Tarja Kokkola

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. ncbi Important amino acids for the function of the human MT1 melatonin receptor
    Tarja Kokkola
    Department of Physiology, University of Kuopio, 70211, Kuopio, Finland
    Biochem Pharmacol 65:1463-71. 2003
  2. ncbi S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner
    Tarja Kokkola
    Department of Physiology, University of Kuopio, POB 1627, FIN 70211, Kuopio, Finland
    BMC Cell Biol 6:21. 2005
  3. ncbi The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor
    Tarja Kokkola
    Department of Physiology, University of Kuopio, Kuopio, Finland
    J Pineal Res 39:1-11. 2005
  4. ncbi Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation
    Tarja Kokkola
    Institute of Biomedicine Physiology, University of Kuopio, Kuopio, Finland
    J Pineal Res 43:255-62. 2007
  5. ncbi Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor
    Juha R Savinainen
    Department of Physiology, University of Kuopio, POB 1627, FIN 70211 Kuopio, Finland
    Br J Pharmacol 145:636-45. 2005

Detail Information

Publications5

  1. ncbi Important amino acids for the function of the human MT1 melatonin receptor
    Tarja Kokkola
    Department of Physiology, University of Kuopio, 70211, Kuopio, Finland
    Biochem Pharmacol 65:1463-71. 2003
    ..Several important amino acids for the human MT1 melatonin receptor function were revealed in the current study, with effects of mutations ranging from slightly reduced affinity or efficacy to complete loss of function...
  2. ncbi S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner
    Tarja Kokkola
    Department of Physiology, University of Kuopio, POB 1627, FIN 70211, Kuopio, Finland
    BMC Cell Biol 6:21. 2005
    ....
  3. ncbi The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor
    Tarja Kokkola
    Department of Physiology, University of Kuopio, Kuopio, Finland
    J Pineal Res 39:1-11. 2005
    ..Taken together, these data show that the two conserved cysteines in the end of transmembrane domain III of the MT1 melatonin receptor, especially C130 (Cys(3.55)), are needed for normal G protein activation and receptor trafficking...
  4. ncbi Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation
    Tarja Kokkola
    Institute of Biomedicine Physiology, University of Kuopio, Kuopio, Finland
    J Pineal Res 43:255-62. 2007
    ..Luzindole also stimulates downregulation of the MT1 receptor protein, interfering with the synthesis and/or degradation of the receptor...
  5. ncbi Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor
    Juha R Savinainen
    Department of Physiology, University of Kuopio, POB 1627, FIN 70211 Kuopio, Finland
    Br J Pharmacol 145:636-45. 2005
    ..WIN55212-3 offers a valuable tool for further characterization of ligand activities at the CB(2) receptor and may serve as a lead compound in further efforts to develop more potent and selective neutral CB(2) receptor antagonists...