Juhani Knuuti

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi Liver uptake of free fatty acids in vivo in humans as determined with 14( R, S)-[18F]fluoro-6-thia-heptadecanoic acid and PET
    Patricia Iozzo
    Turku PET Centre, Department of Nuclear Medicine and Medicine, University of Turku, Turku, Finland
    Eur J Nucl Med Mol Imaging 30:1160-4. 2003
  2. ncbi Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver
    P Iozzo
    Turku PET Centre, University of Turku, Finland
    Diabetologia 47:1149-56. 2004
  3. ncbi PET as a cardiovascular and metabolic research tool
    J Knuuti
    Turku PET Centre, Finland
    Ann Med 31:450-6. 1999
  4. ncbi Imaging of the failing heart
    J Knuuti
    Turku PET Centre, University of Turku, University Hospital, Finland
    Scand J Surg 96:96-101. 2007
  5. ncbi Is it time for cardiac innervation imaging?
    J Knuuti
    Turku PET Centre, PO Box 52, University of Turku, FI 20521 Turku, Finland
    Q J Nucl Med Mol Imaging 49:97-105. 2005
  6. ncbi Highlights of the annual congress of the European Association of Nuclear Medicine, Copenhagen 2007
    Juhani Knuuti
    Turku PET Centre, Turku University Central Hospital, 20521 Turku, Finland
    Eur J Nucl Med Mol Imaging 35:655-72. 2008
  7. ncbi Effect of estradiol-drospirenone hormone treatment on myocardial perfusion reserve in postmenopausal women with angina pectoris
    Juhani Knuuti
    Turku PET Centre, University of Turku, Finland
    Am J Cardiol 99:1648-52. 2007
  8. ncbi Positron emission tomography and molecular imaging
    J Knuuti
    Turku PET Centre, University of Turku, Turku, Finland
    Heart 94:360-7. 2008
  9. ncbi Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose uptake and their relation to visceral fat in type 2 diabetes
    Patricia Iozzo
    Turku PET Centre, Department of Nuclear Medicine, University of Turku, Turku, Finland
    Diabetes Care 26:2069-74. 2003
  10. ncbi Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals
    Patricia Iozzo
    Turku PET Centre, and Department of Medicine, University of Turku, Turku, Finland
    Gastroenterology 139:846-56, 856.e1-6. 2010

Detail Information

Publications137 found, 100 shown here

  1. ncbi Liver uptake of free fatty acids in vivo in humans as determined with 14( R, S)-[18F]fluoro-6-thia-heptadecanoic acid and PET
    Patricia Iozzo
    Turku PET Centre, Department of Nuclear Medicine and Medicine, University of Turku, Turku, Finland
    Eur J Nucl Med Mol Imaging 30:1160-4. 2003
    ..In conclusion, our data provide non-invasive quantification of hepatic FFA uptake in humans, showing the liver to handle a high FFA flux. [(18)F]FTHA-PET appears a valuable tool for the investigation of hepatic FFA turnover in humans...
  2. ncbi Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver
    P Iozzo
    Turku PET Centre, University of Turku, Finland
    Diabetologia 47:1149-56. 2004
    ..We investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male subjects...
  3. ncbi PET as a cardiovascular and metabolic research tool
    J Knuuti
    Turku PET Centre, Finland
    Ann Med 31:450-6. 1999
    ..In the detection of myocardial viability PET is regarded as the golden standard, and it is the only method available for the quantitative assessment of myocardial blood flow...
  4. ncbi Imaging of the failing heart
    J Knuuti
    Turku PET Centre, University of Turku, University Hospital, Finland
    Scand J Surg 96:96-101. 2007
  5. ncbi Is it time for cardiac innervation imaging?
    J Knuuti
    Turku PET Centre, PO Box 52, University of Turku, FI 20521 Turku, Finland
    Q J Nucl Med Mol Imaging 49:97-105. 2005
    ..Although innervation imaging holds great promise for clinical use, the method has not received wider clinical acceptance. Larger randomized studies are required to confirm the value of innervation imaging in various specific indications...
  6. ncbi Highlights of the annual congress of the European Association of Nuclear Medicine, Copenhagen 2007
    Juhani Knuuti
    Turku PET Centre, Turku University Central Hospital, 20521 Turku, Finland
    Eur J Nucl Med Mol Imaging 35:655-72. 2008
    ..OBJECTIVE: This paper emphasizes the major findings and trends at this important gathering. This review is, however, only a brief summary of the large amount of data discussed...
  7. ncbi Effect of estradiol-drospirenone hormone treatment on myocardial perfusion reserve in postmenopausal women with angina pectoris
    Juhani Knuuti
    Turku PET Centre, University of Turku, Finland
    Am J Cardiol 99:1648-52. 2007
    ..These data suggest that drospirenone has the desired progestin actions on the endometrium, but does not abolish the beneficial effects of estradiol on cardiac microcirculation...
  8. ncbi Positron emission tomography and molecular imaging
    J Knuuti
    Turku PET Centre, University of Turku, Turku, Finland
    Heart 94:360-7. 2008
    ..Finally, there are also promising future applications that involve molecular imaging of cardiac targets, which may further enhance the clinical utility of PET and hybrid imaging...
  9. ncbi Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose uptake and their relation to visceral fat in type 2 diabetes
    Patricia Iozzo
    Turku PET Centre, Department of Nuclear Medicine, University of Turku, Turku, Finland
    Diabetes Care 26:2069-74. 2003
    ..We examined the effects of metformin (2 g/day) and rosiglitazone (8 mg/day) monotherapy on HGU and its relation to subcutaneous fat, visceral fat (VF), and whole-body insulin-mediated glucose metabolism in type 2 diabetic patients...
  10. ncbi Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals
    Patricia Iozzo
    Turku PET Centre, and Department of Medicine, University of Turku, Turku, Finland
    Gastroenterology 139:846-56, 856.e1-6. 2010
    ..We combined (11)C-palmitate imaging by positron emission tomography (PET) with compartmental modeling to determine rates of hepatic FA uptake, oxidation, and storage, as well as triglyceride release in pigs and human beings...
  11. ncbi Differential effects of rosiglitazone and metformin on adipose tissue distribution and glucose uptake in type 2 diabetic subjects
    Kirsi A Virtanen
    Turku PET Centre, University of Turku and Turku University Hospital, Finland
    Diabetes 52:283-90. 2003
    ....
  12. ncbi Myocardial perfusion reserve and oxidative metabolism contribute to exercise capacity in patients with dilated cardiomyopathy
    Kira Q Stolen
    Turku PET Centre, Department of Clinical Physiology, University of Turku, Turku, Finland
    J Card Fail 10:132-40. 2004
    ..CONCLUSIONS: Impaired perfusion reserve and an exaggerated imbalance in right to left ventricular oxidative metabolism appear to significantly contribute to the impaired exercise capacity in these DCM patients...
  13. ncbi Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins
    Jarna C Hannukainen
    Turku PET Centre, University of Turku, Turku, Finland
    J Physiol 578:347-58. 2007
    ..Further, increased physical activity together with decreased intra-abdominal adiposity seems to decrease hepatic FFA uptake but has no effects on skeletal muscle or myocardial FFA uptake...
  14. ncbi Blunted coronary vasoreactivity to insulin is an early alteration in hypertension
    Jan Sundell
    Turku PET Centre, Turku University, Turku, Finland
    J Vasc Res 40:58-67. 2003
    ..While we do not know whether the same results can be extrapolated to female or older subjects, these results indicate a novel defect in the regulation of coronary arteries in the early phase of hypertension...
  15. ncbi Insulin-mediated hepatic glucose uptake is impaired in type 2 diabetes: evidence for a relationship with glycemic control
    Patricia Iozzo
    Turku PET Centre, Department of Nuclear Medicine and Medicine, University of Turku, FIN 20520 Turku, Finland
    J Clin Endocrinol Metab 88:2055-60. 2003
    ..36, P = 0.029). We conclude that insulin-mediated HGU is impaired, in type 2 diabetes, in some proportion to the degree of glycemic control...
  16. ncbi Comparison of exogenous adenosine and voluntary exercise on human skeletal muscle perfusion and perfusion heterogeneity
    Ilkka Heinonen
    Turku PET Centre, PO Box 52, Turku FIN 20521, Finland
    J Appl Physiol 108:378-86. 2010
    ....
  17. ncbi Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs
    Patricia Iozzo
    Turku PET Centre, University of Turku, Turku, Finland
    Gastroenterology 132:531-42. 2007
    ....
  18. ncbi The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans
    Sara Rigazio
    Turku Positron Emission Tomography Centre, University of Turku, Turku, Finland
    Am J Physiol Endocrinol Metab 295:E413-9. 2008
    ..Liver FFA uptake was decreased in proportion to FFA delivery. As a consequence, liver and systemic insulin sensitivity were improved, together with liver function, independently of changes in hepatic triglyceride accumulation...
  19. ncbi Obesity affects myocardial vasoreactivity and coronary flow response to insulin
    Jan Sundell
    Turku PET Centre, Department of Medicine, Turku University, Turku, Finland
    Obes Res 10:617-24. 2002
    ..Obesity is associated with increased risk for cardiovascular diseases and peripheral endothelial dysfunction. We examined whether myocardial vasoreactivity and coronary-flow response to insulin stimulation are altered in obesity...
  20. ncbi Regulation of human skeletal muscle perfusion and its heterogeneity during exercise in moderate hypoxia
    Ilkka H Heinonen
    Turku PET Centre, Turku University Hospital, University of Turku, Turku, Finland
    Am J Physiol Regul Integr Comp Physiol 299:R72-9. 2010
    ....
  21. ncbi Exercise training improves insulin stimulated skeletal muscle glucose uptake independent of changes in perfusion in patients with dilated cardiomyopathy
    Jukka Kemppainen
    Turku PET Centre, University of Turku, PO Box 52, 20521 Turku, Finland
    J Card Fail 9:286-95. 2003
    ..The improved insulin sensitivity is not explained by changes in muscle perfusion suggesting enhanced cellular glucose extraction...
  22. ncbi Intrapericardial, but not extrapericardial, fat is an independent predictor of impaired hyperemic coronary perfusion in coronary artery disease
    Marco Bucci
    University of Turku, Turku, Finland
    Arterioscler Thromb Vasc Biol 31:211-8. 2011
    ....
  23. ncbi Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure
    Helena Tuunanen
    Turku PET Centre, Turku, Finland
    Circulation 114:2130-7. 2006
    ..Thus, failing hearts are unexpectedly more dependent than healthy hearts on FFA availability. We propose that both glucose and fatty acid oxidation are required for optimal function of the failing heart...
  24. ncbi Myocardial perfusion reserve and peripheral endothelial function in patients with idiopathic dilated cardiomyopathy
    Kira Q Stolen
    Turku PET Centre, Turku, Finland
    Am J Cardiol 93:64-8. 2004
    ..57; p = 0.04). Thus, abnormal myocardial perfusion characterizes patients with IDC. Myocardial perfusion reserve and peripheral endothelial function do not parallel each other in patients with IDC...
  25. ncbi Insulin improves myocardial blood flow in patients with type 2 diabetes and coronary artery disease
    Riikka Lautamaki
    Turku PET Centre, Turku University Hospital, Finland
    Diabetes 55:511-6. 2006
    ....
  26. ncbi Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese men
    Kirsti Hallsten
    Turku PET Centre and Department of Medicine, University of Helsinki, Finland Department of Medicine, University of Turku, Finland
    Obes Res 11:257-65. 2003
    ..g., skeletal muscle. In the present study, we determined whether insulin resistance in obesity is associated with an impaired ability of exercise to stimulate muscle blood flow, oxygen delivery, or glucose uptake...
  27. ncbi Clinical Value of Absolute Quantification of Myocardial Perfusion With 15O-Water in Coronary Artery Disease
    Sami A Kajander
    Turku PET Centre, Department of Medicine, and Department of Clinical Physiology and Nuclear Medicine, University of Turku, Turku, Finland
    Circ Cardiovasc Imaging 4:678-84. 2011
    ..As expected, multivessel disease is more accurately detected. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00627172...
  28. ncbi Contribution of glucose tolerance and gender to cardiac adiposity
    Patricia Iozzo
    Turku PET Centre, University of Turku, 20521 Turku, Finland
    J Clin Endocrinol Metab 94:4472-82. 2009
    ....
  29. ncbi Exercise training improves insulin-stimulated myocardial glucose uptake in patients with dilated cardiomyopathy
    Kira Q Stolen
    Turku PET Centre, University of Turku, Turku, Finland
    J Nucl Cardiol 10:447-55. 2003
    ..This improvement in glucose uptake may be indicative of a switch in myocardial preference to a more energy-efficient substrate...
  30. ncbi The effects of cardiac resynchronization therapy on left ventricular function, myocardial energetics, and metabolic reserve in patients with dilated cardiomyopathy and heart failure
    Jan Sundell
    Department of Medicine, University Central Hospital, University of Turku, FIN-20521 Turku, Finland
    J Am Coll Cardiol 43:1027-33. 2004
    ..These effects are not associated with changes in myocardial perfusion or oxygen consumption. During dobutamine-induced stress, CRT does not affect functional parameters, but myocardial efficiency and metabolic reserve may be increased...
  31. ncbi Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a pet study with nitric oxide and cyclooxygenase inhibition
    Ilkka Heinonen
    Turku PET Centre, Turku, Finland
    Am J Physiol Heart Circ Physiol 300:H1510-7. 2011
    ....
  32. ncbi Effects of adenosine, exercise, and moderate acute hypoxia on energy substrate utilization of human skeletal muscle
    Ilkka Heinonen
    Turku PET Centre, Finland
    Am J Physiol Regul Integr Comp Physiol 302:R385-90. 2012
    ..In conclusion, exogenous adenosine at rest and acute moderate hypoxia during low-intensity knee-extension exercise increases skeletal muscle glucose uptake, but the increase in hypoxia appears not to be mediated by adenosine...
  33. ncbi High intensity exercise decreases global brain glucose uptake in humans
    Jukka Kemppainen
    Turku PET Centre, University of Turku, PO Box 52, 20521 Turku, Finland
    J Physiol 568:323-32. 2005
    ..Moreover, it seems that exercise training could be related to adaptive metabolic changes locally in the frontal cortical regions...
  34. ncbi Myocardial perfusion during exercise in endurance-trained and untrained humans
    Marko S Laaksonen
    Turku PET Centre, University of Turku, Turku, Finland
    Am J Physiol Regul Integr Comp Physiol 293:R837-43. 2007
    ..Endurance training seems to affect myocardial blood flow pattern during submaximal exercise and leads to more efficient myocardial pump function...
  35. ncbi Increased fat mass compensates for insulin resistance in abdominal obesity and type 2 diabetes: a positron-emitting tomography study
    Kirsi A Virtanen
    Turku PET Centre, University of Turku, P O Box 52 20521, Turku, Finland
    Diabetes 54:2720-6. 2005
    ....
  36. ncbi Simultaneous evaluation of myocardial blood flow, cardiac function and lung water content using [15O]H2O and positron emission tomography
    Alexandru Naum
    Turku PET Centre, Turku University Central Hospital, P O Box 52, 20521, Turku, Finland
    Eur J Nucl Med Mol Imaging 34:563-72. 2007
    ....
  37. ncbi Motion detection and correction for dynamic ( 15)O-water myocardial perfusion PET studies
    Alexandru Naum
    Turku PET Centre, University of Turku, P.O. Box 52, 20521 Turku, Finland
    Eur J Nucl Med Mol Imaging 32:1378-83. 2005
    ..Applying motion correction for the data acquired during exercise clearly changed the MBF results, indicating that motion correction is required for these studies...
  38. ncbi Myocardial perfusion after marathon running
    Kari K Kalliokoski
    Turku PET Centre, University of Turku, Turku, Finland
    Scand J Med Sci Sports 14:208-14. 2004
    ..Strenuous exercise also seems to enhance coronary reactivity, which could thereby serve as a protective mechanism to vascular events after exercise...
  39. ncbi Biodistribution of the fatty acid analogue 18F-FTHA: plasma and tissue partitioning between lipid pools during fasting and hyperinsulinemia
    Letizia Guiducci
    Turku PET Centre, University of Turku, Turku, Finland
    J Nucl Med 48:455-62. 2007
    ....
  40. ncbi Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice
    Johanna M U Silvola
    Turku PET Centre, Department of Medicine, Turku University Hospital, and Institute of Forensic Medicine and Turku Center for Disease Modeling, University of Turku, Kiinamyllynkatu 4 8, PO Box 52, FI 20520 Turku, Finland
    Arterioscler Thromb Vasc Biol 31:1011-5. 2011
    ..We examined the uptake of 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide ([18F]EF5), a specific marker of hypoxia labeled for positron emission tomography, in mouse atherosclerotic plaques...
  41. ncbi 18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study
    Patricia Iozzo
    Turku PET Centre, University of Turku, Turku, Finland
    J Nucl Med 47:1016-22. 2006
    ....
  42. ncbi Positive family history of coronary artery disease is associated with reduced myocardial vasoreactivity in healthy men
    Jan Sundell
    Turku PET Centre, Turku University, Central Hospital, Turku, Finland
    Int J Cardiol 112:289-94. 2006
    ..We examined the association between family history of coronary artery disease and myocardial vasoreactivity in healthy men...
  43. ncbi Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities
    Marco Bucci
    Turku PET Centre, University of Turku, Turku, Finland
    Am J Physiol Endocrinol Metab 301:E105-12. 2011
    ....
  44. ncbi Dose-dependent vasodilating effects of insulin on adenosine-stimulated myocardial blood flow
    Jan Sundell
    Turku PET Centre, Turku University, Turku, Finland. Department of Medicine, Turku University, Turku, Finland
    Diabetes 51:1125-30. 2002
    ..These effects might contribute to the known beneficial dose-dependent effects of insulin on myocardial ischemia...
  45. ncbi Coronary flow reserve is reduced in young men with IDDM
    O P Pitkanen
    Department of Medicine, University of Turku, Finland
    Diabetes 47:248-54. 1998
    ..The results imply early impairment of coronary vascular reactivity in IDDM patients, which may represent an early precursor of future coronary heart disease or may contribute to the pathogenesis of diabetic cardiomyopathy...
  46. ncbi Increased lipoprotein(a) is associated with reduced myocardial vasoreactivity in young healthy men
    Jan Sundell
    Turku PET Centre, Turku University Central Hospital, P O Box 52, FIN 20521 Turku, Finland
    Atherosclerosis 179:185-91. 2005
    ..We examined the association between lipoprotein(a) and myocardial vasoreactivity in healthy men...
  47. ncbi Effects of age, diet, and type 2 diabetes on the development and FDG uptake of atherosclerotic plaques
    Johanna M U Silvola
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    JACC Cardiovasc Imaging 4:1294-301. 2011
    ..This study investigated the effects of age, duration of a high-fat diet, and type 2 diabetes on atherosclerotic plaque development and uptake of (18)F-fluorodeoxyglucose ((18)F-FDG) in 2 mouse models...
  48. ncbi Non-specific binding of [18F]FDG to calcifications in atherosclerotic plaques: experimental study of mouse and human arteries
    Iina Laitinen
    Turku PET Centre, University of Turku, Turku, Finland
    Eur J Nucl Med Mol Imaging 33:1461-7. 2006
    ..18)F]FDG has been used as an inflammation marker and shown to accumulate in inflammatory atherosclerotic plaques. The aim of this study was to investigate the uptake and location of [(18)F]FDG in atherosclerotic plaque compartments...
  49. ncbi Effect of caloric restriction on myocardial fatty acid uptake, left ventricular mass, and cardiac work in obese adults
    Antti P M Viljanen
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Am J Cardiol 103:1721-6. 2009
    ..These results show that the increased fatty acid uptake found in the hearts of obese patients can be reversed by weight loss...
  50. ncbi Defective liver disposal of free fatty acids in patients with impaired glucose tolerance
    Patricia Iozzo
    Turku PET Centre, Department of Nuclear Medicine, University of Turku, FI 20521 Turku, Finland
    J Clin Endocrinol Metab 89:3496-502. 2004
    ..The reciprocal relationship between hepatic FFA extraction and glucose/lactate flux may derive from intrahepatic substrate competition...
  51. ncbi Effect of pravastatin on low-density lipoprotein oxidation and myocardial perfusion in young adults with type 1 diabetes
    Tuula Janatuinen
    Turku PET Centre, Turku University Central Hospital, PO Box 52, FIN 20521 Turku, Finland
    Arterioscler Thromb Vasc Biol 24:1303-8. 2004
    ..We studied whether pravastatin decreases LDL oxidation and improves myocardial perfusion in normocholesterolemic subjects with type 1 diabetes...
  52. ncbi Assessment of right ventricular oxidative metabolism by PET in patients with idiopathic dilated cardiomyopathy undergoing cardiac resynchronization therapy
    Juhani Knuuti
    Turku PET Centre, University of Turku, Turku, Finland
    Eur J Nucl Med Mol Imaging 31:1592-8. 2004
    ..The purpose of the study was to investigate RV oxidative metabolism, metabolic reserve and the effects of CRT in patients with CHF and left bundle brach block. In addition, the role of the RV in the response to CRT was evaluated...
  53. ncbi Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus
    Jyri K Koort
    Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, University of Turku, FIN-20520 Turku, Finland
    Antimicrob Agents Chemother 49:1502-8. 2005
    ..The collaborative results of bacteriologic and [18F-FDG] PET studies showed that use of the multifunctional composite was successful for eradication of the S. aureus pathogen from bone...
  54. ncbi Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men
    Ilkka Heinonen
    Turku PET Centre, Departments of Clinical Physiology and Nuclear Medicine, University of Turku, Turku, Finland
    J Physiol 586:5193-202. 2008
    ..On the other hand hyperaemic perfusion is reduced, but is not explained by A2AR density...
  55. ncbi High serum leptin is associated with attenuated coronary vasoreactivity
    Jan Sundell
    Department of Medicine, Turku University, Turku, Finland
    Obes Res 11:776-82. 2003
    ..We examined the association between circulating leptin concentration and coronary vasoreactivity in young obese and nonobese males...
  56. ncbi Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels
    Mikko Kankaanpaa
    Turku PET Centre, University of Turku, FIN 20521, Turku, Finland
    J Clin Endocrinol Metab 91:4689-95. 2006
    ..We evaluated myocardial and epicardial fat, left ventricular (LV) function, and metabolic risk factors in nine (five lean, four moderately obese) men...
  57. ncbi [11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia
    Letizia Guiducci
    SSSUP Medical Sciences Branch, Pisa 56100, Italy; Turku PET Centre, University of Turku, Turku 20520, Finland
    Nucl Med Biol 33:521-8. 2006
    ..Labeled TG constitute an additional [11C]palmitate source in the modeling of PET data...
  58. ncbi Role of adenosine in regulating the heterogeneity of skeletal muscle blood flow during exercise in humans
    Ilkka Heinonen
    Turku PET Centre, FIN 20521, Turku, Finland
    J Appl Physiol 103:2042-8. 2007
    ..Adenosine seems to play a role in muscle BF heterogeneity even in the absence of changes in bulk BF at low and moderate one-leg intermittent isometric exercise intensities...
  59. ncbi Rosiglitazone improves myocardial glucose uptake in patients with type 2 diabetes and coronary artery disease: a 16-week randomized, double-blind, placebo-controlled study
    Riikka Lautamaki
    Turku PET Centre, Turku University Central Hospital, Kiinamyllynkatu 4 8, P O Box 52, FIN 20521 Turku, Finland
    Diabetes 54:2787-94. 2005
    ..These results suggest that rosiglitazone therapy may facilitate myocardial glucose storage and utilization in these patients...
  60. ncbi Fractal scaling properties of heart rate dynamics and myocardial efficiency in dilated cardiomyopathy
    Tiina Marjatta Salo
    Department of Medicine, University of Turku, 20520 Turku, Finland
    Clin Res Cardiol 98:725-30. 2009
    ..Since altered heart rate (HR) fluctuations provide prognostic information in heart failure, we examined the associations between HR dynamics, myocardial efficiency and perfusion, among patients with dilated cardiomyopathy...
  61. ncbi Insulin stimulates liver glucose uptake in humans: an 18F-FDG PET Study
    Patricia Iozzo
    Turku PET Centre, Department of Nuclear Medicine, University of Turku, Turku, Finland
    J Nucl Med 44:682-9. 2003
    ..The liver is vital for the regulation of glucose metabolism, but inaccessibility of the organ for direct assessments has limited the study of its metabolic role in vivo...
  62. ncbi Dual gated PET/CT imaging of small targets of the heart: method description and testing with a dynamic heart phantom
    Tommi Kokki
    Turku PET Centre, University of Turku, Kiinamyllynkatu 4 8, P O Box 52, 20521 Turku, Finland
    J Nucl Cardiol 17:71-84. 2010
    ..In PET imaging respiratory and cardiac contraction motions interfere the imaging of heart. The aim was to develop and evaluate dual gating method for improving the detection of small targets of the heart...
  63. ncbi Integrated anatomy and viability assessment PET-CT
    Antti Saraste
    Turku PET Centre, University of Turku, Turku, Finland
    EuroIntervention 6:G132-7. 2010
    ..This review will describe the principles of viability assessment by PET, and discuss the possibilities provided by hybrid PET-CT in this setting...
  64. ncbi Low serum adiponectin is associated with high circulating oxidized low-density lipoprotein in patients with type 2 diabetes mellitus and coronary artery disease
    Riikka Lautamaki
    Turku PET Centre, University of Turku, 20521 Turku, Finland
    Metabolism 56:881-6. 2007
    ..In conclusion, our results suggest that low adiponectin concentration indicates increased oxidative state in the arterial wall, which further supports previous data on the role of adipose tissue in atherogenesis...
  65. ncbi Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques
    Iina Laitinen
    Turku PET Centre, University of Turku, Kiinamyllynkatu 4 8, FI 20520, Turku, Finland
    Eur J Nucl Med Mol Imaging 36:73-80. 2009
    ..The purpose of this study was to explore the feasibility of [(11)C]PK11195 in imaging inflammation in the atherosclerotic plaques...
  66. ncbi Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects
    Amir Snapir
    Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Itainen Pitkakatu 4B, FI 20520 Turku, Finland
    Anesthesiology 105:902-10; quiz 1069-70. 2006
    ..The goal of this study was to determine the effects of therapeutic and high concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy subjects...
  67. ncbi Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes
    Kirsti Hallsten
    Turku PET Centre, University of Turku, FIN 20521 Turku, Finland
    Diabetes 51:3479-85. 2002
    ..Our results suggest that rosiglitazone improves synergic action of insulin and exercise...
  68. ncbi Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy
    Helena Tuunanen
    Turku PET Centre, PO Box 52, FI 20521 Turku, Finland
    Circulation 118:1250-8. 2008
    ..However, FFA oxidation remains unmeasured in humans. We investigated the effects of trimetazidine on cardiac perfusion, efficiency of work, and FFA oxidation in idiopathic dilated cardiomyopathy...
  69. ncbi Myocardial perfusion quantitation with 15O-labelled water PET: high reproducibility of the new cardiac analysis software (Carimas)
    Sergey V Nesterov
    Turku PET Centre, University of Turku, P O Box 52, Turku, 20521, Finland
    Eur J Nucl Med Mol Imaging 36:1594-602. 2009
    ..The goal of this study was to assess the reproducibility of results the package provides for myocardial perfusion (MP) quantitation using (15)O-labelled water...
  70. ncbi Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans
    Kirsi A Virtanen
    Turku PET Centre, University of Turku, Turku University Central Hospital, Turku 20521, Finland
    J Clin Endocrinol Metab 87:3902-10. 2002
    ....
  71. ncbi Myocardial oxygen consumption is unchanged but efficiency is reduced in patients with essential hypertension and left ventricular hypertrophy
    H Laine
    Department of Medicine, and Clinical Physiology, University of Turku, Finland
    Circulation 100:2425-30. 1999
    ..We tested the hypothesis that compensatory LVH is associated with normalization of myocardial oxygen consumption and that this occurs at the expense of a decrease in the ratio between cardiac work and oxygen consumption (efficiency)...
  72. ncbi Myocardial and skeletal muscle glucose uptake during exercise in humans
    Jukka Kemppainen
    Turku PET Centre, University of Turku, PO Box 52, 20521 Turku, Finland
    J Physiol 542:403-12. 2002
    ..This finding suggests that the increased myocardial energy that is needed during high-intensity exercise is supplied by substrates other than glucose...
  73. ncbi Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity
    H Laine
    Department of Medicine, University of Turku, Turku, Finland
    J Clin Invest 101:1156-62. 1998
    ..Since a 75% increase in blood flow does not alter glucose uptake, insulin resistance in obesity cannot be overcome by normalizing muscle blood flow...
  74. ncbi Impaired myocardial perfusion reserve but preserved peripheral endothelial function in patients with Fabry disease
    R J Kalliokoski
    Turku PET Centre, University of Turku, Turku, Finland
    J Inherit Metab Dis 28:563-73. 2005
    ..6, p=0.02), while the brachial artery flow-mediated dilatation was similar (5.9%+/-3.9% vs 4.5%+/-3.6%, p=0.27). Thus, inFabry disease, myocardial perfusion reserve is reduced while the peripheral artery endothelial function is preserved...
  75. ncbi Exercise restores skeletal muscle glucose delivery but not insulin-mediated glucose transport and phosphorylation in obese subjects
    L Slimani
    Turku PET Centre, University of Turku, P.O. Box 52, FIN-20521 Turku, Finland
    J Clin Endocrinol Metab 91:3394-403. 2006
    ..Our data support the use of 2-deoxy-2-[18F]fluoro-d-glucose-positron emission tomography in the dissection between substrate supply and intrinsic tissue metabolism...
  76. ncbi Uncoupling of fatty acid and glucose metabolism in malignant lymphoma: a PET study
    J Nuutinen
    Department of Oncology and Radiotherapy, Turku University Central Hospital, Finland
    Br J Cancer 80:513-8. 1999
    ..Although acipimox and other anti-lipolytic drugs have potential for treatment of catabolic state induced by cancer, they are not likely to interfere with tumour energy metabolism which is fuelled by glucose...
  77. ncbi Myocardial fatty acid oxidation in patients with impaired glucose tolerance
    J Knuuti
    Turku PET Centre, University of Turku, Finland
    Diabetologia 44:184-7. 2001
    ..Thus, it is not likely that altered NEFA metabolism contributes to the deterioration of the cardiac function in patients with IGT or Type II diabetes...
  78. ncbi Insulin induced increase in coronary flow reserve is abolished by dexamethasone in young men with uncomplicated type 1 diabetes
    H Laine
    Turku PET Centre, Turku University Central Hospital, Turku, Finland
    Heart 90:270-6. 2004
    ....
  79. ncbi Myocardial fatty acid metabolism and cardiac performance in heart failure
    Helena Tuunanen
    Turku PET Centre, Turku University Central Hospital, PO Box 52, FIN 20521 Turku, Finland
    Curr Cardiol Rep 10:142-8. 2008
    ..However, it has been found that acute FFA deprivation is harmful to the cardiac performance. Optimizing myocardial energy metabolism may serve as an additional approach for managing HF, but further studies are warranted...
  80. ncbi 14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle
    Teemu O Takala
    Turku PET Centre, Turku University Central Hospital, PO Box 52, 20521 Turku, Finland
    Eur J Nucl Med Mol Imaging 29:1617-22. 2002
    ....
  81. ncbi Insulin signalling and resistance in patients with chronic heart failure
    Jukka Kemppainen
    Turku PET Centre, University of Turku, Turku, Finland and Department of Surgical Sciences, Karolinska Hospital, Stockholm, Sweden
    J Physiol 550:305-15. 2003
    ..However, these changes in insulin action after exercise training appear to be independent of enhanced insulin signalling at the level of IRS-1, PI-3-kinase or Akt...
  82. ncbi Use of [11C]acetate and [15O]O2 PET for the assessment of myocardial oxygen utilization in patients with chronic myocardial infarction
    H Ukkonen
    Department of Medicine, Turku University Hospital and Turku PET Centre, POB 52, 20521 Turku, Finland
    Eur J Nucl Med 28:334-9. 2001
    ..28 +/- 0.35, P = 0.037). It is concluded that kmono of [11C]acetate correlates linearly with rMMRO2 determined by [15O]O2 inhalation. However, kmono appears to yield higher rMMRO2 estimates than the [15O]O2 method in low-flow areas...
  83. ncbi Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose ([(18)F]FDG) and PET in combination with microdialysis
    K A Virtanen
    Turku PET Centre, University of Turku, P.O. Box 52, 20521 Turku, Finland
    Diabetologia 44:2171-9. 2001
    ..14 for [(18)F]FDG in human adipose tissue during insulin stimulation and the LC does not appear to be altered in insulin resistance. Furthermore, the obese patients show insulin resistance in both adipose tissue and skeletal muscle...
  84. ncbi In vivo measurements of glucose uptake in human Achilles tendon during different exercise intensities
    J Hannukainen
    Turku PET Centre, University of Turku, Turku, Finland
    Int J Sports Med 26:727-31. 2005
    ..This may be partly explained by the cycle ergometry exercise used in the present study, which probably causes only a little increase in strain to the AT with increasing exercise intensity...
  85. ncbi Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults
    Tuula Janatuinen
    Turku PET Centre, University of Turku, Finland
    Vasc Med 8:185-9. 2003
    ..004), whereas high baseline ADMA (> or = median) was associated with no increase in adenosine-induced flow...
  86. ncbi Exercise training improves biventricular oxidative metabolism and left ventricular efficiency in patients with dilated cardiomyopathy
    Kira Q Stolen
    Turku PET Centre, University of Turku and Turku University Central Hospital, FIN-20521 Turku, Finland
    J Am Coll Cardiol 41:460-7. 2003
    ..Therefore, exercise training elicits an energetically favorable improvement in myocardial function and exercise tolerance in patients with DCM...
  87. ncbi Myocardial perfusion and perfusion reserve in endurance-trained men
    Kari K Kalliokoski
    Turku PET Centre, Turku, Finland
    Med Sci Sports Exerc 34:948-53. 2002
    ..This study was undertaken to determine whether endurance training is associated with changes in myocardial perfusion in humans...
  88. ncbi Perfusion heterogeneity in human skeletal muscle: fractal analysis of PET data
    K K Kalliokoski
    Turku PET Centre, University of Turku, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Eur J Nucl Med 28:450-6. 2001
    ..Analysis of flow heterogeneity using PET and fractals could provide new insight into physiological conditions and diseases associated with changes in peripheral vascular function...
  89. ncbi Enhanced oxygen extraction and reduced flow heterogeneity in exercising muscle in endurance-trained men
    K K Kalliokoski
    Turku PET Centre, University of Turku, FIN 20521 Turku, Finland
    Am J Physiol Endocrinol Metab 280:E1015-21. 2001
    ..These changes may be associated with improved exercise efficiency in the endurance-trained subjects...
  90. ncbi The effect of 12-month enzyme replacement therapy on myocardial perfusion in patients with Fabry disease
    R J Kalliokoski
    Turku PET Centre, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    J Inherit Metab Dis 29:112-8. 2006
    ..However, individual variation in the response to therapy was large and the results suggest that the success of the therapy may depend on the degree of cardiac hypertrophy...
  91. ncbi Increased coronary vascular resistance cannot be reduced by inhibiting sympathetic overactivity in hypertension
    Jan Sundell
    Turku PET Centre, Turku University, Turku, Finland
    J Vasc Res 39:456-62. 2002
    ....
  92. ncbi Coronary artery flow velocity profile measured by transthoracic Doppler echocardiography predicts myocardial viability after acute myocardial infarction
    Antti Saraste
    Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Kiinamyllynkatu 6 8, 20520 Turku, Finland
    Heart 93:456-7. 2007
    ....
  93. ncbi Cardiac MRI: accuracy of simultaneous measurement of left and right ventricular parameters using three different sequences
    Juha W Koskenvuo
    Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital, Turku, Finland
    Clin Physiol Funct Imaging 27:385-93. 2007
    ..Furthermore, we studied whether shortened acquisition time has an effect on the accuracy of left and right ventricular parameters both in healthy volunteers and in patients with cardiovascular disease...
  94. ncbi Insulin and myocardial blood flow
    Jan Sundell
    Turku PET Centre, Turku University Central Hospital, P O Box 52, FIN 20521 Turku, Finland
    Cardiovasc Res 57:312-9. 2003
    ..The present article review the physiological and pathophysiological role of insulin in cardiac vasculature and its clinical importance during myocardial ischemia and development of coronary artery disease...
  95. ncbi The need for standardisation of cardiac FDG PET imaging in the evaluation of myocardial viability in patients with chronic ischaemic left ventricular dysfunction
    Juhani Knuuti
    Turku PET Centre, Turku University Central Hospital, P O Box 52, 20521 Turku, Finland
    Eur J Nucl Med Mol Imaging 29:1257-66. 2002
    ..In addition, multi-centre trials seem warranted on prediction of long-term function, congestive heart failure symptoms, survival and quality of life...
  96. ncbi An autoradiographic study of [(18)F]FDG uptake to islets of Langerhans in NOD mouse
    Teemu Kalliokoski
    DIPP project, Department of Pediatrics, University of Turku, Turku, Finland
    Diabetes Res Clin Pract 70:217-24. 2005
    ....
  97. ncbi Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes
    Riikka Lautamaki
    Turku PET Centre, University of Turku, Turku, Finland
    Am J Physiol Endocrinol Metab 291:E282-90. 2006
    ..Further studies will reveal the effect of hepatic fat reduction on myocardial metabolism and coronary function...
  98. ncbi Comparison of MRI and positron emission tomography for measuring myocardial perfusion reserve in healthy humans
    Jussi P Pärkkä
    Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
    Magn Reson Med 55:772-9. 2006
    ..04) between MRI and PET. However, we noticed that MRI provided lower MPR values compared to PET (2.5 +/- 1.0 vs. 4.3 +/- 1.8). We conclude that MRI supplemented with tracer kinetic modeling can be used to quantify myocardial perfusion...
  99. ncbi Muscle oxygen extraction and perfusion heterogeneity during continuous and intermittent static exercise
    Kari K Kalliokoski
    Turku Positron Emission Tomography Centre, and Department of Medicine, University of Turku, FIN 20521 Turku, Finland
    J Appl Physiol 94:953-8. 2003
    ....
  100. ncbi Relationship between muscle blood flow and oxygen uptake during exercise in endurance-trained and untrained men
    Kari K Kalliokoski
    Turku PET Centre, PO Box 52, University of Turku, FIN 20521 Turku, Finland
    J Appl Physiol 98:380-3. 2005
    ..Furthermore, this matching seems to be better in the endurance-trained than in untrained men...
  101. ncbi Anatomy and function: PET-CT
    Sami Kajander
    Turku PET Centre, University of Turku, Turku, Finland
    EuroIntervention 6:G87-93. 2010
    ....