Moilanen L, HÃ¤mÃ¤lÃ¤inen M, Nummenmaa E, Ilmarinen P, Vuolteenaho K, Nieminen R, et al. Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis. Osteoarthritis Cartilage. 2015;23:2017-26 pubmed publisher
..TRPA1 was found to mediate acute inflammation and the development of degenerative cartilage changes and joint pain in MIA-induced experimental OA in the mouse. The results reveal TRPA1 as a potential mediator and drug target in OA. ..
Nummenmaa E, Hamalainen M, Moilanen L, Paukkeri E, Nieminen R, Moilanen T, et al. Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes. Arthritis Res Ther. 2016;18:185 pubmed publisher
..The presence and inflammatory and catabolic effects of TRPA1 in human OA chondrocytes propose a highly intriguing role for TRPA1 as a pathogenic factor and drug target in OA. ..