Päivi K Myllynen

Summary

Affiliation: University of Oulu
Country: Finland

Publications

  1. ncbi request reprint Transplacental passage of oxcarbazepine and its metabolites in vivo
    P Myllynen
    Department of Pharmacology and Toxicology, University Hospital of Oulu, Oulu, Finland
    Epilepsia 42:1482-5. 2001
  2. ncbi request reprint Transplacental passage of lamotrigine in a human placental perfusion system in vitro and in maternal and cord blood in vivo
    Päivi K Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, PO Box 5000, FIN 90014, Oulu, Finland
    Eur J Clin Pharmacol 58:677-82. 2003
  3. ncbi request reprint An examination of whether human placental perfusion allows accurate prediction of placental drug transport: studies with diazepam
    P Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    J Pharmacol Toxicol Methods 48:131-8. 2002
  4. ncbi request reprint Human placenta: a human organ for developmental toxicology research and biomonitoring
    P Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, PO Box 5000, FIN 90014 Oulu, Finland
    Placenta 26:361-71. 2005
  5. ncbi request reprint Human placental perfusion method in the assessment of transplacental passage of antiepileptic drugs
    Päivi Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, PO Box 5000, 90014 Oulu, Finland
    Toxicol Appl Pharmacol 207:489-94. 2005
  6. ncbi request reprint DNA damage caused by benzo(a)pyrene in MCF-7 cells is increased by verapamil, probenecid and PSC833
    P Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland
    Toxicol Lett 169:3-12. 2007
  7. doi request reprint Kinetics of gold nanoparticles in the human placenta
    Päivi K Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland
    Reprod Toxicol 26:130-7. 2008
  8. doi request reprint Aflatoxin B1 transfer and metabolism in human placenta
    Heidi A Partanen
    Department of Pharmacology and Toxicology, University of Kuopio, FIN 70211 Kuopio, Finland
    Toxicol Sci 113:216-25. 2010

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Transplacental passage of oxcarbazepine and its metabolites in vivo
    P Myllynen
    Department of Pharmacology and Toxicology, University Hospital of Oulu, Oulu, Finland
    Epilepsia 42:1482-5. 2001
    ..The purpose of this study was to investigate human fetal exposure to oxcarbazepine (OCBZ) in vivo...
  2. ncbi request reprint Transplacental passage of lamotrigine in a human placental perfusion system in vitro and in maternal and cord blood in vivo
    Päivi K Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, PO Box 5000, FIN 90014, Oulu, Finland
    Eur J Clin Pharmacol 58:677-82. 2003
    ..We studied transplacental passage of lamotrigine (3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine; LTG) using an ex vivo human placental perfusion method and in in vivo samples...
  3. ncbi request reprint An examination of whether human placental perfusion allows accurate prediction of placental drug transport: studies with diazepam
    P Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    J Pharmacol Toxicol Methods 48:131-8. 2002
    ..We studied the transplacental passage of diazepam (DZP) in a recirculating dual human placental perfusion and compared the data with in vivo clinical data from the literature...
  4. ncbi request reprint Human placenta: a human organ for developmental toxicology research and biomonitoring
    P Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, PO Box 5000, FIN 90014 Oulu, Finland
    Placenta 26:361-71. 2005
    ..The toxicological effects of maternal medications, smoking, and environmental exposures (dioxins, pesticides) as well as some possibilities for biomonitoring will be highlighted...
  5. ncbi request reprint Human placental perfusion method in the assessment of transplacental passage of antiepileptic drugs
    Päivi Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, PO Box 5000, 90014 Oulu, Finland
    Toxicol Appl Pharmacol 207:489-94. 2005
    ..According to perfusion data, it seems that most of the antiepileptic drugs are transferred across the placenta meaning significant fetal exposure...
  6. ncbi request reprint DNA damage caused by benzo(a)pyrene in MCF-7 cells is increased by verapamil, probenecid and PSC833
    P Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland
    Toxicol Lett 169:3-12. 2007
    ....
  7. doi request reprint Kinetics of gold nanoparticles in the human placenta
    Päivi K Myllynen
    Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland
    Reprod Toxicol 26:130-7. 2008
    ..Whether PEGylated gold nanoparticles eventually are able to cross placenta and whether nanoparticles affect placental functions needs to be further studied...
  8. doi request reprint Aflatoxin B1 transfer and metabolism in human placenta
    Heidi A Partanen
    Department of Pharmacology and Toxicology, University of Kuopio, FIN 70211 Kuopio, Finland
    Toxicol Sci 113:216-25. 2010
    ..AFL was the only metabolite detected in both perfusions and in vitro incubations. Since AFL is less mutagenic, but putatively as carcinogenic as AFB1, the formation of AFL may not protect the fetus from the toxicity of AFB1...