Susanna Miettinen

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. ncbi request reprint Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells
    Susanna Miettinen
    Department of Cell Biology, Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 108:367-73. 2004
  2. doi request reprint Characterization of zinc-releasing three-dimensional bioactive glass scaffolds and their effect on human adipose stem cell proliferation and osteogenic differentiation
    Suvi Haimi
    Regea Institute for Regenerative Medicine, University of Tampere, Biokatu 12, 33520 Tampere, Finland
    Acta Biomater 5:3122-31. 2009
  3. pmc Differential gene expression in adipose stem cells cultured in allogeneic human serum versus fetal bovine serum
    Bettina Lindroos
    Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    Tissue Eng Part A 16:2281-94. 2010
  4. doi request reprint Calcium phosphate surface treatment of bioactive glass causes a delay in early osteogenic differentiation of adipose stem cells
    Suvi Haimi
    Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Biomed Mater Res A 91:540-7. 2009
  5. pmc Characterizing and optimizing poly-L-lactide-co-ε-caprolactone membranes for urothelial tissue engineering
    Reetta Sartoneva
    Institute of Biomedical Technology, University of Tampere, Tampere, Finland
    J R Soc Interface 9:3444-54. 2012
  6. pmc The effects of vibration loading on adipose stem cell number, viability and differentiation towards bone-forming cells
    Laura Tirkkonen
    Institute of Biomedical Technology, University of Tampere, Finland
    J R Soc Interface 8:1736-47. 2011
  7. ncbi request reprint Expression of nuclear receptors and cofactors in human endometrium and myometrium
    Annika Vienonen
    Department of Cell Biology, Medical School, University of Tampere, Tampere, Finland
    J Soc Gynecol Investig 11:104-12. 2004
  8. pmc Comparison of a poly-L-lactide-co-ε-caprolactone and human amniotic membrane for urothelium tissue engineering applications
    Reetta Sartoneva
    Regea Institute for Regenerative Medicine, University of Tampere, Tampere, Finland
    J R Soc Interface 8:671-7. 2011
  9. ncbi request reprint Steroid hormone receptors and coregulators in endocrine-resistant and estrogen-independent breast cancer cells
    Nanna Sarvilinna
    Department of Cell Biology, Medical School, University of Tampere, Finland
    Int J Cancer 118:832-40. 2006
  10. pmc Use of adipose stem cells and polylactide discs for tissue engineering of the temporomandibular joint disc
    Katja Mäenpää
    Department of Cell Biology, Medical School, and REGEA Institute for Regenerative Medicine, FM5 Regea, University of Tampere, 33014 Tampere, Finland
    J R Soc Interface 7:177-88. 2010

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells
    Susanna Miettinen
    Department of Cell Biology, Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 108:367-73. 2004
    ..The possible mitogenic effects of vitamin D should be considered when evaluating treatment of ovarian cancer with vitamin D...
  2. doi request reprint Characterization of zinc-releasing three-dimensional bioactive glass scaffolds and their effect on human adipose stem cell proliferation and osteogenic differentiation
    Suvi Haimi
    Regea Institute for Regenerative Medicine, University of Tampere, Biokatu 12, 33520 Tampere, Finland
    Acta Biomater 5:3122-31. 2009
    ..Our results suggest that the possible stimulatory effect of addition of zinc on hASC proliferation and osteogenesis was not detected because addition of zinc slowed down the degradation rate of the studied bioactive glass scaffolds...
  3. pmc Differential gene expression in adipose stem cells cultured in allogeneic human serum versus fetal bovine serum
    Bettina Lindroos
    Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    Tissue Eng Part A 16:2281-94. 2010
    ..The data presented here underscore the importance of thorough investigation of ASCs for utilization in cell therapies. This study is a step forward in the understanding of these potential cells...
  4. doi request reprint Calcium phosphate surface treatment of bioactive glass causes a delay in early osteogenic differentiation of adipose stem cells
    Suvi Haimi
    Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Biomed Mater Res A 91:540-7. 2009
    ..In conclusion, osteogenic differentiation appears to be delayed on the Ca-P surface-treated scaffolds. This delay is more pronounced with thick Ca-P treatment of the scaffolds...
  5. pmc Characterizing and optimizing poly-L-lactide-co-ε-caprolactone membranes for urothelial tissue engineering
    Reetta Sartoneva
    Institute of Biomedical Technology, University of Tampere, Tampere, Finland
    J R Soc Interface 9:3444-54. 2012
    ..In conclusion, in light of our cell culture results and mechanical characterization, both sPLCL and tPLCL should be further studied for urothelial tissue engineering...
  6. pmc The effects of vibration loading on adipose stem cell number, viability and differentiation towards bone-forming cells
    Laura Tirkkonen
    Institute of Biomedical Technology, University of Tampere, Finland
    J R Soc Interface 8:1736-47. 2011
    ..Vibration did not affect cell number or viability. These findings suggest that osteogenic culture conditions amplify the stimulatory effect of vibration loading on differentiation of hASCs towards bone-forming cells...
  7. ncbi request reprint Expression of nuclear receptors and cofactors in human endometrium and myometrium
    Annika Vienonen
    Department of Cell Biology, Medical School, University of Tampere, Tampere, Finland
    J Soc Gynecol Investig 11:104-12. 2004
    ..To study the expression of nuclear receptors and cofactors in human endometrium and myometrium in proliferative and secretory phases of the menstrual cycle...
  8. pmc Comparison of a poly-L-lactide-co-ε-caprolactone and human amniotic membrane for urothelium tissue engineering applications
    Reetta Sartoneva
    Regea Institute for Regenerative Medicine, University of Tampere, Tampere, Finland
    J R Soc Interface 8:671-7. 2011
    ..The PLCL membranes supported the hUC proliferation significantly more than the hAM. These results revealed the significant potential of PLCL membranes in urothelial tissue engineering applications...
  9. ncbi request reprint Steroid hormone receptors and coregulators in endocrine-resistant and estrogen-independent breast cancer cells
    Nanna Sarvilinna
    Department of Cell Biology, Medical School, University of Tampere, Finland
    Int J Cancer 118:832-40. 2006
    ..Their growth was inhibited by toremifene, but estradiol was able to abrogate this effect, which might have interesting clinical implications concerning the use of postmenopausal hormone replacement therapy...
  10. pmc Use of adipose stem cells and polylactide discs for tissue engineering of the temporomandibular joint disc
    Katja Mäenpää
    Department of Cell Biology, Medical School, and REGEA Institute for Regenerative Medicine, FM5 Regea, University of Tampere, 33014 Tampere, Finland
    J R Soc Interface 7:177-88. 2010
    ..Accordingly, the combination of ASCs and PLA discs has potential for the development of a tissue-engineered TMJ disc replacement...
  11. doi request reprint Adipose stromal cell tubule network model provides a versatile tool for vascular research and tissue engineering
    Jertta Riina Sarkanen
    Department of Cell Biology, Finnish Center for Alternative Methods, School of Medicine, University of Tampere, Tampere, Finland
    Cells Tissues Organs 196:385-97. 2012
    ..This tubular network model is an excellent tool for studying cell interactions during vascular development, for chemical and drug testing and for developing natural-like, multilayered, vascularized, scaffold-free tissue models...
  12. doi request reprint Serum-free, xeno-free culture media maintain the proliferation rate and multipotentiality of adipose stem cells in vitro
    Bettina Lindroos
    University of Tampere and Tampere University Hospital, Regea Institute for Regenerative Medicine, Tampere, Finland
    Cytotherapy 11:958-72. 2009
    ....
  13. ncbi request reprint Behavioural anomalies in mice evoked by "Tokyo" disruption of the Vitamin D receptor gene
    Allan V Kalueff
    Medical School, University of Tampere, Finland
    Neurosci Res 54:254-60. 2006
    ..Taken together, these findings confirm the important role postulated for the VDR in the regulation of behaviour, and suggest the mice lacking functional VDR may be a useful tool to model different brain disorders...
  14. doi request reprint Inhibition of P-glycoprotein-mediated docetaxel efflux sensitizes ovarian cancer cells to concomitant docetaxel and SN-38 exposure
    Susanna Miettinen
    Department of Cell Biology, Medical School, University of Tampere, Finland
    Anticancer Drugs 20:267-76. 2009
    ..The simultaneous administration of a P-gp inhibitor may prevent docetaxel efflux, thereby sensitizing cells to docetaxel and other chemotherapeutic agents...
  15. ncbi request reprint Regulation of nuclear receptor and cofactor expression in breast cancer cell lines
    Annika Vienonen
    Department of Cell Biology, Medical School, University of Tampere, FIN 33014 Tampere, Finland
    Eur J Endocrinol 148:469-79. 2003
    ..The aim of this study was to compare the expression profile of nuclear receptors (NRs) and cofactors in different breast cancer cell lines as well as their regulation by estradiol, insulin and progestin R5020...
  16. ncbi request reprint Thalamic calcification in vitamin D receptor knockout mice
    Allan Kalueff
    Department of Anatomy, Medical School, University of Tampere, Finland
    Neuroreport 17:717-21. 2006
    ..Our results suggest that nuclear vitamin D receptor deficiency leads to brain mineralization in vitamin D receptor knockout mice, which may represent an experimental model of intracranial calcification...
  17. doi request reprint Human adipose tissue extract induces angiogenesis and adipogenesis in vitro
    Jertta Riina Sarkanen
    Department of Cell Biology, Medical School, University of Tampere, Tampere, Finland
    Tissue Eng Part A 18:17-25. 2012
    ..ATE is also efficient for reproduction and modeling of natural adipogenesis in vitro for, for example, obesity and diabetes studies...
  18. pmc A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells
    Kristiina Rajala
    Regea Institute for Regenerative Medicine, University of Tampere, Tampere University Hospital, Tampere, Finland
    PLoS ONE 5:e10246. 2010
    ..For clinical application of stem cells, the use of completely defined conditions and elimination of all animal-derived materials from the establishment, culture, and differentiation processes is desirable...
  19. doi request reprint Autologous adipose stem cells and polylactide discs in the replacement of the rabbit temporomandibular joint disc
    Katja Ahtiainen
    Department of Cell Biology, School of Medicine, University of Tampere, 33014 Tampere, Finland
    J R Soc Interface 10:20130287. 2013
    ..While adverse tissue reactions were not shown, the authors suggest that with improved attachment and design, the PLA disc and biomaterial itself would hold potential for TMJ disc replacement...
  20. doi request reprint The potential of adipose stem cells in regenerative medicine
    Bettina Lindroos
    Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    Stem Cell Rev 7:269-91. 2011
    ..In this review, some of the aspects of examination on ASCs in vitro and the utilization of ASCs in clinical studies are discussed...
  21. ncbi request reprint Expression of progesterone receptor isoforms A and B is differentially regulated by estrogen in different breast cancer cell lines
    Annika Vienonen
    Tampere Graduate School of Biomedicine, Medical School, FIN 33014, University of Tampere, Finland
    J Steroid Biochem Mol Biol 80:307-13. 2002
    ..This is the first report describing that in different breast cancer cell lines the expression of PR-A and PR-B is regulated by E(2) in a distinct way...
  22. pmc Osteogenic differentiation of human dental pulp stem cells on β-tricalcium phosphate/poly (l-lactic acid/caprolactone) three-dimensional scaffolds
    Rashi Khanna-Jain
    Adult Stem Cells Group, Institute of Biomedical Technology, University of Tampere, Tampere, Finland BioMediTech, Tampere, Finland Science Centre, Tampere University Hospital, Tampere, Finland
    J Tissue Eng 3:2041731412467998. 2012
    ....
  23. pmc Novel polypyrrole-coated polylactide scaffolds enhance adipose stem cell proliferation and early osteogenic differentiation
    Jani Pelto
    VTT Technical Research Centre of Finland, Tampere, Finland
    Tissue Eng Part A 19:882-92. 2013
    ..ES did not have a significant effect on hASCs. This study highlights the potential of novel PPy-coated PLA scaffolds in bone tissue engineering...
  24. doi request reprint Concomitant exposure of ovarian cancer cells to docetaxel, CPT-11 or SN-38 and adenovirus-mediated p53 gene therapy
    Susanna Miettinen
    Department of Cell Biology, Medical School, Tampere University Hospital, Tampere, Finland
    Anticancer Drugs 20:589-600. 2009
    ..Increased expression ratios of Bax/Bcl-2 and Bax/Bcl-XL might serve as positive markers for effective p53 gene therapy and concomitant topoisomerase I inhibitor therapy...
  25. doi request reprint Addition of BMP-2 or BMP-6 to dexamethasone, ascorbic acid, and β-glycerophosphate may not enhance osteogenic differentiation of human periodontal ligament cells
    Rashi Khanna-Jain
    Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Biokatu 12, 33520, Tampere, Finland
    Growth Factors 28:437-46. 2010
    ..The mineralization ability was not enhanced by the addition of BMP-2 or BMP-6. These findings suggest that the addition of BMP-2 or BMP-6 to OS may not enhance an osteogenic differentiation of hPDLCs...
  26. ncbi request reprint Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells
    Yan Ru Lou
    Department of Anatomy Medical School, FIN 33014 University of Tampere, Finland
    Biochem Biophys Res Commun 338:1973-81. 2005
    ..Our data suggest that ATRA suppresses 24-hydroxylase expression through RARalpha-dependent signaling pathway and can enhance vitamin D action in suppression of cell growth...
  27. ncbi request reprint Antiproliferative action of vitamin D
    Timo Ylikomi
    Graduate School of Biomedicine, Department of Cell Biology, 33014 University of Tampere, Finland
    Vitam Horm 64:357-406. 2002
    ..In the present review we discuss the mechanisms whereby vitamin D regulates cell proliferation and whether it could be used in prevention and treatment of hyperproliferative disorders like cancers...
  28. pmc Effects of bioactive glass S53P4 or beta-tricalcium phosphate and bone morphogenetic protein-2 and bone morphogenetic protein-7 on osteogenic differentiation of human adipose stem cells
    Martin Waselau
    Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland Adult Stem Cell Group, Institute of Biomedical Technology, University of Tampere, Tampere, Finland
    J Tissue Eng 3:2041731412467789. 2012
    ..Effects of culture medium on human adipose stem cells are biomaterial dependent; bioactive glass in control medium enhanced osteogenic differentiation most effectively...
  29. doi request reprint Growth and osteogenic differentiation of adipose stem cells on PLA/bioactive glass and PLA/beta-TCP scaffolds
    Suvi Haimi
    Regea Institute for Regenerative Medicine, University of Tampere, Tampere, Finland
    Tissue Eng Part A 15:1473-80. 2009
    ..This supports the potential future use of PLA/beta-TCP composites as effective scaffolds for tissue engineering and as bone replacement materials...
  30. ncbi request reprint Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Neurosci Lett 394:69-73. 2006
    ..Our findings suggest that VDRs modulate seizure susceptibility in mice, and that the Vitamin D/VDR endocrine system may be involved in the pathogenesis of epilepsy...
  31. ncbi request reprint Fat tissue: views on reconstruction and exploitation
    Sanna Mari Niemelä
    Department of Cell Biology, Medical School, University of Tampere, Tampere, and Department of Surgery, Oulu University Hospital, Oulu, Finland
    J Craniofac Surg 18:325-35. 2007
    ..The multipotent characteristics of adipose tissue-derived stem cells, as well as their abundance and accessibility in the human body, make them a potential cell source for tissue engineering applications...
  32. ncbi request reprint Human mesenchymal stem cells lack tumor tropism but enhance the antitumor activity of oncolytic adenoviruses in orthotopic lung and breast tumors
    Tanja Hakkarainen
    Cancer Gene Therapy Group, Molecular Cancer Biology Program and Haartman Institute, University of Helsinki, 00014 Helsinki, Finland
    Hum Gene Ther 18:627-41. 2007
    ..These results suggest that MSCs loaded with oncolytic adenoviruses might be a useful approach for improving the bioavailability of systemically administered oncolytic adenoviruses...