J Kuikka

..There is evidence that abnormalities in brain dopamine, norepinephrine and serotonin metabolism may play an important role in binge eating. Serotonin-active antidepressant drugs have also been found to decrease binge eating...

..47; P<0.05) was found in the midbrain. The decline in [123I]nor-beta-CIT binding in the serotonin transporter-rich area is much less than that in dopamine transporters in the striatum (6% per decade)...

..89+/-0.19 vs. 1.10+/-0.19; P<0.05). The results suggest that the specific binding of dopamine D(2)/D(3) receptors in late type 1 alcoholics is decreased and its laterality in the temporal brain is altered from normal...

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..Most of the variability of transit times through the lungs is due to the heterogeneity of the transit times through the capillaries and venules...

..We demonstrate the heterogeneity of regional cerebral blood flow using a fractal approach and single-photon emission computed tomography (SPECT)...

..The findings confirm the suitability of [(123)I]PE2I for SPET imaging in clinical routine but emphasize the necessity of using age-matched controls in patient studies...

..The results support the views that without accounting the regional flow heterogeneity, glucose metabolic rate will be underestimated...

..As a conclusion, triple-head coincidence gamma camera provides relatively high-count rate imaging with good contrast and resolution...

..This is probably due to the recruitment of the open capillaries without vessel distension...

..We examine the quantitative accuracy and reproducibility that can be achieved with high-resolution SPECT of serotonergic neurotransmission...

..This review highlights recent findings in SPET receptor imaging and the use of fractal analysis in the interpretation of images representing various neuropsychiatric disorders...

..Recognition of the normal variation in heterogeneity is important in evaluation of the striatal dopamine transporter density between controls and patients suffering from various neuropsychiatric disorders...

..In addition, in young violent offenders there was no normal left-to-right asymmetry observed in control subjects of the same age. The normalisation of the left-to-right asymmetry may reflect late neurobiological maturation...

..86 to -0.90) and negative (r from -0.37 to -0.55) schizophrenic symptoms. These results support the previous hypothesis on dysfunction of mesocortical DA function behind the cognitive and negative symptoms in schizophrenia...

..Photon scatter is one of the most important factors degrading the quantitative accuracy of SPECT images. Many scatter correction methods have been proposed. The single isotope method was proposed by us...

..We examined the influence of the physical performance on the binding potential...

..3 and 26.0%. Thus, the redispersion of the budesonide particles can be altered by the properties of the carrier system...

..These findings imply alterations in arousal and involuntary adaptive processes in cortical networks associated with violent behaviour and alcoholism...

..The results are consistent with the general hypothesis that high regional heterogeneity of perfusion, metabolism and receptor density is necessary to maintain adaptation ability in the living organism...

..The results suggest that MT contributes to the metabolism of copper that is localized mainly in the liver after copper administration and that copper can concentrate into mouse tumor cells followed by the reduction of MT in tumor cells...

..According to the present data, fentanyl decreases [123I]beta-CIT binding in the basal ganglia both in human and rats, suggesting that opiates possibly directly affect DA reuptake...

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..Left hemisphere and its frontal and pre-frontal regions could thus play a role in binge eating behavior in humans...

..01). In conclusion, the radiochemical purity of 99Tcm-Q12 has a significant inverse correlation with the liver-to-heart ratio; thus, the high radiochemical purity of 99Tcm-Q12 should be confirmed to prevent interference by liver uptake...

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..The purpose of this study was to determine whether combined DWI and PWI in acute (<24 hours) ischemic stroke can predict infarct growth and final size...

..The CBF heterogeneity index after acetazolamide injection is a sensitive marker of the haemodynamic consequences of carotid artery stenosis and its operative treatment...

..To compare findings with different magnetic resonance (MR) perfusion maps in acute ischemic stroke...

..Sex may have effect on chronic stress response at the brain level in athletes, which may be a confusing factor in the overtraining studies, and has to be taken into consideration in the future...

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..We conclude, that that the severe overtraining state could have been related to decreased serotonin reuptake in the brain and signs of major depression...

..CONCLUSION: In this small group of patients, the reduced post-exercise FFA metabolic rate tentatively suggests a parsimonious workload of the exercising myocardium by reducing oxygen consumption in patients with coronary artery disease...

..These data indicate that human whole hemisphere autoradiography with the analysis of binding heterogeneity may be a relevant tool to measure pathological processes in the brain...