M Laakso

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi Prevention of type 2 diabetes
    M Laakso
    Department of Medicine, University of Kuopio, Finland
    Curr Mol Med 5:365-74. 2005
  2. ncbi Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease
    S Helisalmi
    Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, PL 1627, 70211 Kuopio, Finland
    J Neurol 255:668-73. 2008
  3. ncbi Hyperglycemia and cardiovascular disease in type 2 diabetes
    M Laakso
    Department of Medicine, University of Kuopio, Finland
    Diabetes 48:937-42. 1999
  4. ncbi The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study
    Markku Vänttinen
    Department of Medicine, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    J Clin Endocrinol Metab 90:4249-54. 2005
  5. ncbi Hyperglycemia as a risk factor for cardiovascular disease in type 2 diabetes
    M Laakso
    Professor and Chair, Department of Medicine, Univeristy of Kuopio, Kuopio, Finland
    Prim Care 26:829-39. 1999
  6. ncbi Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM
    L Saarinen
    Department of Medicine, University of Kuopio, Finland
    Diabetes Care 21:849-50. 1998
  7. ncbi Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia
    J Pihlajamaki
    Department of Medicine, University of Kuopio, Finland
    Arterioscler Thromb Vasc Biol 17:1039-44. 1997
  8. ncbi Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects
    H M Vidgren
    Department of Clinical Nutrition, University of Kuopio, Finland
    Eur J Clin Invest 27:405-8. 1997
  9. ncbi Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects
    L Niskanen
    Department of Clinical Nutrition, University of Kuopio, Finland
    J Clin Endocrinol Metab 85:2266-9. 2000
  10. ncbi Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes
    T O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Physiol Genomics 31:264-72. 2007

Detail Information

Publications99

  1. ncbi Prevention of type 2 diabetes
    M Laakso
    Department of Medicine, University of Kuopio, Finland
    Curr Mol Med 5:365-74. 2005
    ..However, we can safely conclude that the current evidence strongly favors the notion that lifestyle changes are the primary means to tackle the epidemic of T2DM...
  2. ncbi Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease
    S Helisalmi
    Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, PL 1627, 70211 Kuopio, Finland
    J Neurol 255:668-73. 2008
    ..We conclude that there is no real association with SNPs available in the present study between SIRT1, PPARD or PGC-1alpha genes and AD risk in the Finnish population...
  3. ncbi Hyperglycemia and cardiovascular disease in type 2 diabetes
    M Laakso
    Department of Medicine, University of Kuopio, Finland
    Diabetes 48:937-42. 1999
    ..However, in addition to intensive therapy of hyperglycemia, other conventional risk factors should also be normalized to prevent cardiovascular disease in patients with type 2 diabetes...
  4. ncbi The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study
    Markku Vänttinen
    Department of Medicine, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    J Clin Endocrinol Metab 90:4249-54. 2005
    ..Obesity is a major risk factor for insulin resistance, but the association of the Pro(12)Ala polymorphism with body weight has been controversial. Furthermore, obesity may modulate the effect of this polymorphism on insulin sensitivity...
  5. ncbi Hyperglycemia as a risk factor for cardiovascular disease in type 2 diabetes
    M Laakso
    Professor and Chair, Department of Medicine, Univeristy of Kuopio, Kuopio, Finland
    Prim Care 26:829-39. 1999
    ..However, in the treatment and prevention of cardiovascular disease in type 2 diabetes, all known cardiovascular risk factors should be attacked simultaneously...
  6. ncbi Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM
    L Saarinen
    Department of Medicine, University of Kuopio, Finland
    Diabetes Care 21:849-50. 1998
    ..To investigate the association of variants of the fatty acid-binding protein (FABP) 2 gene with coronary heart disease (CHD) in nondiabetic subjects and in patients with NIDDM...
  7. ncbi Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia
    J Pihlajamaki
    Department of Medicine, University of Kuopio, Finland
    Arterioscler Thromb Vasc Biol 17:1039-44. 1997
    ..042), and high LDL triglycerides (P = .013) but not with insulin resistance in subjects from FCHL families. The FABP2 gene is unlikely to be a major gene for FCHL, but it might affect lipid metabolism in subjects with FCHL...
  8. ncbi Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects
    H M Vidgren
    Department of Clinical Nutrition, University of Kuopio, Finland
    Eur J Clin Invest 27:405-8. 1997
    ..13, for trend). In conclusion, our findings suggest that a polymorphism at codon 54 of the I-FABP2 gene does not substantially modify the fatty acid composition of serum lipids in obese Finns...
  9. ncbi Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects
    L Niskanen
    Department of Clinical Nutrition, University of Kuopio, Finland
    J Clin Endocrinol Metab 85:2266-9. 2000
    ..165; P = 0.024) after adjustment for known risk factors. Thus, the presence of the Pro7 substitution in the prepro-NPY associates with increased carotid atherosclerosis...
  10. ncbi Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes
    T O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Physiol Genomics 31:264-72. 2007
    ..022-0.027 for the SNPs in SLC2A2, and P = 0.007 for rs3758947). We conclude that moderate-to-vigorous PA may modify the risk of developing T2D associated with genes regulating insulin secretion (SLC2A2, ABCC8) in persons with IGT...
  11. ncbi Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study
    N Siitonen
    Department of Clinical Nutrition and Food and Health Research Center, University of Kuopio, Kuopio, Finland
    Diabetologia 47:1416-24. 2004
    ....
  12. ncbi Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study
    N Siitonen
    Department of Public Health and Clinical Nutrition, Clinical Nutrition, and Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Diabetologia 49:1795-805. 2006
    ..Our aim was to study the association of ADIPOR1 gene variations with body size and risk of type 2 diabetes in subjects with impaired glucose tolerance, who participated in the Finnish Diabetes Prevention Study (DPS)...
  13. ncbi Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene
    J J Agren
    Departments of Clinical Nutrition and Physiology, Clinical Nutrition, and Medicine, University of Kuopio, Kuopio, Finland
    Arterioscler Thromb Vasc Biol 18:1606-10. 1998
    ..The lipemic response was associated with postprandial insulin response, suggesting that in the Thr-54 homozygotes, altered postprandial lipemia may also modify insulin action or vice versa...
  14. ncbi Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects
    M Kolehmainen
    Department of Clinical Nutrition and Food and Health Research Center, University of Kuopio, Finland
    J Clin Endocrinol Metab 88:1717-22. 2003
    ..Expression of both PPARgamma splice variants is dependent on fat depot: omental fat shows lower mRNA levels, compared with sc fat depots...
  15. ncbi Retinopathy predicts coronary heart disease events in NIDDM patients
    H Miettinen
    Department of Medicine, University of Kuopio, Finland
    Diabetes Care 19:1445-8. 1996
    ....
  16. ncbi Association of the Leu72Met polymorphism of the ghrelin gene with the risk of Type 2 diabetes in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study
    U Mager
    Department of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Diabet Med 23:685-9. 2006
    ..We investigated whether the Leu72Met polymorphism is associated with the incidence of Type 2 diabetes in subjects with impaired glucose tolerance (IGT) participating in the Finnish Diabetes Prevention Study (DPS)...
  17. ncbi New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes
    H Wang
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Diabetes 50:1949-51. 2001
    ..Thus, the variants in the coding part of the IRS-2 gene are unlikely to have a major role in the development of type 2 diabetes in Finnish or Chinese subjects...
  18. ncbi Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease
    A T Erkkilä
    Department of Clinical Nutrition, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Nutr Metab Cardiovasc Dis 12:53-9. 2002
    ....
  19. ncbi Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns
    R Sipiläinen
    Department of Clinical Nutrition, University of Kuopio, Finland
    Diabetes 46:77-80. 1997
    ..We conclude that the Trp64Arg polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns but does not have significant effect on glucose metabolism...
  20. ncbi Proteinuria predicts stroke and other atherosclerotic vascular disease events in nondiabetic and non-insulin-dependent diabetic subjects
    H Miettinen
    Department of Medicine, University of Kuopio, Finland
    Stroke 27:2033-9. 1996
    ..We assessed the relationship between the different degrees of proteinuria at baseline and the incidence of stroke, as well as other atherosclerotic vascular disease events, in a prospective study of nondiabetic and NIDDM subjects...
  21. ncbi Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study
    T Salopuro
    Department of Clinical Nutrition and Food and Health Research Center, University of Kuopio, Kuopio, Finland
    Int J Obes (Lond) 29:1245-51. 2005
    ..We wanted to evaluate the association between LEPR polymorphisms, diabetes risk and body weight in Finnish subjects with impaired glucose tolerance (IGT)...
  22. ncbi Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes
    J Pihlajamaki
    University of Kuopio, Department of Medicine, Kuopio, Finland
    Diabetologia 49:1560-6. 2006
    ....
  23. ncbi Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene
    J J Agren
    Departments of Physiology, Clinical Nutrition, and Medicine, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 73:31-5. 2001
    ..We found earlier that the threonine-encoding allele (Thr54) is associated with an increased postprandial lipemic response...
  24. ncbi Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease
    L Viitanen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Mol Med (Berl) 79:732-7. 2001
    ..We conclude that in addition to the epsilon 4 allele, also the -219G/T promoter polymorphism of the apo E gene is associated with early onset CHD...
  25. ncbi Hyperinsulinemia cluster predicts the development of type 2 diabetes independently of family history of diabetes
    P Kekäläinen
    Department of Medicine, Kuopio University Hospital, Finland
    Diabetes Care 22:86-92. 1999
    ..The aim of this prospective study was to determine risk factor clusters predicting type 2 diabetes in subjects with and without family history of diabetes by applying factor analyses...
  26. ncbi Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects
    R Sipiläinen
    Department of Clinical Nutrition, University of Kuopio, Finland
    J Clin Endocrinol Metab 82:2629-32. 1997
    ..We conclude that obesity is not associated with specific variants in the FABP2 gene. Furthermore, the codon 54 Ala to Thr polymorphism of this gene does not influence insulin levels or basal metabolic rate in obese Finns...
  27. ncbi High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients
    U Salmenniemi
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Int J Obes (Lond) 29:1464-70. 2005
    ..CONCLUSIONS: The metabolic changes relating to obesity are largely attributable to high IAFM, and are present even in normal weight subjects with high IAFM...
  28. ncbi Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men
    J Kuusisto
    Department of Medicine, University of Kuopio, FIN-70211 Kuopio, Finland
    Diabetes Care 24:1629-33. 2001
    ..34, 1.03-1.74, P = 0.03). CONCLUSIONS: IRS is a risk factor for CHD in elderly type 2 diabetic men...
  29. ncbi Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion
    J Wang
    Department of Medicine, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
    Diabetologia 50:1192-200. 2007
    ..e. IGT or IFG) in a cross-sectional study (Study II); and (3) insulin secretion, insulin sensitivity and adipose tissue expression of TCF7L2 in offspring of type 2 diabetic probands (III)...
  30. ncbi A novel surrogate index for hepatic insulin resistance
    J Vangipurapu
    Department of Medicine, University of Eastern Finland, Kuopio University Hospital, 70210, Kuopio, Finland
    Diabetologia 54:540-3. 2011
    ..In epidemiological and genetic studies surrogate indices are needed to investigate insulin resistance in different insulin-sensitive tissues. Our objective was to develop a surrogate index for hepatic insulin resistance...
  31. ncbi Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes
    L Niskanen
    Department of Clinical Nutrition, University of Kuopio, Finland
    Exp Clin Endocrinol Diabetes 108:235-6. 2000
    ..97 (95% confidence intervals 1.09-98.0; p=0.049). Our finding based on elderly Finnish Type 2 diabetic subjects suggests that the Leu7Pro7-genotype in preproNPY gene is associated with the development of diabetic retinopathy...
  32. ncbi Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes
    J Pihlajamaki
    Department of Medicine, University of Kuopio, P O Box 1627, 70210, Kuopio, Finland
    Diabetologia 48:1331-4. 2005
    ..Therefore, we investigated the effects of single nucleotide polymorphisms in PPARGC1A on body composition and glucose tolerance and on insulin sensitivity and secretion...
  33. ncbi Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men
    J Vangipurapu
    Department of Medicine, University of Eastern Finland, Kuopio University Hospital, 70210, Kuopio, Finland
    Diabetologia 54:563-71. 2011
    ..We examined the association of indices of hepatic and adipocyte insulin resistance (IR) with 19 confirmed type 2 diabetes risk loci in a large population-based study...
  34. ncbi Effect of a three-amino acid deletion in the alpha2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects
    K Sivenius
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Int J Obes Relat Metab Disord 25:1609-14. 2001
    ..We investigated the effects of this polymorphism on changes in body weight in Finnish non-diabetic and type 2 diabetic subjects during a 10 y follow-up...
  35. ncbi Effects of losartan on insulin sensitivity in hypertensive subjects
    M Laakso
    Department of Medicine, Kuopio University Hospital, Finland
    Hypertension 28:392-6. 1996
    ..In conclusion, losartan is metabolically neutral, without any significant adverse effect on glucose and lipid metabolism...
  36. ncbi Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects
    L Niskanen
    Department of Clinical Nutrition, and the A I Virtanen Institute of Molecular Sciences, University of Kuopio, Kuopio, Finland
    Metabolism 52:213-7. 2003
    ..Genotype may therefore modulate the oxidative modification of LDL in hyperglycemic milieu...
  37. ncbi Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass
    M Simonen
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Obes Surg 22:1473-80. 2012
    ..Laparoscopic Roux-en-Y gastric bypass (RYGB) induces a more favorable metabolic profile than expected by weight loss alone. In this study, we investigated the effect of RYGB on serum bile acid levels and their relation to clinical outcomes...
  38. ncbi Glucose control in diabetes: which target level to aim for?
    M Laakso
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    J Intern Med 272:1-12. 2012
    ..5% may be reasonable for patients with a short duration of type 2 diabetes and without extensive atherosclerosis...
  39. ncbi APOE polymorphism and the hypertriglyceridemic effect of dietary sucrose
    A T Erkkilä
    Departments of Clinical Nutrition and Medicine, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 73:746-52. 2001
    ..However, less is known about the interaction between APOE polymorphism and other macronutrients in the diet...
  40. ncbi Cardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary heart disease
    A Kareinen
    Department of Medicine, North Karelia Central Hospital, Joensuu, Finland
    Arterioscler Thromb Vasc Biol 21:1346-52. 2001
    ....
  41. ncbi Proteinuria modifies the effects of physical activity on total and cardiovascular disease mortality rates in patients with type 2 diabetes
    T Vepsäläinen
    Department of Medicine, University of Turku, Kiinamyllynkatu 4 8, Turku, Finland
    Diabetologia 53:1886-9. 2010
    ..However, it is not known whether or not the effects of physical activity on mortality rates depend on the presence of proteinuria in type 2 diabetic patients...
  42. ncbi Association between liver insulin resistance and cardiovascular risk factors
    J Vangipurapu
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio
    J Intern Med 272:402-8. 2012
    ..The objective of this study was to examine the associations between indices of liver insulin resistance (IR) and whole-body insulin sensitivity and different cardiovascular disease (CVD) risk factors...
  43. ncbi Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study
    M Laakso
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Diabetologia 51:502-11. 2008
    ..We examined the phenotype of individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) with regard to insulin release and insulin resistance...
  44. ncbi The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study
    T O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Exp Clin Endocrinol Diabetes 118:757-9. 2010
    ..In conclusion, the rs1800629 SNP in the TNF gene may modify the effect of moderate-to-vigorous physical activity on serum levels of CRP...
  45. ncbi Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes
    K Sivenius
    Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabet Med 21:1325-33. 2004
    ....
  46. ncbi Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study
    O Laukkanen
    Department of Medicine, University of Kuopio, Finland
    Diabetologia 47:871-7. 2004
    ....
  47. ncbi A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia
    J Pihlajamaki
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Diabetes 50:2396-401. 2001
    ..001). These results provide evidence for a major gene regulating insulin sensitivity in FCHL families. Possible pleiotropic effects of this insulin sensitivity locus on dyslipidemias in FCHL remain to be elucidated...
  48. ncbi Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease
    L Viitanen
    Department of Medicine, University of Kuopio, PO Box 1627, 70 211 Kuopio, Finland
    Atherosclerosis 157:57-64. 2001
    ..In conclusion, the ACE and PAI-1 gene polymorphisms are not linked with early-onset CHD. However, the ACE gene polymorphism is associated with features of the insulin resistance syndrome...
  49. ncbi The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance
    J Pihlajamaki
    Department of Medicine, University of Kuopio, Kuopio, Finland
    Eur J Clin Invest 31:302-8. 2001
    ..Insulin resistance in the most common familial dyslipidemia, familial combined hyperlipidemia (FCHL), could be due to variations in the hormone sensitive lipase (HSL) gene...
  50. ncbi Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
    Alena Stancakova
    Department of Medicine, University of Kuopio and University Hospital, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 93:1924-30. 2008
    ..CDKAL1 is a recently discovered susceptibility gene for type 2 diabetes...
  51. ncbi Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes
    S Heikkinen
    Department of Medicine, University of Kuopio, FIN 70211 Kuopio, Finland
    J Biol Chem 274:22517-23. 1999
    ....
  52. ncbi The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    J Zacharova
    Department of Medicine, University of Kuopio, Kuopio, Finland
    J Intern Med 257:185-93. 2005
    ..The purpose of the study was to investigate whether the G-250A promoter polymorphism of the LIPC gene predicts the conversion from impaired glucose tolerance (IGT) to type 2 diabetes...
  53. ncbi Simultaneous hypertrophic cardiomyopathy and ventricular septal defect in children
    T Tikanoja
    Department of Pediatrics, Kuopio University Hospital, University of Kuopio, Finland
    Am J Cardiol 84:485-6. 1999
    ..Importantly, in children with a muscular VSD, the possibility of HC as an underlying pathology should be kept in mind...
  54. ncbi Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women
    A Juutilainen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetologia 49:56-65. 2006
    ..Metabolic syndrome predicted CVD mortality in non-diabetic women and in diabetic men, independently of the presence of proteinuria...
  55. ncbi Plasma insulin and all-cause, cardiovascular, and noncardiovascular mortality: the 22-year follow-up results of the Helsinki Policemen Study
    M Pyörälä
    Department of Medicine, University of Kuopio, Finland
    Diabetes Care 23:1097-102. 2000
    ..To investigate the association of plasma insulin with all-cause, cardiovascular, and noncardiovascular mortality...
  56. ncbi Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern
    S Heikkinen
    Department of Medicine, University of Kuopio, Finland
    Mamm Genome 11:91-6. 2000
    ..The mouse HKII gene is predominantly expressed in skeletal muscle, heart, and adipose tissue. The transcription initiation and polyadenylation sites for the mouse HKII mRNA were similar to those of the rat and human genes...
  57. ncbi Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1
    A Lumiaho
    Department of Medicine, Kuopio University Hospital, Finland
    Am J Kidney Dis 38:1208-16. 2001
    ..Mitral valve prolapse is a characteristic finding in patients with PKD1. Conversely, mitral regurgitation and LVH are likely to be secondary to elevated blood pressure in these patients...
  58. ncbi Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial
    L Andrulionyte
    Department of Medicine, University of Kuopio, 70210, Kuopio, Finland
    Diabetologia 47:2176-84. 2004
    ..This trial aimed to study the effect of acarbose in the prevention of type 2 diabetes...
  59. ncbi Proteinuria modifies the effect of systolic blood pressure on total and cardiovascular disease mortality in patients with type 2 diabetes
    T Vepsäläinen
    Department of Medicine, Turku University Hospital, University of Turku, Turku, Finland
    J Intern Med 272:611-9. 2012
    ..However, no long-term population-based studies have been reported on the interaction between BP and proteinuria with respect to total and CVD mortality in patients with type 2 diabetes...
  60. ncbi Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects
    K Sivenius
    Department of Clinical Nutrition, University of Kuopio, Finland
    Int J Obes Relat Metab Disord 24:514-9. 2000
    ....
  61. ncbi Alpha-synuclein pathology is highly dependent on the case selection
    L Parkkinen
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Neuropathol Appl Neurobiol 27:314-25. 2001
    ..The load of alpha-synuclein pathology was significantly greater in the demented patients versus non-demented subjects indicating that alpha-synuclein pathology is indeed of importance in the pathogenesis of dementia...
  62. ncbi Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes
    P Jakala
    Department of Neuroscience and Neurology, University Hospital and University of Kuopio, Finland
    J Clin Invest 100:331-8. 1997
    ..The data suggest minor abnormalities in temporal lobe structures in adult fra(X) subjects with fM...
  63. ncbi Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism
    H Huopio
    Department of Pediatrics, Kuopio University Hospital, FIN 70211 Kuopio, Finland
    J Clin Endocrinol Metab 87:4502-7. 2002
    ..Our results, however, also demonstrate the complexity of these responses and the difficulties in their interpretation...
  64. ncbi Cognitive function in an elderly population with persistent impaired glucose tolerance
    M Vanhanen
    Department of Neurology, Kuopio University Hospital, Finland
    Diabetes Care 21:398-402. 1998
    ..To study cognitive function in an elderly population with persistent impaired glucose tolerance (IGT)...
  65. ncbi Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects
    T Laitinen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Diabetes 48:1295-9. 1999
    ..In insulin-resistant subjects, autonomic dysfunction may be an earlier defect than hitherto acknowledged...
  66. ncbi Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention
    M Laakso
    Department of Medicine, University of Kuopio, Kuopio, Finland
    J Intern Med 249:225-35. 2001
    ..Beta-blocking agents, angiotensin-converting enzyme inhibitors, aspirin, and thrombolytic therapy are also effective in the treatment of CVD amongst diabetic patients...
  67. ncbi Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomy
    A Hedman
    Department of Medicine, Kuopio University Hospital, 70211 Kuopio, Finland
    J Mol Cell Cardiol 36:91-9. 2004
    ....
  68. ncbi The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population
    P Jääskeläinen
    Department of Medicine, University of Kuopio, Finland
    J Am Coll Cardiol 32:1709-16. 1998
    ....
  69. ncbi Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1
    H Huopio
    Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
    J Clin Invest 106:897-906. 2000
    ..In conclusion, we describe the first dominantly inherited SUR1 mutation that causes CHI in early life and predisposes to later insulin deficiency...
  70. ncbi The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients
    A Pulkkinen
    Department of Medicine, University of Kuopio, Finland
    Metabolism 48:853-6. 1999
    ..These results indicate that the Trp64Arg allele of the beta3-adrenergic receptor gene does not contribute to the risk of CHD in nondiabetic subjects and NIDDM patients...
  71. ncbi The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM
    M Malkki
    Department of Medicine, University of Washington, Seattle 98195, USA
    Diabetologia 40:1461-9. 1997
    ..In addition, the region between -215 and -184 contains a negative regulatory element for expression in 3T3F442A but not in C2C12F3 cells...
  72. ncbi Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy White population
    H Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabet Med 24:817-22. 2007
    ..We set out to determine whether genetic variation within the APPL locus (encoding APPL1) contributes to insulin resistance, changes in lipid metabolism or inflammatory parameters in a healthy White population...
  73. ncbi High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects
    A Hammarstedt
    The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine Diabetes, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Intern Med 263:440-9. 2008
    ..High levels of circulating retinol-binding protein 4 (RBP4) and baseline expression of adipogenic genes correlate with subsequent improvement in insulin sensitivity following Thiazolidinedione (TZD) treatment...
  74. ncbi Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects
    Fabrice Bonnet
    Department of Medicine, Endocrinology Unit, Centre Hospitalier Universitaire, université Rennes, Rennes, France
    Diabetes Care 31:789-94. 2008
    ..The purpose of this study was to investigate the relationship between the ACE gene I/D polymorphism and both insulin sensitivity and glucose intolerance in a large cohort of healthy subjects...
  75. ncbi Determinants for the effectiveness of lifestyle intervention in the Finnish Diabetes Prevention Study
    Jaana Lindström
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Diabetes Care 31:857-62. 2008
    ..We investigated whether and to what extent risk factors for type 2 diabetes and other baseline characteristics of the study participants modified the effectiveness of the lifestyle intervention...
  76. ncbi Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects
    P Heinonen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    J Clin Endocrinol Metab 84:2429-33. 1999
    ..84; P = 0.009, by ANOVA). Thus, a genetic polymorphism of the alpha2B-adrenoceptor subtype can partly explain the variation in basal metabolic rate in an obese population and may therefore contribute to the pathogenesis of obesity...
  77. ncbi The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study
    T W Boesgaard
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 12, DK 2820, Gentofte, Copenhagen, Denmark
    Diabetologia 51:816-20. 2008
    ..Here, we investigate whether the polymorphism is related to altered insulin release in response to intravenous and oral glucose loads in non-diabetic offspring of type 2 diabetic patients...
  78. ncbi Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study
    J Saltevo
    Department of Internal Medicine, Central Hospital of Middle Finland, Jyvaskyla, Finland
    Diabet Med 25:747-50. 2008
    ....
  79. ncbi Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes
    Markku Saraheimo
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Diabetes Care 31:1165-9. 2008
    ..The purpose of this study was to elucidate whether serum adiponectin is associated with progression of diabetic nephropathy in type 1 diabetic patients...
  80. ncbi Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy
    S Kärkkäinen
    Heart 92:524-6. 2006
  81. ncbi Association of metabolic syndrome with Alzheimer disease: a population-based study
    M Vanhanen
    Department of Neurology and Neuroscience, Kuopio University Hospital and the University of Kuopio, Finland
    Neurology 67:843-7. 2006
    ..To assess the association of metabolic syndrome (MetS) with Alzheimer disease (AD)...
  82. ncbi Association of neck circumference with insulin resistance-related factors
    M Laakso
    Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
    Int J Obes Relat Metab Disord 26:873-5. 2002
    ..The aim of the present study was to test the association of neck circumference with abdominal and general obesity as well as with insulin resistance related factors...
  83. ncbi Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population
    J L Gonzalez Sanchez
    Department of Internal Medicine II, Hospital Universitario Clinico San Carlos, Madrid, Spain
    Eur J Endocrinol 147:495-501. 2002
    ....
  84. ncbi A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference
    M Heo
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Int J Obes Relat Metab Disord 26:640-6. 2002
    ....
  85. ncbi Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome
    S Korhonen
    Department of Obstetrics and Gynaecology, Central Hospital of Mikkeli, 50100 Mikkeli, Finland
    Hum Reprod 18:540-3. 2003
    ....
  86. ncbi Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population
    F Reimann
    Department of Clinical Biochemistry, University of Cambridge, UK
    Diabetologia 46:241-9. 2003
    ..The aim of this study was to analyse the functional consequences of four CHI mutations (A1457T, V1550D and L1551V in SUR1, and K67N in Kir6.2) recently identified in the Finnish population...
  87. ncbi Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity
    M Heo
    New York Obesity Research Center, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Genetics 159:1163-78. 2001
    ..Although certain genotypic effects could be population specific, there was no statistically compelling evidence that any of the three LEPR alleles is associated with BMI or waist circumference in the general population...
  88. ncbi Partial trisomy 10q with mild phenotype caused by an unbalanced X;10 translocation
    T Mononen
    J Med Genet 40:e61. 2003
  89. ncbi The effects of the Pro12Ala polymorphism of the PPARgamma-2 gene on lipid metabolism interact with body size at birth
    J Eriksson
    National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
    Clin Genet 64:366-70. 2003
    ..These interactions between the effects of the PPARgamma-2 gene on adult traits and the effects of birth weight may be interpreted as examples of gene-environmental interactions, which underlie plasticity during development...
  90. ncbi Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data
    J L Chiasson
    Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Department of Medicine, University of Montreal, 3850 St Urbain Street, Rm 8 202, Montreal, Quebec H2W 1T7, Canada
    Diabetologia 47:969-75; discussion 976-7. 2004
    ..The investigators stand strongly behind these results demonstrating that acarbose treatment is associated with a delay in the development of diabetes, hypertension and cardiovascular complications in a high-risk population with IGT...
  91. ncbi Blood pressure and atherosclerotic plaques in carotid, aortic and femoral arteries in elderly Finns with diabetes mellitus or impaired glucose tolerance
    U Rajala
    Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
    J Hum Hypertens 19:85-91. 2005
    ..1 (95% CI 1.5-6.5) in subjects with high SBP compared to those with lower SBP. When SBP was replaced by high MBP, the adjusted odds ratio for it was 2.3 (95% CI 1.1-4.8)...
  92. ncbi Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes. The Finnish Diabetes Prevention Study
    T Salopuro
    Clin Genet 66:365-7. 2004
  93. ncbi Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity
    K Malmberg
    Department of Cardiology, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden
    Eur Heart J 26:650-61. 2005
    ..However, an epidemiological analysis confirms that the glucose level is a strong, independent predictor of long-term mortality in this patient category, underlining that glucose control seems to be an important part of their management...
  94. ncbi Effect of the Pro12Ala polymorphism of the PPAR-gamma2 gene on long-term weight change in Finnish non-diabetic subjects
    V Lindi
    Diabetologia 44:925-6. 2001
  95. ncbi A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients
    A Pätäri
    Department of Bacteriology and Immunology, University of Helsinki and Research Program in Molecular Medicine, Biomedicum Helsinki, Helsinki, Finland
    Diabetologia 48:1844-50. 2005
    ..We investigated whether the offspring of type 2 diabetic patients show nephrin in urine and whether possible nephrinuria is associated with insulin resistance...
  96. ncbi Long-term effects of pioglitazone and metformin on insulin sensitivity in patients with Type 2 diabetes mellitus
    M Roden
    I. Medical Department, Hanusch Hospital, Vienna, Austria
    Diabet Med 22:1101-6. 2005
    ..CONCLUSION: Pioglitazone differed from metformin in its effects on insulin sensitivity despite both drugs having comparable glycaemic effects...
  97. ncbi Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
    A Keech
    Lancet 366:1849-61. 2005
    ..The higher rate of starting statin therapy in patients allocated placebo might have masked a moderately larger treatment benefit...
  98. ncbi Amino acid substitutions in hexokinase II among patients with NIDDM
    M Laakso
    Department of Genetics, University of Washington, Seattle
    Diabetes 44:330-4. 1995
    ..1%) control subjects. None of these mutations were located close to the glucose- and ATP-binding sites of HKII. We conclude that mutations of the HKII gene are not a major etiological factor for NIDDM in the Finnish population...
  99. ncbi Serum homocysteine, creatinine, and glucose as predictors of the severity and extent of coronary artery disease in asymptomatic members of high-risk families
    P Pajunen
    Hilsinki University Central Hospotal, Helsinki, Finland
    Eur J Clin Invest 32:472-8. 2002
    ..There has been no previous study to determine the severity and extent of coronary artery disease (CAD) in subjects with no diagnosis or symptoms of CAD at the time of the angiography...