Tapio Nevalainen

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. Nevalainen T, Kananen L, Marttila S, Jylhä M, Hervonen A, Hurme M, et al. Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study. Age (Dordr). 2015;37:9814 pubmed publisher
    ..These differences point to the genomic regulation of inflammatory response and suggest that the gender-specific immune system dimorphism in older individuals could be accounted for, in part, by DNA methylation. ..
  2. Kananen L, Nevalainen T, Jylhävä J, Marttila S, Hervonen A, Jylhä M, et al. Cytomegalovirus infection accelerates epigenetic aging. Exp Gerontol. 2015;72:227-9 pubmed publisher
    ..5 vs. 24.0 (p < 0.02,Mann–Whitney U-test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes. ..
  3. Kananen L, Marttila S, Nevalainen T, Jylhävä J, Mononen N, Kähönen M, et al. Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. BMC Genomics. 2016;17:103 pubmed publisher
    ..We speculate that the a-CpGs identified here in a population with a narrow age-range represent clock-like changes, as they showed concordant methylation behavior in population spanning whole adulthood as well. ..
  4. Marttila S, Kananen L, Häyrynen S, Jylhävä J, Nevalainen T, Hervonen A, et al. Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics. 2015;16:179 pubmed publisher