P Nieminen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc Candidate gene analysis of tooth agenesis identifies novel mutations in six genes and suggests significant role for WNT and EDA signaling and allele combinations
    Sirpa Arte
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    PLoS ONE 8:e73705. 2013
  2. doi request reprint Genetic basis of tooth agenesis
    Pekka Nieminen
    Institute of Dentistry, Biomedicum, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 312:320-42. 2009
  3. doi request reprint Frameshift mutations in dentin phosphoprotein and dependence of dentin disease phenotype on mutation location
    Pekka Nieminen
    Institute of Dentistry, Biomedicum, University of Helsinki, Helsinki, Finland
    J Bone Miner Res 26:873-80. 2011
  4. doi request reprint DLX3 homeodomain mutations cause tricho-dento-osseous syndrome with novel phenotypes
    Pekka Nieminen
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Cells Tissues Organs 194:49-59. 2011
  5. ncbi request reprint MSX1 gene is deleted in Wolf-Hirschhorn syndrome patients with oligodontia
    P Nieminen
    Institute of Dentistry, Biomedicum, PO Box 63, FIN 00014 University of Helsinki, Finland
    J Dent Res 82:1013-7. 2003
  6. ncbi request reprint Identification of a nonsense mutation in the PAX9 gene in molar oligodontia
    P Nieminen
    Institute of Biotechnology, University of Helsinki, Finland
    Eur J Hum Genet 9:743-6. 2001
  7. pmc Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth
    Pekka Nieminen
    Institute of Dentistry, Biomedicum, University of Helsinki, Finland
    Am J Hum Genet 89:67-81. 2011
  8. ncbi request reprint A graphical WWW-database on gene expression in tooth
    P Nieminen
    Institute of Biotechnology, University of Helsinki, Finland
    Eur J Oral Sci 106:7-11. 1998
  9. ncbi request reprint TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis
    J Laurikkala
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 229:443-55. 2001
  10. ncbi request reprint Effect of organised screening on cervical cancer incidence and mortality in Finland, 1963-1995: recent increase in cervical cancer incidence
    A Anttila
    Finnish Cancer Registry, Helsinki, Finland
    Int J Cancer 83:59-65. 1999

Collaborators

Detail Information

Publications30

  1. pmc Candidate gene analysis of tooth agenesis identifies novel mutations in six genes and suggests significant role for WNT and EDA signaling and allele combinations
    Sirpa Arte
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    PLoS ONE 8:e73705. 2013
    ..An EDARADD variant were in seven probands present together with variants in EDAR or WNT10A, suggesting combined phenotypic effects of alleles in distinct genes. ..
  2. doi request reprint Genetic basis of tooth agenesis
    Pekka Nieminen
    Institute of Dentistry, Biomedicum, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 312:320-42. 2009
    ....
  3. doi request reprint Frameshift mutations in dentin phosphoprotein and dependence of dentin disease phenotype on mutation location
    Pekka Nieminen
    Institute of Dentistry, Biomedicum, University of Helsinki, Helsinki, Finland
    J Bone Miner Res 26:873-80. 2011
    ..Furthermore, we propose that the location of the mutation is reflected in the phenotypic features as a gradient from DD-II to more severe disease that does not conform to the classic definitions of DI-II...
  4. doi request reprint DLX3 homeodomain mutations cause tricho-dento-osseous syndrome with novel phenotypes
    Pekka Nieminen
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Cells Tissues Organs 194:49-59. 2011
    ..After mutational analysis of DLX3, we identified 2 missense mutations affecting the conserved homeodomain. We suggest that TDO is essentially caused by loss of function and haploinsufficiency of DLX3...
  5. ncbi request reprint MSX1 gene is deleted in Wolf-Hirschhorn syndrome patients with oligodontia
    P Nieminen
    Institute of Dentistry, Biomedicum, PO Box 63, FIN 00014 University of Helsinki, Finland
    J Dent Res 82:1013-7. 2003
    ..One of these presented with the only case of cleft palate among the patients. Our result confirms that haploinsufficiency for MSX1 serves as a mechanism that causes selective tooth agenesis but, alone, is not enough to cause oral clefts...
  6. ncbi request reprint Identification of a nonsense mutation in the PAX9 gene in molar oligodontia
    P Nieminen
    Institute of Biotechnology, University of Helsinki, Finland
    Eur J Hum Genet 9:743-6. 2001
    ..The phenotype is presumably a consequence of haploinsufficiency of PAX9. In another Finnish family with molar tooth agenesis, we could not find similar sequence changes in PAX9...
  7. pmc Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth
    Pekka Nieminen
    Institute of Dentistry, Biomedicum, University of Helsinki, Finland
    Am J Hum Genet 89:67-81. 2011
    ..The results open up the possibility of modulation of IL11 signaling for the treatment of craniosynostosis...
  8. ncbi request reprint A graphical WWW-database on gene expression in tooth
    P Nieminen
    Institute of Biotechnology, University of Helsinki, Finland
    Eur J Oral Sci 106:7-11. 1998
    ..The pages also provide links to other biological databases on the Internet, both as context-dependent and as general links. We welcome submissions from researches elsewhere to include their information of gene expression and function...
  9. ncbi request reprint TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis
    J Laurikkala
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 229:443-55. 2001
    ..This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways...
  10. ncbi request reprint Effect of organised screening on cervical cancer incidence and mortality in Finland, 1963-1995: recent increase in cervical cancer incidence
    A Anttila
    Finnish Cancer Registry, Helsinki, Finland
    Int J Cancer 83:59-65. 1999
    ..Expanding the coverage of and attendance in the pap-screening programme among women in young target ages would still be effective. Increasing emphasis on quality assessment in screening is also needed...
  11. ncbi request reprint Characteristics of incisor-premolar hypodontia in families
    S Arte
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    J Dent Res 80:1445-50. 2001
    ..We conclude that incisor-premolar hypodontia is a genetic condition with autosomal-dominant transmission and that it is associated with several other dental abnormalities...
  12. ncbi request reprint Organised vs. spontaneous Pap-smear screening for cervical cancer: A case-control study
    P Nieminen
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Cancer 83:55-8. 1999
    ..Our results indicate that the substantial decrease in the incidence of and mortality due to cervical cancer in Finland is mainly due to the organised mass-screening...
  13. ncbi request reprint Tooth morphogenesis and cell differentiation
    I Thesleff
    Institute of Biotechnology, PO Box 56, FIN 00014 University of Helsinki, Finland
    Curr Opin Cell Biol 8:844-50. 1996
    ..It has recently become evident that the signaling networks that operate in the development of mammalian teeth are similar to those that are involved in the development of other vertebrate organs...
  14. doi request reprint Pregnancy incidence and outcome among patients with cervical intraepithelial neoplasia: a retrospective cohort study
    I Kalliala
    Mass Screening Registry, Finnish Cancer Registry, Helsinki, Finland
    BJOG 119:227-35. 2012
    ..To investigate the effect of cervical intraepithelial neoplasia (CIN) treatment on incidence of pregnancy and pregnancy outcome...
  15. ncbi request reprint Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion
    M L Mikkola
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Helsinki, Finland
    Mech Dev 88:133-46. 1999
    ..Ectodysplasin is the first TNF-like signaling molecule described known to be required for epithelial morphogenesis...
  16. doi request reprint Large performance variation does not affect outcome in the Finnish cervical cancer screening programme
    S Lönnberg
    Finnish Cancer Registry, Helsinki, Finland
    Cytopathology 23:172-80. 2012
    ....
  17. ncbi request reprint Prerequisites for human papillomavirus vaccine trial: results of feasibility studies
    J Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290, Helsinki, Finland
    J Clin Virol 19:25-30. 2000
    ..First generation preventive vaccines against HPVs are entering clinical trials. Therefore, it is time to consider prerequisites of field trials in Finland...
  18. doi request reprint Elevation of surfactant protein A in plasma and sputum in cigarette smokers
    W Mazur
    Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Eur Respir J 38:277-84. 2011
    ..001). In conclusion, SP-A may be involved in pathogenesis of cigarette smoking-related lung diseases. Further studies are needed to elucidate the role of SP-A in chronic obstructive pulmonary disease...
  19. ncbi request reprint Cervical cancer screening programme in Finland
    A Anttila
    Finnish Cancer Registry, Liisankatu 21B, FIN 00170, Helsinki, Finland
    Eur J Cancer 36:2209-14. 2000
    ..By introducing modern screening technologies and more systematic quality control activities in the programme, and by expanding the coverage and compliance we expect to further increase the impact of the programme...
  20. doi request reprint Investigating the etiology of multiple tooth agenesis in three sisters with severe oligodontia
    S Swinnen
    Department of Orthodontics, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University Leuven, Leuven, Belgium
    Orthod Craniofac Res 11:24-31. 2008
    ..Based on the phenotypes in the pedigree of this family, the different possible patterns of transmission are discussed...
  21. ncbi request reprint Chicken B-cell-activating factor: regulator of B-cell survival in the bursa of fabricius
    K Koskela
    Turku Graduate School of Biomedical Sciences, Department of Medical Microbiology, University of Turku, Turku, Finland
    Scand J Immunol 59:449-57. 2004
    ..In conclusion, cBAFF is highly conserved structurally, but as a novel observation we suggest cBAFF to function in an autocrine fashion to promote the growth and maturation of follicular B cells in bursa of Fabricius...
  22. ncbi request reprint Novel mutation of the initiation codon of PAX9 causes oligodontia
    M L Klein
    Department of Pediatric Dentistry and Clinical Genetics, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Nørre Allé 20, DK 2200 Copenhagen, Denmark
    J Dent Res 84:43-7. 2005
    ..This is the first mutation found in the initiation codon of PAX9, and we suggest that it causes haploinsufficiency...
  23. ncbi request reprint Educational consequences of mental disorders treated in hospital. A 31-year follow-up of the Northern Finland 1966 Birth Cohort
    I Isohanni
    Department of Psychiatry, University of Oulu and Oulu Polytechnic, Finland
    Psychol Med 31:339-49. 2001
    ..Failure to complete higher education may contribute to the 'social exclusion' of the mentally ill through reduced opportunities in later occupational life and failure to accumulate social capital...
  24. ncbi request reprint Effects of seasonality and fasting on the body mass and plasma growth hormone concentrations of the raccoon dog (Nyctereutes procyonoides) and the blue fox (Alopex lagopus)
    A M Mustonen
    University of Joensuu, Department of Biology, Finland
    Z Naturforsch C 56:437-43. 2001
    ..The raccoon dog which spends the coldest part of the winter in winter sleep seems to be better adapted to a total fast than the actively wintering blue fox...
  25. ncbi request reprint Effects of moult, age, and sex on the accumulation of heavy metals in the otter (Lutra lutra) in Finland
    H Hyvärinen
    University of Joensuu, Department of Biology, Post Office Box 111, FIN 80101, Joensuu, Finland
    Bull Environ Contam Toxicol 70:278-84. 2003
  26. ncbi request reprint I. Genotype-environment interaction in the schizophrenia spectrum: genetic liability and global family ratings in the Finnish Adoption Study
    Lyman C Wynne
    Department of Psychiatry, University of Rochester, Rochester, New York, USA
    Fam Process 45:419-34. 2006
    ..Either low genetic liability or healthy rearing protected against a spectrum outcomes for the adoptees. Initial adoptive parent diagnosis, as a proxy for rearing family dysfunction, predicted to adoptee outcome only as a trend...
  27. ncbi request reprint Body size from birth to adulthood and bone mineral content and density at 31 years of age: results from the northern Finland 1966 birth cohort study
    J Laitinen
    Oulu Regional Institute of Occupational Health, Oulu, Finland
    Osteoporos Int 16:1417-24. 2005
    ..Thinness and a low calcium intake are associated with low bone mineral content and density at 31 years of age. Further studies are needed to evaluate if these groups are at increased risk of osteoporosis in old age...
  28. ncbi request reprint Cytopathology in Finland
    T Toivonen
    Department of Pathology, Pirkanmaa Hospital District Laboratory Centre, Finland
    Cytopathology 16:210-4. 2005
  29. ncbi request reprint Exclusion of coding region mutations in MSX1, PAX9 and AXIN2 in eight patients with severe oligodontia phenotype
    A Gerits
    Department of Orthodontics, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium
    Orthod Craniofac Res 9:129-36. 2006
    ..This paper describes the screening of eight patients with severe oligodontia for PAX9 and AXIN2 mutations...
  30. ncbi request reprint Risk factors associated with abundant dental caries and periodontal pocketing
    T Tervonen
    Department of Periodontology, University of Oulu, Finland
    Community Dent Oral Epidemiol 19:82-7. 1991
    ..In addition to social variables, behavioral factors were found to be significantly associated with periodontal pocketing and abundant untreated dental caries...