M L Mikkola

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion
    M L Mikkola
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Helsinki, Finland
    Mech Dev 88:133-46. 1999
  2. ncbi p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
    Johanna Laurikkala
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 133:1553-63. 2006
  3. ncbi Genetic basis of skin appendage development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, P O Box 56 Viikinkaari 9, University of Helsinki, 00014 Helsinki, Finland
    Semin Cell Dev Biol 18:225-36. 2007
  4. ncbi Molecular aspects of hypohidrotic ectodermal dysplasia
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Am J Med Genet A 149:2031-6. 2009
  5. ncbi TNF superfamily in skin appendage development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
    Cytokine Growth Factor Rev 19:219-30. 2008
  6. ncbi p63 in skin appendage development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Finland
    Cell Cycle 6:285-90. 2007
  7. ncbi Controlling the number of tooth rows
    Marja L Mikkola
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Sci Signal 2:pe53. 2009
  8. ncbi Ectodysplasin signaling in development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, PO Box 56, Helsinki 00014, Finland
    Cytokine Growth Factor Rev 14:211-24. 2003
  9. ncbi Signaling and subcellular localization of the TNF receptor Edar
    P Koppinen
    Developmental Biology Program, University of Helsinki, Helsinki, 00014, Finland
    Exp Cell Res 269:180-92. 2001
  10. ncbi Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development
    Johanna Pispa
    Developmental Biology Program, Institute of Biotechnology, 00014 University of Helsinki, PO Box 56, Finland
    Hum Mol Genet 17:3380-91. 2008

Collaborators

Detail Information

Publications19

  1. ncbi Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion
    M L Mikkola
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Helsinki, Finland
    Mech Dev 88:133-46. 1999
    ..Ectodysplasin is the first TNF-like signaling molecule described known to be required for epithelial morphogenesis...
  2. ncbi p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
    Johanna Laurikkala
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 133:1553-63. 2006
    ..We also demonstrate that BMP2, BMP7 and FGF10 are potent inducers of p63 in cultured tissue explants. Hence, we suggest that p63 regulates the morphogenesis of surface ectoderm and its derivatives via multiple signalling pathways...
  3. ncbi Genetic basis of skin appendage development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, P O Box 56 Viikinkaari 9, University of Helsinki, 00014 Helsinki, Finland
    Semin Cell Dev Biol 18:225-36. 2007
    ..After the bud stage, these organs adopt diverse patterns of epithelial growth, reflected in the usage of more divergent genes in each...
  4. ncbi Molecular aspects of hypohidrotic ectodermal dysplasia
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Am J Med Genet A 149:2031-6. 2009
    ..The developmental role of Eda will be discussed in light of loss- and gain-of-function mouse models with emphasis on the past few years...
  5. ncbi TNF superfamily in skin appendage development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P O Box 56, 00014 Helsinki, Finland
    Cytokine Growth Factor Rev 19:219-30. 2008
    ..This review focuses on the novel discoveries of Eda and other TNF related cytokines in skin appendage development made since the previous review on this topic in Cytokine and Growth Factor reviews in 2003...
  6. ncbi p63 in skin appendage development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Finland
    Cell Cycle 6:285-90. 2007
    ..This review discusses the current knowledge on the role of p63 in skin appendage development with emphasis on teeth and hair follicles...
  7. ncbi Controlling the number of tooth rows
    Marja L Mikkola
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Sci Signal 2:pe53. 2009
    ....
  8. ncbi Ectodysplasin signaling in development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, PO Box 56, Helsinki 00014, Finland
    Cytokine Growth Factor Rev 14:211-24. 2003
    ....
  9. ncbi Signaling and subcellular localization of the TNF receptor Edar
    P Koppinen
    Developmental Biology Program, University of Helsinki, Helsinki, 00014, Finland
    Exp Cell Res 269:180-92. 2001
    ..This together with differences in NF-kappaB responses suggests an explanation for the different mode of inheritance of the different downless alleles...
  10. ncbi Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development
    Johanna Pispa
    Developmental Biology Program, Institute of Biotechnology, 00014 University of Helsinki, PO Box 56, Finland
    Hum Mol Genet 17:3380-91. 2008
    ....
  11. ncbi Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes
    Ingrid Fliniaux
    Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 320:60-71. 2008
    ..Several pieces of evidence suggest Lrp4 as a Wnt inhibitor, as well. The finding that Eda-A1 induces placode inhibitors was unexpected, and underlines the importance of delicate fine-tuning of signalling during placode formation...
  12. ncbi Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages
    Tuija Mustonen
    Developmental Biology Program, Institute of Biotechnology, PO Box 56 Viikinkaari 9, University of Helsinki, Finland
    Development 131:4907-19. 2004
    ..Taken together, our results suggest that Eda-A1 signalling promotes placodal cell fate during early development of ectodermal organs...
  13. ncbi Stimulation of ectodermal organ development by Ectodysplasin-A1
    Tuija Mustonen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 259:123-36. 2003
    ..We conclude that ectodysplasin-Edar signaling has several roles in ectodermal organ development controlling their initiation, as well as morphogenesis and differentiation...
  14. ncbi Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation
    Katja Närhi
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN 00014, Helsinki, Finland
    Development 135:1019-28. 2008
    ..Our data suggest that BMPs are downstream of Wnt/beta-catenin and that their interplay may be a critical component in establishing correct patterning of hair follicles through the reaction-diffusion mechanism...
  15. ncbi Death receptor signaling giving life to ectodermal organs
    Irma Thesleff
    Developmental Biology Program, Insitute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, 00014 Helsinki, Finland
    Sci STKE 2002:pe22. 2002
    ..It is also necessary for the development of fish scales, indicating that this pathway and its function have been conserved during the evolution of ectodermal organs...
  16. ncbi Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    Dev Dyn 231:432-40. 2004
    ..In addition, tooth enamel formation is defective in a dose-dependent manner. We speculate that the tooth patterning defects are caused by ectopic Edar activity outside the signaling centers...
  17. ncbi Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression
    Marja Pummila
    Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014 Helsinki, Finland
    Development 134:117-25. 2007
    ..Moreover, our data indicate that Shh is a likely transcriptional target of Edar, but, unlike noggin, recombinant Shh was unable to rescue primary hair placode formation in Eda-deficient skin explants...
  18. ncbi Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Gene Expr Patterns 3:675-9. 2003
    ..We also studied the expression pattern of a related TNF receptor, TNFRSF19, and show that it is expressed in an overlapping domain with Edar in the tooth, mammary gland, whiskers, and limb bud suggesting a potentially redundant role...
  19. ncbi The mammary bud as a skin appendage: unique and shared aspects of development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, PO Box 56, Viikinkaari 9, Helsinki, 00014, Finland
    J Mammary Gland Biol Neoplasia 11:187-203. 2006
    ....