Joni J Palmgrén

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi Characterization of Caco-2 cell monolayer drug transport properties by cassette dosing using UV/fluorescence HPLC
    Joni J Palmgrén
    Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio, Finland
    Eur J Pharm Biopharm 57:319-28. 2004
  2. ncbi Quantitative determination of cholesterol, sitosterol, and sitostanol in cultured Caco-2 cells by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry
    Joni J Palmgrén
    Department of Pharmaceutical Chemistry, University of Kuopio, P O B 1627, FIN 70211 Kuopio, Finland
    J Chromatogr B Analyt Technol Biomed Life Sci 821:144-52. 2005
  3. ncbi Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions
    Joni J Palmgrén
    Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio, Finland
    Eur J Pharm Biopharm 64:369-78. 2006
  4. ncbi Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines
    Timo Korjamo
    Department of Pharmaceutics, University of Kuopio, Harjulantie 1, P O Box 1627, FI 70211 Kuopio, Finland
    Eur J Pharm Sci 26:266-79. 2005
  5. ncbi Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols
    Joni J Palmgrén
    Department of Pharmaceutical Chemistry, University of Kuopio, P O B 1627, FIN 70211 Kuopio, Finland
    J Chromatogr A 976:165-70. 2002
  6. ncbi High-performance liquid chromatography/electrospray ionization tandem mass spectrometry for characterization of enzymatic degradation of 2,2'-bis(2-oxazoline)-linked poly-epsilon-caprolactone
    Mika Pulkkinen
    Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
    Rapid Commun Mass Spectrom 22:121-9. 2008

Detail Information

Publications6

  1. ncbi Characterization of Caco-2 cell monolayer drug transport properties by cassette dosing using UV/fluorescence HPLC
    Joni J Palmgrén
    Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio, Finland
    Eur J Pharm Biopharm 57:319-28. 2004
    ..All drugs can be applied to the Caco-2 cell culture as a mixture, and the cassette dosing method is suitable for permeability studies...
  2. ncbi Quantitative determination of cholesterol, sitosterol, and sitostanol in cultured Caco-2 cells by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry
    Joni J Palmgrén
    Department of Pharmaceutical Chemistry, University of Kuopio, P O B 1627, FIN 70211 Kuopio, Finland
    J Chromatogr B Analyt Technol Biomed Life Sci 821:144-52. 2005
    ..51 to 101.77%. The lowest limit of quantitation (LLOQ) was 0.225 microM for sitosterol and sitostanol, and 0.45 microM for cholesterol. The accuracy range was 95-106% and precision was lower than 9% for all LLOQ values...
  3. ncbi Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions
    Joni J Palmgrén
    Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio, Finland
    Eur J Pharm Biopharm 64:369-78. 2006
    ..15%, 43.80%, 23.57% and 11.22% for atenolol, metoprolol, medetomidine, propranolol, midazolam, and diazepam, respectively. Overall, these findings will benefit development and validation of further in vitro drug permeation experiments...
  4. ncbi Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines
    Timo Korjamo
    Department of Pharmaceutics, University of Kuopio, Harjulantie 1, P O Box 1627, FI 70211 Kuopio, Finland
    Eur J Pharm Sci 26:266-79. 2005
    ..Passive transcellular permeability was modestly elevated in all modified cell lines. In addition, several compounds showed pH-dependent permeability properties...
  5. ncbi Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols
    Joni J Palmgrén
    Department of Pharmaceutical Chemistry, University of Kuopio, P O B 1627, FIN 70211 Kuopio, Finland
    J Chromatogr A 976:165-70. 2002
    ..Paracellular pores are negatively charged and it was in our interest to characterize the interactions of positive charge and size of the molecules with the paracellular pores...
  6. ncbi High-performance liquid chromatography/electrospray ionization tandem mass spectrometry for characterization of enzymatic degradation of 2,2'-bis(2-oxazoline)-linked poly-epsilon-caprolactone
    Mika Pulkkinen
    Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
    Rapid Commun Mass Spectrom 22:121-9. 2008
    ..This novel mass spectrometric method provides important knowledge about the enzymatic degradation process and structure of the polymer which is difficult to ascertain by other conventional methods...