Affiliation: University of Tampere
Nevalainen T, Kananen L, Marttila S, JylhÃ¤ M, Hervonen A, Hurme M, et al
. Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study. Age (Dordr). 2015;37:9814 pubmed publisher
..These differences point to the genomic regulation of inflammatory response and suggest that the gender-specific immune system dimorphism in older individuals could be accounted for, in part, by DNA methylation. ..
Kananen L, Nevalainen T, JylhÃ¤vÃ¤ J, Marttila S, Hervonen A, JylhÃ¤ M, et al
. Cytomegalovirus infection accelerates epigenetic aging. Exp Gerontol. 2015;72:227-9 pubmed publisher
..5 vs. 24.0 (p < 0.02,Mannâ€“Whitney U-test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes. ..
Kananen L, Marttila S, Nevalainen T, JylhÃ¤vÃ¤ J, Mononen N, KÃ¤hÃ¶nen M, et al
. Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. BMC Genomics. 2016;17:103 pubmed publisher
..We speculate that the a-CpGs identified here in a population with a narrow age-range represent clock-like changes, as they showed concordant methylation behavior in population spanning whole adulthood as well. ..
Marttila S, Kananen L, HÃ¤yrynen S, JylhÃ¤vÃ¤ J, Nevalainen T, Hervonen A, et al
. Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics. 2015;16:179 pubmed publisher