Jukka S Pakkanen
Affiliation: University of Helsinki
- Up-regulation of beta2 and alpha7 subunit containing nicotinic acetylcholine receptors in mouse striatum at cellular levelJukka S Pakkanen
Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, P O Box 56, FIN 00014 Finland
Eur J Neurosci 21:2681-91. 2005..This suggests that the trafficking of nAChR subunits is increased as a result of chronic nicotine treatment and nAChRs in all parts of neurons could have functional roles in the formation of nicotine addiction...
- Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptorsJukka S Pakkanen
Division of Pharmacology and Toxicology, University of Helsinki, Helsinki, Finland
J Neurochem 94:1329-41. 2005..Collectively, our results suggest that methadone engages in complex and potentially pharmacologically significant interactions with nAChRs...
- Effect of chronic nicotine treatment on localization of neuronal nicotinic acetylcholine receptors at cellular levelJukka S Pakkanen
Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Finland
Synapse 59:383-93. 2006..Chronic nicotine treatment does not change endocytotic trafficking of nAChRs. Chronic nicotine treatment increased clustering of nAChRs, which could have a role in the release of dopamine (DA) evoked by nicotine...
- Cell-polymer interactions of fluorescent polystyrene latex particles coated with thermosensitive poly(N-isopropylacrylamide) and poly(N-vinylcaprolactam) or grafted with poly(ethylene oxide)-macromonomerHenna Vihola
Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, PB 56, FIN 00014 Helsinki, Finland
Int J Pharm 343:238-46. 2007..The results suggest feasibility of the PNIPAM and PVCL for biotechnological/pharmaceutical applications, as the cell-particle interactions may be modified by size, surface charge, hydrophobicity, steric repulsion and temperature...