P Lahermo

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe
    Elina Salmela
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    PLoS ONE 3:e3519. 2008
  2. pmc Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
    Ville Holmberg
    Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland
    Malar J 11:61. 2012
  3. pmc Population substructure in Finland and Sweden revealed by the use of spatial coordinates and a small number of unlinked autosomal SNPs
    Ulf Hannelius
    Department of Biosciences and Nutrition, Karolinska Institutet, 14157 Huddinge, Sweden
    BMC Genet 9:54. 2008
  4. ncbi request reprint Y chromosomal polymorphisms reveal founding lineages in the Finns and the Saami
    P Lahermo
    Department of Medical Genetics, University of Turku, Finland
    Eur J Hum Genet 7:447-58. 1999
  5. ncbi request reprint MtDNA polymorphism in the Hungarians: comparison to three other Finno-Ugric-speaking populations
    P Lahermo
    Department of Medical Genetics, University of Turku, Finland
    Hereditas 132:35-42. 2000
  6. pmc The genetic relationship between the Finns and the Finnish Saami (Lapps): analysis of nuclear DNA and mtDNA
    P Lahermo
    Department of Medical Genetics, University of Turku, Finland
    Am J Hum Genet 58:1309-22. 1996
  7. ncbi request reprint mtDNA haplotype analysis in Finnish families with leber hereditary optic neuroretinopathy
    T Lamminen
    Department of Medical Genetics, University of Turku, Finland
    Eur J Hum Genet 5:271-9. 1997
  8. doi request reprint Population structure in contemporary Sweden--a Y-chromosomal and mitochondrial DNA analysis
    T Lappalainen
    Finnish Genome Center, Institute for Molecular Medicine Finland, University of Helsinki, Tukholmankatu 8, P O Box 20, 00014 Helsinki, Finland
    Ann Hum Genet 73:61-73. 2009
  9. doi request reprint Migration waves to the Baltic Sea region
    T Lappalainen
    Finnish Genome Center, Institute for Molecular Medicine Finland, University of Helsinki, Haartmaninkatu 8, P O Box 63, 00014 University of Helsinki, Finland
    Ann Hum Genet 72:337-48. 2008
  10. pmc Subpopulation difference scanning: a strategy for exclusion mapping of susceptibility genes
    E Salmela
    Finnish Genome Center, University of Helsinki, Finland
    J Med Genet 43:590-7. 2006

Collaborators

Detail Information

Publications13

  1. pmc Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe
    Elina Salmela
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    PLoS ONE 3:e3519. 2008
    ..Genome-wide data provide a powerful tool for inferring patterns of genetic variation and structure of human populations...
  2. pmc Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
    Ville Holmberg
    Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland
    Malar J 11:61. 2012
    ..Innate immunity plays a crucial role in the host defense against malaria including Plasmodium falciparum malaria in pregnancy, but the roles of the various underlying genes and mechanisms predisposing to the disease are poorly understood...
  3. pmc Population substructure in Finland and Sweden revealed by the use of spatial coordinates and a small number of unlinked autosomal SNPs
    Ulf Hannelius
    Department of Biosciences and Nutrition, Karolinska Institutet, 14157 Huddinge, Sweden
    BMC Genet 9:54. 2008
    ..However, some studies have suggested that this number could be reduced if the individual spatial coordinates are taken into account in the analysis...
  4. ncbi request reprint Y chromosomal polymorphisms reveal founding lineages in the Finns and the Saami
    P Lahermo
    Department of Medical Genetics, University of Turku, Finland
    Eur J Hum Genet 7:447-58. 1999
    ..The presence of a bottleneck or founding effect in the male lineages of some of the populations, namely in the Finns and the Saami, would appear to be one likely interpretation for these findings...
  5. ncbi request reprint MtDNA polymorphism in the Hungarians: comparison to three other Finno-Ugric-speaking populations
    P Lahermo
    Department of Medical Genetics, University of Turku, Finland
    Hereditas 132:35-42. 2000
    ..The Hungarians could not be distinguished from the neighboring populations (e.g., the Austrians) any more than from their Finno-Ugric linguistic relatives...
  6. pmc The genetic relationship between the Finns and the Finnish Saami (Lapps): analysis of nuclear DNA and mtDNA
    P Lahermo
    Department of Medical Genetics, University of Turku, Finland
    Am J Hum Genet 58:1309-22. 1996
    ..The distribution of the pairwise nucleotide differences in the Saami suggested that this population has not experienced an expansion similar to what was indicated for the Finns and the reference populations...
  7. ncbi request reprint mtDNA haplotype analysis in Finnish families with leber hereditary optic neuroretinopathy
    T Lamminen
    Department of Medical Genetics, University of Turku, Finland
    Eur J Hum Genet 5:271-9. 1997
    ..However, the frequency of ND4/11778-positive families in haplogroup J was high, which may indicate that background mutations in this haplogroup together with the ND4/11778 primary mutation promote the penetrance of LHON...
  8. doi request reprint Population structure in contemporary Sweden--a Y-chromosomal and mitochondrial DNA analysis
    T Lappalainen
    Finnish Genome Center, Institute for Molecular Medicine Finland, University of Helsinki, Tukholmankatu 8, P O Box 20, 00014 Helsinki, Finland
    Ann Hum Genet 73:61-73. 2009
    ..Our sampling strategy, nonselective on the current population rather than stratified according to ancestry, is informative for capturing the contemporary variation in the increasingly panmictic populations of the world...
  9. doi request reprint Migration waves to the Baltic Sea region
    T Lappalainen
    Finnish Genome Center, Institute for Molecular Medicine Finland, University of Helsinki, Haartmaninkatu 8, P O Box 63, 00014 University of Helsinki, Finland
    Ann Hum Genet 72:337-48. 2008
    ..The possible explanations for the high frequencies of several haplogroups with an origin in the Iberian refugia (H1, U5b, I1a) are also discussed...
  10. pmc Subpopulation difference scanning: a strategy for exclusion mapping of susceptibility genes
    E Salmela
    Finnish Genome Center, University of Helsinki, Finland
    J Med Genet 43:590-7. 2006
    ..Association mapping is a common strategy for finding disease-related genes in complex disorders. Different association study designs exist, such as case-control studies or admixture mapping...
  11. ncbi request reprint Mapping of the second locus for the Van der Woude syndrome to chromosome 1p34
    H Koillinen
    Department of Medical Genetics, University of Helsinki, Finland
    Eur J Hum Genet 9:747-52. 2001
    ..This finding has a special interest because the phenotype in VWS closely resembles the phenotype in non-syndromic forms of cleft lip and palate...
  12. pmc Common candidate gene variants are associated with QT interval duration in the general population
    A Marjamaa
    Research Program in Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Intern Med 265:448-58. 2009
    ..As 30-40% of the QT-interval variability is heritable, we tested the association of common LQTS and NOS1AP gene variants with QT interval in a Finnish population-based sample...
  13. pmc A genome scan for developmental dyslexia confirms linkage to chromosome 2p11 and suggests a new locus on 7q32
    N Kaminen
    Department of Medical Genetics, Biomedicum, University of Helsinki, Finland
    J Med Genet 40:340-5. 2003
    ..No mutations were identified. We conclude that DYX3 appears to be important for dyslexia susceptibility in many Finnish families, and a suggested linkage of dyslexia to chromosome 7q32 will need verification in other data sets...