Research Topics
Genomes and Genes | K LindforsSummaryAffiliation: University of Tampere Country: Finland Publications
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Publications
Future treatment strategies for celiac diseaseKatri Lindfors
University of Tampere and Tampere University Hospital, School of Medicine, Pediatric Research Center, Finn Medi 3, FIN 33014, Tampere, Finland
Expert Opin Ther Targets 16:665-75. 2012..It is thus likely that the first medication entering the market will be supplementary to rather than substitute the gluten-free diet...- In vitro models for gluten toxicity: relevance for celiac disease pathogenesis and development of novel treatment optionsKatri Lindfors
Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
Exp Biol Med (Maywood) 237:119-25. 2012.... 
Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA depositsSatumarja M Stenman
Medical School, Pediatric Research Center, University of Tampere, Tampere, Finland
BMC Immunol 9:6. 2008....- Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosaHanna Haveri
Children s Hospital, University of Helsinki, Helsinki, Finland
BMC Gastroenterol 8:9. 2008..The expression of the carcinogenesis-related protein Indian hedgehog was also investigated in comparison to GATA factors... - Transglutaminase 2-targeted autoantibodies in celiac disease: Pathogenetic players in addition to diagnostic tools?Katri Lindfors
Paediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland
Autoimmun Rev 9:744-9. 2010..In this review we discuss the role of TG2, the autoantigen and the autoantibodies targeted against it in the pathogenesis of celiac disease... - TGF-beta induces the expression of SAP30L, a novel nuclear proteinKatri Lindfors
Paediatric Research Centre, Tampere University Hospital, Tampere, Finland
BMC Genomics 4:53. 2003..The aim of this study was to identify novel genes whose products would play a role in this TGF-beta-induced differentiation... - Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin AT Rauhavirta
Paediatric Research Centre, Medical School, University of Tampere, Tampere 33014, Finland
Clin Exp Immunol 164:127-36. 2011..Our results suggest that coeliac patient IgA could play a role in the transepithelial passage of gliadin peptides, a process during which they might be deamidated... - Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell cultureK Lindfors
Paediatric Research Centre, Medical School, University of Tampere, Finland, Department of Peadiatrics, Tampere University Hospital, Tampere, Finland
Clin Exp Immunol 152:552-8. 2008..lactis bacteria can counteract directly the harmful effects exerted by coeliac-toxic gliadin and would clearly warrant further studies of its potential as a novel dietary supplement in the treatment of coeliac disease... - Galactosylation of serum IgA1 O-glycans in celiac diseaseKatri Lindfors
Pediatric Research Center, University of Tampere and Tampere University Hospital, Finn Medi 3, FIN 33014 Tampere, Finland
J Clin Immunol 31:74-9. 2011..Thus, the undergalactosylated IgA1 molecules are not pathognomonic for celiac disease, but galactose deficiency in IgA1 could be an aggravating factor... - Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cellsS M Stenman
Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
Clin Exp Immunol 161:242-9. 2010..In future, these enzymes might be utilized as a novel medical treatment for coeliac disease or in food processing in order to develop high-quality coeliac-safe food products... - Coeliac disease-specific autoantibodies targeted against transglutaminase 2 disturb angiogenesisE Myrsky
Paediatric Research Centre, Medical School, University of Tampere, Tampere, Finland
Clin Exp Immunol 152:111-9. 2008..This disturbance of the angiogenic process could lead in vivo to the disruption of the mucosal vasculature seen in coeliac disease patients on a gluten-containing diet... - A role for anti-transglutaminase 2 autoantibodies in the pathogenesis of coeliac disease?K Lindfors
Paediatric Research Centre, Medical School, University of Tampere and Tampere University Hospital, 33014, Tampere, Finland
Amino Acids 36:685-91. 2009..Although coeliac disease has traditionally been regarded as a T cell-mediated disorder, this review discusses the role of the gluten-induced disease-specific anti-transglutaminase 2-autoantibodies in the pathogenesis of the disease... - SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolusK M Viiri
Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland
Nucleic Acids Res 34:3288-98. 2006..Finally, we characterize a functional nucleolar localization signal in SAP30L and show that SAP30L and SAP30 are able to target Sin3A to the nucleolus... - Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac diseaseOuti Koskinen
Pediatric Research Center, University of Tampere, Tampere, Finland
J Clin Gastroenterol 44:483-8. 2010..Furthermore, as the often compromised quality of biopsy specimens renders diagnosis difficult, new diagnostic tools are warranted... - Extracellular transglutaminase 2 has a role in cell adhesion, whereas intracellular transglutaminase 2 is involved in regulation of endothelial cell proliferation and apoptosisC Nadalutti
Paediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
Cell Prolif 44:49-58. 2011..In efforts to elucidate the role of TG2 in endothelial cell biology, in this study, we measured several endothelial cell characteristics in cells where TG2 was specifically knocked down by RNAi... - Blisters in the small intestinal mucosa of coeliac patients contain T cells positive for cyclooxygenase 2H Kainulainen
Institute of Medical Technology, University of Tampere, Tampere, Finland
Gut 50:84-9. 2002..We have investigated expression of COX-2 in the coeliac disease affected small intestinal mucosa where it may be an indicator of either disease induction or mucosal restoration processes... - Altered small-bowel mucosal vascular network in untreated coeliac diseaseEssi Myrsky
Paediatric Research Centre, Medical School, University of Tampere
Scand J Gastroenterol 44:162-7. 2009..The purpose of this study was to establish whether the small-bowel mucosal vasculature is altered in coeliac disease and whether the putative changes are gluten dependent... - Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoAEssi Myrsky
Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
Cell Mol Life Sci 66:3375-85. 2009.... 
Differentially expressed CC3/TIP30 and rab11 along in vivo and in vitro intestinal epithelial cell crypt-villus axisK Lindfors
Institute of Medical Technology, University of Tampere, Finland
Life Sci 69:1363-72. 2001....- Oats do not induce systemic or mucosal autoantibody response in children with coeliac diseaseOuti Koskinen
Paediatric Research Centre, University of Tampere, Tampere, Finland
J Pediatr Gastroenterol Nutr 48:559-65. 2009.... - Persistent small bowel mucosal villous atrophy without symptoms in coeliac diseaseK Kaukinen
Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
Aliment Pharmacol Ther 25:1237-45. 2007..Refractory sprue with malabsorption carries a risk of lymphoma... - Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodiesSergio Caja
Paediatric Research Centre, Medical School, University of Tampere, Tampere, Finland
Scand J Gastroenterol 45:421-7. 2010..In addition, we studied whether the monoclonal patient autoantibodies modulate endothelial cell TG2 activity and whether such modulation is related to the anti-angiogenic effects... - Coeliac disease--a diagnostic and therapeutic challengeKatri Kaukinen
Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
Clin Chem Lab Med 48:1205-16. 2010..Currently, the only effective treatment for the condition is a life-long strict gluten-free diet. Long-term regular follow-up of patients is recommended in order to maintain good adherence to the diet... - A novel human glycosyltransferase: primary structure and characterization of the gene and transcriptsTaisto Y K Heinonen
Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland
Biochem Biophys Res Commun 309:166-74. 2003..The B3GTL gene lacks canonical TATA and CAAT boxes and contains three functional polyadenylation sites. It is transcribed in a wide range of tissues and in TGF-beta-treated T84 epithelial cells... - Inhibition of epithelial growth factor receptor signalling does not preserve epithelial barrier function after in vitro gliadin insultKati Juuti-Uusitalo
Paediatric Research Centre, Medical School, University of Tampere, Finland
Scand J Gastroenterol 44:820-5. 2009.... - Enzymatic detoxification of gluten by germinating wheat proteases: implications for new treatment of celiac diseaseSatumarja M Stenman
Pediatric Research Center, Medical School, University of Tampere, Finland
Ann Med 41:390-400. 2009..We isolated proteases from germinating wheat grain naturally meant for total digestion of wheat storage proteins and investigated whether these enzymes can diminish toxic effects of gluten in vitro and ex vivo... - Identification of novel transcription factor-like gene from human intestinal cellsK Lindfors
Institute of Medical Technology, Tampere, FIN 33014, Finland
Biochem Biophys Res Commun 276:660-6. 2000..Human AATF-mRNA was expressed at high levels in human brain, heart, thymus, kidney, and placenta while in skeletal muscle and colon the expression was lower. The gene was mapped to chromosome 17q11.2-q12...