K Lindfors

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. doi request reprint Future treatment strategies for celiac disease
    Katri Lindfors
    University of Tampere and Tampere University Hospital, School of Medicine, Pediatric Research Center, Finn Medi 3, FIN 33014, Tampere, Finland
    Expert Opin Ther Targets 16:665-75. 2012
  2. doi request reprint In vitro models for gluten toxicity: relevance for celiac disease pathogenesis and development of novel treatment options
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Exp Biol Med (Maywood) 237:119-25. 2012
  3. pmc Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits
    Satumarja M Stenman
    Medical School, Pediatric Research Center, University of Tampere, Tampere, Finland
    BMC Immunol 9:6. 2008
  4. pmc Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa
    Hanna Haveri
    Children s Hospital, University of Helsinki, Helsinki, Finland
    BMC Gastroenterol 8:9. 2008
  5. doi request reprint Transglutaminase 2-targeted autoantibodies in celiac disease: Pathogenetic players in addition to diagnostic tools?
    Katri Lindfors
    Paediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Autoimmun Rev 9:744-9. 2010
  6. pmc TGF-beta induces the expression of SAP30L, a novel nuclear protein
    Katri Lindfors
    Paediatric Research Centre, Tampere University Hospital, Tampere, Finland
    BMC Genomics 4:53. 2003
  7. pmc Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A
    T Rauhavirta
    Paediatric Research Centre, Medical School, University of Tampere, Tampere 33014, Finland
    Clin Exp Immunol 164:127-36. 2011
  8. pmc Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture
    K Lindfors
    Paediatric Research Centre, Medical School, University of Tampere, Finland, Department of Peadiatrics, Tampere University Hospital, Tampere, Finland
    Clin Exp Immunol 152:552-8. 2008
  9. doi request reprint Galactosylation of serum IgA1 O-glycans in celiac disease
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Finn Medi 3, FIN 33014 Tampere, Finland
    J Clin Immunol 31:74-9. 2011
  10. pmc Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells
    S M Stenman
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    Clin Exp Immunol 161:242-9. 2010

Collaborators

Detail Information

Publications27

  1. doi request reprint Future treatment strategies for celiac disease
    Katri Lindfors
    University of Tampere and Tampere University Hospital, School of Medicine, Pediatric Research Center, Finn Medi 3, FIN 33014, Tampere, Finland
    Expert Opin Ther Targets 16:665-75. 2012
    ..Currently, the only effective treatment is a strict life-long gluten-free diet excluding all gluten-containing food products. In view of the extremely restricted nature of the diet, new treatment options would clearly be desirable...
  2. doi request reprint In vitro models for gluten toxicity: relevance for celiac disease pathogenesis and development of novel treatment options
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Exp Biol Med (Maywood) 237:119-25. 2012
    ....
  3. pmc Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits
    Satumarja M Stenman
    Medical School, Pediatric Research Center, University of Tampere, Tampere, Finland
    BMC Immunol 9:6. 2008
    ....
  4. pmc Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa
    Hanna Haveri
    Children s Hospital, University of Helsinki, Helsinki, Finland
    BMC Gastroenterol 8:9. 2008
    ..The expression of the carcinogenesis-related protein Indian hedgehog was also investigated in comparison to GATA factors...
  5. doi request reprint Transglutaminase 2-targeted autoantibodies in celiac disease: Pathogenetic players in addition to diagnostic tools?
    Katri Lindfors
    Paediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
    Autoimmun Rev 9:744-9. 2010
    ..In this review we discuss the role of TG2, the autoantigen and the autoantibodies targeted against it in the pathogenesis of celiac disease...
  6. pmc TGF-beta induces the expression of SAP30L, a novel nuclear protein
    Katri Lindfors
    Paediatric Research Centre, Tampere University Hospital, Tampere, Finland
    BMC Genomics 4:53. 2003
    ..The aim of this study was to identify novel genes whose products would play a role in this TGF-beta-induced differentiation...
  7. pmc Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A
    T Rauhavirta
    Paediatric Research Centre, Medical School, University of Tampere, Tampere 33014, Finland
    Clin Exp Immunol 164:127-36. 2011
    ..Our results suggest that coeliac patient IgA could play a role in the transepithelial passage of gliadin peptides, a process during which they might be deamidated...
  8. pmc Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture
    K Lindfors
    Paediatric Research Centre, Medical School, University of Tampere, Finland, Department of Peadiatrics, Tampere University Hospital, Tampere, Finland
    Clin Exp Immunol 152:552-8. 2008
    ..lactis bacteria can counteract directly the harmful effects exerted by coeliac-toxic gliadin and would clearly warrant further studies of its potential as a novel dietary supplement in the treatment of coeliac disease...
  9. doi request reprint Galactosylation of serum IgA1 O-glycans in celiac disease
    Katri Lindfors
    Pediatric Research Center, University of Tampere and Tampere University Hospital, Finn Medi 3, FIN 33014 Tampere, Finland
    J Clin Immunol 31:74-9. 2011
    ..Thus, the undergalactosylated IgA1 molecules are not pathognomonic for celiac disease, but galactose deficiency in IgA1 could be an aggravating factor...
  10. pmc Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells
    S M Stenman
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    Clin Exp Immunol 161:242-9. 2010
    ..In future, these enzymes might be utilized as a novel medical treatment for coeliac disease or in food processing in order to develop high-quality coeliac-safe food products...
  11. pmc Coeliac disease-specific autoantibodies targeted against transglutaminase 2 disturb angiogenesis
    E Myrsky
    Paediatric Research Centre, Medical School, University of Tampere, Tampere, Finland
    Clin Exp Immunol 152:111-9. 2008
    ..This disturbance of the angiogenic process could lead in vivo to the disruption of the mucosal vasculature seen in coeliac disease patients on a gluten-containing diet...
  12. doi request reprint A role for anti-transglutaminase 2 autoantibodies in the pathogenesis of coeliac disease?
    K Lindfors
    Paediatric Research Centre, Medical School, University of Tampere and Tampere University Hospital, 33014, Tampere, Finland
    Amino Acids 36:685-91. 2009
    ..Although coeliac disease has traditionally been regarded as a T cell-mediated disorder, this review discusses the role of the gluten-induced disease-specific anti-transglutaminase 2-autoantibodies in the pathogenesis of the disease...
  13. pmc SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus
    K M Viiri
    Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland
    Nucleic Acids Res 34:3288-98. 2006
    ..Finally, we characterize a functional nucleolar localization signal in SAP30L and show that SAP30L and SAP30 are able to target Sin3A to the nucleolus...
  14. doi request reprint Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease
    Outi Koskinen
    Pediatric Research Center, University of Tampere, Tampere, Finland
    J Clin Gastroenterol 44:483-8. 2010
    ..Furthermore, as the often compromised quality of biopsy specimens renders diagnosis difficult, new diagnostic tools are warranted...
  15. doi request reprint Extracellular transglutaminase 2 has a role in cell adhesion, whereas intracellular transglutaminase 2 is involved in regulation of endothelial cell proliferation and apoptosis
    C Nadalutti
    Paediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    Cell Prolif 44:49-58. 2011
    ..In efforts to elucidate the role of TG2 in endothelial cell biology, in this study, we measured several endothelial cell characteristics in cells where TG2 was specifically knocked down by RNAi...
  16. pmc Blisters in the small intestinal mucosa of coeliac patients contain T cells positive for cyclooxygenase 2
    H Kainulainen
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Gut 50:84-9. 2002
    ..We have investigated expression of COX-2 in the coeliac disease affected small intestinal mucosa where it may be an indicator of either disease induction or mucosal restoration processes...
  17. doi request reprint Altered small-bowel mucosal vascular network in untreated coeliac disease
    Essi Myrsky
    Paediatric Research Centre, Medical School, University of Tampere
    Scand J Gastroenterol 44:162-7. 2009
    ..The purpose of this study was to establish whether the small-bowel mucosal vasculature is altered in coeliac disease and whether the putative changes are gluten dependent...
  18. doi request reprint Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA
    Essi Myrsky
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    Cell Mol Life Sci 66:3375-85. 2009
    ....
  19. ncbi request reprint Differentially expressed CC3/TIP30 and rab11 along in vivo and in vitro intestinal epithelial cell crypt-villus axis
    K Lindfors
    Institute of Medical Technology, University of Tampere, Finland
    Life Sci 69:1363-72. 2001
    ....
  20. doi request reprint Oats do not induce systemic or mucosal autoantibody response in children with coeliac disease
    Outi Koskinen
    Paediatric Research Centre, University of Tampere, Tampere, Finland
    J Pediatr Gastroenterol Nutr 48:559-65. 2009
    ....
  21. ncbi request reprint Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease
    K Kaukinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Aliment Pharmacol Ther 25:1237-45. 2007
    ..Refractory sprue with malabsorption carries a risk of lymphoma...
  22. doi request reprint Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies
    Sergio Caja
    Paediatric Research Centre, Medical School, University of Tampere, Tampere, Finland
    Scand J Gastroenterol 45:421-7. 2010
    ..In addition, we studied whether the monoclonal patient autoantibodies modulate endothelial cell TG2 activity and whether such modulation is related to the anti-angiogenic effects...
  23. doi request reprint Coeliac disease--a diagnostic and therapeutic challenge
    Katri Kaukinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Clin Chem Lab Med 48:1205-16. 2010
    ..Currently, the only effective treatment for the condition is a life-long strict gluten-free diet. Long-term regular follow-up of patients is recommended in order to maintain good adherence to the diet...
  24. ncbi request reprint A novel human glycosyltransferase: primary structure and characterization of the gene and transcripts
    Taisto Y K Heinonen
    Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland
    Biochem Biophys Res Commun 309:166-74. 2003
    ..The B3GTL gene lacks canonical TATA and CAAT boxes and contains three functional polyadenylation sites. It is transcribed in a wide range of tissues and in TGF-beta-treated T84 epithelial cells...
  25. doi request reprint Inhibition of epithelial growth factor receptor signalling does not preserve epithelial barrier function after in vitro gliadin insult
    Kati Juuti-Uusitalo
    Paediatric Research Centre, Medical School, University of Tampere, Finland
    Scand J Gastroenterol 44:820-5. 2009
    ....
  26. doi request reprint Enzymatic detoxification of gluten by germinating wheat proteases: implications for new treatment of celiac disease
    Satumarja M Stenman
    Pediatric Research Center, Medical School, University of Tampere, Finland
    Ann Med 41:390-400. 2009
    ..We isolated proteases from germinating wheat grain naturally meant for total digestion of wheat storage proteins and investigated whether these enzymes can diminish toxic effects of gluten in vitro and ex vivo...
  27. ncbi request reprint Identification of novel transcription factor-like gene from human intestinal cells
    K Lindfors
    Institute of Medical Technology, Tampere, FIN 33014, Finland
    Biochem Biophys Res Commun 276:660-6. 2000
    ..Human AATF-mRNA was expressed at high levels in human brain, heart, thymus, kidney, and placenta while in skeletal muscle and colon the expression was lower. The gene was mapped to chromosome 17q11.2-q12...