Y T Konttinen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc BMPs in periprosthetic tissues around aseptically loosened total hip implants
    Ville Waris
    Mikkeli Central Hospital, Mikkeli, Finland
    Acta Orthop 81:420-6. 2010
  2. pmc Systematic review and meta-analysis of the efficacy and safety of existing TNF blocking agents in treatment of rheumatoid arthritis
    Kalle J Aaltonen
    Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    PLoS ONE 7:e30275. 2012
  3. pmc Whole-mount specimens in the analysis of en bloc samples obtained from revisions of resurfacing hip implants. A report of 4 early failures
    Ioannis Stogiannidis
    Department of Orthopaedic Surgery, COXA Hospital for Joint Replacement, Tampere, Finland
    Acta Orthop 81:324-30. 2010
  4. pmc Outcome of prosthesis exchange for infected knee arthroplasty: the effect of treatment approach
    Esa Jämsen
    Medical School, University of Tampere, Tampere, Finland
    Acta Orthop 80:67-77. 2009
  5. pmc Low rate of infected knee replacements in a nationwide series--is it an underestimate?
    Esa Jämsen
    Medical School, University of Tampere, Tampere, Finland
    Acta Orthop 80:205-12. 2009
  6. doi request reprint Adverse reactions to metal-on-metal implants
    Yrjo T Konttinen
    Department of Medicine, Institute of Clinical Medicine, BMH1, P O Box 700, FI 00029 HUS, Finland
    Nat Rev Rheumatol 9:5-6. 2013
  7. doi request reprint Exosomal secretion of death bullets: a new way of apoptotic escape?
    Nina Trokovic
    Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    Am J Physiol Endocrinol Metab 303:E1015-24. 2012
  8. doi request reprint Sex steroids in Sjögren's syndrome
    Yrjo T Konttinen
    Department of Medicine, Helsinki University Central Hospital, PO Box 700, 00029 HUS, Helsinki, Finland
    J Autoimmun 39:49-56. 2012
  9. pmc The effect of geometry and abduction angle on the stresses in cemented UHMWPE acetabular cups--finite element simulations and experimental tests
    Rami K Korhonen
    Department of Applied Physics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biomed Eng Online 4:32. 2005
  10. pmc Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion
    Guo Feng Ma
    Department of Medicine Invärtes Medicin, Helsinki University Central Hospital, PO Box 700, Helsinki, Finland
    BMC Microbiol 9:55. 2009

Collaborators

Detail Information

Publications98

  1. pmc BMPs in periprosthetic tissues around aseptically loosened total hip implants
    Ville Waris
    Mikkeli Central Hospital, Mikkeli, Finland
    Acta Orthop 81:420-6. 2010
    ..We hypothesized that there is an increased local synthesis of BMPs in the synovial membrane-like interface around aseptically loosened total hip replacement (THR) implants, as body attempts to generate or maintain implant fixation...
  2. pmc Systematic review and meta-analysis of the efficacy and safety of existing TNF blocking agents in treatment of rheumatoid arthritis
    Kalle J Aaltonen
    Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    PLoS ONE 7:e30275. 2012
    ....
  3. pmc Whole-mount specimens in the analysis of en bloc samples obtained from revisions of resurfacing hip implants. A report of 4 early failures
    Ioannis Stogiannidis
    Department of Orthopaedic Surgery, COXA Hospital for Joint Replacement, Tampere, Finland
    Acta Orthop 81:324-30. 2010
    ..In this consecutive revision case series, early failures of femoral implants (at < 4 years) were studied...
  4. pmc Outcome of prosthesis exchange for infected knee arthroplasty: the effect of treatment approach
    Esa Jämsen
    Medical School, University of Tampere, Tampere, Finland
    Acta Orthop 80:67-77. 2009
    ..The purpose of this literature review is to compare the clinical outcome achieved with one-stage revision and two-stage revision with different types of spacers...
  5. pmc Low rate of infected knee replacements in a nationwide series--is it an underestimate?
    Esa Jämsen
    Medical School, University of Tampere, Tampere, Finland
    Acta Orthop 80:205-12. 2009
    ..Specialist hospitals have reported an incidence of early deep infections of < 1% following primary knee replacement. The purpose of this study was to estimate the infection rate in a nationwide series using register-based data...
  6. doi request reprint Adverse reactions to metal-on-metal implants
    Yrjo T Konttinen
    Department of Medicine, Institute of Clinical Medicine, BMH1, P O Box 700, FI 00029 HUS, Finland
    Nat Rev Rheumatol 9:5-6. 2013
    ....
  7. doi request reprint Exosomal secretion of death bullets: a new way of apoptotic escape?
    Nina Trokovic
    Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    Am J Physiol Endocrinol Metab 303:E1015-24. 2012
    ..According to the CRISP-3 and LIV-1 markers, DHEA probably exerted its effects via intracrine conversion to DHT...
  8. doi request reprint Sex steroids in Sjögren's syndrome
    Yrjo T Konttinen
    Department of Medicine, Helsinki University Central Hospital, PO Box 700, 00029 HUS, Helsinki, Finland
    J Autoimmun 39:49-56. 2012
    ....
  9. pmc The effect of geometry and abduction angle on the stresses in cemented UHMWPE acetabular cups--finite element simulations and experimental tests
    Rami K Korhonen
    Department of Applied Physics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biomed Eng Online 4:32. 2005
    ..The aim of the present study was to test the hypotheses that the cup geometry, abduction angle, thickness and clearance can modify the stresses in cemented polyethylene cups...
  10. pmc Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion
    Guo Feng Ma
    Department of Medicine Invärtes Medicin, Helsinki University Central Hospital, PO Box 700, Helsinki, Finland
    BMC Microbiol 9:55. 2009
    ..The aim of the study was to investigate expression of ADAMs (A Disintegrin and A Metalloproteinase) of host cell origin during cell-cell fusion induced by human parainfluenza virus type 2 (HPIV2)...
  11. pmc Chronic arthritis leads to disturbances in the bone collagen network
    Joana Caetano-Lopes
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisbon, Portugal
    Arthritis Res Ther 12:R9. 2010
    ..In this study we used a mice model of chronic arthritis to evaluate if bone fragility induced by chronic inflammation is associated with an imbalance in bone turnover and also a disorganization of the bone type I collagen network...
  12. ncbi request reprint Removal of hyaline articular cartilage reduces lymphocyte infiltration and activation in rheumatoid synovial membrane
    Y T Konttinen
    Department of Anatomy, Institute of Biomedicine, University of Helsinki, Finland
    J Rheumatol 28:2184-9. 2001
    ..To analyze the effect of removal of hyaline articular cartilage on synovial membrane pathology in chronic arthritis...
  13. ncbi request reprint Current management: Management of rheumatic diseases in the era of biological anti-rheumatic drugs
    Yrjo T Konttinen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Acta Orthop 76:614-9. 2005
  14. ncbi request reprint Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjögren's syndrome
    Yrjo T Konttinen
    Department of Medicine Invärtes Medicin, Helsinki University Central Hospital, Helsinki, Finland
    J Rheumatol 32:1071-5. 2005
    ..To localize aquaporin-5 in healthy salivary gland acinar cells and to check if it is abnormally translocated in an experimental NOD mouse model for Sjögren's syndrome (SS)...
  15. ncbi request reprint Interleukin-6 in aseptic loosening of total hip replacement prostheses
    Y T Konttinen
    Department of Medicine Invärtes Medicin, Helsinki University Hospital, Finland
    Clin Exp Rheumatol 20:485-90. 2002
    ....
  16. ncbi request reprint Sjögren's syndrome: viewpoint on pathogenesis. One of the reasons I was never asked to write a textbook chapter on it
    Yrjo T Konttinen
    Department of Medicine Invärtes Medicin, Helsinki University Central Hospital and ORTON Research Institute and the Orthopaedic Hospital of the Invalid Foundation, Finland
    Scand J Rheumatol Suppl 116:15-22. 2002
    ..To critically consider the public opinion/consensus on SS formulated by opinion leaders and textbook chapters...
  17. ncbi request reprint Hyaluronan synthases, hyaluronan, and its CD44 receptor in tissue around loosened total hip prostheses
    Y T Konttinen
    Department of Anatomy, Institute of Biomedicine, FIN 00014 University of Helsinki, Helsinki, Finland
    J Pathol 194:384-90. 2001
    ..HA may be responsible for the induction of a synovial-like lining at the interface through HA-CD44 signalling...
  18. ncbi request reprint Chondrocyte-mediated collagenolysis correlates with cartilage destruction grades in osteoarthritis
    Y T Konttinen
    Department of Medicine, Helsinki University Central Hospital, Finland
    Clin Exp Rheumatol 23:19-26. 2005
    ..In addition, we assessed whether these fragments could be measured in joint fluid and serve as diagnostic markers...
  19. ncbi request reprint Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis
    Yrjo T Konttinen
    Helsinki University Hospital and ORTON Research Institute, The Orthopaedic Hospital of The Invalid Foundation, Helsinki, Finland
    Arthritis Rheum 46:953-60. 2002
    ..To measure cartilage pH in patients with osteoarthritis (OA) and to analyze the presence of cathepsin K, the recently discovered acidic endoproteinase, in phenotypically altered chondrocytes...
  20. ncbi request reprint Disease-associated increased HIF-1, alphavbeta3 integrin, and Flt-1 do not suffice to compensate the damage-inducing loss of blood vessels in inflammatory myopathies
    Yrjo T Konttinen
    Department of Medicine Invärtes Medicin, Biomedicum, P O Box 700, 00029 Helsinki University Central Hospital, Helsinki, Finland
    Rheumatol Int 24:333-9. 2004
    ....
  21. ncbi request reprint Vascular damage and lack of angiogenesis in systemic sclerosis skin
    Y T Konttinen
    Department of Medicine, Orton Research Institute and the Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland
    Clin Rheumatol 22:196-202. 2003
    ....
  22. ncbi request reprint [Clinical picture and treatment of osteoarthritis]
    Yrjo T Konttinen
    Tieteellinen tutkimus ORTON ja Invalidisäätiön ortopedinen sairaala Biomedicum Helsinki, Invärtes medicin PL 700, 00029 HUS
    Duodecim 119:1537-44. 2003
  23. ncbi request reprint Otitis externa sicca/fibrotising external otitis (FEO) as a complication of Sjögren's syndrome
    Y T Konttinen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Clin Exp Rheumatol 18:746-8. 2000
    ..Secondly, local moisturing and/or topical corticosteroid treatment in SS patients with sicca symptoms in the auditory canal could help to avoid reconstructive surgical treatment...
  24. ncbi request reprint Immunohistochemical evaluation of inflammatory mediators in failing implants
    Yrjo T Konttinen
    Department of Medicine lnvartes Medicin, Helsinki University Central Hospital, Finland
    Int J Periodontics Restorative Dent 26:135-41. 2006
    ..These cytokines may contribute to peri-implant bone loss/loosening by stimulating formation and activity of osteoclasts and might be an amenable target for local therapies with cytokine modulators...
  25. ncbi request reprint Plasmacytoid dendritic cells, Janus-faced sentinels: progesterone, guilty or innocent?
    Yrjo T Konttinen
    Department of Medicine, Biomedicum 1, FIN 00029 HUS, Finland
    Immunotherapy 1:929-31. 2009
    ..TLR7-related pathways offer many potential targets for the treatment of viral and autoimmune diseases...
  26. doi request reprint Salivary glands - "an unisex organ'?
    Y T Konttinen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Oral Dis 16:577-85. 2010
    ..Female dominance of Sjögren's syndrome and certain forms of salivary gland cancer probably reflect these gender-based differences...
  27. pmc Fibroblast biology. Signals targeting the synovial fibroblast in arthritis
    Y T Konttinen
    Department of Anatomy, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Arthritis Res 2:348-55. 2000
    ..Aggressive, transformed or transfected mesenchymal cells containing proto-oncogenes can act in the absence of lymphocytes, but whether these cells represent regressed fibroblasts, chondrocytes or bone marrow stem cells is unclear...
  28. doi request reprint Regenerative medicine--initiative à la carte. A remedy to the blood thirsty count Dracula?
    Yrjo T Konttinen
    Dept Medicine, Institute of Clinical Medicine, Helsinki University Central Hospital, Biomedicum Helsinki, P O B 700, FIN 00029 HUS, Finland
    J Cell Mol Med 12:1192-3. 2008
  29. ncbi request reprint Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate
    Y T Konttinen
    Department of Medicine, Helsinki University Central Hospital, Finland
    Matrix Biol 18:401-12. 1999
    ..Alendronate, at concentrations attainable in vivo, is able to inhibit collagenase-3. This might offer an option to control collagenase-3-mediated tissue destruction in rheumatoid arthritis...
  30. ncbi request reprint Immunohistopathology of Sjögren's syndrome
    Yrjo T Konttinen
    Department of Medicine, FIN 00029 HUS, Finland
    Autoimmun Rev 6:16-20. 2006
    ..Patients with SS seem to have low concentrations of dehydroepiandrosterone, which may predispose women and the exocrine glands to this syndrome...
  31. ncbi request reprint Roadmap to vasculitis
    Yrjo T Konttinen
    Department of Medicine Invärtes Medicin, Hesinki University Central Hospital, Helsinki, Finland
    Acta Reumatol Port 31:15-36. 2006
    ..After this, patients should be urgently referred to a specialized centre, where the required histological and radiological tests are performed for diagnosis and immunosuppressive and other necessary treatment is initiated...
  32. ncbi request reprint Innervation of the joint and role of neuropeptides
    Yrjo T Konttinen
    Department of Medicine, Helsinki University Central Hospital, Finland
    Ann N Y Acad Sci 1069:149-54. 2006
    ..More attention needs to be paid to aging of proprioception, not only to the terminal disease target...
  33. ncbi request reprint Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate
    O Teronen
    Department of Oral and Maxillofacial Surgery, University of Helsinki, Finland
    J Dent Res 76:1529-37. 1997
    ....
  34. ncbi request reprint Expression of vascular endothelial growth factor receptors coincide with blood vessel in-growth and reactive bone remodelling in experimental intervertebral disc degeneration
    J Salo
    Department of Orthopaedic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Clin Exp Rheumatol 26:1018-26. 2008
    ..To analyze immunohistochemically the localization of the VEGF receptors in experimental intervertebral disc degeneration tissues in a pig model...
  35. ncbi request reprint Tyrosine hydroxylase-immunoreactive nerve fibres in rat posterior longitudinal ligament
    S Imai
    Department of Anatomy, University of Helsinki, Finland
    J Auton Nerv Syst 63:51-60. 1997
    ..This may represent a neuroanatomical equivalent reflecting modulatory functions, which could participate in the pathogenesis of low back pain...
  36. ncbi request reprint Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis
    D Nordstrom
    Department of Rheumatology, Helsinki University Central Hospital, Finland
    Rheumatol Int 17:175-80. 1998
    ....
  37. ncbi request reprint Acid attack and cathepsin K in bone resorption around total hip replacement prosthesis
    Y T Konttinen
    Institute of Biomedicine, Department of Anatomy, University of Helsinki, Finland
    J Bone Miner Res 16:1780-6. 2001
    ....
  38. ncbi request reprint Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis
    T Tervahartiala
    Department of Anatomy, University of Helsinki, Finland
    J Clin Periodontol 23:68-75. 1996
    ..Cathepsin G may contribute to periodontal tissue destruction directly and indirectly, via proteolytic activation of latent neutrophil procollagenase (promatrix metalloproteinase-8 [proMMP-8])...
  39. ncbi request reprint Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement
    J Mandelin
    Institute of Biomedicine Anatomy, Biomedicum Helsinki, University of Helsinki, Finland
    J Bone Joint Surg Br 85:1196-201. 2003
    ..Endothelial cell OPG mRNA levels were regulated by TNF-alpha and VEGF, but not by hypoxia. It is concluded that activated cells in the interface tissue overproduce both RANKL and RANK and they can interact without interference by OPG...
  40. ncbi request reprint Gingival tissue and crevicular fluid co-operation in adult periodontitis
    A Beklen
    Department of Medicine Invärtes Medicin, Helsinki University Hospital, Biomedicum Helsinki, FIN 00029 HUS, Helsinki, Finland
    J Dent Res 85:59-63. 2006
    ..Active MMP-3 then activates neutrophil-derived pro-MMP-8 and -9. Different tissue compartments/cells exert co-operative actions in mutual local MMP activation cascades...
  41. ncbi request reprint Dendritic cells in rheumatoid synovial membrane after total removal of the hyaline articular cartilage
    T F Li
    Department of Orthopaedics and Traumatology, Helsinki University Hospital, Finland
    Rheumatology (Oxford) 41:319-23. 2002
    ..To investigate the effect of total removal of the hyaline articular cartilage on dendritic cells in synovial membrane in rheumatoid arthritis (RA) or ankylosing spondylitis (AS)...
  42. ncbi request reprint Increased interleukin-8 (IL-8) expression is related to aseptic loosening of total hip replacement
    J Lassus
    Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland
    Arch Orthop Trauma Surg 120:328-32. 2000
    ..The results reveal a high rise in IL-8 concentration in SLIM and in synovial tissues. This finding moves us one step forward in solving the complex network of multiple factors affecting loosening of hip implants...
  43. ncbi request reprint Studies of host response to orthopedic implants and biomaterials
    S Santavirta
    Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland
    J Long Term Eff Med Implants 9:67-76. 1999
    ..Because many promising materials and designs have failed in clinical use, extensive theoretical and experimental testing is mandatory before introducing new materials and implants in a clinical setting...
  44. ncbi request reprint Dual effects of caspase-1, interleukin-1 beta, tumour necrosis factor-alpha and nerve growth factor receptor in inflammatory myopathies
    Z Mackiewicz
    Institute of Biomedicine Anatomy, Biomedicum Helsinki, University of Helsinki, Finland
    Clin Exp Rheumatol 21:41-8. 2003
    ....
  45. ncbi request reprint Tumor necrosis factor-alpha and its receptors, p55 and p75, in gingiva of adult periodontitis
    T Tervahartiala
    Department of Medicine Invärtes Medicin, Helsinki University Central Hospital, University of Helsinki, Finland
    J Dent Res 80:1535-9. 2001
    ..664+/-191, p > 0.001). Thus, AP gingival tissue has an elevated expression of TNF-alpha and especially its p55 receptor, suggesting that TNF-alpha may contribute to tissue degradation in periodontitis...
  46. ncbi request reprint Expression of ADAM9 (meltrin-gamma) around aseptically loosened total hip replacement implants
    G F Ma
    Department of Medicine Invärtes Medicin, P O Box 700, FIN 00029 Helsinki University Central Hospital, Finland
    Rheumatology (Oxford) 45:808-14. 2006
    ..To investigate the involvement of a disintegrin and the metalloproteinase ADAM9 (meltrin-gamma) in the formation of multinuclear giant cells and osteoclasts in aseptic loosening of hip replacement implants...
  47. ncbi request reprint Distribution of adhesion receptors in recurrent oral ulcers
    R Hayrinen-Immonen
    Department of Oral and Maxillofacial Surgery, University of Helsinki, Finland
    J Oral Pathol Med 21:199-202. 1992
    ..1%, 70 +/- 16% and 80 +/- 1%, respectively, of all mononuclear cells. The findings indicate that LFA-1/ICAM-1 and CD2/LFA-3 interactions may play roles in cell to cell adhesion events in ROU...
  48. ncbi request reprint Insulin-like growth factors I and II in the aseptic loosening of total hip implants
    V Waris
    Molecular Biology Laboratory, Musculoskeletal Diseases and Inflammation Research Group TULES RYHMA, Institute of Biomedicine, Department of Anatomy, University of Helsinki, Helsinki, Finland
    Scand J Rheumatol 33:428-31. 2004
    ..In pseudocapsular tissue we found fewer IGF-I positive cells and an equal amount of IGF-II positive cells compared to control tissues. Decreased bone formation may contribute to net loss of bone around aseptically loosened hip implants...
  49. ncbi request reprint MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis
    A Beklen
    Department of Medicine Invärtes Medicin, Helsinki University Central Hospital, Helsinki, Finland
    J Dent Res 86:347-51. 2007
    ..Gingival fibroblasts may play an important role in tissue destruction in periodontitis via cytokine-inducible MMP-1 and MMP-3 production, in which IL-17 plays a role as a key regulatory cytokine...
  50. ncbi request reprint Expression of parathyroid hormone related protein in the tissue around loosened hip prostheses
    T F Li
    Department of Orthopaedics, Helsinki University Hospital, Finland
    Clin Exp Rheumatol 19:689-95. 2001
    ..Locally accumulated PTHrP may contribute to periprosthetic osteolysis and aseptic loosening of THR through its direct effects on bone, or indirectly via the induction of inflammatory mediators...
  51. ncbi request reprint Imbalanced expression of RANKL and osteoprotegerin mRNA in pannus tissue of rheumatoid arthritis
    M Ainola
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Clin Exp Rheumatol 26:240-6. 2008
    ..To test if the pannus tissue is characterized by a high receptor activator of nuclear factor kappaB ligand to osteoprotegerin (RANKL:OPG) ratio, which could explain local osteoclastogenesis and formation of bony erosions...
  52. pmc Expression of epidermal growth factor and transforming growth factor alpha in interfacial membranes retrieved at revision total hip arthroplasty
    J W Xu
    Institute of Biomedicine, Department of Anatomy, University of Helsinki, Finland
    Ann Rheum Dis 59:822-7. 2000
    ..Both epidermal growth factor (EGF) and transforming growth factor alpha (TGFalpha) have similar biological functions. They have been found to stimulate bone resorption...
  53. ncbi request reprint Expression of caspase-1 in synovial membrane-like interface tissue around loosened hip prostheses
    T F Li
    ORTON Research Institute, The Orthopaedic Hospital of The Invalid Foundation, Helsinki, Finland
    Rheumatol Int 22:97-102. 2002
    ..Caspase-1 can be involved in implant loosening by processing IL-1beta precursor into its mature form, which is a potent osteoclast-activating factor and a major proinflammatory mediator...
  54. ncbi request reprint Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjögren's syndrome
    Y T Konttinen
    Department of Anatomy, University of Helsinki, Finland
    Matrix Biol 17:335-47. 1998
    ..Due to the role of basal lamina as an important molecular sieve and extracellular matrix-cell signal, these pathological changes may contribute to the pathogenesis of the syndrome...
  55. ncbi request reprint Distribution of tenascin-X in different synovial samples and synovial membrane-like interface tissue from aseptic loosening of total hip replacement
    T F Li
    Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland
    Rheumatol Int 19:177-83. 2000
    ..Our results suggest that Tn-X is an essential component of normal synovial membrane, and that inflammatory mediators may increase local Tn-X production. Tn-X distribution is not always reciprocal to that of Tn-C...
  56. ncbi request reprint Mast cells in bronchiectasis
    R Sepper
    Institute of Biomedicine, Department of Anatomy, University of Helsinki
    Ann Med 30:307-15. 1998
    ....
  57. doi request reprint Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction
    M Ainola
    Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    Ann Rheum Dis 68:427-34. 2009
    ..The eventual role of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis was studied in erosive rheumatoid arthritis (RA) and in vitro...
  58. ncbi request reprint Receptor activator of nuclear factor kappa B ligand in an experimental intervertebral disc degeneration
    Z Mackiewicz
    COXA Hospital for Joint Replacement, Tampere, Finland
    Clin Exp Rheumatol 27:299-306. 2009
    ..It was speculated that these changes in vertebral bone remodelling could be reflected in an increased RANKL expression...
  59. ncbi request reprint Protein kinase C expression in salivary gland acinar epithelial cells in non-obese diabetic mice, an experimental model for Sjögren's syndrome
    E K Tensing
    Department of Anatomy, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Rheumatol Int 25:28-32. 2005
    ..The lack of PKC alpha and beta isoforms found in Sjögren's syndrome was not reproduced in NOD mice, which discloses one more difference between the human disease and its NOD mouse model...
  60. ncbi request reprint Pannus invasion and cartilage degradation in rheumatoid arthritis: involvement of MMP-3 and interleukin-1beta
    M M Ainola
    Institute of Biomedicine, Department of Anatomy, University of Helsinki, Helsinki, Finland
    Clin Exp Rheumatol 23:644-50. 2005
    ..Our intention was to analyze some of the key matrix metalloproteinases (MMPs) in pannus tissue overlying evolving cartilage erosions in RA...
  61. ncbi request reprint MMP inhibition and downregulation by bisphosphonates
    O Teronen
    Department of Oral and Maxillofacial Surgery, University of Helsinki, Finland
    Ann N Y Acad Sci 878:453-65. 1999
    ....
  62. ncbi request reprint Increased expression of EMMPRIN in the tissue around loosened hip prostheses
    T F Li
    Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland
    Acta Orthop Scand 70:446-51. 1999
    ..These biological responses, combined with mechanical stress caused by micromotion and oscillating fluid pressure, may eventually cause aseptic loosening of THR...
  63. ncbi request reprint Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis
    T Ingman
    Department of Periodontology, University of Helsinki, Finland
    Oral Microbiol Immunol 8:298-305. 1993
    ..abstract truncated at 250 words)..
  64. ncbi request reprint Biodegradable polydioxanone and poly(l/d)lactide implants: an experimental study on peri-implant tissue response
    R Kontio
    Department of Oral and Maxillofacial Surgery, Helsinki University Hospital, P O Box 263, HUCH, Helsinki 00029, Finland
    Int J Oral Maxillofac Surg 34:766-76. 2005
    ..Thus, the new polylactide copolymer implant may support the orbital contents long enough to give way to bone growth over the wall defect...
  65. doi request reprint Bovine chronic osteoarthritis causes minimal change in synovial fluid
    T Heinola
    Faculty of Veterinary Medicine, Department of Veterinary Biosciences, University of Helsinki, Agnes Sjöbergin katu 2, FIN 00014 Helsinki, Finland
    J Comp Pathol 148:335-44. 2013
    ..The only exception was ICTP concentration, which reflects enhanced destruction/remodelling...
  66. ncbi request reprint Symptomatic lumbar spondylolysis. Neuroimmunologic studies
    D Nordstrom
    Fourth Department of Medicine, Helsinki University Central Hospital, Finland
    Spine (Phila Pa 1976) 19:2752-8. 1994
    ..This study characterized the defect using neuroimmunologic and inflammatory cell analysis...
  67. ncbi request reprint Silver impregnation and immunohistochemical study of nerves in lumbar facet joint plical tissue
    M Gronblad
    Department of Physical Medicine and Rehabilitation, University of Helsinki, Central Hospital, Finland
    Spine (Phila Pa 1976) 16:34-8. 1991
    ....
  68. doi request reprint Toll-like receptors 2 and 5 in human gingival epithelial cells co-operate with T-cell cytokine interleukin-17
    A Beklen
    Department of Medicine Invärtes Medicin, Helsinki University Central Hospital, Helsinki, Finland
    Oral Microbiol Immunol 24:38-42. 2009
    ....
  69. doi request reprint Abnormal basement membrane type IV collagen alpha-chain composition in labial salivary glands in Sjögren's syndrome
    P Poduval
    University of Helsinki, Helsinki, Finland
    Arthritis Rheum 60:938-45. 2009
    ..The aim of this study was to investigate whether type IV collagen alpha-chain composition of acinar cell compartments could be abnormal in diseased glands...
  70. ncbi request reprint Musculoskeletal pain and functional ability in haemophilia A and B. Physiotherapy and rehabilitation in haemophilia patients
    N Santavirta
    Department of Education, University of Helsinki, Finland
    Rheumatol Int 21:15-9. 2001
    ..One of the important contributions of physiotherapy and rehabilitation is their educational role...
  71. ncbi request reprint Expression of stem cell factor (SCF) and SCF receptor (c-kit) in synovial membrane in arthritis: correlation with synovial mast cell hyperplasia and inflammation
    A Ceponis
    ORTON Research Institute, Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland
    J Rheumatol 25:2304-14. 1998
    ..We investigated expression of SCF and c-kit in synovial membrane with particular reference to the mechanism of local MC hyperplasia and inflammation in arthritis...
  72. ncbi request reprint Effects of low-dose, noncytotoxic, intraarticular liposomal clodronate on development of erosions and proteoglycan loss in established antigen-induced arthritis in rabbits
    A Ceponis
    University of Helsinki, Finland
    Arthritis Rheum 44:1908-16. 2001
    ..Over the long-term, the loss of cartilage proteoglycans was halted. This observed treatment effect may be related to the inhibition of TNFalpha production and processing in the synovium...
  73. ncbi request reprint No lymphokines in T-cells around loosened hip prostheses
    T F Li
    Department of Orthopaedics, Helsinki University Hospital, ORTON Research Institute, Invalid Foundation, Finland
    Acta Orthop Scand 72:241-7. 2001
    ..Our results suggest that T-cell-mediated immune response is not actively involved in aseptic loosening of THR...
  74. ncbi request reprint Effect of oral clodronate on structural damage and bone turnover in rheumatoid arthritis
    H Valleala
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Clin Exp Rheumatol 30:114-7. 2012
    ..To study the effect of oral clodronate on structural damage and bone metabolism in rheumatoid arthritis (RA)...
  75. ncbi request reprint Acinar epithelial cell laminin-receptors in labial salivary glands in Sjögren's syndrome
    M Laine
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Clin Exp Rheumatol 26:807-13. 2008
    ..To analyze the epithelial cell-basement membrane attachment, in particular in the secretory end pieces (responsible for secretion of saliva) and in Sjögren's syndrome (SS) characterized by acinar cell failure...
  76. ncbi request reprint Regulation of MMP-9 (gelatinase B) in activated human monocyte/macrophages by two different types of bisphosphonates
    H Valleala
    Department of Medicine, Helsinki University Central Hospital, Kasarmikatu 11 13 FIN 00130, Helsinki, Finland
    Life Sci 73:2413-20. 2003
    ..These findings may have implications for the therapeutic use of these compounds...
  77. ncbi request reprint High mobility group box-1 (HMGB-1) in osteoarthritic cartilage
    T Heinola
    Department of Medicine Invärtes Medicin, Helsinki University Central Hospital, Helsinki, Finland
    Clin Exp Rheumatol 28:511-8. 2010
    ..It was hypothesised that it plays a role in osteoarthritis (OA). characterised by cellular activation, inflammation and enchondral bone formation...
  78. doi request reprint Immunohistochemical localization of Toll-like receptors 1-10 in periodontitis
    A Beklen
    Department of Medicine Invärtes Medicin, Institute of Clinical Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Oral Microbiol Immunol 23:425-31. 2008
    ..In this study, the expression and distribution of TLRs (TLR-1 to TLR-10) were immunohistochemically detected in gingival epithelium and connective tissue...
  79. ncbi request reprint Role of TNF-alpha and its receptors in pericoronitis
    A Beklen
    Department of Medicine Invärtes Medicin, Helsinki University Hospital, Helsinki, Finland
    J Dent Res 84:1178-82. 2005
    ..These findings suggest that, in pericoronitis, inflammatory and resident cells produce and respond to potent pro-inflammatory cytokine TNF-alpha, with pathogenic and potential therapeutic relevance...
  80. ncbi request reprint Subchondral bone reaction associated with chondral defect and attempted cartilage repair in goats
    A I Vasara
    Department of Orthopaedics and Traumatology, Helsinki University Hospital, Helsinki, Finland
    Calcif Tissue Int 74:107-14. 2004
    ..The goat model used here proved not to be an optimal model for ACT. The changes in subchondral bone may alter the biomechanical properties of the subchondral plate and thus the long-term survival of the repair tissue after ACT...
  81. ncbi request reprint Immunohistochemical demonstration of subclasses of inflammatory cells and active, collagen-producing fibroblasts in the synovial plicae of lumbar facet joints
    Y T Konttinen
    Fourth Department of Medicine, University of Helsinki, Central Hospital, Finland
    Spine (Phila Pa 1976) 15:387-90. 1990
    ....
  82. ncbi request reprint Expression of c-erbB-2 protein in keratinocytes of oral mucosal lichen planus and subsequent squamous cell carcinoma
    A Kilpi
    School of Dental Science, University of Melbourne, Australia
    Eur J Oral Sci 104:278-84. 1996
    ..The results indicated the probability of the absence of c-erbB-2 staining being an indication of a potential for neoplastic transformation in OMLP with dysplastic changes...
  83. ncbi request reprint Activation of type IV procollagenases by human tumor-associated trypsin-2
    T Sorsa
    Departments of Medical Chemistry and Periodontology, University of Helsinki, FIN 00014 Helsinki, Finland
    J Biol Chem 272:21067-74. 1997
    ..The ability of human tumor cell-derived trypsin-2 to activate latent MMPs suggests a role for trypsin-2 in initiating the proteinase cascade that mediates tumor invasion and metastasis formation...
  84. ncbi request reprint An ultrastructural study of calcitonin gene-related peptide-immunoreactive nerve fibers innervating the rat posterior longitudinal ligament. A morphologic basis for their possible efferent actions
    S Imai
    Department of Anatomy, University of Helsinki, Finland
    Spine (Phila Pa 1976) 22:1941-7. 1997
    ....
  85. ncbi request reprint Type IV collagen alpha-chain composition in synovial lining from trauma patients and patients with rheumatoid arthritis
    P Poduval
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Arthritis Rheum 56:3959-67. 2007
    ..We undertook this study to determine the alpha-chain composition of type IV collagen in normal and arthritic synovial lining, using monoclonal alpha-chain antibodies...
  86. ncbi request reprint Effect of nitric oxide donor nitroglycerin on bone mineral density in a rat model of estrogen deficiency-induced osteopenia
    M Hukkanen
    Institute of Biomedicine Anatomy, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Bone 32:142-9. 2003
    ..Organic nitrates may thus be beneficial in conditions where bone turnover is compromised such as in osteoporosis...
  87. ncbi request reprint Collagenases (MMP-1, -8 and -13) and trypsinogen-2 in fluid from benign and malignant ovarian cysts
    M Stenman
    Department of Internal Medicine, ORTON Research Institute, Helsinki, Finland
    Tumour Biol 24:9-12. 2003
    ..The strong expression of MMP-8 over MMP-1 and MMP-13 in malignant ovarian tumors may indicate that MMP-8 participates in the protease cascades associated with the invasiveness of ovarian tumors...
  88. ncbi request reprint Tumor necrosis factor-alpha and receptors for it in labial salivary glands in Sjögren's syndrome
    H Koski
    Institute of Biomedicine, Department of Anatomy, University of Helsinki, Finland
    Clin Exp Rheumatol 19:131-7. 2001
    ..Although TNF-alpha is one possible mediator in these processes, nothing is known about the spatial distribution of TNF-alpha in relation to its receptors/target cells in salivary gland tissue...
  89. doi request reprint Blood vessels of human islets of Langerhans are surrounded by a double basement membrane
    I Virtanen
    Institute of Biomedicine Anatomy, University of Helsinki, 00014, Helsinki, Finland
    Diabetologia 51:1181-91. 2008
    ..Based on mouse study findings, pancreatic islet cells are supposed to lack basement membrane (BM) and interact directly with vascular endothelial BM. Until now, the BM composition of human islets has remained elusive...
  90. ncbi request reprint Bioabsorbable fixation devices in trauma and bone surgery: current clinical standing
    Eero Waris
    Peijas Hospital, Helsinki University Central Hospital, Finland and Biomedicum Helsinki, Institute of Biomedicine Anatomy, PO Box 63, FIN 00014 University of Helsinki, Finland
    Expert Rev Med Devices 1:229-40. 2004
    ..The risk of implant-associated stress shielding, peri-implant osteoporosis and infections is reduced. Implants do not interfere with clinical imaging. Current clinical use of bioabsorbable devices is reviewed...
  91. ncbi request reprint Modulation of visceral nociceptive responses of rat spinal dorsal horn neurons by sympathectomy
    J Kalmari
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    Neuroreport 12:797-801. 2001
    ....
  92. ncbi request reprint Characterization of human primary osteoblast response on bioactive glass (BaG 13-93)- coated poly-L,DL-lactide (SR-PLA70) surface in vitro
    P Ruuttila
    Institute of Biomedicine Anatomy, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Biomed Mater Res B Appl Biomater 78:97-104. 2006
    ..Therefore, the SR-PLA70 + BaG composites appear as promising osteoconductive scaffold candidates for reconstruction and regeneration of bone matrix...
  93. ncbi request reprint Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis
    R Sepper
    Department of Anatomy, University of Helsinki, Finland
    J Clin Immunol 15:27-34. 1995
    ..The results indicate that insufficient endogenous downregulation of catalytically active elastase and cathepsin G in BALF leads to tissue injury, resulting in alterative and deformative processes in the bronchiectasis lung...
  94. ncbi request reprint Expression of interleukin-8 and its receptor IL-8RA in chronic hyperplastic candidosis
    A Ali
    Department of Anatomy Biomedicum, University of Helsinki, Helsinki, Finland
    Oral Microbiol Immunol 21:223-30. 2006
    ..They migrate from the circulation to the epithelium where they form microabscesses. We therefore hypothesized that the neutrophil chemokine interleukin-8 (IL-8) might play a role in the neutrophil-Candida interaction...
  95. ncbi request reprint Neuropeptides in experimental and degenerative arthritis
    S Niissalo
    Biomedicum Helsinki, Institute of Biomedicine Anatomy, University of Helsinki, Finland
    Ann N Y Acad Sci 966:384-99. 2002
    ....
  96. ncbi request reprint Immune responses to osteoarticular allografts of the knee--cytokine studies
    D C Nordstrom
    Department of Medicine, Helsinki University Central Hospital, Finland
    Arch Orthop Trauma Surg 119:195-8. 1999
    ..The elevated IL-1beta and TNF-alpha levels detected support this statement...
  97. ncbi request reprint Coping strategies, pain, and disability in patients with hemophilia and related disorders
    N Santavirta
    Department of Education, Helsinki University, Helsinki University Central Hospital, Finland
    Arthritis Rheum 45:48-55. 2001
    ..We confirmed the role of age and the use of the CAT strategy as, respectively, moderator and mediator in the pattern of relationships between the clinical state of the disease and psychosocial well-being...
  98. ncbi request reprint The influence of chemical sympathectomy on pain responsivity and alpha 2-adrenergic antinociception in neuropathic animals
    H Wei
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Neuroscience 114:655-68. 2002
    ....