- Mykkänen K, Savontaus M, Juvonen V, Sistonen P, Tuisku S, Tuominen S, et al. Detection of the founder effect in Finnish CADASIL families. Eur J Hum Genet. 2004;12:813-9 pubmed..The age analysis of the founder mutation places the introduction of the mutation in the late 1600s or early 1700s. ..