R K Korhonen

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi Importance of the superficial tissue layer for the indentation stiffness of articular cartilage
    R K Korhonen
    Department of Applied Physics, University of Kuopio, Kuopio, Finland
    Med Eng Phys 24:99-108. 2002
  2. ncbi Can mechanical myotonometry or electromyography be used for the prediction of intramuscular pressure?
    R K Korhonen
    Department of Applied Physics, University of Kuopio, POB 1627, Finland
    Physiol Meas 26:951-63. 2005
  3. doi Compressive and tensile properties of articular cartilage in axial loading are modulated differently by osmotic environment
    Rami K Korhonen
    Department of Physics, University of Kuopio, POB 1627, FI 70211 Kuopio, Finland
    Med Eng Phys 32:155-60. 2010
  4. ncbi Fibril reinforced poroelastic model predicts specifically mechanical behavior of normal, proteoglycan depleted and collagen degraded articular cartilage
    Rami K Korhonen
    Department of Applied Physics, University of Kuopio, 70211, Kuopio, Finland
    J Biomech 36:1373-9. 2003
  5. ncbi Experimental and numerical validation for the novel configuration of an arthroscopic indentation instrument
    Rami K Korhonen
    Department of Applied Physics, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Phys Med Biol 48:1565-76. 2003
  6. doi Osmotic loading of articular cartilage modulates cell deformations along primary collagen fibril directions
    Rami K Korhonen
    Department of Physics, University of Kuopio, POB 1627, FI 70211 Kuopio, Finland
    J Biomech 43:783-7. 2010
  7. ncbi Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and indentation
    R K Korhonen
    Department of Applied Physics, University of Kuopio, POB 1627, 70211 Kuopio, Finland
    J Biomech 35:903-9. 2002
  8. pmc The effect of geometry and abduction angle on the stresses in cemented UHMWPE acetabular cups--finite element simulations and experimental tests
    Rami K Korhonen
    Department of Applied Physics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biomed Eng Online 4:32. 2005
  9. ncbi Biomechanical properties of knee articular cartilage
    M S Laasanen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
    Biorheology 40:133-40. 2003
  10. doi Effect of superficial collagen patterns and fibrillation of femoral articular cartilage on knee joint mechanics-a 3D finite element analysis
    M E Mononen
    Department of Applied Physics, University of Eastern Finland, POB 1627, FI 70211 Kuopio, Finland
    J Biomech 45:579-87. 2012

Detail Information

Publications35

  1. ncbi Importance of the superficial tissue layer for the indentation stiffness of articular cartilage
    R K Korhonen
    Department of Applied Physics, University of Kuopio, Kuopio, Finland
    Med Eng Phys 24:99-108. 2002
    ..The present results suggest that indentation testing is an efficient technique for the characterization of the superficial degeneration of articular cartilage...
  2. ncbi Can mechanical myotonometry or electromyography be used for the prediction of intramuscular pressure?
    R K Korhonen
    Department of Applied Physics, University of Kuopio, POB 1627, Finland
    Physiol Meas 26:951-63. 2005
    ....
  3. doi Compressive and tensile properties of articular cartilage in axial loading are modulated differently by osmotic environment
    Rami K Korhonen
    Department of Physics, University of Kuopio, POB 1627, FI 70211 Kuopio, Finland
    Med Eng Phys 32:155-60. 2010
    ..Tissue PG and collagen contents accounted for the compressive and tensile properties of cartilage...
  4. ncbi Fibril reinforced poroelastic model predicts specifically mechanical behavior of normal, proteoglycan depleted and collagen degraded articular cartilage
    Rami K Korhonen
    Department of Applied Physics, University of Kuopio, 70211, Kuopio, Finland
    J Biomech 36:1373-9. 2003
    ..We conclude that the compression-tension nonlinearity of the tissue is needed to capture realistically the mechanical behavior of normal and degenerated articular cartilage...
  5. ncbi Experimental and numerical validation for the novel configuration of an arthroscopic indentation instrument
    Rami K Korhonen
    Department of Applied Physics, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Phys Med Biol 48:1565-76. 2003
    ....
  6. doi Osmotic loading of articular cartilage modulates cell deformations along primary collagen fibril directions
    Rami K Korhonen
    Department of Physics, University of Kuopio, POB 1627, FI 70211 Kuopio, Finland
    J Biomech 43:783-7. 2010
    ..Findings of this study suggest that osmotic loading modulates chondrocyte shapes in accordance with the primary collagen fibril directions in articular cartilage...
  7. ncbi Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and indentation
    R K Korhonen
    Department of Applied Physics, University of Kuopio, POB 1627, 70211 Kuopio, Finland
    J Biomech 35:903-9. 2002
    ..However, values of the isotropic Young's modulus obtained from the in situ indentation tests are higher than those obtained from the in vitro unconfined or confined compression tests and may depend on the indenter size in use...
  8. pmc The effect of geometry and abduction angle on the stresses in cemented UHMWPE acetabular cups--finite element simulations and experimental tests
    Rami K Korhonen
    Department of Applied Physics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biomed Eng Online 4:32. 2005
    ..The aim of the present study was to test the hypotheses that the cup geometry, abduction angle, thickness and clearance can modify the stresses in cemented polyethylene cups...
  9. ncbi Biomechanical properties of knee articular cartilage
    M S Laasanen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
    Biorheology 40:133-40. 2003
    ..Fibril reinforced poroelastic finite element model was used to capture the experimentally found compression-tension nonlinearity of articular cartilage...
  10. doi Effect of superficial collagen patterns and fibrillation of femoral articular cartilage on knee joint mechanics-a 3D finite element analysis
    M E Mononen
    Department of Applied Physics, University of Eastern Finland, POB 1627, FI 70211 Kuopio, Finland
    J Biomech 45:579-87. 2012
    ..This study provides further evidence on the importance of the collagen fibril organization for the optimal function of articular cartilage...
  11. doi Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics
    S Saarakkala
    Department of Physics, University of Kuopio, Kuopio, Finland
    Osteoarthritis Cartilage 18:73-81. 2010
    ..e., collagen and proteoglycans (PGs), during OA progression. Further, it is unknown how the depth-wise changes affect local tissue strains during compression. Our aim was to address these issues...
  12. doi Alterations in structure and properties of collagen network of osteoarthritic and repaired cartilage modify knee joint stresses
    M E Mononen
    Department of Physics and Mathematics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland
    Biomech Model Mechanobiol 10:357-69. 2011
    ..This study presents a step toward those goals...
  13. ncbi Ultrasonic characterization of articular cartilage
    J Toyras
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Biorheology 39:161-9. 2002
    ..Therefore, ultrasound appears to be a valuable supplement to the mechanical measurements of articular cartilage stiffness...
  14. doi Mechanical characterization of articular cartilage by combining magnetic resonance imaging and finite-element analysis: a potential functional imaging technique
    P Julkunen
    Department of Physics, University of Kuopio, Kuopio, Finland
    Phys Med Biol 53:2425-38. 2008
    ..Contradictorily, high bulk T(2) can also be found in stiff cartilage with a multilaminar collagen fibril network. By emerging MRI and FEM, the present study establishes a step toward functional imaging of articular cartilage...
  15. doi Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking--contribution of steric and electrostatic effects
    K A M Kulmala
    Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
    Med Eng Phys 35:1415-20. 2013
    ..To investigate the effect of threose-induced collagen cross-linking on diffusion of ionic and non-ionic contrast agents in articular cartilage...
  16. doi Importance of depth-wise distribution of collagen and proteoglycans in articular cartilage--a 3D finite element study of stresses and strains in human knee joint
    K S Halonen
    Department of Applied Physics, University of Eastern Finland, POB 1627, FI 70211 Kuopio, Finland
    J Biomech 46:1184-92. 2013
    ....
  17. ncbi Novel mechano-acoustic technique and instrument for diagnosis of cartilage degeneration
    M S Laasanen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, University of Kuopio, Finland
    Physiol Meas 23:491-503. 2002
    ....
  18. ncbi Collagen network primarily controls Poisson's ratio of bovine articular cartilage in compression
    Panu Kiviranta
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    J Orthop Res 24:690-9. 2006
    ..We conclude that Poisson's ratio of articular cartilage is primarily controlled by the content and organization of the collagen network...
  19. doi Diffusion coefficients of articular cartilage for different CT and MRI contrast agents
    K A M Kulmala
    Department of Physics and Mathematics, University of Eastern Finland, POB 1627, 70211 Kuopio, Finland
    Med Eng Phys 32:878-82. 2010
    ..Present method could therefore enable image-based assessment of cartilage composition by determination of diffusion coefficients within cartilage tissue...
  20. doi Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage
    H T Kokkonen
    Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
    Osteoarthritis Cartilage 19:1190-8. 2011
    ..In particular, we investigated the potential of Contrast Enhanced Computed Tomography (CECT) to detect changes in articular cartilage after increased collagen cross-linking, which is an age-related phenomenon...
  21. pmc Structure-function relationships in osteoarthritic human hip joint articular cartilage
    J T A Mäkelä
    Department of Applied Physics, University of Eastern Finland, POB 1627, FI 70211 Kuopio, Finland
    Osteoarthritis Cartilage 20:1268-77. 2012
    ..The objective of this study was to characterize the structure-function relationships of articular cartilage obtained from osteoarthritic human hip joints...
  22. doi Hyperosmolaric contrast agents in cartilage tomography may expose cartilage to overload-induced cell death
    M J Turunen
    Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
    J Biomech 45:497-503. 2012
    ..In conclusion, excessive loading stresses followed by tissue creep might increase the risk for chondrocyte death in articular cartilage when immersed in hypertonic X-ray contrast agent, especially in the deep zone of cartilage...
  23. ncbi Improvement of arthroscopic cartilage stiffness probe using amorphous diamond coating
    Juha Toyras
    Department of Applied Physics, University of Kuopio, POB 1627, FIN 70211 Kuopio, Finland
    J Biomed Mater Res B Appl Biomater 73:15-22. 2005
    ..Sufficient friction between articular surface and reference plate of the arthroscopic probe improves significantly reproducibility of the stiffness measurements...
  24. doi The effect of collagen degradation on chondrocyte volume and morphology in bovine articular cartilage following a hypotonic challenge
    S M Turunen
    Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland
    Biomech Model Mechanobiol 12:417-29. 2013
    ..This emphasizes the role of collagen in modulating cartilage mechanobiology in diseased tissue...
  25. doi Cell deformation behavior in mechanically loaded rabbit articular cartilage 4 weeks after anterior cruciate ligament transection
    S M Turunen
    Department of Applied Physics, University of Eastern Finland, POB 1627, FI 70211 Kuopio, Finland
    Osteoarthritis Cartilage 21:505-13. 2013
    ....
  26. ncbi Ultrasound indentation of bovine knee articular cartilage in situ
    Mikko S Laasanen
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Kuopio, POB 1627, FIN 70211, Kuopio, Finland
    J Biomech 36:1259-67. 2003
    ..Especially, combined measurement of thickness, E(dyn) and R provides valuable diagnostic information on cartilage status...
  27. ncbi Structure-function relationships in enzymatically modified articular cartilage
    Jarno Rieppo
    Department of Anatomy, University of Kuopio, Kuopio, Finland
    Cells Tissues Organs 175:121-32. 2003
    ....
  28. doi Stress-relaxation of human patellar articular cartilage in unconfined compression: prediction of mechanical response by tissue composition and structure
    Petro Julkunen
    Department of Clinical Neurophysiology, Kuopio University Hospital, POB 1777, FI 70211, Kuopio, Finland
    J Biomech 41:1978-86. 2008
    ..98). Our results suggest that specific information on tissue composition and structure might enable assessment of cartilage mechanics without mechanical testing...
  29. ncbi Collagen network of articular cartilage modulates fluid flow and mechanical stresses in chondrocyte
    Rami K Korhonen
    Department of Applied Physics, University of Kuopio, POB 1627, 70211, Kuopio, Finland
    Biomech Model Mechanobiol 5:150-9. 2006
    ..Therefore, the integrity of the collagen network may be an important determinant in cell stimulation and in the control of the matrix maintenance...
  30. ncbi Uncertainties in indentation testing of articular cartilage: a fibril-reinforced poroviscoelastic study
    Petro Julkunen
    Department of Physics, University of Kuopio, Kuopio, Finland Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
    Med Eng Phys 30:506-15. 2008
    ....
  31. ncbi Characterization of articular cartilage by combining microscopic analysis with a fibril-reinforced finite-element model
    Petro Julkunen
    Department of Physics, University of Kuopio, Kuopio, Finland
    J Biomech 40:1862-70. 2007
    ..The present study demonstrates that modern quantitative microscopic methods in combination with the FRPVE model are feasible methods to characterize the structure-function relationships of articular cartilage...
  32. doi Comparison of nonlinear mechanical properties of bovine articular cartilage and meniscus
    E K Danso
    Department of Applied Physics, University of Eastern Finland, P O Box 1627, FI 70211 Kuopio, Finland Department of Clinical Neurophysiology, Kuopio University Hospital, P O Box 1777, FI 70211 Kuopio, Finland Electronic address
    J Biomech 47:200-6. 2014
    ..These findings point out different load carrying demands that both articular cartilage and meniscus have to fulfil during normal physiological loading activities of knee joints. ..
  33. doi Importance of collagen orientation and depth-dependent fixed charge densities of cartilage on mechanical behavior of chondrocytes
    Rami K Korhonen
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB, T2N 1N4, Canada
    J Biomech Eng 130:021003. 2008
    ....
  34. ncbi Mechano-acoustic determination of Young's modulus of articular cartilage
    Simo Saarakkala
    Department of Nuclear Medicine, Etela Savo Hospital District, Mikkeli Central Hospital, Porrassalmenkatu 35 37, 50100 Mikkeli, Finland
    Biorheology 41:167-79. 2004
    ..Ultrasound indentation instrument, when further developed, provides an applicable tool for the in vivo detection of cartilage mechano-acoustic properties. These techniques could promote the diagnostics of osteoarthrosis...
  35. ncbi Depth-dependent analysis of the role of collagen fibrils, fixed charges and fluid in the pericellular matrix of articular cartilage on chondrocyte mechanics
    Rami K Korhonen
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada T2N 1N4
    J Biomech 41:480-5. 2008
    ....