Affiliation: University of Helsinki
Li C, Rezov V, Joensuu E, Vartiainen V, Rönty M, Yin M, et al
. Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo. Sci Rep. 2018;8:10070 pubmed publisher
..By reducing two major upregulated pathways in mesothelioma and by targeting tumor cells and the microenvironment pirfenidone may present a novel anti-fibrotic and anti-cancer adjuvant therapy for mesothelioma. ..
Koli K, Saharinen J, Karkkainen M, Keski Oja J. Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta deposition. J Cell Sci. 2001;114:2869-78 pubmed
..Since LTBPs are a part of the extracellular matrix microfibrils, the LTBP-4delta8-Cys3rd protein may also be involved in various structural functions not related to TGF-beta signaling. ..
Koli K, Hyytiäinen M, Ryynänen M, Keski Oja J. Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts. Exp Cell Res. 2005;310:370-82 pubmed
..Our results suggest that ECM is an important site of deposition also for LTBP-3 and -4 and that the temporal and spatial targeting of the TGF-beta complexes are associated with ECM maturation. ..
Tamminen J, Yin M, RÃ¶nty M, Sutinen E, Pasternack A, Ritvos O, et al
. Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. Exp Cell Res. 2015;332:102-15 pubmed publisher
..Blocking activin activity offers a new therapeutic approach for inhibition of mesothelioma invasive growth. ..
Koli K, Wempe F, Sterner Kock A, Kantola A, Komor M, Hofmann W, et al
. Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung. J Cell Biol. 2004;167:123-33 pubmed
..Treatment with active TGF-beta1 rescued BMP-4 and gremlin expression to wild-type levels. Our results indicate that the lack of LTBP-4-mediated targeting and activation of TGF-beta1 leads to enhanced BMP-4 signaling in mouse lung. ..
Koli K, Myllärniemi M, Vuorinen K, Salmenkivi K, Ryynänen M, Kinnula V, et al
. Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis. Am J Pathol. 2006;169:61-71 pubmed
..The overexpression of this developmental gene in IPF may be a key event in the persistence of myofibroblasts in the lung interstitium and provides a potential target for therapeutic intervention. ..
Koli K, Ryynänen M, Keski Oja J. Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells. Bone. 2008;43:679-88 pubmed publisher
..Our results provide evidence that LTBP isoforms can differentially regulate TGF-beta activation and ECM accumulation during osteogenic differentiation. ..