E Korpi

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi GABA(A)-receptor subtypes: clinical efficacy and selectivity of benzodiazepine site ligands
    E R Korpi
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Ann Med 29:275-82. 1997
  2. ncbi Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits
    E R Korpi
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Neuroscience 109:733-43. 2002
  3. ncbi Drug interactions at GABA(A) receptors
    Esa R Korpi
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4B, Finland
    Prog Neurobiol 67:113-59. 2002
  4. ncbi AMPA/kainate receptor-mediated up-regulation of GABAA receptor delta subunit mRNA expression in cultured rat cerebellar granule cells is dependent on NMDA receptor activation
    Virpi Salonen
    Department of Pharmacology, Drug Design and Therapeutics, University of Turku, Itainen Pitkakatu 4, FIN 20520 Turku, Finland
    Brain Res 1087:33-40. 2006
  5. ncbi Alcohol drinking of alcohol-preferring AA rats is differentially affected by clozapine and olanzapine
    Kimmo Ingman
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itäinen Pitkäkatu 4 B, 3rd Floor, FI 20520 Turku, Finland
    Eur J Pharmacol 534:133-40. 2006
  6. pmc Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes
    Martin Ranna
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, POB 63 Haartmaninkatu 8, FI 00014, Finland
    BMC Pharmacol 6:1. 2006
  7. ncbi The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists
    Anni Maija Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, P O Box 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    J Pharmacol Exp Ther 317:615-26. 2006
  8. ncbi Evidence for a reduction of coupling between GABAA receptor agonist and ionophore binding sites by inorganic phosphate
    Saku T Sinkkonen
    Institute of Biomedicine, Pharmacology, University of Helsinki, P O Box 63, Helsinki, FI 00014, Finland
    Neurochem Res 30:1471-82. 2005
  9. ncbi Subanesthetic ketamine does not affect 11C-flumazenil binding in humans
    Elina Salmi
    Turku PET Centre, PO Box 52, FIN 20521 Turku, Finland
    Anesth Analg 101:722-5, table of contents. 2005
  10. ncbi alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice
    Juuso Juhila
    Department of Pharmacology and Clinical Pharmacology, University of Turku, FI 20520 Turku, Finland
    Eur J Pharmacol 517:74-83. 2005

Collaborators

Detail Information

Publications45

  1. ncbi GABA(A)-receptor subtypes: clinical efficacy and selectivity of benzodiazepine site ligands
    E R Korpi
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Ann Med 29:275-82. 1997
    ..Partial agonism, receptor subtype selectivity and novel binding sites are discussed as possible strategies to develop new drugs with fewer adverse effects than are seen in the clinical use of benzodiazepines...
  2. ncbi Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits
    E R Korpi
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Neuroscience 109:733-43. 2002
    ..These results support the idea of subunit competition during the assembly of native GABA(A) receptors...
  3. ncbi Drug interactions at GABA(A) receptors
    Esa R Korpi
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4B, Finland
    Prog Neurobiol 67:113-59. 2002
    ....
  4. ncbi AMPA/kainate receptor-mediated up-regulation of GABAA receptor delta subunit mRNA expression in cultured rat cerebellar granule cells is dependent on NMDA receptor activation
    Virpi Salonen
    Department of Pharmacology, Drug Design and Therapeutics, University of Turku, Itainen Pitkakatu 4, FIN 20520 Turku, Finland
    Brain Res 1087:33-40. 2006
    ..Up-regulation of delta during prolonged glutamate receptor activation or cell membrane depolarization may be a mechanism to increase tonic inhibition to counteract excessive excitation...
  5. ncbi Alcohol drinking of alcohol-preferring AA rats is differentially affected by clozapine and olanzapine
    Kimmo Ingman
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itäinen Pitkäkatu 4 B, 3rd Floor, FI 20520 Turku, Finland
    Eur J Pharmacol 534:133-40. 2006
    ..In conclusion, the atypical antipsychotic olanzapine non-selectively reduced alcohol drinking, while clozapine failed to do so, even if both were administered at pharmacologically effective doses...
  6. pmc Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes
    Martin Ranna
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, POB 63 Haartmaninkatu 8, FI 00014, Finland
    BMC Pharmacol 6:1. 2006
    ..Here, we studied the pharmacology of the human alpha3beta1, alpha3beta1epsilon, alpha3beta1theta and alpha3beta1epsilontheta receptor subtypes expressed in Xenopus oocytes and compared them with the gamma2 subunit-containing receptors...
  7. ncbi The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists
    Anni Maija Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, P O Box 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    J Pharmacol Exp Ther 317:615-26. 2006
    ..03 mg/kg s.c.), suggesting a role for the TASK-1 channels in the modulation of function of the adrenergic locus coeruleus nuclei and/or other neuronal systems...
  8. ncbi Evidence for a reduction of coupling between GABAA receptor agonist and ionophore binding sites by inorganic phosphate
    Saku T Sinkkonen
    Institute of Biomedicine, Pharmacology, University of Helsinki, P O Box 63, Helsinki, FI 00014, Finland
    Neurochem Res 30:1471-82. 2005
    ..These results suggest that inorganic phosphate affects coupling between agonist and ionophore sites in GABAA receptors...
  9. ncbi Subanesthetic ketamine does not affect 11C-flumazenil binding in humans
    Elina Salmi
    Turku PET Centre, PO Box 52, FIN 20521 Turku, Finland
    Anesth Analg 101:722-5, table of contents. 2005
    ..Ketamine did not affect (11)C-flumazenil binding to GABA(A) receptor in the brain, indicating that this mechanism is of minor importance in the actions of subanesthetic ketamine...
  10. ncbi alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice
    Juuso Juhila
    Department of Pharmacology and Clinical Pharmacology, University of Turku, FI 20520 Turku, Finland
    Eur J Pharmacol 517:74-83. 2005
    ..Drugs antagonizing the alpha(2A)-adrenoceptor subtype may provide a novel approach for reducing drug sensitization and motor complications caused by dopaminergic agents...
  11. ncbi Effects of aripiprazole on alcohol intake in an animal model of high-alcohol drinking
    Kimmo Ingman
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itäinen Pitkäkatu 4 B, 3rd Floor, FI 20520 Turku, Finland
    Alcohol Alcohol 41:391-8. 2006
    ..This study examined the effects of aripiprazole, a novel atypical antipsychotic drug with partial agonist properties at dopamine D2 receptors, on the voluntary limited access alcohol drinking of alcohol-preferring AA (Alko, Alcohol) rats...
  12. doi K+ channel TASK-1 knockout mice show enhanced sensitivities to ataxic and hypnotic effects of GABA(A) receptor ligands
    Anni Maija Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    J Pharmacol Exp Ther 327:277-86. 2008
    ..Furthermore, because inhalation anesthetics act partially through GABA(A) receptors, the up-regulation of GABA(A) receptor function in TASK-1 KO mice might mask TASK-1 channel's significance as a target for inhalation anesthetics...
  13. ncbi Lifelong ethanol consumption and brain regional GABAA receptor subunit mRNA expression in alcohol-preferring rats
    Maija Sarviharju
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Alcohol 40:159-66. 2006
    ..The results suggest that prolonged ethanol consumption leading to blood concentrations of about 10 mM may downregulate the mRNA expression of selected GABAA receptor subunits and that aging might have partly similar effects...
  14. pmc From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors
    Peer Wulff
    Department of Clinical Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Nat Neurosci 10:923-9. 2007
    ..This combined molecular and pharmacological technique has demonstrable advantages over targeted cell ablation and will be invaluable for investigating many neuronal circuits...
  15. ncbi Does ethanol act preferentially via selected brain GABAA receptor subtypes? the current evidence is ambiguous
    Esa R Korpi
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, FI 00014 University of Helsinki, Helsinki, Finland
    Alcohol 41:163-76. 2007
    ..Therefore, we finish the review by discussing more generally alcohol and GABAA receptors and by suggesting potential future directions for this research...
  16. ncbi TASK-3 knockout mice exhibit exaggerated nocturnal activity, impairments in cognitive functions, and reduced sensitivity to inhalation anesthetics
    Anni Maija Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    J Pharmacol Exp Ther 323:924-34. 2007
    ..Overall, our results suggest important contributions of TASK-3 channels in the neuronal circuits regulating circadian rhythms, cognitive functions, and mediating specific pharmacological effects...
  17. ncbi Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic alpha6beta GABA(A) receptors
    Kati S Saarelainen
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Neurochem 105:338-50. 2008
    ....
  18. ncbi The impact of sub-cellular location and intracellular neuronal proteins on properties of GABA(A) receptors
    Bryndis Birnir
    Lund University, School of Medicine, CRC, Entry 72, house 91, Level 11, UMAS, 205 02 Malmo, Sweden
    Curr Pharm Des 13:3169-77. 2007
    ..g. phosphorylation) plus the sub-cellular location have on the "fine-tuning" of the functional and pharmacological properties of the GABA(A) receptor channels...
  19. doi Xenon does not affect gamma-aminobutyric acid type A receptor binding in humans
    Elina Salmi
    Turku PET Centre, Turku, Finland
    Anesth Analg 106:129-34, table of contents. 2008
    ..The mechanism of anesthetic action of xenon in the living human brain still remains to be determined...
  20. pmc Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear
    James M Sonner
    Department of Anesthesiology, University of California, San Francisco, San Francisco, California, USA
    Mol Pharmacol 68:61-8. 2005
    ..These results indicate that alpha1-containing GABA(A)-Rs in the hippocampus, amygdala, and/or cortex influence the amnestic effects of inhaled anesthetics and may be an important molecular target of the drug isoflurane...
  21. ncbi Maturation of cultured hippocampal slices results in increased excitability in granule cells
    Markus M Lindroos
    Department of Pharmacology, University of Turku, Itainen Pitkakatu 4, FIN 20520 Turku, Finland
    Int J Dev Neurosci 23:65-73. 2005
    ..Cultured immature hippocampal slices could thus serve as an additional in vitro model to elucidate mechanisms of synaptic plasticity and cellular reactivity in response to external damage in the developing hippocampus...
  22. ncbi Ethanol inhibits alpha-amino-3-hydyroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function in central nervous system neurons by stabilizing desensitization
    Tommi Möykkynen
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tenessee, USA
    J Pharmacol Exp Ther 306:546-55. 2003
    ..Our results can explain some of the variation observed in EtOH inhibition in previous studies, and support the idea that physiologically relevant concentrations of EtOH can have a strong effect on AMPA receptor function...
  23. ncbi Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug
    Saku T Sinkkonen
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, P O Box 63, University of Helsinki, Helsinki FIN 00014, Finland
    Mol Pharmacol 64:753-63. 2003
    ....
  24. ncbi Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy
    Hanna B Laurén
    Department of Pharmacology and Clinical Pharmacology, PharmaCity, University of Turku, Itainen Pitkakatu 4, FIN 20520 Turku, Finland
    Neurosci Lett 349:58-62. 2003
    ..Our results suggest that GABA(A) receptor undergoes region selective subunit changes during epileptogenesis in the hippocampus of rats with chronic temporal lobe epilepsy...
  25. ncbi Tolerance to diazepam-induced motor impairment: a study with GABAA receptor alpha6 subunit knockout mice
    Olga Vekovischeva
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Neurochem Res 28:757-64. 2003
    ....
  26. ncbi Brain regional heterogeneity of pH effects on GABA(A) receptor-associated [35s]TBPS binding
    Mikko Uusi-Oukari
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Neurochem Res 29:771-80. 2004
    ..Therefore the alpha1beta2gamma2 and alpha2beta3gamma2 receptor subtypes are suggested to be preferentially responsible for brain regional heterogeneity of the pH modulation of [35S]TBPS binding...
  27. ncbi Comparison of deramciclane to benzodiazepine agonists in behavioural activity of mice and in alcohol drinking of alcohol-preferring rats
    Kimmo Ingman
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4B, FIN 20520 Turku, Finland
    Pharmacol Biochem Behav 77:847-54. 2004
    ..Deramciclane appears to be a safe and well-tolerated drug and we suggest that it might be useful in the treatment of anxiety in alcoholics...
  28. ncbi Selective reduction of gamma-aminobutyric acid type A receptor delta subunit mRNA levels by MK-801 in rat dentate gyrus
    Saku T Sinkkonen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Neurosci Lett 364:106-9. 2004
    ..Other subunits did not display statistically significant alterations. These data demonstrate selective actions on GABAA receptor subunit levels that result from blockade of excitation by MK-801...
  29. ncbi Autoradiographic imaging of altered synaptic alphabetagamma2 and extrasynaptic alphabeta GABAA receptors in a genetic mouse model of anxiety
    Saku T Sinkkonen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Neurochem Int 44:539-47. 2004
    ....
  30. ncbi The alpha2-adrenoceptor antagonist atipamezole reduces the development and expression of d-amphetamine-induced behavioural sensitization
    Juuso Juhila
    Department of Pharmacology and Clinical Pharmacology, University of Turku, 20520 Turku, Finland
    Naunyn Schmiedebergs Arch Pharmacol 367:274-80. 2003
    ....
  31. ncbi Behavioural correlates of an altered balance between synaptic and extrasynaptic GABAAergic inhibition in a mouse model
    Saku T Sinkkonen
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, PO Box 63, FI 00014 University of Helsinki, Helsinki, Finland
    Eur J Neurosci 20:2168-78. 2004
    ..Importantly, the increased extrasynaptic inhibition, even when facilitated in the presence of tiagabine, was not able fully to counteract enhanced seizure induction by GABAA antagonists...
  32. ncbi Reduced adrenal activation in a rat line selected for high alcohol sensitivity
    Kristina Raatesalmi
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Alcohol Clin Exp Res 26:1344-9. 2002
    ..In the present study, we determined possible differences in adrenal activation after alcohol and motor performance testing between the alcohol-sensitive alcohol-nontolerant and alcohol-insensitive alcohol-tolerant rats...
  33. ncbi Brain regional mu-opioid receptor function in rat lines selected for differences in alcohol preference
    Sanna L Soini
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Itainen Pitkakatu 4B, FIN 20520 Turku, Finland
    Eur J Pharmacol 448:157-63. 2002
    ..These results of the selective breeding experiment suggest that brain region-specific differences in mu-opioid receptor function may correlate with innate differences in alcohol preference...
  34. ncbi Low brain histamine content affects ethanol-induced motor impairment
    Minnamaija Lintunen
    Department of Biology, Abo Akademi University, Turku, Finland
    Neurobiol Dis 9:94-105. 2002
    ..Brain histamine levels and possibly signaling via H3 receptors may thus correlate with genetic differences in ethanol-induced motor impairment...
  35. ncbi Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans
    Elina Salmi
    Turku PET Centre, Turku University Hospital, PO Box 52, FIN 20521 Turku, Finland
    Anesth Analg 99:1420-6; table of contents. 2004
    ..Our findings support the involvement of GABA(A) receptors in the mechanism of action of both anesthetics in humans...
  36. ncbi Selective delta-opioid receptor antagonist N,N(CH3)2-Dmt-Tic-OH does not reduce ethanol intake in alcohol-preferring AA rats
    Kimmo Ingman
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Addict Biol 8:173-9. 2003
    ..p.), which confirmed its efficacy as a delta-opioid receptor antagonist in rat brain. Our results support the idea that delta-opioid receptors do not mediate alcohol reward in AA rats...
  37. doi Morphine-nicotine interaction in conditioned place preference in mice after chronic nicotine exposure
    Tanja Vihavainen
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, P O Box 56 Viikinkaari 5 E, University of Helsinki, FI 00014, Finland
    Eur J Pharmacol 587:169-74. 2008
    ..In conclusion, chronic oral nicotine treatment augments the reinforcing effects of morphine in mice, and this cross-sensitization does not seem to be mediated by micro-opioid receptors...
  38. ncbi Compensation by reduced L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor responses in a mouse model with reduced gamma-aminobutyric acid type A receptor-mediated synaptic inhibition
    Tommi P Möykkynen
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Neurosci Res 85:668-72. 2007
    ....
  39. ncbi Kainate down-regulates a subset of GABAA receptor subunits expressed in cultured mouse cerebellar granule cells
    Ilkka K Martikainen
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Cerebellum 3:27-38. 2004
    ..In conclusion, chronic kainate treatment of cerebellar granule cells selectively down-regulates oil, alpha6 and beta2 subunits resulting in altered GABAA receptor pharmacology...
  40. ncbi Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons
    M Isabel Aller
    Department of Clinical Neurobiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 25:11455-67. 2005
    ..However, TASK channel subunit composition does not alter the resting excitability of CGNs but does influence sensitivity to endogenous modulators such as Zn2+ and H+...
  41. ncbi The neuroprotective KDI domain of gamma 1-laminin is a universal and potent inhibitor of ionotropic glutamate receptors
    Tommi Möykkynen
    Institute of Biomedicine Pharmacology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Neurosci Res 81:797-804. 2005
    ....
  42. ncbi Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptors
    Jukka S Pakkanen
    Division of Pharmacology and Toxicology, University of Helsinki, Helsinki, Finland
    J Neurochem 94:1329-41. 2005
    ..Collectively, our results suggest that methadone engages in complex and potentially pharmacologically significant interactions with nAChRs...
  43. ncbi GABA(A) receptor subtypes as targets for neuropsychiatric drug development
    Esa R Korpi
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, P O Box 63 Haartmaninkatu 8, FI 00014 University of Helsinki, Finland
    Pharmacol Ther 109:12-32. 2006
    ....
  44. pmc GABAA receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines
    Dev Chandra
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    BMC Neurosci 6:30. 2005
    ..To further investigate the role of the gamma2 subunit in behavior and whole animal drug action, we used gene targeting to create a novel mouse line with attenuated gamma2 expression, i.e., gamma2 knockdown mice...
  45. ncbi Antinociception by spinal and systemic oxycodone: why does the route make a difference? In vitro and in vivo studies in rats
    Kim K Lemberg
    Department of Pharmacology, Institute of Biomedicine, FIN 00014 University of Helsinki, Helsinki, Finland
    Anesthesiology 105:801-12. 2006
    ....