disease candidate genes by liquid association
    Ker Chau Li
    Department of Statistics, UCLA, 8125 Math Sciences Bldg, Los Angeles, California 90095 1554, USA
    Genome Biol 8:R205. 2007
  9. pmc Consistently replicating locus linked to migraine on 10q22-q23
    Verneri Anttila
    Biomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland
    Am J Hum Genet 82:1051-63. 2008
  10. pmc Molecular pathology of aneurysms
    Mika Niemela
    Surg Neurol 70:36-8. 2008

Detail Information

Publications24

  1. pmc From genetic discovery to future personalized health research
    Aarno Palotie
    The Wellcome Trust Sanger Institute, Cambridge, UK
    N Biotechnol 30:291-5. 2013
    ....
  2. ncbi request reprint [Do we need a Finnish biobank? Availability of epidemiologic data should benefit everybody]
    Aarno Palotie
    Suomen genomikeskus, Helsingin yliopisto
    Duodecim 120:1710-2. 2004
  3. pmc Pubertal timing and growth influences cardiometabolic risk factors in adult males and females
    Elisabeth Widen
    Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    Diabetes Care 35:850-6. 2012
    ....
  4. pmc Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits
    Kati Kristiansson
    National Institute for Health and Welfare, University of Helsinki, Biomedicum, Helsinki, Finland
    Circ Cardiovasc Genet 5:242-9. 2012
    ..Furthermore, we tested for loci associated with multiple MetS component traits using factor analysis, and built a genetic risk score for MetS...
  5. pmc A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol
    Ida Surakka
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    PLoS Genet 7:e1002333. 2011
    ..However, more refined measures of both body-fat distribution and metabolic measures are needed to understand how their joint dynamics are modified by the newly found locus...
  6. doi request reprint Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy
    Annukka M Lahtinen
    Research Program for Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Heart Rhythm 8:1214-21. 2011
    ..Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive myocardial disorder caused by mutations of desmosomal cell adhesion proteins. The prevalence of these variants in the general population is unknown...
  7. pmc Distinct variants at LIN28B influence growth in height from birth to adulthood
    Elisabeth Widen
    Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    Am J Hum Genet 86:773-82. 2010
    ..These findings imply a critical role for LIN28B in the regulation of human growth...
  8. pmc Finding disease candidate genes by liquid association
    Ker Chau Li
    Department of Statistics, UCLA, 8125 Math Sciences Bldg, Los Angeles, California 90095 1554, USA
    Genome Biol 8:R205. 2007
    ..A novel approach to finding candidate genes by using gene expression data through liquid association is developed and used to identify multiple sclerosis susceptibility candidate genes...
  9. pmc Consistently replicating locus linked to migraine on 10q22-q23
    Verneri Anttila
    Biomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland
    Am J Hum Genet 82:1051-63. 2008
    ..These results support the use of symptomology-based phenotyping in migraine and suggest that the 10q22-q23 locus probably contains one or more migraine susceptibility variants...
  10. pmc Molecular pathology of aneurysms
    Mika Niemela
    Surg Neurol 70:36-8. 2008
  11. ncbi request reprint Migraine: a complex genetic disorder
    Maija Wessman
    Folkhalsan Research Center, Helsinki, Finland
    Lancet Neurol 6:521-32. 2007
    ..These include new phenotyping methods for genetic studies and new study designs-such as case-control and whole-genome association studies-to identify common variants contributing to the trait...
  12. ncbi request reprint Genetic component of identification, intensity and pleasantness of odours: a Finnish family study
    Antti Knaapila
    Department of Food Technology, University of Helsinki, Helsinki, Finland
    Eur J Hum Genet 15:596-602. 2007
    ..Thus, perception of odours is potentially modified by genes other than those encoding odorant receptors...
  13. ncbi request reprint A quality assessment survey of SNP genotyping laboratories
    Paivi Lahermo
    Finnish Genome Center, University of Helsinki, Helsinki, Finland
    Hum Mutat 27:711-4. 2006
    ..Lessons from the survey are that special attention should be given to the quality of the DNA samples prior to genotyping, and that a conservative approach for calling the genotypes should be used to achieve a high accuracy...
  14. ncbi request reprint Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24
    Janna Saarela
    Department of Human Genetics, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Hum Mol Genet 11:2257-67. 2002
    ..5 Mb. Thus, this study describes the restriction of an MS locus outside the HLA region into a segment approachable by molecular tools...
  15. ncbi request reprint CD14 and TNfa promoter polymorphisms in patients with acute arthritis. Special reference to development of chronic spondyloarthropathy
    Heikki Repo
    Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, Haartman Institute, University of Helsinki, Finland
    Scand J Rheumatol 31:355-61. 2002
    ..To examine CD14 and TNFalpha gene polymorphisms in early arthritis in relation to clinical outcome...
  16. ncbi request reprint Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes
    Eun Hwa Choi
    Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute NIH, Advanced Technology Center, Gaithersburg, MD 20892 4605, USA
    J Infect Dis 187:1153-6. 2003
    ..16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P= .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia...
  17. ncbi request reprint Genetic and environmental influences on migraine: a twin study across six countries
    Elles J Mulder
    Dept of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Twin Res 6:422-31. 2003
    ..After migraine definitions are homogenized among the participating countries, the GenomEUtwin project will provide a powerful resource to identify the genes involved in migraine...
  18. ncbi request reprint Chromosome 19p13 loci in Finnish migraine with aura families
    Mari A Kaunisto
    Biomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 132:85-9. 2005
    ..The overall conclusion is that our study did not provide evidence of a major MA susceptibility region on 19p13 and thus we were not able to replicate the INSR locus finding...
  19. ncbi request reprint Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients
    Eun Hwa Choi
    Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Med Mycol 43:349-53. 2005
    ..Common variants in the six studied genes most likely do not contribute to the risk for chronic disseminated candidiasis in patients with acute leukemia...
  20. ncbi request reprint Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12
    Hilde Monica F Riise Stensland
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Neuroimmunol 170:122-33. 2005
    ....
  21. pmc PRKCA and multiple sclerosis: association in two independent populations
    Janna Saarela
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    PLoS Genet 2:e42. 2006
    ....
  22. ncbi request reprint Lessons from studying monogenic disease for common disease
    Leena Peltonen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 15:R67-74. 2006
  23. pmc A susceptibility locus for migraine with aura, on chromosome 4q24
    Maija Wessman
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles 90095 7088, USA
    Am J Hum Genet 70:652-62. 2002
    ..000011). Multipoint parametric (HLOD = 4.45; P=.0000058) and nonparametric (NPL(all) = 3.43; P=.0007) analyses support linkage in this region. Statistically significant linkage was not observed in any other chromosomal region...