J Kuikka

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi Reduced serotonin transporter binding in binge eating women
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Psychopharmacology (Berl) 155:310-4. 2001
  2. ncbi Effects of ageing on serotonin transporters in healthy females
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Eur J Nucl Med 28:911-3. 2001
  3. ncbi Specific binding and laterality of human extrastriatal dopamine D2/D3 receptors in late onset type 1 alcoholic patients
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, FIN 70210, Kuopio, Finland
    Neurosci Lett 292:57-9. 2000
  4. ncbi Imaging of the endothelial dysfunction in coronary atherosclerosis
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and Niuvanniemi Hospital, Finland
    Eur J Nucl Med 28:1567-78. 2001
  5. ncbi Effect of increasing blood flow on distribution of pulmonary transit times in man
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and Niuvanniemi Hospital, Finland
    Physiol Meas 21:241-50. 2000
  6. ncbi Heterogeneity of cerebral blood flow: a fractal approach
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Nuklearmedizin 39:37-42. 2000
  7. ncbi Iodine-123 labelled PE2I for dopamine transporter imaging: influence of age in healthy subjects
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, FIN 70210 Kuopio, Finland
    Eur J Nucl Med 26:1486-8. 1999
  8. ncbi Effect of flow and vascular heterogeneity on glucose metabolism in isolated dog hearts
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Clin Physiol Funct Imaging 22:134-8. 2002
  9. ncbi PET imaging using a triple-head gamma camera
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
    Clin Physiol Funct Imaging 22:328-31. 2002
  10. ncbi Transit time heterogeneity of bolus flow through the heart and lungs in patients with left-to-right intracardiac shunt
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Physiol Meas 20:207-14. 1999

Collaborators

Detail Information

Publications36

  1. ncbi Reduced serotonin transporter binding in binge eating women
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Psychopharmacology (Berl) 155:310-4. 2001
    ..There is evidence that abnormalities in brain dopamine, norepinephrine and serotonin metabolism may play an important role in binge eating. Serotonin-active antidepressant drugs have also been found to decrease binge eating...
  2. ncbi Effects of ageing on serotonin transporters in healthy females
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Eur J Nucl Med 28:911-3. 2001
    ..47; P<0.05) was found in the midbrain. The decline in [123I]nor-beta-CIT binding in the serotonin transporter-rich area is much less than that in dopamine transporters in the striatum (6% per decade)...
  3. ncbi Specific binding and laterality of human extrastriatal dopamine D2/D3 receptors in late onset type 1 alcoholic patients
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, FIN 70210, Kuopio, Finland
    Neurosci Lett 292:57-9. 2000
    ..89+/-0.19 vs. 1.10+/-0.19; P<0.05). The results suggest that the specific binding of dopamine D(2)/D(3) receptors in late type 1 alcoholics is decreased and its laterality in the temporal brain is altered from normal...
  4. ncbi Imaging of the endothelial dysfunction in coronary atherosclerosis
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and Niuvanniemi Hospital, Finland
    Eur J Nucl Med 28:1567-78. 2001
    ....
  5. ncbi Effect of increasing blood flow on distribution of pulmonary transit times in man
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and Niuvanniemi Hospital, Finland
    Physiol Meas 21:241-50. 2000
    ..Most of the variability of transit times through the lungs is due to the heterogeneity of the transit times through the capillaries and venules...
  6. ncbi Heterogeneity of cerebral blood flow: a fractal approach
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Nuklearmedizin 39:37-42. 2000
    ..We demonstrate the heterogeneity of regional cerebral blood flow using a fractal approach and single-photon emission computed tomography (SPECT)...
  7. ncbi Iodine-123 labelled PE2I for dopamine transporter imaging: influence of age in healthy subjects
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, FIN 70210 Kuopio, Finland
    Eur J Nucl Med 26:1486-8. 1999
    ..The findings confirm the suitability of [(123)I]PE2I for SPET imaging in clinical routine but emphasize the necessity of using age-matched controls in patient studies...
  8. ncbi Effect of flow and vascular heterogeneity on glucose metabolism in isolated dog hearts
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Clin Physiol Funct Imaging 22:134-8. 2002
    ..The results support the views that without accounting the regional flow heterogeneity, glucose metabolic rate will be underestimated...
  9. ncbi PET imaging using a triple-head gamma camera
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
    Clin Physiol Funct Imaging 22:328-31. 2002
    ..As a conclusion, triple-head coincidence gamma camera provides relatively high-count rate imaging with good contrast and resolution...
  10. ncbi Transit time heterogeneity of bolus flow through the heart and lungs in patients with left-to-right intracardiac shunt
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Physiol Meas 20:207-14. 1999
    ..This is probably due to the recruitment of the open capillaries without vessel distension...
  11. ncbi Quantitative accuracy of serotonergic neurotransmission imaging with high-resolution 123I SPECT
    J T Kuikka
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    Nuklearmedizin 43:185-9. 2004
    ..We examine the quantitative accuracy and reproducibility that can be achieved with high-resolution SPECT of serotonergic neurotransmission...
  12. ncbi Fractal analysis--a new approach in brain receptor imaging
    J Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Ann Med 30:242-8. 1998
    ..This review highlights recent findings in SPET receptor imaging and the use of fractal analysis in the interpretation of images representing various neuropsychiatric disorders...
  13. ncbi Imaging the structure of the striatum: a fractal approach to SPECT image interpretation
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Physiol Meas 19:367-74. 1998
    ..Recognition of the normal variation in heterogeneity is important in evaluation of the striatal dopamine transporter density between controls and patients suffering from various neuropsychiatric disorders...
  14. ncbi Abnormal structure of human striatal dopamine re-uptake sites in habitually violent alcoholic offenders: a fractal analysis
    J T Kuikka
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Neurosci Lett 253:195-7. 1998
    ..In addition, in young violent offenders there was no normal left-to-right asymmetry observed in control subjects of the same age. The normalisation of the left-to-right asymmetry may reflect late neurobiological maturation...
  15. ncbi Extrastriatal dopamine D 2/3 receptor density and distribution in drug-naive schizophrenic patients
    H Tuppurainen
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    Mol Psychiatry 8:453-5. 2003
    ..86 to -0.90) and negative (r from -0.37 to -0.55) schizophrenic symptoms. These results support the previous hypothesis on dysfunction of mesocortical DA function behind the cognitive and negative symptoms in schizophrenia...
  16. ncbi Evaluation of scatter correction using a single isotope for simultaneous emission and transmission data. Phantom and clinical patient studies
    J Yang
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Nuklearmedizin 38:49-55. 1999
    ..Photon scatter is one of the most important factors degrading the quantitative accuracy of SPECT images. Many scatter correction methods have been proposed. The single isotope method was proposed by us...
  17. ncbi Quantitation of neuroreceptors: a need for better SPECT imaging
    T Kauppinen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Nuklearmedizin 40:102-6. 2001
    ..We examined the influence of the physical performance on the binding potential...
  18. ncbi Imaging D2-receptors in quinolinic acid lesioned rat striatum with high resolution pinhole SPECT
    A Sohlberg
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Nuklearmedizin 44:N43-5. 2005
  19. ncbi Pulmonary deposition of lactose carriers used in inhalation powders
    M Karhu
    Department of Pharmaceutics, University of Kuopio, P O Box 1627, Kuopio, Finland
    Int J Pharm 196:95-103. 2000
    ..3 and 26.0%. Thus, the redispersion of the budesonide particles can be altered by the properties of the carrier system...
  20. ncbi Altered frontal lobe function suggested by source analysis of event-related potentials in impulsive violent alcoholics
    I M Tarkka
    Department of Neurology and Brain Research and Rehabilitation Center Neuron, Kuopio University Hospital, University of Kuopio, Finland
    Alcohol Alcohol 36:323-8. 2001
    ..These findings imply alterations in arousal and involuntary adaptive processes in cortical networks associated with violent behaviour and alcoholism...
  21. ncbi Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis
    J Tiihonen
    Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Finland
    Mol Psychiatry 2:463-71. 1997
    ..The results are consistent with the general hypothesis that high regional heterogeneity of perfusion, metabolism and receptor density is necessary to maintain adaptation ability in the living organism...
  22. ncbi Biodistribution of [64Cu]Cu2+ and variance of metallothionein during tumor treatment by copper
    M Yu
    Technical Physics Department, Peking University, Beijing, China
    Nucl Med Biol 25:111-6. 1998
    ..The results suggest that MT contributes to the metabolism of copper that is localized mainly in the liver after copper administration and that copper can concentrate into mouse tumor cells followed by the reduction of MT in tumor cells...
  23. ncbi Fentanyl decreases beta-CIT binding to the dopamine transporter
    K A Bergstrom
    Department of Clinical Physiology, Kuopio University Hospital, Finland
    Synapse 29:413-5. 1998
    ..According to the present data, fentanyl decreases [123I]beta-CIT binding in the basal ganglia both in human and rats, suggesting that opiates possibly directly affect DA reuptake...
  24. ncbi Serum leptin and regional cerebral blood flow during exposure to food in obese and normal-weight women
    L J Karhunen
    Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Neuroendocrinology 69:154-9. 1999
    ....
  25. ncbi Regional cerebral blood flow during exposure to food in obese binge eating women
    L J Karhunen
    Department of Clinical Nutrition, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    Psychiatry Res 99:29-42. 2000
    ..Left hemisphere and its frontal and pre-frontal regions could thus play a role in binge eating behavior in humans...
  26. ncbi Effect of radiochemical purity of 99Tcm-Q12 on myocardial SPET image quality
    M Yu
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland
    Nucl Med Commun 20:747-53. 1999
    ..01). In conclusion, the radiochemical purity of 99Tcm-Q12 has a significant inverse correlation with the liver-to-heart ratio; thus, the high radiochemical purity of 99Tcm-Q12 should be confirmed to prevent interference by liver uptake...
  27. doi Effects of fluoxetine treatment on striatal dopamine transporter binding and cerebrospinal fluid insulin-like growth factor-1 in children with autism
    I Makkonen
    Department of Pediatrics, Unit of Child Neurology, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
    Neuropediatrics 42:207-9. 2011
    ....
  28. ncbi Combined diffusion and perfusion MRI with correlation to single-photon emission CT in acute ischemic stroke. Ischemic penumbra predicts infarct growth
    J O Karonen
    Department of Clinical Radiology, Clinical Physiology and Nuclear Medicine, Kuopio, Finland
    Stroke 30:1583-90. 1999
    ..The purpose of this study was to determine whether combined DWI and PWI in acute (<24 hours) ischemic stroke can predict infarct growth and final size...
  29. ncbi Heterogeneity of cerebral blood flow in symptomatic patients undergoing carotid endarterectomy
    E Vanninen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
    Nucl Med Commun 24:893-900. 2003
    ..The CBF heterogeneity index after acetazolamide injection is a sensitive marker of the haemodynamic consequences of carotid artery stenosis and its operative treatment...
  30. ncbi Combined perfusion- and diffusion-weighted MR imaging in acute ischemic stroke during the 1st week: a longitudinal study
    J O Karonen
    Depts of Clinical Radiology, Kuopio University Hospital, Puijonlaaksontie 2, FIN 70210 Kuopio, Finland
    Radiology 217:886-94. 2000
    ..To compare findings with different magnetic resonance (MR) perfusion maps in acute ischemic stroke...
  31. ncbi Brain serotonin reuptake did not change during one year in overtrained athletes
    A L T Uusitalo
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Int J Sports Med 27:702-8. 2006
    ..Sex may have effect on chronic stress response at the brain level in athletes, which may be a confusing factor in the overtraining studies, and has to be taken into consideration in the future...
  32. doi Heterogeneity of cerebral perfusion 1 week after haemorrhage is an independent predictor of clinical outcome in patients with aneurysmal subarachnoid haemorrhage
    T Mustonen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
    J Neurol Neurosurg Psychiatry 79:1128-33. 2008
    ....
  33. ncbi Abnormal serotonin reuptake in an overtrained, insomnic and depressed team athlete
    A L T Uusitalo
    Kuopio University Hospital, Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Kuopio, Finland
    Int J Sports Med 25:150-3. 2004
    ..We conclude, that that the severe overtraining state could have been related to decreased serotonin reuptake in the brain and signs of major depression...
  34. ncbi Performance characteristics of gamma cameras
    J T Kuikka
    Nucl Med Commun 24:439; author reply 440. 2003
  35. ncbi Myocardial fatty acid utilisation during exercise induced ischemia in patients with coronary artery disease
    K S Virtanen
    First Department of Medicine, Helsinki University Central Hospital, Finland
    Nuklearmedizin 41:157-61. 2002
    ..To compare myocardial free fatty acid (FFA) metabolism and flow during exercise induced ischemia we studied ten patients with coronary artery disease but without previous myocardial infarction...
  36. ncbi Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography
    E Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, Finland
    Neuroimage 14:87-94. 2001
    ..These data indicate that human whole hemisphere autoradiography with the analysis of binding heterogeneity may be a relevant tool to measure pathological processes in the brain...