Matti Lehtinen

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. ncbi request reprint Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial
    Matti Lehtinen
    University of Tampere, School of Public Health, Tampere, Finland
    Lancet Oncol 13:89-99. 2012
  2. pmc Three factor eating questionnaire-R18 as a measure of cognitive restraint, uncontrolled eating and emotional eating in a sample of young Finnish females
    Susanna Anglé
    School of Public Health, University of Tampere, Tampere, Finland
    Int J Behav Nutr Phys Act 6:41. 2009
  3. ncbi request reprint Chapter 28: Studies to assess the long-term efficacy and effectiveness of HPV vaccination in developed and developing countries
    Matti Lehtinen
    National Public Health Institute, Department of Infectious Disease Epidemiology, KTL, Oulu, Finland
    Vaccine 24:S3/233-41. 2006
  4. ncbi request reprint Preparations for implementing human papillomavirus vaccination should begin
    Matti Lehtinen
    National Public Health Institute, Oulu, Finland
    Euro Surveill 10:E050915.1. 2005
  5. ncbi request reprint Vaccination against human papillomaviruses shows great promise
    Matti Lehtinen
    National Public Health Institute, Department of Infectious Disease Epidemiology, 00300 Helsinki, Finland
    Lancet 364:1731-2. 2004
  6. ncbi request reprint Maternal Epstein-Barr virus and cytomegalovirus infections and risk of testicular cancer in the offspring: a nested case-control study
    Katsiaryna Holl
    Department of Child and Adolescent Health, National Public Health Institute, Oulu, Finland
    APMIS 116:816-22. 2008
  7. ncbi request reprint Associations between three types of maternal bacterial infection and risk of leukemia in the offspring
    Matti Lehtinen
    National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 162:662-7. 2005
  8. doi request reprint Is smoking an independent risk factor for invasive cervical cancer? A nested case-control study within Nordic biobanks
    Aline Simen Kapeu
    National Public Health Institute, P O Box 310, 90101 Oulu, Finland
    Am J Epidemiol 169:480-8. 2009
  9. pmc A discrepancy of Chlamydia trachomatis incidence and prevalence trends in Finland 1983-2003
    Erika Lyytikäinen
    National Public Health Institute, Oulu and Helsinki, Finland
    BMC Infect Dis 8:169. 2008
  10. doi request reprint Understanding long-term protection of human papillomavirus vaccination against cervical carcinoma: Cancer registry-based follow-up
    Muhammad Mohsin Rana
    School of Health Sciences, University of Tampere, Tampere, Finland
    Int J Cancer 132:2833-8. 2013

Detail Information

Publications68

  1. ncbi request reprint Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial
    Matti Lehtinen
    University of Tampere, School of Public Health, Tampere, Finland
    Lancet Oncol 13:89-99. 2012
    ..We report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PATRICIA (PApilloma TRIal against Cancer In young Adults)...
  2. pmc Three factor eating questionnaire-R18 as a measure of cognitive restraint, uncontrolled eating and emotional eating in a sample of young Finnish females
    Susanna Anglé
    School of Public Health, University of Tampere, Tampere, Finland
    Int J Behav Nutr Phys Act 6:41. 2009
    ..abstract:..
  3. ncbi request reprint Chapter 28: Studies to assess the long-term efficacy and effectiveness of HPV vaccination in developed and developing countries
    Matti Lehtinen
    National Public Health Institute, Department of Infectious Disease Epidemiology, KTL, Oulu, Finland
    Vaccine 24:S3/233-41. 2006
    ..Much of the research is already ongoing. Depending on the results of the planned immuno bridging studies among HIV-negative and HIV-positive women, further phase III and/or phase IV trials may be warranted...
  4. ncbi request reprint Preparations for implementing human papillomavirus vaccination should begin
    Matti Lehtinen
    National Public Health Institute, Oulu, Finland
    Euro Surveill 10:E050915.1. 2005
  5. ncbi request reprint Vaccination against human papillomaviruses shows great promise
    Matti Lehtinen
    National Public Health Institute, Department of Infectious Disease Epidemiology, 00300 Helsinki, Finland
    Lancet 364:1731-2. 2004
  6. ncbi request reprint Maternal Epstein-Barr virus and cytomegalovirus infections and risk of testicular cancer in the offspring: a nested case-control study
    Katsiaryna Holl
    Department of Child and Adolescent Health, National Public Health Institute, Oulu, Finland
    APMIS 116:816-22. 2008
    ..05, 7.04). In contrast, offspring of CMV IgG-seropositive mothers had a decreased risk of TC diagnosed under 8 years of age (OR, 0.35; 95% CI, 0.14, 0.89). Our results suggest that EBV and CMV infections may be associated with TC...
  7. ncbi request reprint Associations between three types of maternal bacterial infection and risk of leukemia in the offspring
    Matti Lehtinen
    National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 162:662-7. 2005
    ..8, 95% confidence interval: 1.1, 6.9). Since H. pylori immunoglobulin G indicates chronic carriage of the microorganism, early colonization of the offspring probably differs between Iceland and Finland, two affluent countries...
  8. doi request reprint Is smoking an independent risk factor for invasive cervical cancer? A nested case-control study within Nordic biobanks
    Aline Simen Kapeu
    National Public Health Institute, P O Box 310, 90101 Oulu, Finland
    Am J Epidemiol 169:480-8. 2009
    ..This study confirms that smoking is an independent risk factor for cervical cancer/SCC in women infected with oncogenic HPVs. These findings emphasize the importance of cervical cancer prevention among women exposed to tobacco smoke...
  9. pmc A discrepancy of Chlamydia trachomatis incidence and prevalence trends in Finland 1983-2003
    Erika Lyytikäinen
    National Public Health Institute, Oulu and Helsinki, Finland
    BMC Infect Dis 8:169. 2008
    ..We studied C. trachomatis occurrence during the past 20 years in Finland comparing incidence rate data based on serology and reported C. trachomatis laboratory notifications...
  10. doi request reprint Understanding long-term protection of human papillomavirus vaccination against cervical carcinoma: Cancer registry-based follow-up
    Muhammad Mohsin Rana
    School of Health Sciences, University of Tampere, Tampere, Finland
    Int J Cancer 132:2833-8. 2013
    ....
  11. ncbi request reprint Chlamydial antibodies and risk of prostate cancer
    Tarja Anttila
    National Public Health Institute, Oulu, Finland
    Cancer Epidemiol Biomarkers Prev 14:385-9. 2005
    ..We assessed the risk of prostate cancer by exposure to Chlamydia trachomatis...
  12. ncbi request reprint Smoking impairs human papillomavirus (HPV) type 16 and 18 capsids antibody response following natural HPV infection
    Aline Simen-Kapeu
    National Public Health Institute, Youth Sexual Health Unit, Oulu, Finland
    Scand J Infect Dis 40:745-51. 2008
    ..1, 95% CI 0.0-0.8). Smoking did not affect the development of HPV antibody responses in women over 30 y of age. Our results suggest that smoking may induce impaired antibody response in HPV16/18-infected young women...
  13. doi request reprint Endogenous steroid hormone levels in early pregnancy and risk of testicular cancer in the offspring: a nested case-referent study
    Katsiaryna Holl
    Department of Child and Adolescent Health, National Institute for Health and Welfare, Oulu, Finland
    Int J Cancer 124:2923-8. 2009
    ..98-1,090). We report the first direct evidence that interplay of maternal steroid hormones in the early pregnancy is important in the etiology of TC in the offspring...
  14. ncbi request reprint Risk of being seropositive for multiple human papillomavirus types among Finnish and Ugandan women
    Proscovia Bazanya Namujju
    National Institute for Health and Welfare, Oulu, Finland
    Scand J Infect Dis 42:522-6. 2010
    ..In addition to biological and behavioural factors, iatrogenic and societal factors (screening vs no screening) may also result in the different occurrence of infections with the high-risk HPV types in Finland and Uganda...
  15. ncbi request reprint Impact of smoking on the quantity and quality of antibodies induced by human papillomavirus type 16 and 18 AS04-adjuvanted virus-like-particle vaccine - a pilot study
    Proscovia B Namujju
    School of Health Sciences, University of Tampere, Tampere, Finland
    BMC Res Notes 7:445. 2014
    ....
  16. ncbi request reprint Impact of HPV16/18 vaccination on quality of life: a pilot study
    Tiina Eriksson
    School of Health Sciences, University of Tampere, Tampere, Finland
    Eur J Contracept Reprod Health Care 18:364-71. 2013
    ..HPV vaccines provide effective protection against these conditions. We therefore investigated the impact of HPV vaccination on HRQoL in young women five years after participation in a phase III HPV vaccination trial...
  17. pmc Circulating insulin-like growth factor-I in pregnancy and maternal risk of breast cancer
    Adetunji T Toriola
    National Institute for Health and Welfare, Oulu, Finland
    Cancer Epidemiol Biomarkers Prev 20:1798-801. 2011
    ..Previously, we reported a similar association in samples obtained during pregnancy. This study was conducted to further characterize the association of IGF-I during pregnancy with maternal breast cancer risk...
  18. ncbi request reprint Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries
    Pentti Tuohimaa
    Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 108:104-8. 2004
    ..It is recommended that vitamin D deficiency be supplemented, but too high vitamin D serum level might also enhance cancer development...
  19. ncbi request reprint Evaluation of antibody response to human papillomavirus early proteins in women in whom cervical cancer developed 1 to 20 years later
    Matti Lehtinen
    Department of Infectious Disease Epidemiology and Microbiology, National Public Health Institute, Helsinki, Finland
    Am J Obstet Gynecol 188:49-55. 2003
    ..Our purpose was to evaluate whether antibodies to HPV16 and HPV18 E6 and E7 proteins are useful for early diagnosis of cervical cancer by measuring the antibody response in women in whom cervical cancer later developed...
  20. pmc Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy
    Adetunji T Toriola
    National Institute for Health and Welfare, Oulu, Finland
    Cancer Causes Control 22:925-8. 2011
    ..Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored...
  21. ncbi request reprint Maternal herpesvirus infections and risk of acute lymphoblastic leukemia in the offspring
    Matti Lehtinen
    Department of Infectious Disease Epidemiology, National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 158:207-13. 2003
    ..9, 95% confidence interval: 1.5, 5.8). Results indicate that reactivation of maternal EBV infection is probably associated with childhood ALL...
  22. doi request reprint Association between Epstein-Barr virus infection and risk for development of pregnancy-associated breast cancer: joint effect with vitamin D?
    Calypse B Agborsangaya
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Eur J Cancer 47:116-20. 2011
    ..We studied, prospectively, the association of EBV and vitamin D status with the risk of pregnancy-associated breast cancer (PABC), breast cancer diagnosed during pregnancy or 1 year post-partum, using a nested case-control study...
  23. ncbi request reprint Time trends in incidence and prevalence of human papillomavirus type 6, 11 and 16 infections in Finland
    Päivi Laukkanen
    National Public Health Institute, Helsinki and Oulu, Mannerheimintie 166, 00300 Helsinki, Finland
    J Gen Virol 84:2105-9. 2003
    ..Epidemic spread of the oncogenic HPV-16, but not the non-oncogenic HPV-types, throughout the 1980s and 1990s preceded an increase in the incidence of cervical carcinoma in fertile-aged Finnish women...
  24. ncbi request reprint Geographic distribution of cervical cancer-associated human leucocyte antigens and cervical cancer incidence in Finland
    Felipe A Castro
    National Public Health Institute, Oulu, Finland
    Int J STD AIDS 18:672-9. 2007
    ..Whether or not HLA type determines also regional susceptibility to persistent HPV infection, and the success of HPV vaccination in preventing both the persistent infection and CxCa warrants further investigation...
  25. doi request reprint Serum 25-hydroxyvitamin D at pregnancy and risk of breast cancer in a prospective study
    Calypse B Agborsangaya
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Eur J Cancer 46:467-70. 2010
    ..In a longitudinal study, we evaluated the association between vitamin D levels at pregnancy over time with the risk of breast cancer, and pregnancy-associated breast cancer...
  26. pmc Chlamydia trachomatis infection and risk of cervical intraepithelial neoplasia
    Matti Lehtinen
    School of Health Sciences, University of Tampere, Tampere 33014, Finland
    Sex Transm Infect 87:372-6. 2011
    ..As Chlamydia trachomatis is also linked to cervical cancer, its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined...
  27. ncbi request reprint Population dynamics of serologically identified coinfections with human papillomavirus types 11, 16, 18 and 31 in fertile-aged Finnish women
    Marjo Kaasila
    National Institute for Health and Welfare, Oulu, Finland
    Int J Cancer 125:2166-72. 2009
    ..9, 95% CI: 2.5, 6.1). Our observations favor a coinfection rather than superinfection model for the different HPV types and are not suggestive for type-replacement following HPV vaccination...
  28. doi request reprint Differences in incidence and co-occurrence of vaccine and nonvaccine human papillomavirus types in Finnish population before human papillomavirus mass vaccination suggest competitive advantage for HPV33
    Marko Merikukka
    National Institute for Health and Welfare, Oulu, Finland
    Int J Cancer 128:1114-9. 2011
    ..6 (95% CI 2.1-5.9). Our findings suggest a possible competitive advantage for HPV33 over other genital HPV types in the unvaccinated population. HPV33 should be monitored for type replacement after HPV mass vaccination...
  29. ncbi request reprint Enrolment of 22,000 adolescent women to cancer registry follow-up for long-term human papillomavirus vaccine efficacy: guarding against guessing
    Matti Lehtinen
    University of Tampere, Tampere, Finland
    Int J STD AIDS 17:517-21. 2006
    ..This enrolment in addition to our earlier enrolment in another phase III trial guarantees enough power so that by 2020 we can ultimately provide data on the efficacy of HPV16/18 vaccination against CIS+...
  30. doi request reprint The effects of storage time and sampling season on the stability of serum 25-hydroxy vitamin D and androstenedione
    Calypse Agborsangaya
    University of Tampere, Tampere, Finland
    Nutr Cancer 62:51-7. 2010
    ..Stored serum samples can be used to study disease associations with both hormones. However, sampling season needs to be taken into account for 25-OHD by considering matching and stratification and, if possible, serial sampling...
  31. pmc Effect of long-term storage on hormone measurements in samples from pregnant women: the experience of the Finnish Maternity Cohort
    Katsiaryna Holl
    Department of Child and Adolescent Health, National Public Health Institute, Oulu, Finland
    Acta Oncol 47:406-12. 2008
    ..In conclusion, the stored FMC serum samples can be used to study hormone-disease associations, but close matching for storage time and gestational day are necessary design components of all related biobank studies...
  32. ncbi request reprint Seroprevalence atlas of infections with oncogenic and non-oncogenic human papillomaviruses in Finland in the 1980s and 1990s
    Matti Lehtinen
    National Public Health Institute, Oulu and Kuopio, Finland
    Int J Cancer 119:2612-9. 2006
    ..6-9.7). Similar clustering of HPV16 and HPV6/11 infections was not found. The epidemic and the clustering may be due to high transmission probability of the hrHPV types and increase in sexual activity of the index birth cohorts...
  33. doi request reprint An increasing proportion of reported Chlamydia trachomatis infections are repeated diagnoses
    Erika Wikström
    National Institute for Health and Welfare, Helsinki, Finland
    Sex Transm Dis 39:968-72. 2012
    ..We elucidated the conflicting trends by studying incidence of repeated Chlamydia infections over time...
  34. doi request reprint Tobacco smoking and chewing as risk factors for multiple human papillomavirus infections and cervical squamous intraepithelial lesions in two countries (Côte d'Ivoire and Finland) with different tobacco exposure
    Aline Simen-Kapeu
    Department of Child and Adolescent Health, National Public Health Institute, P O Box 310, Oulu, 90101, Finland
    Cancer Causes Control 20:163-70. 2009
    ..In the latter, the risk was statistically significant. Our findings emphasize the need for health initiatives targeted to prevent tobacco smoking or chewing among women especially in less industrialized countries...
  35. doi request reprint Clinical trials of human papillomavirus vaccines and beyond
    Matti Lehtinen
    University of Tampere, School of Health Sciences, Kalevantie 4, FI 33014 Tampere, Finland
    Nat Rev Clin Oncol 10:400-10. 2013
    ..Eradication of the major oncogenic HPV types should be pursued...
  36. ncbi request reprint Long-term persistence of systemic and mucosal immune response to HPV-16/18 AS04-adjuvanted vaccine in preteen/adolescent girls and young women
    Tiina Petaja
    University of Tampere, School of Public Health, Tampere, Finland
    Int J Cancer 129:2147-57. 2011
    ....
  37. ncbi request reprint Anticipated acceptance of HPV vaccination at the baseline of implementation: a survey of parental and adolescent knowledge and attitudes in Finland
    Sarah C Woodhall
    University of Tampere, Tampere, Finland
    J Adolesc Health 40:466-9. 2007
    ....
  38. pmc Low avidity of human papillomavirus (HPV) type 16 antibodies is associated with increased risk of low-risk but not high-risk HPV type prevalence
    Proscovia B Namujju
    National Institute for Health and Welfare, Oulu, Finland
    BMC Res Notes 4:170. 2011
    ..abstract:..
  39. ncbi request reprint Herpes simplex virus and risk of cervical cancer: a longitudinal, nested case-control study in the nordic countries
    Matti Lehtinen
    School of Public Health, University of Tampere, Finland
    Am J Epidemiol 156:687-92. 2002
    ..6, 1.7) and 0.7 (95% CI: 0.3, 1.6), respectively, for HPV seropositives. In the meta-analysis, the relative risk for HSV-2 was 0.9 (95% CI: 0.6, 1.3). In both sets of data, HSV-2 did not play a role in cervical carcinogenesis...
  40. pmc Aspects of prophylactic vaccination against cervical cancer and other human papillomavirus-related cancers in developing countries
    Kari Natunen
    School of Health Sciences, University of Tampere, Tampere, Finland
    Infect Dis Obstet Gynecol 2011:675858. 2011
    ..Considering cost-effectiveness versus justice further research on optional vaccination strategies is warranted...
  41. doi request reprint LINDA - a solution-focused low-intensity intervention aimed at improving health behaviors of young females: a cluster-randomized controlled trial
    Päivi Valve
    School of Medicine, University of Tampere, 33014 Tampere, Finland
    BMC Public Health 13:1044. 2013
    ..The counseling approach's intensity was designed to be low enough to be implementable in primary health care...
  42. pmc Impact of vaccination on 14 high-risk HPV type infections: a mathematical modelling approach
    Simopekka Vänskä
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, Helsinki, Finland
    PLoS ONE 8:e72088. 2013
    ..Limiting the epidemiological model to infection yielded improved understanding of the hrHPV epidemiology and of mechanisms with which vaccination impacts on hrHPV infections. ..
  43. doi request reprint Immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in healthy boys aged 10-18 years
    Tiina Petaja
    School of Public Health, 33014 University of Tampere, Tampere, Finland
    J Adolesc Health 44:33-40. 2009
    ..This study is the first to evaluate the immunogenicity and safety of the vaccine in males...
  44. pmc Epidemiology of HPV 16 and cervical cancer in Finland and the potential impact of vaccination: mathematical modelling analyses
    Ruanne V Barnabas
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    PLoS Med 3:e138. 2006
    ..How these vaccines will be used in countries with national cervical cancer screening programmes is an important question...
  45. ncbi request reprint Circulating enterolactone and prostate cancer risk: a Nordic nested case-control study
    Par Stattin
    Department of Urology, Umea University Hospital, Umea, Sweden
    Int J Cancer 99:124-9. 2002
    ..21 (95% CI = 0.91-1.60), 1.02 (95% CI = 0.59-1.76) and 0.87 (95% CI = 0.45-1.67), respectively. No support for the hypothesis that high circulating enterolactone is protective against prostate cancer was found...
  46. ncbi request reprint High prevalence of HPV among female students in Finland
    Eeva Auvinen
    Department of Virology, HUSLAB Clinical Microbiology and Haartman Institute, University of Helsinki, Helsinki, Finland
    Scand J Infect Dis 37:873-6. 2005
    ..3% were positive for high-risk HPV. The study demonstrated a strikingly high HPV DNA prevalence among the young women. Self-collected samples proved to be acceptable for HPV DNA detection using liquid hybridization...
  47. ncbi request reprint Maternal human polyomavirus infection and risk of neuroblastoma in the child
    Annika Stolt
    Department of Medical Microbiology, Malmo University Hospital, Malmo, Sweden
    Int J Cancer 113:393-6. 2005
    ..In summary, a comprehensive cohort using both serology and polyomavirus DNA detection found no evidence for association between BKV or JCV polyomaviruses and neuroblastoma...
  48. ncbi request reprint A population-based prospective study of Chlamydia trachomatis infection and cervical carcinoma
    Keng Ling Wallin
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 101:371-4. 2002
    ..trachomatis in both the prediagnostic smear and in the subsequent cervical cancer. In conclusion, a prior cervical C. trachomatis infection was associated with an increased risk for development of invasive cervical cancer...
  49. ncbi request reprint Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Lancet Oncol 6:271-8. 2005
    ....
  50. ncbi request reprint Activation of maternal Epstein-Barr virus infection and risk of acute leukemia in the offspring
    Rosamaria Tedeschi
    Department of Microbiology, Oncological Center, Aviano, Italy
    Am J Epidemiol 165:134-7. 2007
    ..3, 16; odds ratio = 5.6, 95% confidence interval: 1.1, 29, respectively), suggesting EBV reactivation in the mothers of non-ALL cases. EBV reactivation may be associated with a proportion of childhood leukemia...
  51. ncbi request reprint Prevalence and stability of human serum antibodies to simian virus 40 VP1 virus-like particles
    Annika Lundstig
    Department of Medical Microbiology, Malmo University Hospital, Entrance 78, 20502 Malmo, Sweden
    J Gen Virol 86:1703-8. 2005
    ..In conclusion, there is a low prevalence of SV40-specific antibodies in the Nordic population. The SV40 antibodies appear to have a low stability over time and their origin is not clear...
  52. ncbi request reprint Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 4th Floor, 01509 010 Sao Paulo, SP, Brazil
    Vaccine 24:5571-83. 2006
    ..Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported...
  53. ncbi request reprint [A vaccine against papillomavirus infections and cancer]
    Matti Lehtinen
    Kansanterveyslaitos, infektioepidemiologian osasto Mannerheimintie 170, 00300 Helsinki
    Duodecim 118:1397-404. 2002
  54. ncbi request reprint Immunization of early adolescent females with human papillomavirus type 16 and 18 L1 virus-like particle vaccine containing AS04 adjuvant
    Court Pedersen
    Odense University Hospital, Odense, Denmark
    J Adolesc Health 40:564-71. 2007
    ..To establish the feasibility of vaccination in girls 10-14 years of age, we compared the immunogenicity and safety in early adolescent female individuals to those 15-25 years in whom vaccine efficacy has been demonstrated...
  55. ncbi request reprint Preventing common sexually transmitted infections in adolescents: time for rethinking
    Matti Lehtinen
    Eur J Contracept Reprod Health Care 11:247-9. 2006
  56. ncbi request reprint High levels of circulating testosterone are not associated with increased prostate cancer risk: a pooled prospective study
    Par Stattin
    Department of Urology, Umea University Hospital, Umea, Sweden
    Int J Cancer 108:418-24. 2004
    ..bottom quintile of 0.82 (95% CI = 0.60-1.14; p(trend) = 0.44). No support was found for the hypothesis that high levels of circulating androgens within a physiologic range stimulate development and growth of prostate cancer...
  57. ncbi request reprint Chlamydia pneumoniae infection and the risk of female early-onset lung cancer
    Tarja Anttila
    Int J Cancer 107:681-2. 2003
  58. ncbi request reprint Seroepidemiology of the human polyomaviruses
    Annika Stolt
    Department of Medical Microbiology, Malmo University Hospital, Entrance 78, Sweden
    J Gen Virol 84:1499-504. 2003
    ..The stability of the antibodies over time indicates that polyomavirus seropositivity is a valid marker of cumulative virus exposure, and polyoma VLP-based EIAs may therefore be useful for epidemiological studies of these viruses...
  59. ncbi request reprint Human papillomavirus 16, 18, and 33 infections and risk of prostate cancer: a Nordic nested case-control study
    Zoltan Korodi
    Department of Medical Microbiology, Lund University, MAS University Hospital, SE 20502 Malmo, Sweden
    Cancer Epidemiol Biomarkers Prev 14:2952-5. 2005
    ..Our data do not support an association between serologic markers of HPV-16, HPV-18, and HPV-33 infections and risk of prostate cancer...
  60. ncbi request reprint Nordic biological specimen banks as basis for studies of cancer causes and control--more than 2 million sample donors, 25 million person years and 100,000 prospective cancers
    Eero Pukkala
    Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland
    Acta Oncol 46:286-307. 2007
    ..The present paper summarizes optimal study designs of biobank-based studies of cancer...
  61. ncbi request reprint [Preventive vaccines against papillomavirus and cervix cancer will soon enter clinical practice]
    Matti Lehtinen
    Folkhälsoinstitutet, Helsingfors
    Lakartidningen 100:3408-12. 2003
    ..Recruitment of adolescents into population-based phase III vaccination studies should be large to allow reliable cancer registry based evaluation of protective effect against grave dysplasia and cervical cancer...
  62. ncbi request reprint Induction of immune memory following administration of a prophylactic quadrivalent human papillomavirus (HPV) types 6/11/16/18 L1 virus-like particle (VLP) vaccine
    Sven Eric Olsson
    Karolinska Institute at Danderyds Hospital, SE 182 88 Danderyd, Sweden
    Vaccine 25:4931-9. 2007
    ..We evaluated the extent to which the vaccine is able to generate HPV type-specific immune memory...
  63. ncbi request reprint Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290 Helsinki, Finland
    Am J Obstet Gynecol 189:1287-92. 2003
    ..The purpose of this study was to determine whether serum antibody response to the three versions of chlamydial heat shock protein 60 is associated with an increased risk for cervical cancer...
  64. doi request reprint Introducing human papillomavirus vaccines - questions remain
    Jorma Paavonen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Ann Med 40:162-6. 2008
    ..Implementing HPV vaccine is a great opportunity but also a great challenge. However, mandatory HPV vaccination may raise many questions, and more answers are needed...
  65. ncbi request reprint Strengthening prevention programs to eliminate cervical cancer in the Nordic countries
    Lena Dillner
    WHO Global Reference Laboratory for HPV Diagnosis and Control, Department of Clinical Microbiology, University Hospital, Malmo, Sweden
    Acta Obstet Gynecol Scand 87:489-98. 2008
    ..The same principles as set up for organized programs and new HPV technologies may apply for screening and vaccination as key tools to eliminate cervical cancer in the Nordic countries and globally...
  66. pmc In vivo and in vitro intragenomic rearrangement of TT viruses
    Ludmila Leppik
    Division for the Characterization of Tumor Viruses, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Virol 81:9346-56. 2007
    ..These data demonstrate new features of TT viruses suggesting possible similarities to plant viruses of the family Geminiviridae, as well as raise questions about the documented plurality and diversity of anelloviruses...
  67. ncbi request reprint Chlamydial heat shock protein 60--specific T cells in inflamed salpingeal tissue
    Anne Kinnunen
    National Public Health Institute, Oulu, Finland
    Fertil Steril 77:162-6. 2002
    ..To evaluate the role of chlamydial heat shock protein 60 (CHSP60)-specific T-lymphocytes in tubal factor infertility...