Markku Maki

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. pmc Validation of morphometric analyses of small-intestinal biopsy readouts in celiac disease
    Juha Taavela
    Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland
    PLoS ONE 8:e76163. 2013
  2. pmc Clinical benefit of gluten-free diet in screen-detected older celiac disease patients
    Anitta Vilppula
    Department of Neurology, Paijat Hame Central Hospital, Lahti, Finland
    BMC Gastroenterol 11:136. 2011
  3. pmc IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease
    Elisabet Einarsdottir
    Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    BMC Med Genet 10:8. 2009
  4. pmc TGF-beta induces the expression of SAP30L, a novel nuclear protein
    Katri Lindfors
    Paediatric Research Centre, Tampere University Hospital, Tampere, Finland
    BMC Genomics 4:53. 2003
  5. pmc Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa
    Hanna Haveri
    Children s Hospital, University of Helsinki, Helsinki, Finland
    BMC Gastroenterol 8:9. 2008
  6. ncbi request reprint Prevalence of Celiac disease among children in Finland
    Markku Maki
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    N Engl J Med 348:2517-24. 2003
  7. ncbi request reprint Antibodies in relation to gluten intake
    M Maki
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Dig Dis 16:330-2. 1998
  8. pmc Missing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues
    I R Korponay-Szabo
    Paediatric Research Centre, University of Tampere Medical School, Tampere, Finland
    Gut 52:199-204. 2003
  9. ncbi request reprint Antibodies against deamidated gliadin peptides in early-stage celiac disease
    Kalle Kurppa
    Pediatric Research Centre, University of Tampere, Helsinki, Finland
    J Clin Gastroenterol 45:673-8. 2011
  10. doi request reprint Serodiagnostic assays for celiac disease based on the open or closed conformation of the autoantigen, transglutaminase 2
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Clin Immunol 31:436-42. 2011

Detail Information

Publications79

  1. pmc Validation of morphometric analyses of small-intestinal biopsy readouts in celiac disease
    Juha Taavela
    Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland
    PLoS ONE 8:e76163. 2013
    ..g. Marsh groups), but this is often too imprecise and ignores minor but significant changes in the mucosa. Consequently, there is a need for validated continuous variables in everyday practice and in academic and pharmacological research...
  2. pmc Clinical benefit of gluten-free diet in screen-detected older celiac disease patients
    Anitta Vilppula
    Department of Neurology, Paijat Hame Central Hospital, Lahti, Finland
    BMC Gastroenterol 11:136. 2011
    ..It remains obscure whether screening makes good or harm in subjects with long-standing gluten ingestion. We evaluated whether older subjects benefit from active detection and subsequent gluten free dietary treatment of celiac disease...
  3. pmc IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease
    Elisabet Einarsdottir
    Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    BMC Med Genet 10:8. 2009
    ..IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases...
  4. pmc TGF-beta induces the expression of SAP30L, a novel nuclear protein
    Katri Lindfors
    Paediatric Research Centre, Tampere University Hospital, Tampere, Finland
    BMC Genomics 4:53. 2003
    ..The aim of this study was to identify novel genes whose products would play a role in this TGF-beta-induced differentiation...
  5. pmc Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa
    Hanna Haveri
    Children s Hospital, University of Helsinki, Helsinki, Finland
    BMC Gastroenterol 8:9. 2008
    ..The expression of the carcinogenesis-related protein Indian hedgehog was also investigated in comparison to GATA factors...
  6. ncbi request reprint Prevalence of Celiac disease among children in Finland
    Markku Maki
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    N Engl J Med 348:2517-24. 2003
    ....
  7. ncbi request reprint Antibodies in relation to gluten intake
    M Maki
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Dig Dis 16:330-2. 1998
    ..However, slight dietary transgressions and minor mucosal damages cannot always be revealed with the serological tests. Therefore, small-bowel mucosal biopsy remains the most sensitive method to monitor the effect of a gluten-free diet...
  8. pmc Missing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues
    I R Korponay-Szabo
    Paediatric Research Centre, University of Tampere Medical School, Tampere, Finland
    Gut 52:199-204. 2003
    ....
  9. ncbi request reprint Antibodies against deamidated gliadin peptides in early-stage celiac disease
    Kalle Kurppa
    Pediatric Research Centre, University of Tampere, Helsinki, Finland
    J Clin Gastroenterol 45:673-8. 2011
    ..We hypothesized that the antibodies against deamidated gliadin peptides (DGP-AGA) might appear before the other antibodies and would thus be useful in the diagnosis and follow-up of patients with early-stage celiac disease...
  10. doi request reprint Serodiagnostic assays for celiac disease based on the open or closed conformation of the autoantigen, transglutaminase 2
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Clin Immunol 31:436-42. 2011
    ..It thus offers a promising tool in the diagnostics and follow-up of celiac disease...
  11. ncbi request reprint Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study
    Kalle Kurppa
    Paediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    Gastroenterology 136:816-23. 2009
    ..We hypothesized that patients with mild enteropathy but positive endomysial antibodies benefit from a gluten-free diet (GFD) similarly to patients with more severe enteropathy...
  12. pmc Serological responses to microbial antigens in celiac disease patients during a gluten-free diet
    Sara Ashorn
    Paediatric Research Centre and Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Clin Immunol 29:190-5. 2009
    ..Further, we wanted to evaluate whether these serologic specificities could provide new tools for the follow-up of CD patients...
  13. doi request reprint Degree of damage to the small bowel and serum antibody titers correlate with clinical presentation of patients with celiac disease
    Juha Taavela
    Pediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    Clin Gastroenterol Hepatol 11:166-71.e1. 2013
    ..We investigated whether the degree of mucosal damage to the small bowel correlates with clinical presentation and serum markers of celiac disease...
  14. pmc Small- bowel mucosal changes and antibody responses after low- and moderate-dose gluten challenge in celiac disease
    Marja Leena Lähdeaho
    Paediatric Research Centre and School of Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    BMC Gastroenterol 11:129. 2011
    ..We challenged adult celiac patients with gluten with a view to assessing the amount needed to cause some small-bowel mucosal deterioration...
  15. doi request reprint Gluten-dependent small bowel mucosal transglutaminase 2-specific IgA deposits in overt and mild enteropathy coeliac disease
    Outi Koskinen
    Pediatric Research Centre, University of Tampere, Finland
    J Pediatr Gastroenterol Nutr 47:436-42. 2008
    ..We evaluated the gluten dependency of these deposits in overt and mild enteropathy coeliac disease...
  16. ncbi request reprint Burden of illness and use of health care services before and after celiac disease diagnosis in children
    Eeva Mattila
    School of Medicine, University of Tampere, Tampere, Finland
    J Pediatr Gastroenterol Nutr 57:53-6. 2013
    ..We investigated these issues prospectively in newly detected patients with celiac disease before and after diagnosis in a large nationwide cohort of children...
  17. doi request reprint Lower economic status and inferior hygienic environment may protect against celiac disease
    Anita Kondrashova
    Department of Virology, University of Tampere, Medical School, Tampere, Finland
    Ann Med 40:223-31. 2008
    ..The populations in adjacent Russian Karelia and Finland are equally exposed to grain products and share partly the same ancestry, but live in completely different socioeconomic environments...
  18. pmc Endomysial antibodies predict celiac disease irrespective of the titers or clinical presentation
    Kalle Kurppa
    Pediatric Research Centre, University of Tampere and Tampere University Hospital, FIN 33014, Tampere, Finland
    World J Gastroenterol 18:2511-6. 2012
    ..To investigate the association between serum antibody levels and a subsequent celiac disease diagnosis in a large series of children and adults...
  19. doi request reprint Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies
    Sergio Caja
    Paediatric Research Centre, Medical School, University of Tampere, Tampere, Finland
    Scand J Gastroenterol 45:421-7. 2010
    ..In addition, we studied whether the monoclonal patient autoantibodies modulate endothelial cell TG2 activity and whether such modulation is related to the anti-angiogenic effects...
  20. doi request reprint Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease
    Outi Koskinen
    Pediatric Research Center, University of Tampere, Tampere, Finland
    J Clin Gastroenterol 44:483-8. 2010
    ..Furthermore, as the often compromised quality of biopsy specimens renders diagnosis difficult, new diagnostic tools are warranted...
  21. doi request reprint IgA-class autoantibodies against neuronal transglutaminase, TG6 in celiac disease: no evidence for gluten dependency
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Clin Chim Acta 412:1187-90. 2011
    ..We here investigated whether TG6-targeted autoantibodies are a characteristic feature of celiac patients, especially those with neurological symptoms, and further, whether such antibodies are gluten-dependent...
  22. doi request reprint Utility of the new ESPGHAN criteria for the diagnosis of celiac disease in at-risk groups
    Kalle Kurppa
    University of Tampere, Tampere, Finland
    J Pediatr Gastroenterol Nutr 54:387-91. 2012
    ..The utility of these new criteria was evaluated by applying the human red blood cell TG2 antibody test (RBC-TG2ab) to a large cohort of children and adults belonging to at-risk groups...
  23. pmc Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits
    Satumarja M Stenman
    Medical School, Pediatric Research Center, University of Tampere, Tampere, Finland
    BMC Immunol 9:6. 2008
    ....
  24. doi request reprint Transglutaminase 2-targeted autoantibodies in celiac disease: Pathogenetic players in addition to diagnostic tools?
    Katri Lindfors
    Paediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Autoimmun Rev 9:744-9. 2010
    ..In this review we discuss the role of TG2, the autoantigen and the autoantibodies targeted against it in the pathogenesis of celiac disease...
  25. doi request reprint Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease
    Outi Koskinen
    Pediatric Research Center and Medical School, University of Tampere, FIN 33014 Tampere, Finland
    Dig Liver Dis 42:692-7. 2010
    ..We investigated whether small-bowel mucosal transglutaminase-2 specific autoantibody deposits distinguish non-responsive coeliac disease from other enteropathies...
  26. pmc Predictors of persistent symptoms and reduced quality of life in treated coeliac disease patients: a large cross-sectional study
    Pilvi Paarlahti
    Tampere Centre for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland
    BMC Gastroenterol 13:75. 2013
    ..We aimed to find predictors for these continuous health concerns in long-term treated adult coeliac patients...
  27. doi request reprint Factors associated with dietary adherence in celiac disease: a nationwide study
    Kalle Kurppa
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Digestion 86:309-14. 2012
    ..In order to establish whether this has affected the success of treatment, and to identify predictors for dietary non-adherence, we carried out a study in a nationwide cohort of treated celiac patients...
  28. ncbi request reprint Burden of illness in screen-detected children with celiac disease and their families
    Sampsa Kinos
    School of Medicine, University of Tampere, Tampere, Finland
    J Pediatr Gastroenterol Nutr 55:412-6. 2012
    ..We assessed health and well-being and the effect of a 1-year gluten-free diet in a nationwide cohort of children with celiac disease detected by screening in at-risk groups...
  29. doi request reprint Are transglutaminase 2 inhibitors able to reduce gliadin-induced toxicity related to celiac disease? A proof-of-concept study
    Tiina Rauhavirta
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, 33014, Finland
    J Clin Immunol 33:134-42. 2013
    ..In this proof-of-concept study we investigated whether two TG2 inhibitors, cell-impermeable R281 and cell-permeable R283, can prevent the toxic effects of gliadin in vitro and ex vivo...
  30. ncbi request reprint Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2
    Cristina Antonella Nadalutti
    Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, 33014, Tampere, Finland
    Cell Mol Life Sci 71:1315-26. 2014
    ....
  31. doi request reprint Oats do not induce systemic or mucosal autoantibody response in children with coeliac disease
    Outi Koskinen
    Paediatric Research Centre, University of Tampere, Tampere, Finland
    J Pediatr Gastroenterol Nutr 48:559-65. 2009
    ....
  32. ncbi request reprint IgA-class transglutaminase antibodies in evaluating the efficacy of gluten-free diet in coeliac disease
    Katri Kaukinen
    Department of Internal Medicine, University of Tampere, Tampere, Finland
    Eur J Gastroenterol Hepatol 14:311-5. 2002
    ..We investigated whether the tissue transglutaminase antibody test could substitute biopsy in this respect, and whether the test is better than the endomysial antibody test in follow-up...
  33. doi request reprint Symptom-detected and screen-detected celiac disease and adult height: a large cohort study
    Aleksi Pärnänen
    Pediatric Research Centre, Tampere University Hospital, Tampere, Finland
    Eur J Gastroenterol Hepatol 24:1066-70. 2012
    ..We aimed to assess the final height in a large cohort of symptom-detected and screen-detected patients with celiac disease diagnosed in adulthood...
  34. doi request reprint RhoB is associated with the anti-angiogenic effects of celiac patient transglutaminase 2-targeted autoantibodies
    Stefania Martucciello
    Pediatric Research Center, University of Tampere, Tampere University Hospital, Finn Medi 3, School of Medicine 33014, University of Tampere, Finland
    J Mol Med (Berl) 90:817-26. 2012
    ..Taken together, our results would suggest that RhoB plays a key role in the response of endothelial cells to celiac disease-specific anti-TG2 autoantibodies...
  35. doi request reprint Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA
    Essi Myrsky
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    Cell Mol Life Sci 66:3375-85. 2009
    ....
  36. doi request reprint Altered small-bowel mucosal vascular network in untreated coeliac disease
    Essi Myrsky
    Paediatric Research Centre, Medical School, University of Tampere
    Scand J Gastroenterol 44:162-7. 2009
    ..The purpose of this study was to establish whether the small-bowel mucosal vasculature is altered in coeliac disease and whether the putative changes are gluten dependent...
  37. doi request reprint Galactosylation of serum IgA1 O-glycans in celiac disease
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Finn Medi 3, FIN 33014 Tampere, Finland
    J Clin Immunol 31:74-9. 2011
    ..Thus, the undergalactosylated IgA1 molecules are not pathognomonic for celiac disease, but galactose deficiency in IgA1 could be an aggravating factor...
  38. ncbi request reprint Gastrointestinal symptoms and quality of life in screen-detected celiac disease
    Aku Paavola
    School of Medicine, University of Tampere, Tampere, Finland
    Dig Liver Dis 44:814-8. 2012
    ..The effects of a long-term gluten-free diet on possible gastrointestinal symptoms and psychological well-being in screen-detected patients have nevertheless remained obscure...
  39. ncbi request reprint Oats can diversify a gluten-free diet in celiac disease and dermatitis herpetiformis
    Markku Peräaho
    Department of Medicine, Tampere University Hospital, Tampere, Finland
    J Am Diet Assoc 104:1148-50. 2004
    ..There is a market demand for oats, and celiac societies and dietitians should make efforts to promote the development of products free of wheat contamination...
  40. doi request reprint In vitro models for gluten toxicity: relevance for celiac disease pathogenesis and development of novel treatment options
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Exp Biol Med (Maywood) 237:119-25. 2012
    ....
  41. doi request reprint Gluten-sensitive hypertransaminasemia in celiac disease: an infrequent and often subclinical finding
    Satu Korpimäki
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Am J Gastroenterol 106:1689-96. 2011
    ..We investigated the prevalence and gluten dependency of hypertransaminasemia in celiac patients also diagnosed with minor or atypical symptoms...
  42. ncbi request reprint Comparison of a novel whole blood transglutaminase-based ELISA with a whole blood rapid antibody test and established conventional serological celiac disease assays
    Tiina Raivio
    Paediatric Research Centre, University of Tampere, Finland
    J Pediatr Gastroenterol Nutr 47:562-7. 2008
    ..We assessed the value of this new test in celiac disease antibody detection...
  43. pmc Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA
    Cristina Antonella Nadalutti
    Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland
    PLoS ONE 8:e77277. 2013
    ..To investigate the role of thioredoxin (TRX), a novel regulator of extracellular transglutaminase 2 (TG2), in celiac patients IgA (CD IgA) mediated TG2 enzymatic activation...
  44. pmc Use of health care services and pharmaceutical agents in coeliac disease: a prospective nationwide study
    Anniina Ukkola
    School of Medicine, FinnMedi3, University of Tampere, FIN 33014, Tampere, Finland
    BMC Gastroenterol 12:136. 2012
    ..Unexplained symptoms may lead to incremented medical consultations and productivity losses. The aim here was to estimate the possible concealed burden of untreated coeliac disease and the effects of a gluten-free diet...
  45. doi request reprint Changes in body mass index on a gluten-free diet in coeliac disease: a nationwide study
    Anniina Ukkola
    School of Medicine, University of Tampere, Tampere, Finland
    Eur J Intern Med 23:384-8. 2012
    ..The aim of the study was to evaluate the impact of a GFD on the body mass index (BMI) in a nationwide cohort of coeliac patients and to determine variables predictive of favourable or unfavourable BMI changes...
  46. doi request reprint Future treatment strategies for celiac disease
    Katri Lindfors
    University of Tampere and Tampere University Hospital, School of Medicine, Pediatric Research Center, Finn Medi 3, FIN 33014, Tampere, Finland
    Expert Opin Ther Targets 16:665-75. 2012
    ..Currently, the only effective treatment is a strict life-long gluten-free diet excluding all gluten-containing food products. In view of the extremely restricted nature of the diet, new treatment options would clearly be desirable...
  47. pmc Increasing prevalence and high incidence of celiac disease in elderly people: a population-based study
    Anitta Vilppula
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    BMC Gastroenterol 9:49. 2009
    ....
  48. doi request reprint Gastrointestinal symptoms, quality of life and bone mineral density in mild enteropathic coeliac disease: a prospective clinical trial
    Kalle Kurppa
    Paediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 45:305-14. 2010
    ..The aim of this study was to evaluate gastrointestinal symptoms, quality of life and bone mineral density in patients with mild enteropathy, and the effect of a gluten-free diet...
  49. ncbi request reprint Celiac disease: from inflammation to atrophy: a long-term follow-up study
    Marja Leena Lähdeaho
    Department of Pediatrics and Internal Medicine, Tampere University Hospital and Medical School, University of Tampere, Finland
    J Pediatr Gastroenterol Nutr 41:44-8. 2005
    ..The aim of this study was to evaluate the role of intraepithelial lymphocytosis and marginally decreased villous height/crypt depth ratio in the development of overt villous atrophy in a long-term follow-up...
  50. pmc Latent coeliac disease or coeliac disease beyond villous atrophy?
    Katri Kaukinen
    Medical School, University of Tampere, Finland
    Gut 56:1339-40. 2007
  51. ncbi request reprint Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure
    Katri Kaukinen
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Gastroenterology 122:881-8. 2002
    ..Mild liver abnormalities are common in patients with celiac disease and usually resolve with a gluten-free diet. We investigated the occurrence of celiac disease in patients with severe liver failure...
  52. ncbi request reprint Intraepithelial lymphocytes in celiac disease
    Teea T Järvinen
    Department of Internal Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
    Am J Gastroenterol 98:1332-7. 2003
    ..The aim of this study was to investigate the value of immunohistochemical characterization of different intraepithelial lymphocytes (IELs) in the diagnostic workup of celiac disease (CD)...
  53. doi request reprint Celiac disease without villous atrophy in children: a prospective study
    Kalle Kurppa
    Pediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Pediatr 157:373-80, 380.e1. 2010
    ..To establish whether children who are endomysial antibody (EmA) positive and have normal small-bowel mucosal villous morphology are truly gluten-sensitive and may benefit from early treatment with a gluten-free diet...
  54. doi request reprint Inhibition of epithelial growth factor receptor signalling does not preserve epithelial barrier function after in vitro gliadin insult
    Kati Juuti-Uusitalo
    Paediatric Research Centre, Medical School, University of Tampere, Finland
    Scand J Gastroenterol 44:820-5. 2009
    ....
  55. doi request reprint Celiac disease and health-related quality of life
    Kalle Kurppa
    Paediatric Research Center, University of Tampere and Tampere University Hospital, FIN 33014, Finland
    Expert Rev Gastroenterol Hepatol 5:83-90. 2011
    ..This article highlights the studies of health-related quality of life and celiac disease conducted to date. Particular attention is paid to the extraintestinal and atypical forms of the disorder...
  56. doi request reprint Phosphoinositides as regulators of protein-chromatin interactions
    Keijo Viiri
    Paediatric Research Centre, University of Tampere, School of Medicine and Tampere University Hospital, 33520 Tampere, Finland
    Sci Signal 5:pe19. 2012
    ..We propose that a phosphoinositide-mediated detachment of proteins from chromatin is a general biological mechanism that partly underlies the signaling effects of nuclear phosphoinositides...
  57. doi request reprint Prognosis of unrecognized coeliac disease as regards mortality: a population-based cohort study
    Sini Lohi
    Paediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    Ann Med 41:508-15. 2009
    ..Clinically diagnosed coeliac disease patients carry an increased risk of mortality. As coeliac disease is markedly underdiagnosed, we aimed to quantify the risk of mortality in subjects with unrecognized and thus untreated coeliac disease...
  58. doi request reprint Diet improves perception of health and well-being in symptomatic, but not asymptomatic, patients with celiac disease
    Anniina Ukkola
    Medical School, University of Tampere, Tampere, Finland
    Clin Gastroenterol Hepatol 9:118-23. 2011
    ..We investigated the impact of a gluten-free diet on self-perceived health and well-being in symptomatic and asymptomatic patients with celiac disease...
  59. doi request reprint Serum fatty acid profile in subjects with irritable bowel syndrome
    Tiina Solakivi
    Department of Medical Biochemistry, University of Tampere, Finland
    Scand J Gastroenterol 46:299-303. 2011
    ..We wanted to investigate subjects with IBS for signs of disturbed intestinal absorption of fatty acids, as reflected in serum composition...
  60. doi request reprint Coeliac disease--a diagnostic and therapeutic challenge
    Katri Kaukinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Clin Chem Lab Med 48:1205-16. 2010
    ..Currently, the only effective treatment for the condition is a life-long strict gluten-free diet. Long-term regular follow-up of patients is recommended in order to maintain good adherence to the diet...
  61. doi request reprint Antibodies in celiac disease: implications beyond diagnostics
    Sergio Caja
    Pediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    Cell Mol Immunol 8:103-9. 2011
    ..The article summarizes the diagnostic utility of different celiac-related antibodies and discusses their roles in the pathogenesis of the disease...
  62. doi request reprint Enzymatic detoxification of gluten by germinating wheat proteases: implications for new treatment of celiac disease
    Satumarja M Stenman
    Pediatric Research Center, Medical School, University of Tampere, Finland
    Ann Med 41:390-400. 2009
    ..We isolated proteases from germinating wheat grain naturally meant for total digestion of wheat storage proteins and investigated whether these enzymes can diminish toxic effects of gluten in vitro and ex vivo...
  63. pmc DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides
    Keijo M Viiri
    Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, 33520 Tampere, Finland
    Mol Cell Biol 29:342-56. 2009
    ..Our results suggest that SAP30L and SAP30 play active roles in recruitment of deacetylating enzymes to nucleosomes, and mediate key protein-protein and protein-DNA interactions involved in chromatin remodeling and transcription...
  64. pmc Type 1 diabetes is associated with enterovirus infection in gut mucosa
    Maarit Oikarinen
    Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
    Diabetes 61:687-91. 2012
    ..This finding opens new opportunities for studying the viral etiology of type 1 diabetes...
  65. doi request reprint Recent advances in the development of new treatments for celiac disease
    Marja Leena Lähdeaho
    University of Tampere, Tampere University Hospital, Pediatric Research Centre, Tampere, Finland
    Expert Opin Biol Ther 12:1589-600. 2012
    ..However, gluten-free dieting is restrictive, and nutritionally less than optimal, and gluten is difficult to avoid...
  66. doi request reprint Serum fatty acid profile in celiac disease patients before and after a gluten-free diet
    Tiina Solakivi
    Department of Medical Biochemistry, University of Tampere, Finland
    Scand J Gastroenterol 44:826-30. 2009
    ..In untreated CD, fat malabsorption can occur. The aim of this study was to investigate the profile of serum fatty acids in newly detected CD before and after treatment with a gluten-free diet...
  67. doi request reprint The prevalence of celiac disease in Europe: results of a centralized, international mass screening project
    Kirsi Mustalahti
    Paediatric Research Centre, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Ann Med 42:587-95. 2010
    ....
  68. ncbi request reprint Murine ortholog of the novel glycosyltransferase, B3GTL: primary structure, characterization of the gene and transcripts, and expression in tissues
    Taisto Y K Heinonen
    Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland
    DNA Cell Biol 25:465-74. 2006
    ..The findings reported here make possible the design of a B3GTL "knock-out" mouse, provide a framework for analyzing the regulation of the gene, and provide an extensive catalog of tissues in which this novel protein acts...
  69. doi request reprint The duodenal microbiota composition of adult celiac disease patients is associated with the clinical manifestation of the disease
    Pirjo Wacklin
    Finnish Red Cross Blood Service, Helsinki, Finland
    Inflamm Bowel Dis 19:934-41. 2013
    ..In this study, the role of duodenal microbiota in the celiac disease outcome was studied by analyzing mucosa-associated microbiota in celiac disease patients with a variety of intestinal and extraintestinal symptoms...
  70. ncbi request reprint A novel human glycosyltransferase: primary structure and characterization of the gene and transcripts
    Taisto Y K Heinonen
    Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland
    Biochem Biophys Res Commun 309:166-74. 2003
    ..The B3GTL gene lacks canonical TATA and CAAT boxes and contains three functional polyadenylation sites. It is transcribed in a wide range of tissues and in TGF-beta-treated T84 epithelial cells...
  71. ncbi request reprint Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease: a biopsy-proven European multicentre study
    Pekka Collin
    Tampere University Hospital and University of Tampere, Finland
    Eur J Gastroenterol Hepatol 17:85-91. 2005
    ..The setting allowed a further comparison between the antibody results and the conventional small-intestinal histology...
  72. ncbi request reprint Resurrection of gliadin antibodies in coeliac disease. Deamidated gliadin peptide antibody test provides additional diagnostic benefit
    Katri Kaukinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Finland
    Scand J Gastroenterol 42:1428-33. 2007
    ..The purpose of this study was to compare these serological tests with a new test recognizing antibodies against deamidated and defined gliadin peptides...
  73. pmc Phylogenetic analysis of the SAP30 family of transcriptional regulators reveals functional divergence in the domain that binds the nuclear matrix
    Keijo M Viiri
    Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, 33520 Tampere, Finland
    BMC Evol Biol 9:149. 2009
    ..In this report we examine the evolution of two proteins in this complex, the Sin3-associated proteins SAP30L and SAP30, by using an archive of protein sequences from 62 species...
  74. doi request reprint Interactions of functional apolipoprotein E gene promoter polymorphisms with smoking on aortic atherosclerosis
    Leena E Viiri
    Department of Forensic Medicine, University of Tampere Medical School and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    Circ Cardiovasc Genet 1:107-16. 2008
    ..We also studied the previously unknown effects of +113G/C on transcriptional activity...
  75. pmc Elevated serum anti-Saccharomyces cerevisiae, anti-I2 and anti-OmpW antibody levels in patients with suspicion of celiac disease
    Sara Ashorn
    Paediatric Research Centre and Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Clin Immunol 28:486-94. 2008
    ....
  76. pmc Gene expression in TGFbeta-induced epithelial cell differentiation in a three-dimensional intestinal epithelial cell differentiation model
    Kati M Juuti-Uusitalo
    Paediatric Research Centre, Tampere University and Tampere University Hospital, Tampere, Finland
    BMC Genomics 7:279. 2006
    ....
  77. doi request reprint Prospective antibody case finding of coeliac disease in type-1 diabetes children: need of biopsy revisited
    Alina Popp
    University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
    Acta Paediatr 102:e102-6. 2013
    ..To evaluate whether coeliac disease (CD) can be diagnosed by measuring autoantibodies without small-intestinal mucosal biopsies in children with type 1 diabetes...
  78. doi request reprint Peters'-plus syndrome is a congenital disorder of glycosylation caused by a defect in the beta1,3-glucosyltransferase that modifies thrombospondin type 1 repeats
    Taisto Y K Heinonen
    Paediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    Ann Med 41:2-10. 2009
    ....
  79. ncbi request reprint Alternative mRNA splicing of SAP30L regulates its transcriptional repression activity
    Hanna Korkeamäki
    Paediatric Research Centre, University of Tampere Medical School, Tampere University Hospital, Tampere, Finland
    FEBS Lett 582:379-84. 2008
    ..These data suggest that the transcriptional repression of a Sin3A corepressor complex can be regulated not only by sequence-specific transcriptional repressors, but also by modification of associated proteins, such as SAP30L...