T Otonkoski

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc Distinct differentiation characteristics of individual human embryonic stem cell lines
    Milla Mikkola
    Program of Developmental and Reproductive Biology, Biomedicum Helsinki, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
    BMC Dev Biol 6:40. 2006
  2. pmc The N-glycome of human embryonic stem cells
    Tero Satomaa
    Glykos Finland Ltd, Helsinki, Finland
    BMC Cell Biol 10:42. 2009
  3. ncbi request reprint Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release
    Timo Otonkoski
    Program for Developmental and Reproductive Biology, Biomedicum, Helsinki, Finland
    Diabetes 52:199-204. 2003
  4. ncbi request reprint A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland
    T Otonkoski
    Transplantation Laboratory, Haartman Institute, and University of Helsinki, Finland
    Diabetes 48:408-15. 1999
  5. ncbi request reprint Stem cells in the treatment of diabetes
    Timo Otonkoski
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Ann Med 37:513-20. 2005
  6. ncbi request reprint Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography
    Timo Otonkoski
    Hospital for Children and Adolescents, and Program of Developmental and Reproductive Biology, Biomedicum Helsinki, Room C503b, PO Box 63, FIN 00014 University of Helsinki, Helsinki, Finland
    Diabetes 55:13-8. 2006
  7. doi request reprint Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation
    T Otonkoski
    Biomedicum Stem Cell Center and Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Diabetes Obes Metab 10:119-27. 2008
  8. pmc Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells
    Timo Otonkoski
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Am J Hum Genet 81:467-74. 2007
  9. ncbi request reprint Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells
    M Roivainen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Clin Endocrinol Metab 85:432-40. 2000
  10. ncbi request reprint Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta-cell mitogen
    M A Huotari
    Transplantation Laboratory, Haartman Institute and Children s Hospital, University of Helsinki, Finland
    Endocrinology 139:1494-9. 1998

Detail Information

Publications52

  1. pmc Distinct differentiation characteristics of individual human embryonic stem cell lines
    Milla Mikkola
    Program of Developmental and Reproductive Biology, Biomedicum Helsinki, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
    BMC Dev Biol 6:40. 2006
    ..Here, we describe the derivation of five hESC lines (called FES 21, 22, 29, 30 and 61) from frozen-thawed human embryos and compare their individual differentiation characteristic...
  2. pmc The N-glycome of human embryonic stem cells
    Tero Satomaa
    Glykos Finland Ltd, Helsinki, Finland
    BMC Cell Biol 10:42. 2009
    ..Structural analyses were performed by specific glycosidase enzymes and mass spectrometric fragmentation analyses...
  3. ncbi request reprint Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release
    Timo Otonkoski
    Program for Developmental and Reproductive Biology, Biomedicum, Helsinki, Finland
    Diabetes 52:199-204. 2003
    ..In conclusion, EIHI represents a new autosomal-dominant hyperinsulinemia syndrome that may be more common than has been realized. The pyruvate test provides a simple, safe, and specific diagnostic test for this condition...
  4. ncbi request reprint A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland
    T Otonkoski
    Transplantation Laboratory, Haartman Institute, and University of Helsinki, Finland
    Diabetes 48:408-15. 1999
    ..This unique SUR1 mutation explains the majority of PHHI cases in Finland and is strongly associated with a severe form of the disease. These findings provide diagnostic and prognostic utility for suspected PHHI patients...
  5. ncbi request reprint Stem cells in the treatment of diabetes
    Timo Otonkoski
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Ann Med 37:513-20. 2005
    ..After initial excitement, it appears that much basic research is still required before this goal could be achieved...
  6. ncbi request reprint Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography
    Timo Otonkoski
    Hospital for Children and Adolescents, and Program of Developmental and Reproductive Biology, Biomedicum Helsinki, Room C503b, PO Box 63, FIN 00014 University of Helsinki, Helsinki, Finland
    Diabetes 55:13-8. 2006
    ..In conclusion, [(18)F]-DOPA PET is a promising noninvasive method for the identification and localization of the focal form of CHI...
  7. doi request reprint Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation
    T Otonkoski
    Biomedicum Stem Cell Center and Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Diabetes Obes Metab 10:119-27. 2008
    ..This information has potentially important implications for the generation of an optimal microenvironment for beta-cell function, proliferation and differentiation...
  8. pmc Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells
    Timo Otonkoski
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Am J Hum Genet 81:467-74. 2007
    ..These findings describe a novel disease mechanism based on the failure of cell-specific transcriptional silencing of a gene that is highly expressed in other tissues...
  9. ncbi request reprint Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells
    M Roivainen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Clin Endocrinol Metab 85:432-40. 2000
    ..Coxsackie B viruses cause functional impairment and beta-cell death characterized by nuclear pyknosis. Apoptosis appears to play a minor role during a productive CBV infection in beta-cells...
  10. ncbi request reprint Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta-cell mitogen
    M A Huotari
    Transplantation Laboratory, Haartman Institute and Children s Hospital, University of Helsinki, Finland
    Endocrinology 139:1494-9. 1998
    ..In addition, we have identified betacellulin as a possible modulator of beta-cell growth...
  11. doi request reprint Blood vessels of human islets of Langerhans are surrounded by a double basement membrane
    I Virtanen
    Institute of Biomedicine Anatomy, University of Helsinki, 00014, Helsinki, Finland
    Diabetologia 51:1181-91. 2008
    ..Based on mouse study findings, pancreatic islet cells are supposed to lack basement membrane (BM) and interact directly with vascular endothelial BM. Until now, the BM composition of human islets has remained elusive...
  12. ncbi request reprint Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells
    P Ylipaasto
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    Diabetologia 47:225-39. 2004
    ..We sought evidence for this through autopsy studies and by investigating known enterovirus receptors in cultured human islets...
  13. ncbi request reprint In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells
    R Gao
    Program of Developmental and Reproductive Biology, Biomedicum Helsinki, University of Helsinki, Finland
    Diabetologia 48:2296-304. 2005
    ..The islet progenitors have been thought to be ductal cells. Since previous experiments have been 'contaminated' by a number of pre-existing islet cells, we examined their involvement in islet cell neogenesis...
  14. ncbi request reprint Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture
    Ru Gao
    Program of Developmental and Reproductive Biology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Diabetes 52:2007-15. 2003
    ..Our results support the previous notion that pancreatic progenitor cells represent a subpopulation of ductal epithelial cells. No evidence was found for the development of endocrine cells from nestin-positive stem cells...
  15. ncbi request reprint Effects of immunosuppressive drugs on in vitro neogenesis of human islets: mycophenolate mofetil inhibits the proliferation of ductal cells
    R Gao
    Program of Developmental and Reproductive Biology, Biomedicum Helsinki, University of Helsinki, Finland
    Am J Transplant 7:1021-6. 2007
    ..Sirolimus and daclizumab have no adverse effects on these parameters. The immunosuppressive protocol may be an important determinant of long-term clinical islet graft function...
  16. doi request reprint Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation
    E Hakonen
    Research Programs Unit, Molecular Neurology, Biomedicum Stem Cell Centre, University of Helsinki, PO Box 63, Haartmaninkatu 8, 00014 Helsinki, Finland
    Diabetologia 54:1735-43. 2011
    ..In this study we investigated the role of EGFR signalling in the physiological states of beta cell mass expansion in adults during metabolic syndrome and pregnancy, as well as in regeneration after pancreatic duct ligation...
  17. ncbi request reprint Transcription factor expression and hormone production in pancreatic AR42J cells
    J Palgi
    Transplantation Laboratory, Haartman Institute and the Hospital for Children and Adolescents, University of Helsinki, PO Box 21 Haartmaninkatu 3, FIN 00014, Helsinki, Finland
    Mol Cell Endocrinol 165:41-9. 2000
    ..However, we were unable to confirm the capacity of these cells to differentiate into insulin-producing cells. Our results indicate that Nkx2.2 plays a role in the transcriptional regulation of PP expression...
  18. ncbi request reprint Neonatal Type I diabetes associated with maternal echovirus 6 infection: a case report
    T Otonkoski
    Hospital for Children and Adolescents and Haartman Institute, Transplantation Laboratory, University of Helsinki, Finland
    Diabetologia 43:1235-8. 2000
    ..Exocrine pancreatic insufficiency was diagnosed at the age of 1 year. CONCLUSION/INTERPRETATION: These observations suggests that enteroviral infections may induce beta-cell autoimmunity even in utero...
  19. ncbi request reprint Maturation of in vitro-generated human islets after transplantation in nude mice
    Ru Gao
    Program of Developmental and Reproductive Biology, Biomedicum Helsinki, University of Helsinki, Finland
    Mol Cell Endocrinol 264:28-34. 2007
    ..Ductal cell differentiation into endocrine cells may be an important factor in sustaining the long-term function of islet transplants...
  20. ncbi request reprint Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth
    Päivi J Miettinen
    Program of Developmental and Reproductive Biology, Biomedicum Helsinki, Room B530b, P O Box 63, FIN 00014 University of Helsinki, Helsinki, Finland
    Diabetes 55:3299-308. 2006
    ..In summary, our results show that even a modest attenuation of EGF-R signaling leads to a severe defect in postnatal growth of the beta-cells, which leads to the development of diabetes...
  21. ncbi request reprint ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture
    Mari Anne Huotari
    Biomedicum Helsinki, Program for Developmental and Reproductive Biology and Haartman Institute, University of Helsinki, Helsinki 00014, Finland
    Endocrinology 143:4437-46. 2002
    ..BTC, acting through EGF-R/erbB-1, is important for the differentiation of beta-cells. This could be applied in the targeted differentiation of stem cells into insulin-producing cells...
  22. ncbi request reprint A syndrome with multiple malformations, mental retardation, and ACTH deficiency
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    Am J Med Genet A 126:313-8. 2004
    ..Family history was negative. Adrenal insufficiency is an uncommon feature in multiple malformation syndromes and may thus serve as a diagnostic handle for recognizing other possible patients with a similar syndrome...
  23. ncbi request reprint Mechanisms of coxsackievirus B5 mediated beta-cell death depend on the multiplicity of infection
    Suvi Rasilainen
    Biomedicum Helsinki, Program of Developmental and Reproductive Biology, University of Helsinki, Helsinki, Finland
    J Med Virol 72:586-96. 2004
    ..These data suggest that the pattern and mechanisms of coxsackievirus B5 infection induced beta-cell death depend on the MOI...
  24. ncbi request reprint Mechanisms of beta cell death during restricted and unrestricted enterovirus infection
    Suvi Rasilainen
    Haartman Institute, Transplantation Laboratory, University of Helsinki, Helsinki, Finland
    J Med Virol 72:451-61. 2004
    ..However, restriction of viral replication shifts the mechanism of cell death from necrosis toward apoptosis. A slowly progressing subclinical infection of islets could thus lead to increased beta-cell apoptosis...
  25. ncbi request reprint Dose-dependent cysteine-mediated protection of insulin-producing cells from damage by hydrogen peroxide
    Suvi Rasilainen
    Haartman Institute, Transplantation Laboratory, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland
    Biochem Pharmacol 63:1297-304. 2002
    ..The defence mechanisms depend heavily on glutathione, the synthesis of which is dependent on the availability of cysteine. We investigated whether an increased amount of cysteine available could protect beta cells from oxidative damage...
  26. doi request reprint Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support
    Sanna Vuoristo
    Biomedicum Stem Cell Center, University of Helsinki, Helsinki, Finland
    J Cell Mol Med 13:2622-33. 2009
    ..These results provide consequential information of the biological role of BM in hESCs, warranting further investigation of BM biology of human pluripotent stem cells...
  27. ncbi request reprint The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells
    Mari Anne Pulkkinen
    Biomedicum Helsinki, Program for Developmental and Reproductive Biology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mech Dev 120:167-75. 2003
    ..Our results thus suggest that Fgfr2b-mediated signaling plays a major role in pancreatic ductal proliferation and branching morphogenesis, but has little effect on endocrine and exocrine differentiation...
  28. pmc Induced pluripotent stem cell clones reprogrammed via recombinant adeno-associated virus-mediated transduction contain integrated vector sequences
    J Weltner
    Research Programs Unit, Molecular Neurology, Biomedicum Stem Cell Centre, University of Helsinki, Helsinki, Finland
    J Virol 86:4463-7. 2012
    ..It thus appears that rAAV vectors are not compatible with the derivation of integration-free iPSC...
  29. ncbi request reprint A simple two-step protocol for the purification of human pancreatic beta cells
    M Banerjee
    Biomedicum Stem Cell Center, University of Helsinki, Room C507b, PO Box 63, 00014, Helsinki, Finland
    Diabetologia 52:621-5. 2009
    ....
  30. ncbi request reprint Nephrin is expressed in the pancreatic beta cells
    T Palmen
    Haartman Institute, Division of Bacteriology and Immunology, University of Helsinki, and Helsinki University Central Hospital Helsinki, Finland
    Diabetologia 44:1274-80. 2001
    ..The aim of this study was to describe the expression of nephrin mRNA and protein in human pancreas as well as identify the nephrin-expressing cell types...
  31. doi request reprint Prevalence and characteristics of diabetes among Somali children and adolescents living in Helsinki, Finland
    T Oilinki
    Department of Endocrinology and Diabetology, Hospital for Children and Adolescents, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Pediatr Diabetes 13:176-80. 2012
    ..We compared the prevalence and characteristics of diabetes between Somali and Finnish children in the City of Helsinki...
  32. ncbi request reprint Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors
    P J Miettinen
    Department of Pathology and Transplantation Laboratory, The Haartman Institute, and Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Development 127:2617-27. 2000
    ..Upregulated PAI-1 production and decreased gelatinolytic activity correlated to this migration defect. An intact EGF-R pathway appears to be a prerequisite for normal pancreatic development...
  33. ncbi request reprint N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible
    Annamari Heiskanen
    Glykos Finland Ltd, Helsinki, Finland
    Stem Cells 25:197-202. 2007
    ..Definition of safe culture conditions for stem cells is essential for future development of cellular therapies...
  34. ncbi request reprint cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)
    J Bondestam
    Program for Developmental and Reproductive Biology, Biomedicum Helsinki, Helsinki, Finland
    Cytogenet Cell Genet 95:157-62. 2001
    ..Infection with Ad-caALK7 of MIN6 insulinoma cells, in which ALK7 has previously been shown to be endogenously expressed, led to a marked increase in the phosphorylation of Smad2, a signaling molecule also used by TGF-betas and activins...
  35. ncbi request reprint Functional impairment and killing of human beta cells by enteroviruses: the capacity is shared by a wide range of serotypes, but the extent is a characteristic of individual virus strains
    M Roivainen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    Diabetologia 45:693-702. 2002
    ..We extended these studies to additional enterovirus serotypes including several echoviruses, some of which have been associated clinically with the development of Type I (insulin-dependent) diabetes mellitus...
  36. ncbi request reprint IL-17 immunity in human type 1 diabetes
    Jarno Honkanen
    Immune Response Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Immunol 185:1959-67. 2010
    ..Our findings highlight the role of IL-17 immunity in the pathogenesis of human T1D and point to a potential therapeutic strategy...
  37. ncbi request reprint Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas
    Ilkka Ketola
    Children s Hospital and Program for Developmental and Reproductive Biology, Biomedicum Helsinki, PO Box 63, Room B525b, 00014 University of Helsinki, Helsinki, Finland
    Mol Cell Endocrinol 226:51-7. 2004
    ..We conclude that GATA-4 is a marker of exocrine pancreatic differentiation, whereas GATA-6 is a marker of endocrine pancreatic development...
  38. doi request reprint EGF receptor in pancreatic beta-cell mass regulation
    Päivi Miettinen
    Hospital for Children and Adolescents and the Biomedicum Stem Cell Center, University of Helsinki, 00014 Helsinki, Finland
    Biochem Soc Trans 36:280-5. 2008
    ..EGFR thus plays an essential role in beta-cell mass regulation, but its mechanisms of action remain poorly understood...
  39. ncbi request reprint A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1
    Hanna Huopio
    Department of Paediatrics, University of Kuopio, Kuopio, Finland
    Lancet 361:301-7. 2003
    ..We aimed to characterise glucose metabolism in adults heterozygous for the E1506K mutation...
  40. ncbi request reprint [Congenital hyperinsulinism]
    Hanna Huopio
    Lastenklinikka, Kuopion yliopistollinen sairaala, Kuopio
    Duodecim 121:1166-75. 2005
  41. ncbi request reprint Hyperinsulinemic hypoglycemia in children
    P de Lonlay
    Necker Hospital, Paris, France
    Ann Endocrinol (Paris) 65:96-8. 2004
  42. ncbi request reprint Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion
    Hanna Huopio
    Department of Pediatrics, University of Kuopio, Kuopio, Finland
    Diabetes Care 25:101-6. 2002
    ..The aim of our study was to investigate in vivo the glucose homeostasis of heterozygous SUR1 mutation carriers...
  43. ncbi request reprint Rapid genetic analysis in congenital hyperinsulinism
    Henrik B T Christesen
    Department of Paediatrics, Odense University Hospital, Odense, Denmark
    Horm Res 67:184-8. 2007
    ..However, genotyping usually takes too long to be helpful in the absence of a founder mutation...
  44. ncbi request reprint Gene expression signatures of seven individual human embryonic stem cell lines
    Heli Skottman
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, POB 123, 0520 Turku, Finland
    Stem Cells 23:1343-56. 2005
    ..Limited overlap between gene expression profiles illustrates the importance of cross-validation of results between different ESC lines...
  45. ncbi request reprint [Replacement therapy with beta-cells: the way to treat diabetes in the future?]
    Timo Otonkoski
    Biomedicum Helsinki, kehitys ja lisääntymisbiologian ohjelma PL 700, 00029 HUS
    Duodecim 120:1133-4. 2004
  46. doi request reprint Isolation of human embryonic stem cell-derived teratomas for the assessment of pluripotency
    Karin Gertow
    Department of Laboratory Medicine, Clinical Research Center, Unit for Molecular Embryology, Karolinska Institute, Sweden
    Curr Protoc Stem Cell Biol . 2007
    ..Teratomas can also be fixed in Bouin's or cryosectioned for analysis, and they can be analyzed by immunohistochemistry for tissue markers. Methods for these procedures are included in this unit...
  47. ncbi request reprint Dedifferentiation for replication of human beta-cells: a division between mice and men?
    Nils Billestrup
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 57:1457-8. 2008
  48. pmc Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism
    Kathryn S Woods
    London Centre for Paediatric Endocrinology, Biochemistry, Endocrinology, and Metabolism Unit, Institute of Child Health, University College London, London, United Kingdom
    Am J Hum Genet 76:833-49. 2005
    ..We conclude that both over- and underdosage of SOX3 are associated with similar phenotypes, consisting of infundibular hypoplasia and hypopituitarism but not necessarily MR...
  49. ncbi request reprint Weighing up beta-cell mass in mice and humans: self-renewal, progenitors or stem cells?
    Neil A Hanley
    Centre for Human Development, Stem Cells and Regeneration, University of Southampton, Southampton, UK
    Mol Cell Endocrinol 288:79-85. 2008
    ..This article describes the two opposing positions based largely on research in laboratory rodents and its extrapolation to humans...
  50. ncbi request reprint Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
    Oluseun Adewumi
    UK Stem Cell Bank, Division of Cell Biology and Imaging, National Institute for Biological Standards and Control, South Mimms, Herts, EN6 3QG, UK
    Nat Biotechnol 25:803-16. 2007
    ..Also, some female lines expressed readily detectable levels of XIST whereas others did not. No significant contamination of the lines with mycoplasma, bacteria or cytopathic viruses was detected...
  51. ncbi request reprint Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation
    Antonio L Cuesta-Muñoz
    Hospital Carlos Haya Foundation and Department of Endocrinology, Diabetes and Nutrition of Carlos Haya University Hospital, Malaga, Spain
    Diabetes 53:2164-8. 2004
    ..These findings demonstrate that the range of the clinical phenotype caused by GCK mutations varies from complete insulin deficiency to extreme hyperinsulinemia...
  52. ncbi request reprint Lack of association of PAX4 gene with type 1 diabetes in the Finnish and Hungarian populations
    Robert Hermann
    Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN 20520 Turku, Finland
    Diabetes 54:2816-9. 2005
    ..The strong coherence between the datasets of the two ethnic groups studied with highly contrasting disease incidence, socioeconomic characteristics, and profoundly diverse environment emphasizes the impact of this finding...