Research Topics
Genomes and Genes
| Katri KoliSummaryAffiliation: University of Helsinki Country: Finland Publications
| Collaborators
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Detail Information
Publications
Latency, activation, and binding proteins of TGF-betaK Koli
Department of Virology, Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland
Microsc Res Tech 52:354-62. 2001..Biological events, where enhanced or focal proteolysis and activation of latent TGF-beta takes place, include cell invasion, tissue remodeling, and wound healing...- Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta depositionK Koli
Department of Virology, Haartman Institute and Biomedicum Helsinki, University of Helsinki and Helsinki University Hospital, Finland
J Cell Sci 114:2869-78. 2001..Since LTBPs are a part of the extracellular matrix microfibrils, the LTBP-4delta8-Cys3rd protein may also be involved in various structural functions not related to TGF-beta signaling... 
Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lungKatri Koli
Department of Virology, Haartman Institute and Helsinki University Hospital, University of Helsinki, 00014 Helsinki, Finland
J Cell Biol 167:123-33. 2004..Treatment with active TGF-beta1 rescued BMP-4 and gremlin expression to wild-type levels. Our results indicate that the lack of LTBP-4-mediated targeting and activation of TGF-beta1 leads to enhanced BMP-4 signaling in mouse lung...
Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cellsKatri Koli
Departments of Virology and Pathology, Haartman Institute and Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Bone 43:679-88. 2008..Our results provide evidence that LTBP isoforms can differentially regulate TGF-beta activation and ECM accumulation during osteogenic differentiation...- Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblastsKatri Koli
Department of Virology, Haartman Institute and Helsinki University Hospital, University of Helsinki, Biomedicum A506, P O Box 63, Haartmaninkatu 8, 00014 Helsinki, Finland
Exp Cell Res 310:370-82. 2005..Our results suggest that ECM is an important site of deposition also for LTBP-3 and -4 and that the temporal and spatial targeting of the TGF-beta complexes are associated with ECM maturation... - Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosisKatri Koli
Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Am J Pathol 169:61-71. 2006..The overexpression of this developmental gene in IPF may be a key event in the persistence of myofibroblasts in the lung interstitium and provides a potential target for therapeutic intervention... - Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosisMarjukka Myllärniemi
University of Helsinki, Biomedicum A506, P O Box 63, Haartmaninkatu 8, 00014 Helsinki, Finland
Am J Respir Crit Care Med 177:321-9. 2008..We have observed that the BMP antagonist, gremlin, is highly up-regulated in idiopathic pulmonary fibrosis (IPF)... - Regulation of TGF-β storage and activation in the human idiopathic pulmonary fibrosis lungOuti Leppäranta
Department of Medicine, Division of Pulmonary Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Cell Tissue Res 348:491-503. 2012.... - Transcription factor GATA-6 is expressed in quiescent myofibroblasts in idiopathic pulmonary fibrosisOuti Leppäranta
Department of Medicine, Pulmonary Division, FI 00014 University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Am J Respir Cell Mol Biol 42:626-32. 2010..In conclusion, the hallmark of IPF/UIP histopathology, the fibroblast focus, consists of differentiated, quiescent cells that prominently express GATA-6... - Latent TGF-β binding proteins (LTBPs) 1 and 3 differentially regulate transforming growth factor-β activity in malignant mesotheliomaPiia Vehviläinen
Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, 00014 Helsinki, Finland
Hum Pathol 42:269-78. 2011..Current results suggest that LTBPs 1 and 3 may have specific roles in malignant mesothelioma pathogenesis through the regulation of TGF-β activation in the tumor tissue and the structure of the tumor stroma... - Reduced phosphorylation of the TGF-Beta signal transducer Smad2 in emphysematous human lungOuti Leppäranta
Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
COPD 6:234-41. 2009..Our results indicate that TGF-beta signaling activity is differentially regulated in distinct areas of COPD lung and likely contributes to both emphysematous development and small airway obstruction... - Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosisPäivi M Järvinen
Molecular Cancer Biology Program and Haartman Institute, University of Helsinki, Helsinki, Finland
J Cell Physiol 227:2605-12. 2012..The results show that CRP1 is a novel TGF-β1 regulated protein that is expressed in fibrotic lesions and may be relevant in the IPF disease... - Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen speciesKatri Koli
Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Antioxid Redox Signal 10:333-42. 2008..More recently, the oxidative effects of cigarette smoking have been found to activate TGF-beta in chronic obstructive pulmonary disease (COPD), a disease consisting of emphysema, airway fibrosis, and focal lung fibrosis... - Independent regulation of short and long forms of latent TGF-beta binding protein (LTBP)-4 in cultured fibroblasts and human tissuesAnna K Kantola
Department of Virology, Haartman Institute and Helsinki University Hospital, University of Helsinki, Helsinki, Finland
J Cell Physiol 223:727-36. 2010.... - Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signalingJenni A Tamminen
Molecular and Cancer Biology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland
J Cell Biochem 113:2234-47. 2012..Our results suggest that asbestos can induce epithelial plasticity, which can be interfered by blocking the MAPK/Erk kinase activity... - Fibronectin and heparin binding domains of latent TGF-beta binding protein (LTBP)-4 mediate matrix targeting and cell adhesionAnna K Kantola
Departments of Virology and Pathology, Haartman Institute, Univertsity of Helsinki and Helsinki University Hospital, Haartmaninkatu 8, 00014 Helsinki, Finland
Exp Cell Res 314:2488-500. 2008..These results revealed new molecular interactions which are evidently important for the ECM targeting, but which also are evidence of novel functions for LTBP-4 as an adhesion molecule... - TGF-beta activation by traction?Jorma Keski-Oja
Departments of Virology and Pathology, The Haartman Institute, University of Helsinki and Helsinki University Hospital, FIN 00014 Helsinki, Finland
Trends Cell Biol 14:657-9. 2004..Latent-TGF-beta-binding protein 1 has been identified as being the major component of this process, and the integrin-interacting region has been mapped to a poorly conserved sequence stretch called the hinge region... - Expression of latent TGF-beta binding protein LTBP-1 is hormonally regulated in normal and transformed human lung fibroblastsKrista Weikkolainen
Department of Virology, Haartman Institute and Biomedicum Helsinki, University of Helsinki and Helsinki University Hospital, FIN 00014 Helsinki, Finland
Growth Factors 21:51-60. 2003..The responses to these hormonal modulators may either be lost or enhanced in transformed cells, which likely contributes to malignant growth... - Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elementsAnna K Kantola
Department of Virology, Haartman Institute and Helsinki University Hospital, University of Helsinki, Biomedicum Rm A506, P O Box 63, Haartmaninkatu 8, 00014 Helsinki, Finland
Gene 363:142-50. 2005..Our results suggest an important new role for TGF-beta1 in the regulation of its binding protein, LTBP-3... - Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivoOuti Leppäranta
1 Division of Pulmonary Medicine, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland and
Am J Respir Cell Mol Biol 48:448-55. 2013..Mice treated with tilorone showed markedly decreased histological changes, compared with untreated mice. These findings indicate that tilorone has biologically significant antifibrotic properties... - A covalently dimerized recombinant human bone morphogenetic protein-15 variant identifies bone morphogenetic protein receptor type 1B as a key cell surface receptor on ovarian granulosa cellsMinna M Pulkki
Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki and HUSLAB, University Central Hospital of Helsinki, FIN 00029 Helsinki, Finland
Endocrinology 153:1509-18. 2012..The result is well in line with the demonstration of ovarian failure in a recently reported human subject with a homozygous BMPR1B loss-of-function mutant... - Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protectionRaimo Tuuminen
Transplantation Laboratory, Haartman Institute, P O Box 21 Haartmaninkatu 3, FIN 00014, University of Helsinki, Helsinki, Finland
Circulation 124:1138-50. 2011..The underlying mechanisms involve microvascular dysfunction that may culminate in primary graft failure or untreatable chronic rejection... - Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancerAnja Sterner-Kock
Laboratory for Molecular Hematology, University of Frankfurt Medical School, 60596 Frankfurt am Main, Germany
Genes Dev 16:2264-73. 2002..This phenotype supports the predicted dual role of LTBP-4 as a structural component of the extracellular matrix and as a local regulator of TGF-beta tissue deposition and signaling...