- Large vessel cerebral atherosclerosis is not in direct association with neuropathological lesions of Alzheimer's diseaseTeemu M Luoto
Department of Forensic Medicine, University of Tampere, Tampere, Finland
Eur Neurol 62:93-8. 2009..We studied the association between atherosclerosis of the circle of Willis (CW) and AD neuropathology in a large autopsy sample...
- Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle ageEloise Kok
Department of Forensic Medicine, Medical School, University of Tampere, Tampere, Finland
Ann Neurol 65:650-7. 2009....
- CRP gene variation affects early development of Alzheimer's disease-related plaquesEloise Helena Kok
School of Medicine, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
J Neuroinflammation 8:96. 2011..We used the Tampere Autopsy Study (TASTY) series (n = 603, age 0-97 yrs), representing an unselected population outside institutions, to investigate the pathogenic involvement of inflammation in Alzheimer's disease-related lesions...
- CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaquesEloise H Kok
School of Medicine, University of Tampere, Medisiinarinkatu 3, 33014 Tampere, Finland
Alzheimers Res Ther 3:12. 2011..APOE is the strongest risk gene for sporadic Alzheimer's disease (AD) so far. Recent genome wide association studies found links for sporadic AD with CLU and CR1 involved in Aβ clearance, and PICALM affecting intracellular trafficking...