Katri Koli


Affiliation: University of Helsinki
Country: Finland


  1. Li C, Rezov V, Joensuu E, Vartiainen V, Rönty M, Yin M, et al. Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo. Sci Rep. 2018;8:10070 pubmed publisher
    ..By reducing two major upregulated pathways in mesothelioma and by targeting tumor cells and the microenvironment pirfenidone may present a novel anti-fibrotic and anti-cancer adjuvant therapy for mesothelioma. ..
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    Koli K, Saharinen J, Karkkainen M, Keski Oja J. Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta deposition. J Cell Sci. 2001;114:2869-78 pubmed
    ..Since LTBPs are a part of the extracellular matrix microfibrils, the LTBP-4delta8-Cys3rd protein may also be involved in various structural functions not related to TGF-beta signaling. ..
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    Koli K, Hyytiäinen M, Ryynänen M, Keski Oja J. Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts. Exp Cell Res. 2005;310:370-82 pubmed
    ..Our results suggest that ECM is an important site of deposition also for LTBP-3 and -4 and that the temporal and spatial targeting of the TGF-beta complexes are associated with ECM maturation. ..
  4. Tamminen J, Yin M, Rönty M, Sutinen E, Pasternack A, Ritvos O, et al. Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. Exp Cell Res. 2015;332:102-15 pubmed publisher
    ..Blocking activin activity offers a new therapeutic approach for inhibition of mesothelioma invasive growth. ..
  5. Koli K, Wempe F, Sterner Kock A, Kantola A, Komor M, Hofmann W, et al. Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung. J Cell Biol. 2004;167:123-33 pubmed
    ..Treatment with active TGF-beta1 rescued BMP-4 and gremlin expression to wild-type levels. Our results indicate that the lack of LTBP-4-mediated targeting and activation of TGF-beta1 leads to enhanced BMP-4 signaling in mouse lung. ..
  6. Koli K, Myllärniemi M, Vuorinen K, Salmenkivi K, Ryynänen M, Kinnula V, et al. Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis. Am J Pathol. 2006;169:61-71 pubmed
    ..The overexpression of this developmental gene in IPF may be a key event in the persistence of myofibroblasts in the lung interstitium and provides a potential target for therapeutic intervention. ..
  7. Koli K, Ryynänen M, Keski Oja J. Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells. Bone. 2008;43:679-88 pubmed publisher
    ..Our results provide evidence that LTBP isoforms can differentially regulate TGF-beta activation and ECM accumulation during osteogenic differentiation. ..