Taru Muranen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin
    Minja Laulajainen
    Biomedicum Helsinki, Department of Pathology, University of Helsinki, Helsinki, Finland
    Neoplasia 13:643-52. 2011
  2. ncbi request reprint Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin
    Taru Muranen
    Program of Neuroscience, Biomedicum Helsinki, Department of Pathology, University of Helsinki and Helsinki University Hospital, PB 63, Helsinki 00014, Finland
    Oncogene 24:1150-8. 2005
  3. ncbi request reprint The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton
    Taru Muranen
    Program of Neuroscience, Department of Pathology, University of Helsinki, Biomedicum Helsinki C511, PL 63, 0014, Finland
    Hum Mol Genet 16:1742-51. 2007
  4. doi request reprint Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity
    Minja Laulajainen
    Biomedicum Helsinki, Department of Pathology, University of Helsinki, Helsinki, Finland
    J Cell Mol Med 16:2161-75. 2012

Detail Information

Publications4

  1. pmc Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin
    Minja Laulajainen
    Biomedicum Helsinki, Department of Pathology, University of Helsinki, Helsinki, Finland
    Neoplasia 13:643-52. 2011
    ..On the basis of these findings, we propose a model for a posttranslational mechanism of merlin inactivation...
  2. ncbi request reprint Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin
    Taru Muranen
    Program of Neuroscience, Biomedicum Helsinki, Department of Pathology, University of Helsinki and Helsinki University Hospital, PB 63, Helsinki 00014, Finland
    Oncogene 24:1150-8. 2005
    ..Unlike ERK2, nuclear localization of merlin was not, however, dependent on intact actin cytoskeleton. These results link merlin to events related to cell cycle control and may help to resolve its tumour suppressor function...
  3. ncbi request reprint The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton
    Taru Muranen
    Program of Neuroscience, Department of Pathology, University of Helsinki, Biomedicum Helsinki C511, PL 63, 0014, Finland
    Hum Mol Genet 16:1742-51. 2007
    ..The results show that merlin plays a key role in the regulation of the Schwann cell microtubule cytoskeleton and suggest a mechanism by which loss of merlin leads to cytoskeletal defects observed in human schwannomas...
  4. doi request reprint Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity
    Minja Laulajainen
    Biomedicum Helsinki, Department of Pathology, University of Helsinki, Helsinki, Finland
    J Cell Mol Med 16:2161-75. 2012
    ..This study demonstrates that the C-terminus contains distinct but overlapping functional domains important for regulation of the morphogenic activity, intramolecular associations and cell proliferation...