Affiliation: University of Helsinki
MÃ¤kinen L, Atula T, HÃ¤yry V, Jouhi L, Datta N, Lehtonen S, et al
. Predictive role of Toll-like receptors 2, 4, and 9 in oral tongue squamous cell carcinoma. Oral Oncol. 2015;51:96-102 pubmed publisher
..Negative or mild TLR-5 expression predicted poor disease-specific survival. All the studied TLRs showed high expression in early-stage OTSCC. More importantly, TLR-2, -4, and -9 seemed to predict invasive tumor growth. ..
Wasik A, Dumont V, Tienari J, Nyman T, Fogarty C, Forsblom C, et al
. Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion. Exp Cell Res. 2017;350:336-348 pubmed publisher
..Furthermore, we observed that septin 7 reduces the activity of NM-IIA in the SNAP23 complex and thereby hinders GSV docking and fusion with the plasma membrane. ..
Wang H, Semenova S, Kuusela S, Panula P, Lehtonen S. Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae. FASEB J. 2015;29:4435-48 pubmed publisher
..The collective data suggest that TNKS1b modulates glucoregulatory mechanisms and the somatic growth of zebrafish larvae via the central melanocortin system. ..
Datta N, Lindfors S, Miura N, Saleem M, Lehtonen S. Overexpression of transcription factor FOXC2 in cultured human podocytes upregulates injury markers and increases motility. Exp Cell Res. 2016;340:32-42 pubmed publisher
..We also suggest a novel molecular mechanism linking obesity-induced decrease in adiponectin to podocyte dysfunction via upregulation of FOXC2. ..
Tolvanen T, Dash S, Polianskyte Prause Z, Dumont V, Lehtonen S. Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes. J Cell Sci. 2015;128:4588-600 pubmed publisher
..This leads to reduced insulin-stimulated trafficking of GSVs and attenuated glucose uptake into CD2AP(-/-) podocytes. ..
Dash S, Narumanchi S, Paavola J, Perttunen S, Wang H, Lakkisto P, et al
. Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish. Am J Physiol Heart Circ Physiol. 2017;312:H1085-H1095 pubmed publisher
..We further found that sept7b and retinoic acid signaling pathways converge to regulate cardiac function. These data prompt further studies defining the role of sept7b in cardiomyopathies. ..
Dumont V, Tolvanen T, Kuusela S, Wang H, Nyman T, Lindfors S, et al
. PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. FASEB J. 2017;31:3978-3990 pubmed publisher
..Tolvanen, T. A., Kuusela, S., Wang, H., Nyman, T. A., Lindfors, S., Tienari, J., Nisen, H., Suetsugu, S., Plomann, M., Kawachi, H., Lehtonen, S. PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. ..
Saurus P, Tolvanen T, Lindfors S, Kuusela S, Holthofer H, Lehtonen E, et al
. Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis. Sci Rep. 2017;7:10731 pubmed publisher
..The data suggest that inhibition of the catalytic activity of SHIP2 is beneficial in reducing oxidative stress, but leads to deleterious increase in apoptosis in podocytes with reduced expression of CD2AP. ..