Liisa Myllykangas

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Cardiovascular risk factors and Alzheimer's disease: a genetic association study in a population aged 85 or over
    L Myllykangas
    Neurogenetics Laboratory, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurosci Lett 292:195-8. 2000
  2. doi request reprint Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old: a population-based autopsy study
    Liisa Myllykangas
    Folkhälsan Institute of Genetics and Department of Pathology, University of Helsinki and Helsinki University Central Hospital, POB 63, 00014 Helsinki, Finland
    Arch Gerontol Geriatr 49:108-12. 2009
  3. ncbi request reprint [A fruit fly (Drosophila melanogaster) as a model organism for studies of brain diseases]
    Liisa Myllykangas
    Folkhälsanin perinnöllisyystieteen laitos jaa Neurotieteen tutkimuskeskus, Biomedicum Helsinki, Helsingin yliopisto
    Duodecim 122:443-50. 2006
  4. pmc APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis
    Terhi Peuralinna
    University of Helsinki, Research Program of Molecular Neurology, Biomedicum Helsinki, Helsinki, Finland
    J Alzheimers Dis 26:377-85. 2011
  5. ncbi request reprint ApoE epsilon3-haplotype modulates Alzheimer beta-amyloid deposition in the brain
    Liisa Myllykangas
    Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Am J Med Genet 114:288-91. 2002
  6. doi request reprint Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study
    Maarit Tanskanen
    Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Ann Med 40:232-9. 2008
  7. doi request reprint alpha-Synuclein pathology in the spinal cord autonomic nuclei associates with alpha-synuclein pathology in the brain: a population-based Vantaa 85+ study
    Minna Oinas
    Department of Pathology, Helsinki University Central Hospital, University of Helsinki, P O Box 21, Haartmaninkatu 3, 00014 Helsinki, Finland
    Acta Neuropathol 119:715-22. 2010
  8. doi request reprint Matrix metalloproteinase-β19 expressed in cerebral amyloid angiopathy
    Maarit Tanskanen
    Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Amyloid 18:3-9. 2011
  9. pmc Novel mutations consolidate KCTD7 as a progressive myoclonus epilepsy gene
    Maria Kousi
    Folkhalsan Institute of Genetics, Biomedicum Helsinki, PO Box 63, Haartmaninkatu 8, University of Helsinki, FIN 00014 Helsinki, Finland
    J Med Genet 49:391-9. 2012
  10. doi request reprint Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis
    Mervi Kuronen
    Folkhalsan Institute of Genetics, Biomedicum Helsinki, Helsinki, Finland
    Neurobiol Dis 36:488-93. 2009

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Cardiovascular risk factors and Alzheimer's disease: a genetic association study in a population aged 85 or over
    L Myllykangas
    Neurogenetics Laboratory, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurosci Lett 292:195-8. 2000
    ..095) towards protection against neuropathologically defined AD. Our study is based on very elderly Finns. Therefore, further studies are warranted in other populations...
  2. doi request reprint Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old: a population-based autopsy study
    Liisa Myllykangas
    Folkhälsan Institute of Genetics and Department of Pathology, University of Helsinki and Helsinki University Central Hospital, POB 63, 00014 Helsinki, Finland
    Arch Gerontol Geriatr 49:108-12. 2009
    ..035). Our results suggest that the APOE epsilon4, epsilon2 and LPL Ser447Ter variants may have different roles in the atherosclerotic process and their effects are seen even in the oldest old population...
  3. ncbi request reprint [A fruit fly (Drosophila melanogaster) as a model organism for studies of brain diseases]
    Liisa Myllykangas
    Folkhälsanin perinnöllisyystieteen laitos jaa Neurotieteen tutkimuskeskus, Biomedicum Helsinki, Helsingin yliopisto
    Duodecim 122:443-50. 2006
  4. pmc APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis
    Terhi Peuralinna
    University of Helsinki, Research Program of Molecular Neurology, Biomedicum Helsinki, Helsinki, Finland
    J Alzheimers Dis 26:377-85. 2011
    ..Promoter mutations or common allelic variation in the AβPP gene do not have a major contribution to cortical or cerebrovascular Aβ deposition, or very late-onset AD in this Finnish population based study...
  5. ncbi request reprint ApoE epsilon3-haplotype modulates Alzheimer beta-amyloid deposition in the brain
    Liisa Myllykangas
    Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Am J Med Genet 114:288-91. 2002
    ..These results indicate that there is significant allelic variation in the ApoE gene region, which modulates brain amyloid deposition and AD risk, independent of the ApoE protein polymorphism...
  6. doi request reprint Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study
    Maarit Tanskanen
    Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Ann Med 40:232-9. 2008
    ..Senile systemic amyloidosis (SSA) is characterized by deposition of wild-type transthyretin (TTR)-based amyloid in parenchymal organs in elderly individuals. Previously, no population-based studies have been performed on SSA...
  7. doi request reprint alpha-Synuclein pathology in the spinal cord autonomic nuclei associates with alpha-synuclein pathology in the brain: a population-based Vantaa 85+ study
    Minna Oinas
    Department of Pathology, Helsinki University Central Hospital, University of Helsinki, P O Box 21, Haartmaninkatu 3, 00014 Helsinki, Finland
    Acta Neuropathol 119:715-22. 2010
    ..alphaS pathology exclusively in the spinal cord was rare. Our study indicates that in general alphaS pathology in the spinal cord autonomic nuclei is associated with similar pathology in the brain...
  8. doi request reprint Matrix metalloproteinase-β19 expressed in cerebral amyloid angiopathy
    Maarit Tanskanen
    Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Amyloid 18:3-9. 2011
    ..Previous studies have revealed matrix metalloproteinase (MMP) expression in a mouse model of CAA and in human intracerebral haemorrhage. Here we studied the involvement of MMPs in human CAA and CAAH...
  9. pmc Novel mutations consolidate KCTD7 as a progressive myoclonus epilepsy gene
    Maria Kousi
    Folkhalsan Institute of Genetics, Biomedicum Helsinki, PO Box 63, Haartmaninkatu 8, University of Helsinki, FIN 00014 Helsinki, Finland
    J Med Genet 49:391-9. 2012
    ..This study aimed to identify the underlying gene(s) in childhood onset PME patients with unknown molecular genetic background...
  10. doi request reprint Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis
    Mervi Kuronen
    Folkhalsan Institute of Genetics, Biomedicum Helsinki, Helsinki, Finland
    Neurobiol Dis 36:488-93. 2009
    ..Our results warrant further investigation of these mechanisms in the pathogenesis of cathepsin D deficiency...
  11. doi request reprint Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein
    Terhi Peuralinna
    Molecular Neurology Programme, Biomedicum, University of Helsinki, Helsinki, Finland
    Ann Neurol 64:348-52. 2008
    ..These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration...
  12. ncbi request reprint Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses
    Liisa Myllykangas
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB Room 652, Boston, MA 02115, USA
    Neurobiol Dis 19:194-9. 2005
    ..Our results suggest that the metabolic pathway leading to NCL pathology is highly conserved during evolution, and that cathepsin D mutant flies can be used to study the pathogenesis of NCLs...
  13. ncbi request reprint Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study
    Liisa Myllykangas
    Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
    J Neurol Sci 236:17-24. 2005
    ..08). BACE2 haplotype association with AD in two independent datasets provides further evidence for an AD susceptibility locus on chromosome 21q within or close to BACE2...