Research Topics
Genomes and Genes | P NieminenSummaryAffiliation: University of Helsinki Country: Finland Publications
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Detail Information
Publications
MSX1 gene is deleted in Wolf-Hirschhorn syndrome patients with oligodontiaP Nieminen
Institute of Dentistry, Biomedicum, PO Box 63, FIN 00014 University of Helsinki, Finland
J Dent Res 82:1013-7. 2003..One of these presented with the only case of cleft palate among the patients. Our result confirms that haploinsufficiency for MSX1 serves as a mechanism that causes selective tooth agenesis but, alone, is not enough to cause oral clefts...
Genetic basis of tooth agenesisPekka Nieminen
Institute of Dentistry, Biomedicum, University of Helsinki, Helsinki, Finland
J Exp Zool B Mol Dev Evol 312:320-42. 2009....- Frameshift mutations in dentin phosphoprotein and dependence of dentin disease phenotype on mutation locationPekka Nieminen
Institute of Dentistry, Biomedicum, University of Helsinki, Helsinki, Finland
J Bone Miner Res 26:873-80. 2011..Furthermore, we propose that the location of the mutation is reflected in the phenotypic features as a gradient from DD-II to more severe disease that does not conform to the classic definitions of DI-II... - DLX3 homeodomain mutations cause tricho-dento-osseous syndrome with novel phenotypesPekka Nieminen
Institute of Dentistry, University of Helsinki, Helsinki, Finland
Cells Tissues Organs 194:49-59. 2011..After mutational analysis of DLX3, we identified 2 missense mutations affecting the conserved homeodomain. We suggest that TDO is essentially caused by loss of function and haploinsufficiency of DLX3... 
Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teethPekka Nieminen
Institute of Dentistry, Biomedicum, University of Helsinki, Finland
Am J Hum Genet 89:67-81. 2011..The results open up the possibility of modulation of IL11 signaling for the treatment of craniosynostosis...- A graphical WWW-database on gene expression in toothP Nieminen
Institute of Biotechnology, University of Helsinki, Finland
Eur J Oral Sci 106:7-11. 1998..The pages also provide links to other biological databases on the Internet, both as context-dependent and as general links. We welcome submissions from researches elsewhere to include their information of gene expression and function... - Identification of a nonsense mutation in the PAX9 gene in molar oligodontiaP Nieminen
Institute of Biotechnology, University of Helsinki, Finland
Eur J Hum Genet 9:743-6. 2001..The phenotype is presumably a consequence of haploinsufficiency of PAX9. In another Finnish family with molar tooth agenesis, we could not find similar sequence changes in PAX9... - TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesisJ Laurikkala
Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
Dev Biol 229:443-55. 2001..This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways... - Effect of organised screening on cervical cancer incidence and mortality in Finland, 1963-1995: recent increase in cervical cancer incidenceA Anttila
Finnish Cancer Registry, Helsinki, Finland
Int J Cancer 83:59-65. 1999..Expanding the coverage of and attendance in the pap-screening programme among women in young target ages would still be effective. Increasing emphasis on quality assessment in screening is also needed... - Characteristics of incisor-premolar hypodontia in familiesS Arte
Department of Pedodontics and Orthodontics, University of Helsinki, Finland
J Dent Res 80:1445-50. 2001..We conclude that incisor-premolar hypodontia is a genetic condition with autosomal-dominant transmission and that it is associated with several other dental abnormalities... - Organised vs. spontaneous Pap-smear screening for cervical cancer: A case-control studyP Nieminen
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
Int J Cancer 83:55-8. 1999..Our results indicate that the substantial decrease in the incidence of and mortality due to cervical cancer in Finland is mainly due to the organised mass-screening... - Tooth morphogenesis and cell differentiationI Thesleff
Institute of Biotechnology, PO Box 56, FIN 00014 University of Helsinki, Finland
Curr Opin Cell Biol 8:844-50. 1996..It has recently become evident that the signaling networks that operate in the development of mammalian teeth are similar to those that are involved in the development of other vertebrate organs... - Pregnancy incidence and outcome among patients with cervical intraepithelial neoplasia: a retrospective cohort studyI Kalliala
Mass Screening Registry, Finnish Cancer Registry, Helsinki, Finland
BJOG 119:227-35. 2012..To investigate the effect of cervical intraepithelial neoplasia (CIN) treatment on incidence of pregnancy and pregnancy outcome... - Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesionM L Mikkola
Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Helsinki, Finland
Mech Dev 88:133-46. 1999..Ectodysplasin is the first TNF-like signaling molecule described known to be required for epithelial morphogenesis... - Large performance variation does not affect outcome in the Finnish cervical cancer screening programmeS Lönnberg
Finnish Cancer Registry, Helsinki, Finland
Cytopathology 23:172-80. 2012.... - Prerequisites for human papillomavirus vaccine trial: results of feasibility studiesJ Paavonen
Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290, Helsinki, Finland
J Clin Virol 19:25-30. 2000..First generation preventive vaccines against HPVs are entering clinical trials. Therefore, it is time to consider prerequisites of field trials in Finland... - Elevation of surfactant protein A in plasma and sputum in cigarette smokersW Mazur
Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Eur Respir J 38:277-84. 2011..001). In conclusion, SP-A may be involved in pathogenesis of cigarette smoking-related lung diseases. Further studies are needed to elucidate the role of SP-A in chronic obstructive pulmonary disease... - Cervical cancer screening programme in FinlandA Anttila
Finnish Cancer Registry, Liisankatu 21B, FIN 00170, Helsinki, Finland
Eur J Cancer 36:2209-14. 2000..By introducing modern screening technologies and more systematic quality control activities in the programme, and by expanding the coverage and compliance we expect to further increase the impact of the programme... - Investigating the etiology of multiple tooth agenesis in three sisters with severe oligodontiaS Swinnen
Department of Orthodontics, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University Leuven, Leuven, Belgium
Orthod Craniofac Res 11:24-31. 2008..Based on the phenotypes in the pedigree of this family, the different possible patterns of transmission are discussed... - Chicken B-cell-activating factor: regulator of B-cell survival in the bursa of fabriciusK Koskela
Turku Graduate School of Biomedical Sciences, Department of Medical Microbiology, University of Turku, Turku, Finland
Scand J Immunol 59:449-57. 2004..In conclusion, cBAFF is highly conserved structurally, but as a novel observation we suggest cBAFF to function in an autocrine fashion to promote the growth and maturation of follicular B cells in bursa of Fabricius... - Novel mutation of the initiation codon of PAX9 causes oligodontiaM L Klein
Department of Pediatric Dentistry and Clinical Genetics, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Nørre Allé 20, DK 2200 Copenhagen, Denmark
J Dent Res 84:43-7. 2005..This is the first mutation found in the initiation codon of PAX9, and we suggest that it causes haploinsufficiency... - Educational consequences of mental disorders treated in hospital. A 31-year follow-up of the Northern Finland 1966 Birth CohortI Isohanni
Department of Psychiatry, University of Oulu and Oulu Polytechnic, Finland
Psychol Med 31:339-49. 2001..Failure to complete higher education may contribute to the 'social exclusion' of the mentally ill through reduced opportunities in later occupational life and failure to accumulate social capital... - Effects of moult, age, and sex on the accumulation of heavy metals in the otter (Lutra lutra) in FinlandH Hyvärinen
University of Joensuu, Department of Biology, Post Office Box 111, FIN 80101, Joensuu, Finland
Bull Environ Contam Toxicol 70:278-84. 2003 - I. Genotype-environment interaction in the schizophrenia spectrum: genetic liability and global family ratings in the Finnish Adoption StudyLyman C Wynne
Department of Psychiatry, University of Rochester, Rochester, New York, USA
Fam Process 45:419-34. 2006..Either low genetic liability or healthy rearing protected against a spectrum outcomes for the adoptees. Initial adoptive parent diagnosis, as a proxy for rearing family dysfunction, predicted to adoptee outcome only as a trend... - Exclusion of coding region mutations in MSX1, PAX9 and AXIN2 in eight patients with severe oligodontia phenotypeA Gerits
Department of Orthodontics, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium
Orthod Craniofac Res 9:129-36. 2006..In this context the exact number of tested probands also should be mentioned at all cases. Recent evidence of PAX9-MSX1 protein interactions in odontogenesis as well as other genes and developmental factors should receive more attention... - Cytopathology in FinlandT Toivonen
Department of Pathology, Pirkanmaa Hospital District Laboratory Centre, Finland
Cytopathology 16:210-4. 2005 - Body size from birth to adulthood and bone mineral content and density at 31 years of age: results from the northern Finland 1966 birth cohort studyJ Laitinen
Oulu Regional Institute of Occupational Health, Oulu, Finland
Osteoporos Int 16:1417-24. 2005..Thinness and a low calcium intake are associated with low bone mineral content and density at 31 years of age. Further studies are needed to evaluate if these groups are at increased risk of osteoporosis in old age... - Effects of seasonality and fasting on the body mass and plasma growth hormone concentrations of the raccoon dog (Nyctereutes procyonoides) and the blue fox (Alopex lagopus)A M Mustonen
University of Joensuu, Department of Biology, Finland
Z Naturforsch C 56:437-43. 2001..The raccoon dog which spends the coldest part of the winter in winter sleep seems to be better adapted to a total fast than the actively wintering blue fox... - Risk factors associated with abundant dental caries and periodontal pocketingT Tervonen
Department of Periodontology, University of Oulu, Finland
Community Dent Oral Epidemiol 19:82-7. 1991..In addition to social variables, behavioral factors were found to be significantly associated with periodontal pocketing and abundant untreated dental caries...