D E Laaksonen

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. doi Long-term repeatability of measures of early insulin secretion derived from an intravenous glucose tolerance test and conversion from impaired glucose tolerance to diabetes
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Ann Med 40:303-11. 2008
  2. ncbi Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study
    David E Laaksonen
    Department of Clinical Nutrition and Food and Health Research Center, University of Kuopio, P O Box 1627, Kuopio, Finland
    Diabetes 54:158-65. 2005
  3. pmc Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men
    Maarit Valtonen
    Department of Medicine, Central Finland Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    BMC Public Health 9:204. 2009
  4. ncbi Cardiorespiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 26:2156-64. 2003
  5. ncbi C-reactive protein in the prediction of cardiovascular and overall mortality in middle-aged men: a population-based cohort study
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, PO Box 1777, FIN 70211 Kuopio, Finland
    Eur Heart J 26:1783-9. 2005
  6. ncbi Dietary carbohydrate modification enhances insulin secretion in persons with the metabolic syndrome
    David E Laaksonen
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 82:1218-27. 2005
  7. ncbi High dietary nut intake: too much of a good thing?
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, FIN 70211 Kuopio, Finland
    Am J Hypertens 19:637-8. 2006
  8. ncbi Relationships between changes in abdominal fat distribution and insulin sensitivity during a very low calorie diet in abdominally obese men and women
    D E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Nutr Metab Cardiovasc Dis 13:349-56. 2003
  9. ncbi Epidemiology and treatment of the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Ann Med 36:332-46. 2004
  10. ncbi Weight loss and weight maintenance, ambulatory blood pressure and cardiac autonomic tone in obese persons with the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    J Hypertens 21:371-8. 2003

Collaborators

Detail Information

Publications76

  1. doi Long-term repeatability of measures of early insulin secretion derived from an intravenous glucose tolerance test and conversion from impaired glucose tolerance to diabetes
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Ann Med 40:303-11. 2008
    ..We assessed the long-term repeatability of the acute insulin response (AIR) and sensitivity index (S(I)) derived from the frequently sampled intravenous glucose tolerance test (FSIGT)...
  2. ncbi Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study
    David E Laaksonen
    Department of Clinical Nutrition and Food and Health Research Center, University of Kuopio, P O Box 1627, Kuopio, Finland
    Diabetes 54:158-65. 2005
    ..34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals...
  3. pmc Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men
    Maarit Valtonen
    Department of Medicine, Central Finland Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    BMC Public Health 9:204. 2009
    ..Previous studies have focused on physical exercise and depression. We examined the associations of LTPA and cardiorespiratory fitness with feelings of hopelessness...
  4. ncbi Cardiorespiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 26:2156-64. 2003
    ..We studied the association of size at birth with the metabolic syndrome...
  5. ncbi C-reactive protein in the prediction of cardiovascular and overall mortality in middle-aged men: a population-based cohort study
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, PO Box 1777, FIN 70211 Kuopio, Finland
    Eur Heart J 26:1783-9. 2005
    ..We therefore assessed the association of C-reactive protein levels with cardiovascular mortality in a population-based cohort of 2321 middle-aged men stratified by the presence of cardiovascular disease (CVD) at baseline...
  6. ncbi Dietary carbohydrate modification enhances insulin secretion in persons with the metabolic syndrome
    David E Laaksonen
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 82:1218-27. 2005
    ..The metabolic syndrome markedly increases the risk of type 2 diabetes and cardiovascular disease, but the influence of dietary modification on insulin and glucose metabolism independent of weight loss is still poorly understood...
  7. ncbi High dietary nut intake: too much of a good thing?
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, FIN 70211 Kuopio, Finland
    Am J Hypertens 19:637-8. 2006
  8. ncbi Relationships between changes in abdominal fat distribution and insulin sensitivity during a very low calorie diet in abdominally obese men and women
    D E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Nutr Metab Cardiovasc Dis 13:349-56. 2003
    ..We assessed the role of visceral and subcutaneous fat as determinants of insulin sensitivity during rapid weight loss in obese persons with the metabolic syndrome...
  9. ncbi Epidemiology and treatment of the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Ann Med 36:332-46. 2004
    ..In the meantime, efforts to curb obesity and overweight, increase physical activity and improve compliance with current dietary recommendations should continue...
  10. ncbi Weight loss and weight maintenance, ambulatory blood pressure and cardiac autonomic tone in obese persons with the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    J Hypertens 21:371-8. 2003
    ..Most studies on the effects of weight loss on blood pressure and autonomic function do not distinguish between acute or continuing weight loss and steady-state weight maintenance after weight loss...
  11. pmc Dyslipidaemia as a predictor of hypertension in middle-aged men
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Eur Heart J 29:2561-8. 2008
    ..We assessed the association of dyslipidaemia with incident hypertension during a 7-year follow-up in a population-based cohort of middle-aged men without hypertension at baseline...
  12. doi Effect of diet-induced weight loss on plasma apelin and cytokine levels in individuals with the metabolic syndrome
    M V Heinonen
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Nutr Metab Cardiovasc Dis 19:626-33. 2009
    ..The aim of this study was to measure abdominal fat, blood pressure and circulating apelin, adiponectin, leptin, ghrelin, TNF-alpha and IL-6 levels in patients with the metabolic syndrome after a diet-induced weight loss...
  13. ncbi Changes in abdominal subcutaneous fat water content with rapid weight loss and long-term weight maintenance in abdominally obese men and women
    D E Laaksonen
    1Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Int J Obes Relat Metab Disord 27:677-83. 2003
    ..Insulin resistance decreases blood flow and volume in fat tissue. We hypothesised that fat tissue nutritive blood flow and volume, and thereby water content, would increase during weight loss and weight maintenance in obese persons...
  14. ncbi Increased resting and exercise-induced oxidative stress in young IDDM men
    D E Laaksonen
    Department of Physiology, University of Kuopio, Finland
    Diabetes Care 19:569-74. 1996
    ..To assess the effect of acute physical exercise on oxidative stress and glutathione redox status and the relation to physical fitness in otherwise healthy young men with IDDM...
  15. doi Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study
    V D F de Mello
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio 70211, Finland
    Diabetologia 51:2060-7. 2008
    ..The genes studied were: TNF receptors TNFRSF1A and TNFRSF1B, and IL1R1, TLR4, TLR2, ICAM1, CCL5 and IKBKB...
  16. ncbi Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome
    L Niskanen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Obes Metab 6:208-15. 2004
    ..Little is known about the short- and long-term effects of weight loss on sex steroids in abdominally obese men, however...
  17. ncbi C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men
    D E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetologia 47:1403-10. 2004
    ..We investigated the association between C-reactive protein (CRP) levels and the development of the metabolic syndrome and diabetes in men...
  18. doi Serum concentrations and expressions of serum amyloid A and leptin in adipose tissue are interrelated: the Genobin Study
    T Lappalainen
    Department of Clinical Nutrition and Food and Health Research Center, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Eur J Endocrinol 158:333-41. 2008
    ..We investigated the association between SAA and leptin in obese and normal weight subjects and analyzed the effect of weight reduction on serum SAA concentration and gene expression in adipose tissue of the obese subjects...
  19. ncbi Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study
    Petteri Kallio
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 85:1417-27. 2007
    ..Diets rich in whole-grain cereals and foods with a low glycemic index may protect against type 2 diabetes, but the underlying molecular mechanisms are unknown...
  20. ncbi Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Med Sci Sports Exerc 39:227-32. 2007
    ..We assessed the associations of leisure-time physical activity (LTPA), dietary changes, and weight loss on the risk of type 2 diabetes according to the 12Glu9 polymorphism in 481 participants of the Finnish Diabetes Prevention Study...
  21. doi Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line
    Tiina Lappalainen
    Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio, Finland
    J Nutrigenet Nutrigenomics 3:37-45. 2010
    ..We also investigated if mRNA levels of FTO in adipose tissue correlated with the adiposity or inflammatory markers and mRNA levels of genes involved in the response to hypoxia (HIF-1a) and cell death(HMGB1)...
  22. pmc Health economic consequences of reducing salt intake and replacing saturated fat with polyunsaturated fat in the adult Finnish population: estimates based on the FINRISK and FINDIET studies
    J A Martikainen
    ESiOR Oy Ltd, Kuopio, Finland
    Eur J Clin Nutr 65:1148-55. 2011
    ..0 g per day) and replacement of saturated fat (SFA, -1.0 energy percent (E%)) with polyunsaturated fat (PUFA, +1.0 E%) in the Finnish population aged 30-74 years...
  23. doi Exercise training and experimental diabetes modulate heat shock protein response in brain
    Z Lappalainen
    Institute of Biomedicine, Physiology, University of Kuopio, and Institute of Clinical Medicine, Surgery, Kuopio University Hospital, Kuopio, Finland
    Scand J Med Sci Sports 20:83-9. 2010
    ..Altogether, our findings suggest that endurance training increases HSP expression in the brain, and that experimental diabetes is associated with an incomplete HSP response at the protein level...
  24. ncbi Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN study
    M Kolehmainen
    School of Public Health and Clinical Nutrition, Clinical Nutrition and Food and Health Research Center, University of Kuopio, Kuopio, Finland
    Int J Obes (Lond) 32:292-303. 2008
    ....
  25. doi The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study
    T O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Exp Clin Endocrinol Diabetes 118:757-9. 2010
    ..In conclusion, the rs1800629 SNP in the TNF gene may modify the effect of moderate-to-vigorous physical activity on serum levels of CRP...
  26. ncbi Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes
    T O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Physiol Genomics 31:264-72. 2007
    ..022-0.027 for the SNPs in SLC2A2, and P = 0.007 for rs3758947). We conclude that moderate-to-vigorous PA may modify the risk of developing T2D associated with genes regulating insulin secretion (SLC2A2, ABCC8) in persons with IGT...
  27. ncbi The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study
    David E Laaksonen
    Department of Medicine, Kuopio University, P O Box 1627, FIN 70211 Kuopio, Finland
    J Clin Endocrinol Metab 90:712-9. 2005
    ..Prevention of abdominal obesity and the accompanying metabolic syndrome in middle age may decrease the risk of hypogonadism in men, especially in those who quit smoking...
  28. doi Effect of weight loss on cytokine messenger RNA expression in peripheral blood mononuclear cells of obese subjects with the metabolic syndrome
    Vanessa D F de Mello
    School of Public Health and Clinical Nutrition, Food and Health Research Centre, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Metabolism 57:192-9. 2008
    ....
  29. doi Hopelessness -- novel facet of the metabolic syndrome in men
    Maarit Valtonen
    Department of Medicine, Central Finland Central Hospital, Jyvaskyla, Finland
    Scand J Public Health 36:795-802. 2008
    ..Little is known, however, about the relationship of hopelessness and the metabolic syndrome. The aim of this study is to examine the association of hopelessness and the metabolic syndrome...
  30. ncbi Plasma ghrelin levels after two high-carbohydrate meals producing different insulin responses in patients with metabolic syndrome
    Miika V Heinonen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Regul Pept 138:118-25. 2007
    ..This indicates that regulation of ghrelin might be altered in obese patients with metabolic syndrome independently of insulin...
  31. ncbi Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 27:1036-41. 2004
    ..We assessed the association of low levels of testosterone and sex hormone-binding globulin (SHBG) with the development of the metabolic syndrome and diabetes in men...
  32. doi A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults
    Leila J Karhunen
    Food and Health Research Centre, Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    J Nutr 140:737-44. 2010
    ..However, postprandial ratings of appetite were mostly similar after the test meals. In conclusion, solid meals enriched with psyllium fiber strongly modified postprandial signals arising from the GI tract...
  33. ncbi Inflammation, abdominal obesity, and smoking as predictors of hypertension
    Leo Niskanen
    Department of Medicine, Kuopio University Hospital, Finland
    Hypertension 44:859-65. 2004
    ....
  34. ncbi Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland
    Int J Cancer 111:444-50. 2004
    ....
  35. doi Semisolid meal enriched in oat bran decreases plasma glucose and insulin levels, but does not change gastrointestinal peptide responses or short-term appetite in healthy subjects
    K R Juvonen
    Food and Health Research Centre, Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Nutr Metab Cardiovasc Dis 21:748-56. 2011
    ....
  36. doi Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome
    M Lankinen
    VTT Technical Research Centre of Finland, Espoo, Finland
    Nutr Metab Cardiovasc Dis 20:249-57. 2010
    ..We studied the effect of carbohydrate modification on serum metabolic profiles, including lipids and branched chain amino acids, and dependencies between these and specific gene expression pathways in adipose tissue...
  37. ncbi [Dietary fibers: current trends and health benefits in the metabolic syndrome and type 2 diabetes]
    Vanessa D de Mello
    School of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Kuopio P O Box 1627, FIN 70211 Kuopio, Finland
    Arq Bras Endocrinol Metabol 53:509-18. 2009
    ....
  38. doi Dietary fatty acids and cardiovascular disease: an epidemiological approach
    Arja Erkkilä
    Department of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Prog Lipid Res 47:172-87. 2008
    ..Data from metabolic and clinical studies reinforce findings from observational studies supporting recommendations to replace saturated and trans fat with unsaturated fat in the prevention of cardiovascular disease...
  39. ncbi Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome
    Petteri Kallio
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Finland
    Am J Clin Nutr 87:1497-503. 2008
    ..Inflammation may be a mechanism by which high postprandial insulin and glucose responses increase the risk of type 2 diabetes mellitus...
  40. doi Cardiorespiratory fitness as a feature of metabolic syndrome in older men and women: the Dose-Responses to Exercise Training study (DR's EXTRA)
    Maija Hassinen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Diabetes Care 31:1242-7. 2008
    ..We studied the associations of cardiorespiratory fitness with metabolic syndrome in older men and women, because such data are limited in representative population samples...
  41. doi Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome
    Ursula Mager
    Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, Food and Health Research Centre, University of Kuopio PO Box 1627, FIN 70211 Kuopio, Finland
    Eur J Endocrinol 158:499-510. 2008
    ..We examined the expression of ghrelin and ghrelin receptors in peripheral blood mononuclear cells (PBMCs) and evaluated the effect of weight loss or exercise on plasma ghrelin concentrations in subjects with the metabolic syndrome...
  42. ncbi Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Am J Epidemiol 156:1070-7. 2002
    ..The NCEP definition including waist > 102 cm also identifies persons at high risk for diabetes, but it is relatively insensitive in predicting diabetes...
  43. pmc Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study
    Ursula Schwab
    School of Public Health and Clinical Nutrition, Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    PLoS ONE 3:e2630. 2008
    ..The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention...
  44. ncbi Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Diabetes Care 25:1612-8. 2002
    ..We studied the associations of LTPA and cardiorespiratory fitness with development of the metabolic syndrome (World Health Organization [WHO] and the National Cholesterol Education Program [NCEP] definitions)...
  45. doi Viscosity of oat bran-enriched beverages influences gastrointestinal hormonal responses in healthy humans
    Kristiina R Juvonen
    Department of Clinical Nutrition, Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, 70211 Kuopio, Finland
    J Nutr 139:461-6. 2009
    ....
  46. pmc Heat shock proteins in diabetes and wound healing
    Mustafa Atalay
    Institute of Biomedicine, Physiology, University of Kuopio, Finland
    Curr Protein Pept Sci 10:85-95. 2009
    ..Several physical, pharmacological and genetic approaches may be considered to address HSP-directed therapies both in the laboratory and in the clinics...
  47. doi Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention
    Tuomas O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio 70211, Finland
    Metabolism 57:428-36. 2008
    ..In conclusion, genetic variation may modify the magnitude of the beneficial effects of PA on characteristics of the metabolic syndrome in persons with IGT...
  48. ncbi High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women
    Katri S Juntunen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 77:385-91. 2003
    ..Fiber and whole-cereal intakes may protect against hyperinsulinemia and the risk of type 2 diabetes...
  49. ncbi Sex hormones, inflammation and the metabolic syndrome: a population-based study
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Eur J Endocrinol 149:601-8. 2003
    ..Mild hypoandrogenism in men is associated with features of the metabolic syndrome, but the association with the metabolic syndrome itself using an accepted definition has not been described...
  50. ncbi Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread
    Katri S Juntunen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 78:957-64. 2003
    ..Rye bread has a beneficial effect on the postprandial insulin response in healthy subjects. The role of rye fiber in insulin and glucose metabolism is not known...
  51. ncbi Physical activity in prevention and treatment of the metabolic syndrome
    Timo A Lakka
    Institute of Biomedicine, Department of Physiology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Appl Physiol Nutr Metab 32:76-88. 2007
    ..The measurement of maximal oxygen consumption may provide an efficient means to target even individuals with relatively few metabolic risk factors who may benefit from more intensive intervention...
  52. ncbi Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study
    Leo K Niskanen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Arch Intern Med 164:1546-51. 2004
    ..Despite abundant epidemiologic evidence, the role of elevated serum uric acid level as a cardiovascular risk factor is controversial. We assessed the predictive value of serum uric acid levels for cardiovascular and overall mortality...
  53. ncbi Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome
    Maarit Hallikainen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Clin Chim Acta 383:126-32. 2007
    ..The purpose of this study was to investigate whether cholesterol metabolism is associated with serum adipokines and inflammatory markers...
  54. ncbi SNPs in PPARG associate with type 2 diabetes and interact with physical activity
    Tuomas O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Med Sci Sports Exerc 40:25-33. 2008
    ....
  55. ncbi Metabolic syndrome and the risk of prostate cancer in Finnish men: a population-based study
    Jari A Laukkanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211, Finland
    Cancer Epidemiol Biomarkers Prev 13:1646-50. 2004
    ..Individual components of metabolic syndrome have been linked to an increased risk for prostate cancers. We hypothesized that metabolic syndrome itself could confer an increased risk for incident prostate cancer...
  56. ncbi Interaction between cholesterol and glucose metabolism during dietary carbohydrate modification in subjects with the metabolic syndrome
    Maarit Hallikainen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 84:1385-92. 2006
    ..Carbohydrate modification based on rye bread and pasta enhances early insulin secretion in subjects with the metabolic syndrome...
  57. ncbi Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men
    D E Laaksonen
    Department of Physiology, and Research Institute of Public Health, University of Kuopio, and Department of Medicine, Kuopio University Hospital, Kuopio, and Inner Savo Health Centre, Suonerjoki, Finland
    Diabet Med 19:456-64. 2002
    ..We assessed the association of serum fatty acid composition with development of IFG or DM...
  58. ncbi Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland
    Arch Intern Med 165:193-9. 2005
    ..Substitution of dietary polyunsaturated for saturated fat has long been recommended for the primary prevention of cardiovascular disease (CVD), but only a few prospective cohort studies have provided support for this advice...
  59. ncbi Markers of absorption and synthesis of cholesterol in men with type 1 diabetes
    Helena Gylling
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Diabetes Metab Res Rev 23:372-7. 2007
    ..Subjects were categorised into tertiles by the cholestanol to cholesterol ratio of controls indicating low to high absorption of cholesterol...
  60. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  61. doi alpha-Lipoic acid supplementation enhances heat shock protein production and decreases post exercise lactic acid concentrations in exercised standardbred trotters
    S Kinnunen
    Institute of Biomedicine, Physiology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Res Vet Sci 87:462-7. 2009
    ..Our results suggest that LA supplementation may enhance tissue protection and increase oxidative capacity of the muscle in horse...
  62. ncbi Fish oil and vitamin E supplementation in oxidative stress at rest and after physical exercise
    C K Sen
    Department of Physiology, Faculty of Medicine, University of Kuopio, 70211 Kuopio, Finland
    J Appl Physiol (1985) 83:189-95. 1997
    ..Despite higher levels of hepatic lipid peroxidation at rest in FOVE compared with SOVE, liver appeared to be relatively less susceptible to exercise-induced oxidative stress in FOVE...
  63. ncbi Serum uric acid as a harbinger of metabolic outcome in subjects with impaired glucose tolerance: the Finnish Diabetes Prevention Study
    Leo Niskanen
    Department of Medicine, Kuopio University Hospital, Bld nro 5, FIN 70210, Kuopio, Finland
    Diabetes Care 29:709-11. 2006
  64. ncbi Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: the effect of improved glycemic control
    Chaiyasit Sittiwet
    Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland
    Atherosclerosis 194:465-72. 2007
    ..From a clinical point of view, the better the glycemic control, the more antiatherogenic cholesterol metabolism may be in type 1 diabetes...
  65. ncbi Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney
    Niku K J Oksala
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Antioxid Redox Signal 9:497-506. 2007
    ..However, LA supplementation did not affect these HSPs at the protein level. These findings suggest that in addition to its antiglomerulosclerotic effects, LA can induce cytoprotective response in SID...
  66. ncbi Acute exercise and thioredoxin-1 in rat brain, and alpha-lipoic acid and thioredoxin-interacting protein response, in diabetes
    Zekine Lappalainen
    Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland
    Int J Sport Nutr Exerc Metab 20:206-15. 2010
    ..Because lipoic acid increased TRX-interacting protein transcription in diabetes, high doses may impair TRX-1 homeostasis...
  67. ncbi Exercise training modulates heat shock protein response in diabetic rats
    Mustafa Atalay
    Department of Physiology, University of Kuopio, Finland
    J Appl Physiol 97:605-11. 2004
    ..Our results suggest that diabetes impairs HSP protection, possibly via transcriptionally mediated mechanisms...
  68. ncbi Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation
    Niku K J Oksala
    Department of Physiology, University of Kuopio, Finland
    J Diabetes Complications 20:257-61. 2006
    ..Acute exercise increased liver 4-HNE, which was offset by LA. In conclusion, diabetes induced oxidative stress and impaired myocardial HSP60 expression, while LA partially offsets these alterations in a tissue-specific manner...
  69. ncbi Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats
    Mustafa Gul
    Department of Physiology, University of Kuopio, Finland
    Scand J Med Sci Sports 12:163-70. 2002
    ....
  70. doi Influence of 12 weeks of jogging on magnetic resonance-determined left ventricular characteristics in previously sedentary subjects free of cardiovascular disease
    Petri Sipola
    Department of Clinical Radiology, Kuopio University, Kuopio University Hospital, Finland
    Am J Cardiol 103:567-71. 2009
    ....
  71. doi Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain
    Zekine Lappalainen
    Institute of Biomedicine, University of Kuopio, Kuopio, Finland
    J Appl Physiol (1985) 106:461-7. 2009
    ..Increased oxidative stress may be both a cause and a consequence of perturbed antioxidant defenses in the diabetic brain...
  72. doi alpha-Lipoic acid modulates thiol antioxidant defenses and attenuates exercise-induced oxidative stress in standardbred trotters
    Susanna Kinnunen
    Institute of Biomedicine, Physiology, University of Kuopio, PO Box 1627, Kuopio, Finland
    Free Radic Res 43:697-705. 2009
    ..These findings suggest that LA enhances thiol antioxidant defences and decreases exercise-induced oxidative stress in skeletal muscle...
  73. doi Body composition and fitness during strength and/or endurance training in older men
    Elina Sillanpää
    Department of Biology of Physical Activity, University of Jyvaskyla, Jyvaskyla, Finland
    Med Sci Sports Exerc 40:950-8. 2008
    ..We also compared the usefulness of different methods for the analysis of body composition to detect training-induced adaptations...
  74. ncbi Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome
    Timo A Lakka
    Research Institute of Public Health, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 35:1279-86. 2003
    ....
  75. doi Estimation of maximal heart rate using the relationship between heart rate variability and exercise intensity in 40-67 years old men
    Laura Karavirta
    Department of Biology of Physical Activity, University of Jyvaskyla, PO Box 35, 40014 Jyvaskyla, Finland
    Eur J Appl Physiol 103:25-32. 2008
    ..633-0.603(age) + 0.441(HRHF50%) (SEE = 9.8 bpm vs. 11.6 bpm in the equation based on age alone). The decline of HRV during incremental exercise seems to be useful for accurate estimation of maximal heart rate...
  76. ncbi The effect of home biofeedback training on stress incontinence
    Pauliina Aukee
    Department of Obstetrics and Gynecology, Jyvaskyla Central Hospital, Finland
    Acta Obstet Gynecol Scand 83:973-7. 2004
    ..To compare the effectiveness of pelvic floor training (PFT) with the aid of a home biofeedback device to PFT alone for urodynamic stress urinary incontinence (SUI) in women after a 1-year follow-up...