Affiliation: University of Oulu
Laitakari A, Ollonen T, Kietzmann T, Walkinshaw G, Mennerich D, Izzi V, et al
. Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease. Redox Biol. 2019;22:101145 pubmed publisher
Koivunen P, Kietzmann T. Hypoxia-Inducible Factor Prolyl 4-Hydroxylases and Metabolism. Trends Mol Med. 2018;: pubmed publisher
..Here, we discuss the potential of targeting HIF-P4Hs and the HIF pathway for the treatment of obesity, metabolic syndrome, atherosclerosis, and fatty liver diseases (FLDs). ..
Määttä J, Sissala N, Dimova E, Serpi R, Moore L, Koivunen P. Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism. Sci Rep. 2018;8:13583 pubmed publisher
Laukka T, Myllykoski M, Looper R, Koivunen P. Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. J Mol Biol. 2018;430:3081-3092 pubmed publisher
Karsikas S, MyllymÃ¤ki M, HeikkilÃ¤ M, Sormunen R, Kivirikko K, Myllyharju J, et al
. HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury. J Mol Med (Berl). 2016;94:301-10 pubmed publisher
..The mechanisms involved are mediated via normoxic HIF-1Î± and HIF-2Î± stabilization. HIF-P4H-2 deficiency increases capillary size but not number. HIF-P4H-2 deficiency maintains energy metabolism during ischemia-reperfusion. ..
Rahtu Korpela L, Karsikas S, Horkko S, Blanco Sequeiros R, Lammentausta E, Mäkelä K, et al
. HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction. Diabetes. 2014;63:3324-33 pubmed publisher
..HIF-P4H-2 inhibition may be a novel therapy that not only protects against the development of obesity and its consequences but also reverses these conditions. ..
Laukka T, Mariani C, Ihantola T, Cao J, Hokkanen J, Kaelin W, et al
. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem. 2016;291:4256-65 pubmed publisher
..Altogether these data show that hypoxia-inducible genes are regulated in a multilayered manner that includes epigenetic regulation via TETs and 5-hmC levels in addition to HIF stabilization. ..
Rahtu Korpela L, MÃ¤Ã¤ttÃ¤ J, Dimova E, HÃ¶rkkÃ¶ S, Gylling H, Walkinshaw G, et al
. Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016;36:608-17 pubmed publisher
..HIF-P4H-2 inhibition may be a novel strategy for protecting against the development of atherosclerosis. The mechanisms involve beneficial modulation of the serum lipid profile and innate immune system and reduced inflammation. ..
Leinonen H, Rossi M, Salo A, Tiainen P, Hyvärinen J, Pitkänen M, et al
. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum Mol Genet. 2016;25:3810-3823 pubmed publisher
..P4H-TM is therefore imperative for normal vision, and potentially a novel candidate for age-induced diseases, such as AMD. ..