M P Laakso

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi Diagnosis of Alzheimer's disease: MRI of the hippocampus vs delayed recall
    M P Laakso
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Neuropsychologia 38:579-84. 2000
  2. doi Olfactory identification in non-demented elderly population and in mild cognitive impairment: a comparison of performance in clinical odor identification versus Boston Naming Test
    Mikko P Laakso
    Department of Neurology, Kuopio University Hospital, Bldg 5, P O Box 1777, Kuopio 70211, Finland
    J Neural Transm 116:891-5. 2009
  3. ncbi Decreased brain creatine levels in elderly apolipoprotein E epsilon 4 carriers
    M P Laakso
    Department of Neurology, Clinical Radiology, Kuopio University Hospital, Kuopio, Finland
    J Neural Transm 110:267-75. 2003
  4. ncbi Structural imaging in cognitive impairment and the dementias: an update
    Mikko P Laakso
    The Department of Neurology, Building 5, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland
    Curr Opin Neurol 15:415-21. 2002
  5. ncbi Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism
    Mikko P Laakso
    Department of Neurology, Kuopio University Hospital, 70211, Kuopio, Finland
    Psychiatry Res 114:95-102. 2002
  6. ncbi A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism
    M P Laakso
    Department of Neurology, Kuopio University Hospital, Building 5, P O Box 1777, 70211, Kuopio, Finland
    Behav Brain Res 109:177-86. 2000
  7. ncbi A morphometric MRI study of the hippocampus in first-episode, neuroleptic-naïve schizophrenia
    M P Laakso
    Department of Neurology, Bldg 5, Kuopio University Hospital, P O Box 1777, Kuopio, Finland
    Schizophr Res 50:3-7. 2001
  8. ncbi Psychopathy and the posterior hippocampus
    M P Laakso
    Department of Neurology, Bldg 5, Kuopio University Hospital, POB 1777, 70211, Kuopio, Finland
    Behav Brain Res 118:187-93. 2001
  9. ncbi ApoE polymorphism and acute stroke: a study with diffusion- and perfusion-weighted MRI and MR angiography
    Y Liu
    Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland
    Acta Neurol Scand 114:323-8. 2006
  10. pmc Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
    M Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    BMJ 322:1447-51. 2001

Collaborators

Detail Information

Publications33

  1. ncbi Diagnosis of Alzheimer's disease: MRI of the hippocampus vs delayed recall
    M P Laakso
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Neuropsychologia 38:579-84. 2000
    ..93 for the left hippocampus and 0.96 for the VRT. These data suggest that assessment of delayed recall with the VRT is of high diagnostic accuracy, and may surpass the diagnostic accuracy of hippocampal volumetry...
  2. doi Olfactory identification in non-demented elderly population and in mild cognitive impairment: a comparison of performance in clinical odor identification versus Boston Naming Test
    Mikko P Laakso
    Department of Neurology, Kuopio University Hospital, Bldg 5, P O Box 1777, Kuopio 70211, Finland
    J Neural Transm 116:891-5. 2009
    ..Standard assessment of olfactory nerve function is not sufficient to study cognitive impairment in MCI...
  3. ncbi Decreased brain creatine levels in elderly apolipoprotein E epsilon 4 carriers
    M P Laakso
    Department of Neurology, Clinical Radiology, Kuopio University Hospital, Kuopio, Finland
    J Neural Transm 110:267-75. 2003
    ..These findings may be of significant clinical interest as potential indicator of incipient AD, and also from therapeutical point of view given the potential neuroprotective effects of creatine...
  4. ncbi Structural imaging in cognitive impairment and the dementias: an update
    Mikko P Laakso
    The Department of Neurology, Building 5, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland
    Curr Opin Neurol 15:415-21. 2002
    ..Data from dementias other than Alzheimer's disease are reviewed at some length before outlining some novel issues in Alzheimer's disease imaging...
  5. ncbi Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism
    Mikko P Laakso
    Department of Neurology, Kuopio University Hospital, 70211, Kuopio, Finland
    Psychiatry Res 114:95-102. 2002
    ..Moreover, no significant correlations between any of the volumes and the degree of psychopathy were found...
  6. ncbi A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism
    M P Laakso
    Department of Neurology, Kuopio University Hospital, Building 5, P O Box 1777, 70211, Kuopio, Finland
    Behav Brain Res 109:177-86. 2000
    ....
  7. ncbi A morphometric MRI study of the hippocampus in first-episode, neuroleptic-naïve schizophrenia
    M P Laakso
    Department of Neurology, Bldg 5, Kuopio University Hospital, P O Box 1777, Kuopio, Finland
    Schizophr Res 50:3-7. 2001
    ..These data are at odds with the previous reports on hippocampal volume loss in first-episode schizophrenia, and with the hypothesis of regionally specific hippocampal volume deficit in schizophrenia...
  8. ncbi Psychopathy and the posterior hippocampus
    M P Laakso
    Department of Neurology, Bldg 5, Kuopio University Hospital, POB 1777, 70211, Kuopio, Finland
    Behav Brain Res 118:187-93. 2001
    ....
  9. ncbi ApoE polymorphism and acute stroke: a study with diffusion- and perfusion-weighted MRI and MR angiography
    Y Liu
    Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland
    Acta Neurol Scand 114:323-8. 2006
    ..We examined whether the apolipoprotein E (ApoE) allele epsilon4 influences imaging findings in stroke as assessed by diffusion- (DWI) and perfusion-weighted (PWI) magnetic resonance imaging, and MR angiography (MRA)...
  10. pmc Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
    M Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    BMJ 322:1447-51. 2001
    ..To examine the relation of midlife raised blood pressure and serum cholesterol concentrations to Alzheimer's disease in later life...
  11. doi Cerebellar apparent diffusion coefficient changes in patients with supratentorial ischemic stroke
    Y Liu
    Department of Clinical Radiology, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    Acta Neurol Scand 122:316-22. 2010
    ..To evaluate apparent diffusion coefficient (ADC) in cerebellar subregions in patients with stroke...
  12. pmc A voxel based morphometry study on mild cognitive impairment
    C Pennanen
    Department of Neurology, Bldg 5, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland
    J Neurol Neurosurg Psychiatry 76:11-4. 2005
    ..A number of volumetric magnetic resonance imaging (MRI) studies have detected atrophy of the medial temporal lobe in subjects with MCI, but for the other cerebral regions the results have been inconsistent...
  13. ncbi How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer's disease? A review of neuroimaging studies
    M Lehtovirta
    Department of Neurology, Kuopio University Hospital, P O Box 1777, 70211, Kuopio, Finland
    Neurobiol Aging 21:293-300. 2000
    ..Further, the possible clinicopathological implications of these findings are discussed...
  14. ncbi Assessing the outcome of stroke: a comparison between MRI and clinical stroke scales
    J Nuutinen
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Acta Neurol Scand 113:100-7. 2006
    ..The ability of DWI and PWI to predict the outcome was compared with the ability of clinical stroke scales to predict the outcome...
  15. ncbi Serum testosterone levels in males with Alzheimer's disease
    C Pennanen
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    J Neuroendocrinol 16:95-8. 2004
    ..These data provide no support for hypotheses of (disproportionally) decreased levels of serum testosterone in AD. These data also show that all cognitively normal controls had an FAI below the normal range...
  16. ncbi Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease
    N Kemppainen
    Department of Neurology, PO Box 52, University of Turku, FIN 20521 Turku, Finland
    Eur J Neurosci 18:149-54. 2003
    ..002). Our findings suggest a role for temporal lobe D2 receptors in the memory and naming performance in AD, and suggest that studies to evaluate the efficiency of dopaminergic medication on patients with early AD might be warranted...
  17. ncbi Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study
    M Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, Finland
    Neurology 56:1683-9. 2001
    ....
  18. ncbi Visual assessment of medial temporal atrophy on MR films in Alzheimer's disease: comparison with volumetry
    Lorena Bresciani
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Aging Clin Exp Res 17:8-13. 2005
    ..To test the agreement of a visual rating scale of medial temporal lobe atrophy (MTA) with linear and volumetric assessments, and to test its accuracy in discriminating between Alzheimer's disease (AD) patients and controls...
  19. ncbi A comparison between the accuracy of voxel-based morphometry and hippocampal volumetry in Alzheimer's disease
    Cristina Testa
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Magn Reson Imaging 19:274-82. 2004
    ..To compare the accuracy of voxel-based morphometry (VBM) and region of interest (ROI)-based hippocampal volumetry to detect medial temporal lobe atrophy in Alzheimer's disease (AD)...
  20. ncbi The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study
    Corina Pennanen
    Department of Neuroscience and Neurology, University of Kuopio, Canthia, Kuopio, Finland
    Dement Geriatr Cogn Disord 22:60-6. 2006
    ..In cases homozygous for the epsilon4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus...
  21. ncbi MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study
    Tero Tapiola
    Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
    Neurobiol Aging 29:31-8. 2008
    ..The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD...
  22. ncbi Frontotemporal dementia as a neural system disease
    Marina Boccardi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurobiol Aging 26:37-44. 2005
    ..At P<0.001 uncorrected also the periaqueductal gray was atrophic. Atrophy outside the RLS was confined to a few voxels in the frontal and temporal gyri. FTD might be a neural-system disease where the RLS is predominantly damaged...
  23. ncbi MRI volumetry of the vermis and the cerebellar hemispheres in men with schizophrenia
    Christian C Joyal
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland
    Psychiatry Res 131:115-24. 2004
    ..However, the suggestion that schizophrenia is related to abnormal volumes of the lateral cerebellum is not supported...
  24. ncbi Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
    Corina Pennanen
    Department of Neuroscience and Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, P O Box 1627, FIN 70 211 Kuopio, Finland
    Neurobiol Aging 25:303-10. 2004
    ..Our results suggest that the ERC atrophy precedes hippocampal atrophy in AD. The ERC volume loss is dominant over the hippocampal volume loss in MCI, whereas more pronounced hippocampal volume loss appears in mild AD...
  25. ncbi Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: potential for pharmacological intervention
    Miia Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    CNS Drugs 16:435-44. 2002
    ..Based on these data, we propose that proper, early interventions aimed at reducing these cardiovascular risk factors may have an impact on the future incidence and prevalence of Alzheimer's disease...
  26. ncbi The MRI pattern of frontal and temporal brain atrophy in fronto-temporal dementia
    Marina Boccardi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, FBF, via Pilastroni 4, I 25125, Brescia, Italy
    Neurobiol Aging 24:95-103. 2003
    ..To compare patterns of brain atrophy in fronto-temporal dementia (FTD) and Alzheimer's disease (AD) since atrophy in individual areas may not be sufficiently specific as diagnostic marker...
  27. ncbi Clinical characteristics of frontotemporal patients with symmetric brain atrophy
    Marina Boccardi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, FBF, via Pilastroni 4, 25125 Brescia, Italy
    Eur Arch Psychiatry Clin Neurosci 252:235-9. 2002
    ..The presence of the epsilon4 allele is consistent with the hypothesis of greater vulnerability of the brain in epsilon4 carriers...
  28. ncbi Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
    Miia Kivipelto
    University of Kuopio, Department of Neuroscience and Neurology, PO Box 1627, 70211 Kuopio, Finland
    Ann Intern Med 137:149-55. 2002
    ..Elevated midlife values for total cholesterol level and blood pressure have been implicated recently as risk factors for Alzheimer disease...
  29. ncbi Apolipoprotein E polymorphism and acute ischemic stroke: a diffusion- and perfusion-weighted magnetic resonance imaging study
    Yawu Liu
    Department of Clinical Radiology, Kuopio University Hospital, Finland
    J Cereb Blood Flow Metab 22:1336-42. 2002
    ..Thus, the effects of ApoE polymorphism should be accounted for when interpreting diffusion- and perfusion-weighted MRI studies, particularly if predicting lesion growth...
  30. doi Brain anatomy of persistent violent offenders: more rather than less
    Jari Tiihonen
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland
    Psychiatry Res 163:201-12. 2008
    ..Offenders with psychopathy showed the smallest volumes in these areas. The larger volumes in posterior brain areas may reflect atypical neurodevelopmental processes that underlie early-onset persistent antisocial and aggressive behavior...
  31. ncbi Radial width of the temporal horn: a sensitive measure in Alzheimer disease
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    AJNR Am J Neuroradiol 23:35-47. 2002
    ..The aim of this study was to explore the validity of a CT- and MR-based measure of MTL atrophy that would be feasible for routine clinical use...
  32. ncbi Midbrain dopamine D2/3 receptor binding in schizophrenia
    Heli Tuppurainen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, 70240, Kuopio, Finland
    Eur Arch Psychiatry Clin Neurosci 256:382-7. 2006
    ..78 to -0.92). These observations implicate altered dopaminergic activity in the midbrain of schizophrenic patients...
  33. ncbi A volumetric MRI study of the entorhinal cortex in first episode neuroleptic-naive schizophrenia
    Christian C Joyal
    Institut Philippe Pinel de Montreal, Montreal, Canada
    Biol Psychiatry 51:1005-7. 2002
    ..Imaging studies have frequently reported volume loss of limbic structures in schizophrenia, yet there appears to be no quantitative data on entorhinal cortex volumes in patients with neuroleptic naive first-episode schizophrenia...