Mikael Knip

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi Environmental triggers of type 1 diabetes
    Mikael Knip
    Children s Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland Folkhälsan Research Center, FI 00290 Helsinki, Finland
    Cold Spring Harb Perspect Med 2:a007690. 2012
  2. ncbi Descriptive epidemiology of type 1 diabetes--is it still in?
    M Knip
    Children s Hospital, University of Helsinki, PO Box 22, FI 00014 Helsinki, Finland
    Diabetologia 55:1227-30. 2012
  3. ncbi Infant feeding and the risk of type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Finland
    Am J Clin Nutr 91:1506S-1513S. 2010
  4. ncbi Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Am J Clin Nutr 94:1814S-1820S. 2011
  5. ncbi Dietary intervention in infancy and later signs of beta-cell autoimmunity
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    N Engl J Med 363:1900-8. 2010
  6. ncbi Food consumption and advanced β cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes: a nested case-control design
    Suvi M Virtanen
    Unit of Nutrition, Department of Lifestyle and Participation, National Institute for Health and Welfare, Helsinki, Finland
    Am J Clin Nutr 95:471-8. 2012
  7. ncbi Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood
    Kristiina Luopajarvi
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Diabetes 9:434-41. 2008
  8. ncbi Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population
    Heli T A Siljander
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Helsinki, Finland
    Diabetes 58:2835-42. 2009
  9. ncbi Dietary insulin as an immunogen and tolerogen
    Minna Tiittanen
    Department of Viral Diseases and Immunology, Laboratory for Immunology, National Public Health Institute, Helsinki, Finland
    Pediatr Allergy Immunol 17:538-43. 2006
  10. ncbi Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA-conferred disease susceptibility
    Heli Siljander
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, 00014 Helsinki, Finland
    Diabetes Metab Res Rev 25:615-22. 2009

Research Grants

  1. Identification of Biomarkers of Autoimmunity in T1D by Novel Tools
    Mikael Knip; Fiscal Year: 2007

Detail Information

Publications97

  1. ncbi Environmental triggers of type 1 diabetes
    Mikael Knip
    Children s Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland Folkhälsan Research Center, FI 00290 Helsinki, Finland
    Cold Spring Harb Perspect Med 2:a007690. 2012
    ....
  2. ncbi Descriptive epidemiology of type 1 diabetes--is it still in?
    M Knip
    Children s Hospital, University of Helsinki, PO Box 22, FI 00014 Helsinki, Finland
    Diabetologia 55:1227-30. 2012
    ..In addition, descriptive epidemiology needs to be complemented with 'aetiological' epidemiology generating information on the causes of the incidence and prevalence trends...
  3. ncbi Infant feeding and the risk of type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Finland
    Am J Clin Nutr 91:1506S-1513S. 2010
    ..Additional work, which includes the application of modern approaches such as metabolomics and epigenomics, is needed to discern the contribution of dietary factors in infancy to the diabetic disease process...
  4. ncbi Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Am J Clin Nutr 94:1814S-1820S. 2011
    ..The overall retention rate over the first 5 y was 87%, and protocol compliance was 94%. The randomization code will be opened when the last recruited child turns 10 y of age (ie, in 2017)...
  5. ncbi Dietary intervention in infancy and later signs of beta-cell autoimmunity
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    N Engl J Med 363:1900-8. 2010
    ..We tested the hypothesis that supplementing breast milk with highly hydrolyzed milk formula would decrease the cumulative incidence of diabetes-associated autoantibodies in such children...
  6. ncbi Food consumption and advanced β cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes: a nested case-control design
    Suvi M Virtanen
    Unit of Nutrition, Department of Lifestyle and Participation, National Institute for Health and Welfare, Helsinki, Finland
    Am J Clin Nutr 95:471-8. 2012
    ..Evidence for the role of food consumption during childhood in the development of β cell autoimmunity is scarce and fragmentary...
  7. ncbi Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood
    Kristiina Luopajarvi
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Diabetes 9:434-41. 2008
    ..Early exposure to cow's milk (CM) proteins have been implicated in the pathogenesis of type 1 diabetes (T1D)...
  8. ncbi Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population
    Heli T A Siljander
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Helsinki, Finland
    Diabetes 58:2835-42. 2009
    ....
  9. ncbi Dietary insulin as an immunogen and tolerogen
    Minna Tiittanen
    Department of Viral Diseases and Immunology, Laboratory for Immunology, National Public Health Institute, Helsinki, Finland
    Pediatr Allergy Immunol 17:538-43. 2006
    ..However, our results in infants who developed beta-cell autoimmunity suggest that in this subgroup of children breast milk insulin does not promote tolerance...
  10. ncbi Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA-conferred disease susceptibility
    Heli Siljander
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, 00014 Helsinki, Finland
    Diabetes Metab Res Rev 25:615-22. 2009
    ....
  11. ncbi Determinants of breast-feeding in a Finnish birth cohort
    Maijaliisa Erkkola
    Division of Nutrition, Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland
    Public Health Nutr 13:504-13. 2010
    ..To assess milk feeding on the maternity ward and during infancy, and their relationship to sociodemographic determinants. The validity of our 3-month questionnaire in measuring hospital feeding was assessed...
  12. ncbi Risk of asthma and allergic outcomes in the offspring in relation to maternal food consumption during pregnancy: a Finnish birth cohort study
    Maijaliisa Erkkola
    Division of Nutrition, Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland
    Pediatr Allergy Immunol 23:186-94. 2012
    ....
  13. ncbi Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring
    Mirka Lumia
    Nutrition Unit, Department of Lifestyle and Participation, National Institute of Health and Welfare, Helsinki, Finland
    Pediatr Allergy Immunol 22:827-35. 2011
    ..We explored the association of maternal dietary FA composition during pregnancy with the risk of asthma in the offspring...
  14. ncbi Nutrient intake variability and number of days needed to assess intake in preschool children
    Maijaliisa Erkkola
    Division of Nutrition, Department of Food and Environmental Sciences, PO Box 66, FI 00014, University of Helsinki, Helsinki, Finland
    Br J Nutr 106:130-40. 2011
    ..The accuracy of ranking boys is greater than that for girls...
  15. ncbi Early introduction of oats associated with decreased risk of persistent asthma and early introduction of fish with decreased risk of allergic rhinitis
    Suvi M Virtanen
    Department of Lifestyles and Participation, National Institute of Health and Welfare, Helsinki, Finland
    Br J Nutr 103:266-73. 2010
    ..We confirmed the earlier observation that the age at introduction of fish is inversely related to the risk of allergic rhinitis. Clinical implications remain to be determined...
  16. ncbi Diet composition of pregnant Finnish women: changes over time and across seasons
    Marianne Prasad
    Department of Lifestyle and Participation, National Institute for Health and Welfare, PO Box 27, FI 00271, Helsinki, Finland
    Public Health Nutr 13:939-46. 2010
    ..To describe the diet of a population of pregnant Finnish women over a period of 7 years, with special attention paid to seasonal fluctuations in food consumption and nutrient intake...
  17. ncbi Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes
    Samppa J Ryhänen
    Scientific Laboratory, Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, Helsinki, Finland
    Diabetes Care 34:1383-8. 2011
    ..To analyze whether the insulin dose was inadequate to elicit an immunomodulatory response, we compared the changes observed in insulin antibody (IA) affinity and isotypes after treatment with nasal insulin or placebo...
  18. ncbi Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes
    Anna Mäkinen
    Scientific Laboratory, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Biomedicum I, PO Box 63, FI 00014 Helsinki, Finland
    Eur J Endocrinol 159:19-26. 2008
    ....
  19. ncbi Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes?
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatr Diabetes 9:46-9. 2008
    ..Objective: We set out to explore whether any relationship can be seen between the incidence of childhood type 1 diabetes and changes in linear growth and body mass in Finnish children over a 12-yr period...
  20. ncbi Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Am J Med Genet 115:48-54. 2002
    ..In patients with newly diagnosed disease IA-2A may be a more specific marker of beta-cell damage, whereas GADA might reflect a propensity to autoimmunity in general...
  21. ncbi Environmental triggers and determinants of type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, P O Box 281, FI 00029 Huch, Helsinki, Finland
    Diabetes 54:S125-36. 2005
    ..Accordingly, progression to clinical type 1 diabetes typically requires the unfortunate combination of genetic disease susceptibility, a diabetogenic trigger, and a high exposure to a driving antigen...
  22. ncbi Food consumption and nutrient intake in day care and at home in 3-year-old Finnish children
    Jenni Lehtisalo
    Department of Lifestyle and Participation, Nutrition Unit, National Institute for Health and Welfare, PO Box 30, FI 00271, Helsinki, Finland
    Public Health Nutr 13:957-64. 2010
    ..To assess and compare the food consumption and nutrient intake between 3-year-old children cared for at home full-time and those attending day care outside the home. Nutrient intake on weekdays and weekends was also studied...
  23. ncbi Expansion of CD4+CD25+FOXP3+ regulatory T cells in infants of mothers with type 1 diabetes
    Kristiina Luopajarvi
    Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Pediatr Diabetes 13:400-7. 2012
    ..Reduced risk for type 1 diabetes (T1D) has been reported in the offspring of mothers with T1D when compared with children of affected fathers...
  24. ncbi Sociodemographic determinants of early weaning: a Finnish birth cohort study in infants with human leucocyte antigen-conferred susceptibility to type 1 diabetes
    Maijaliisa Erkkola
    Division of Nutrition, Department of Food and Environmental Sciences, PO Box 66, FI 00014 University of Helsinki, Helsinki, Finland
    Public Health Nutr 16:296-304. 2013
    ..To assess the most important sociodemographic determinants of age at introduction of complementary foods in infancy...
  25. ncbi Maternal consumption of dairy products during pregnancy and lactation, and the development of cow's milk antibodies in the offspring
    Maijaliisa Erkkola
    Department of Epidemiology and Health Promotion, Nutrition Unit, National Public Health Institute, Helsinki, Finland
    Acta Paediatr 94:696-704. 2005
    ..The milk and milk products taken by the mother differed in their impact on the emerging CM antibody response in the offspring...
  26. ncbi Prediction of type 1 diabetes in the general population
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Diabetes Care 33:1206-12. 2010
    ..To evaluate the utility of GAD antibodies (GADAs) and islet antigen-2 antibodies (IA-2As) in prediction of type 1 diabetes over 27 years in the general population and to assess the 6-year rates of seroconversion...
  27. ncbi Environmental factors in the etiology of type 1 diabetes
    Hans K Akerblom
    University of Helsinki, Finland
    Am J Med Genet 115:18-29. 2002
    ..Among toxins, N-nitroso compounds are the main candidates. An interaction of genetic and environmental factors is important in evaluating the possible role of a certain environmental factor in the etiology of type 1 diabetes...
  28. ncbi IL-17 immunity in human type 1 diabetes
    Jarno Honkanen
    Immune Response Unit, National Institute for Health and Welfare, Helsinki, Finland
    J Immunol 185:1959-67. 2010
    ..Our findings highlight the role of IL-17 immunity in the pathogenesis of human T1D and point to a potential therapeutic strategy...
  29. ncbi Breastfeeding patterns of mothers with type 1 diabetes: results from an infant feeding trial
    Susa Sorkio
    Nutrition Unit, National Institute for Health and Welfare, Helsinki, Finland
    Diabetes Metab Res Rev 26:206-11. 2010
    ..The aim of this study was to prospectively examine the breastfeeding patterns among mothers with and without T1D participating in a large international randomized infant feeding trial (TRIGR)...
  30. ncbi Cow milk is not responsible for most gastrointestinal immune-like syndromes--evidence from a population-based study
    Laura Paajanen
    Foundation for Nutrition Research, Helsinki, Finland
    Am J Clin Nutr 82:1327-35. 2005
    ..CONCLUSIONS: In an unselected cohort of young adults, 8% reported food-related gastrointestinal symptoms. The finding of immunologic activity implied the existence of a food-related gastrointestinal syndrome but not one induced by CM...
  31. ncbi Some similarities in dietary clusters of pre-school children and their mothers
    Marja Leena Ovaskainen
    Nutrition Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, Helsinki, Finland
    Br J Nutr 102:443-52. 2009
    ..The diets of pre-school children vary by age and only a slight similarity within dietary clusters of mother-child pairs was observed...
  32. ncbi Early nutrition and later diabetes risk
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, P.O. Box 281, FI-00029 HUCH, Helsinki, Finland
    Adv Exp Med Biol 569:142-50. 2005
    ....
  33. ncbi Models for predicting type 1 diabetes in siblings of affected children
    Samy Mrena
    Hospital for Children and Adolescents, University of Helsinki, P.O. Box 281, FI-00029 HUCH, Helsinki, Finland
    Diabetes Care 29:662-7. 2006
    ....
  34. ncbi Pathogenesis of type 1 diabetes: implications for incidence trends
    Mikael Knip
    Hospital for Children, University of Helsinki and Helsinki University Central Hospital, and Folkhälsan Research Center, Helsinki, Finland
    Horm Res Paediatr 76:57-64. 2011
    ....
  35. ncbi Altered phenotype of peripheral blood dendritic cells in pediatric type 1 diabetes
    Janne K Nieminen
    Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Diabetes Care 35:2303-10. 2012
    ..Altered numbers of blood DCs have been reported in type 1 diabetes (T1D). We aimed at characterizing the less well-known phenotypic properties of DCs in T1D...
  36. ncbi Environmental triggers and determinants of beta-cell autoimmunity and type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Rev Endocr Metab Disord 4:213-23. 2003
  37. ncbi Agreement between parental reports and patient records in food allergies among infants and young children in Finland
    Jetta Tuokkola
    Department of Public Health, University of Helsinki, Finland
    J Eval Clin Pract 14:984-9. 2008
    ..The aim of the present study was to validate a study questionnaire by comparing children's use of special diets as reported by parents with patient records at the hospital...
  38. ncbi Autoimmune mechanisms in type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Autoimmun Rev 7:550-7. 2008
    ....
  39. ncbi Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes
    Johanna Rinta-Valkama
    Biomedicum Helsinki, Department of Bacteriology and Immunology, University of Helsinki, Finland
    Diabetes Metab Res Rev 23:119-26. 2007
    ....
  40. ncbi Poor in vitro induction of FOXP3 and ICOS in type 1 cytokine environment activated T-cells from children with type 1 diabetes
    Jarno Honkanen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Diabetes Metab Res Rev 24:635-41. 2008
    ..We set out to study whether an impaired induction of regulatory mechanisms during the generation of T-cell responses upon stimulation is associated with T1D...
  41. ncbi Sucrose in the diet of 3-year-old Finnish children: sources, determinants and impact on food and nutrient intake
    Maijaliisa Erkkola
    Unit of Nutrition, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Br J Nutr 101:1209-17. 2009
    ..The rationale for the recommendation to reduce the intake of refined sugars to ensure adequate intakes of nutrients seems reasonable...
  42. ncbi Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children
    Anna Parkkola
    Corresponding author Mikael Knip
    Diabetes Care 36:348-54. 2013
    ..Autoantibody profiles are similar in familial and sporadic type 1 diabetes, suggesting similar pathogenetic mechanisms...
  43. ncbi Human parechoviruses are frequently detected in stool of healthy Finnish children
    Pekka Kolehmainen
    Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
    J Clin Virol 54:156-61. 2012
    ..Human parechoviruses (HPeVs) are common viruses mainly infecting young children. Most infections are mild, but HPeV3 causes severe CNS infections in new-born infants...
  44. ncbi Anti-insulin activity in IgG-fractions from children with newly-diagnosed type 1 diabetes and negative for insulin autoantibodies
    Minna Tiittanen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Autoimmunity 37:45-9. 2004
    ..Our results suggest that formation of immune complexes results in false negative results in tests for IAA but not for GADA...
  45. ncbi The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up
    H K Akerblom
    Hospital for Children and Adolescents, University of Helsinki, Biomedicum Helsinki 2 U, PO Box 20, 00014, Helsinki, Finland
    Diabetologia 54:627-33. 2011
    ..The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study was designed to establish whether weaning to a highly hydrolysed formula in infancy subsequently reduces the risk of type 1 diabetes...
  46. ncbi Natural course of preclinical type 1 diabetes
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Horm Res 57:6-11. 2002
    ..This indicates that the early prediabetic process may be a suitable target for immunomodulation aimed at delaying or preventing progression to clinical diabetes...
  47. ncbi Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland
    Mira Meriluoto
    University of Helsinki, Helsinki, Finland
    Emerg Infect Dis 18:264-71. 2012
    ....
  48. ncbi Insulin-related metabolic changes during treatment with valproate in patients with epilepsy
    Virpi Pylvänen
    Department of Neurology, University of Oulu, Oulu, and Hospital for Children and Adolescents, Helsinki, Finland
    Epilepsy Behav 8:643-8. 2006
    ....
  49. ncbi Nutritional risk predictors of beta cell autoimmunity and type 1 diabetes at a young age
    Suvi M Virtanen
    Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Am J Clin Nutr 78:1053-67. 2003
    ..The availability of good markers of preclinical type 1 diabetes and of genetic risk have decreased the sample sizes needed and made longitudinal cohort studies of the assessment of children's diets feasible...
  50. ncbi A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study
    Minna Kiviniemi
    Immunogenetics Laboratory and MediCity Research Laboratory, University of Turku, Finland
    Diabetes Technol Ther 9:460-72. 2007
    ..Also, a simple, low-cost, and fast screening system was essential for the primary step of the risk assessment including thousands of samples...
  51. ncbi Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child
    Liisa Uusitalo
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Am J Clin Nutr 88:458-64. 2008
    ..Type 1 diabetes may have its origins in the fetal period of life. Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes...
  52. ncbi Autoimmunity and familial risk of type 1 diabetes
    Anu Maaria Hämäläinen
    Department of Pediatrics, Jorvi Hospital, Helsinki University Hospital, Turuntie 150, Espoo FIN 02740, Finland
    Curr Diab Rep 2:347-53. 2002
    ..The possible protective or predisposing effect of diabetes-associated antibodies detectable at birth on progression to clinical type I diabetes later will be assessed in ongoing prospective birth cohort studies...
  53. ncbi Should we screen for risk of type 1 diabetes?
    Mikael Knip
    Diabetes Care 31:622-3. 2008
  54. ncbi Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility
    Satu Simell
    The JDRF Center for Prevention of Type I Diabetes in Finland, University of Turku, and Tampere University Hospital, Finland
    Scand J Gastroenterol 40:1182-91. 2005
    ..The aim of this study was to investigate the sequence of events leading to overt CD by retrospective analysis of TGA values in serum samples collected frequently from genetically susceptible children since birth or early childhood...
  55. ncbi Circulating CD4+CD25 high regulatory T cells and natural killer T cells in children with newly diagnosed type 1 diabetes or with diabetes-associated autoantibodies
    Viveka Oling
    University of Turku, Immunogenetics Laboratory, Medicity Biocity 4th floor, Tykistokatu 6 A, 20520 Turku, Finland
    Ann N Y Acad Sci 1107:363-72. 2007
    ..002). Our data might be interpreted as indicative of an intensified regulatory response of regulatory T cells and NKT cells during the preclinical phase of the disease...
  56. ncbi Seven distinct dietary patterns identified among pregnant Finnish women--associations with nutrient intake and sociodemographic factors
    Tuula Arkkola
    Department of Paediatrics, PO Box 5000, 90014 University of Oulu, Oulu, Finland
    Public Health Nutr 11:176-82. 2008
    ..To identify and describe dietary patterns in a cohort of pregnant women and investigate whether the dietary patterns are associated with dietary intake and sociodemographic factors...
  57. ncbi Fate of five celiac disease-associated antibodies during normal diet in genetically at-risk children observed from birth in a natural history study
    Satu Simell
    JDRF Center for Prevention of Type 1 Diabetes in Finland, and Department of Pediatrics, University of Turku, Turku, Finland
    Am J Gastroenterol 102:2026-35. 2007
    ....
  58. ncbi ISPAD Clinical Practice Consensus Guidelines 2006-2007. Other complications and associated conditions
    Olga Kordonouri
    Pediatr Diabetes 8:171-6. 2007
  59. ncbi Vitamin D receptor polymorphisms: no association with type 1 diabetes in the Finnish population
    Hannu Turpeinen
    JDRF Centre for Prevention of Type 1 Diabetes in Finland and Department of Virology, University of Turku, Turku, Finland
    Eur J Endocrinol 149:591-6. 2003
    ..Several findings on positive disease associations have been observed and, in addition, a protective effect of vitamin D supplementation has been reported...
  60. ncbi Androgen receptor gene exon 1 CAG repeat polymorphism in Finnish patients with childhood-onset type 1 diabetes
    Zsofia Gombos
    JDRF Centre for Prevention of Type 1 Diabetes in Finland, Turku, Finland
    Eur J Endocrinol 149:597-600. 2003
    ..The aim of this study was to investigate the effect of the human androgen receptor gene exon 1 CAG repeat polymorphisms on type 1 diabetes (T1D) susceptibility...
  61. ncbi Cow's milk antibodies in patients with newly diagnosed type 1 diabetes: primary or secondary?
    Mikael Knip
    Pediatr Diabetes 4:155-6. 2003
  62. ncbi Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: results from the EPIVIR project
    Hanna Viskari
    JDRF Center for Prevention of Type 1 Diabetes, Finland
    J Med Virol 72:610-7. 2004
    ....
  63. ncbi Geographical variation in risk HLA-DQB1 genotypes for type 1 diabetes and signs of beta-cell autoimmunity in a high-incidence country
    Marika Kukko
    Juvenile Diabetes Research Foundation Center for the Prevention of Type 1 Diabetes in Finland, Tampere, Finland
    Diabetes Care 27:676-81. 2004
    ..To assess possible differences in the frequency of HLA-DQB1 risk genotypes and the emergence of signs of beta-cell autoimmunity among three geographical regions in Finland...
  64. ncbi A linkage study of 12 IDDM susceptibility loci in the Finnish population
    Antti Pekka Laine
    JDRF Centre for Prevention of Type 1 Diabetes in Finland, Department of Virology, University of Turku, Turku, Finland
    Diabetes Metab Res Rev 20:144-9. 2004
    ..Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D development...
  65. ncbi [The criteria for good care of children and adolescents with diabetes]
    Jorma Komulainen
    KYS Lastenklinikka PL 1777, 70211 Kuoplo
    Duodecim 120:1135-7. 2004
  66. ncbi [Is diabetes mellitus, type I an autoimmune disease and can we prevent its onset?]
    Mikael Knip
    HYKS Lasten ja nuorten sairaala PL 281, 00029 HUS
    Duodecim 120:1158-65. 2004
  67. ncbi Detection of autoantibodies to protein tyrosine phosphatase-like protein IA-2 with a novel time-resolved fluorimetric assay
    Annette Westerlund-Karlsson
    Department of Biochemistry and Pharmacy, Abo Akademi University, FIN 20521 Turku, Finland
    Clin Chem 49:916-23. 2003
    ....
  68. ncbi Increased frequency of islet cell antibodies in unaffected brothers of children with type 1 diabetes
    Vesa Eskola
    University of Tampere Medical School and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Horm Res 59:195-200. 2003
    ..Accordingly, judged from demographic characteristics, the yield of ICA screening in first-degree relatives would be maximized by targeting young brothers of affected cases...
  69. ncbi Genetic risk determines the emergence of diabetes-associated autoantibodies in young children
    Antti Kupila
    Department of Pediatrics, The Juvenile Diabetes Research Foundation Center for Prevention of Type 1 Diabetes in Finland, University of Turku, Turku, Finland
    Diabetes 51:646-51. 2002
    ..Seroconversion to multiple autoantibody positivity usually occurred tightly clustered in time...
  70. ncbi Can we predict type 1 diabetes in the general population?
    Mikael Knip
    Diabetes Care 25:623-5. 2002
  71. ncbi Autoantibodies to GAD, IA-2 and insulin in ICA-positive first-degree relatives of children with type 1 diabetes: a comparison between parents and siblings
    Sari Korhonen
    Department of Pediatrics, University of Oulu, Oulu, Finland
    Diabetes Metab Res Rev 18:43-8. 2002
    ..We conclude that ICA immunofluorescence is not only due to GADA and IA-2A, but there are other additional antigens contributing to the ICA reactivity. Antibodies to such antigens appear to be more common among adults than in children...
  72. ncbi Prevalence and fate of type 1 diabetes-associated autoantibodies in cord blood samples from newborn infants of non-diabetic mothers
    Anu Maaria Hämäläinen
    Department of Paediatrics, University of Oulu, Oulu, Finland
    Diabetes Metab Res Rev 18:57-63. 2002
    ..Cord blood samples were collected from 1002 consecutive births at Turku University Hospital to study the prevalence and fate of type 1 diabetes-associated autoantibodies in newborn infants of unaffected mothers...
  73. ncbi Estimation of genetic risk for type 1 diabetes
    Jorma Ilonen
    Institute of Microbiology and Pathology, University of Turku, Finland
    Am J Med Genet 115:30-6. 2002
    ..The efficiency of the procedure has also been tested in Finnish and Greek populations...
  74. ncbi Lack of physiological suppression of circulating IGFBP-1 in puberty in patients with insulin-dependent diabetes mellitus
    Päivi H Riihimaa
    Department of Pediatrics, Oulu University Hospital, Oulu, Finland
    Eur J Endocrinol 147:235-41. 2002
    ..To evaluate the interaction between serum free insulin, insulin-like binding protein (IGFBP)-1 and leptin concentrations during puberty in insulin-dependent diabetes mellitus (IDDM)...
  75. ncbi Enterovirus infections are associated with the induction of beta-cell autoimmunity in a prospective birth cohort study
    Kimmo Salminen
    Juvenile Diabetes Research Foundation Center for Prevention of Type 1 Diabetes in Finland
    J Med Virol 69:91-8. 2003
    ..The present results imply that enterovirus infections are associated with the appearance of beta-cell autoantibodies. A possible causal relationship is supported by the clustering of infections to the time when autoantibodies appeared...
  76. ncbi A simulation model for estimating direct costs of type 1 diabetes prevention
    Jarmo Hahl
    Department of Economics, Turku School of Economics and Business Administration, Turku, Finland
    Pharmacoeconomics 21:295-303. 2003
    ....
  77. ncbi Distinct idiotypes of insulin autoantibody in autoimmune polyendocrine syndrome type 2 and childhood onset type 1 diabetes
    Devasenan Devendra
    Department of University Medicine, Peninsula Medical School, Plymouth PL6 8DH, United Kingdom
    J Clin Endocrinol Metab 89:5266-70. 2004
    ....
  78. ncbi [Stiff person syndrome]
    Laura Airas
    TYKS:n neurologian klinikka, Turku
    Duodecim 120:1899-902. 2004
  79. ncbi Human leukocyte antigen non-class II determinants for type 1 diabetes in the Finnish population
    Zsofia Gombos
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Hum Immunol 67:714-21. 2006
    ..Another locus close to D6S273 may also have an effect. For the first time we report that a locus near the C143 marker appear to affect disease association of the DRB1*08-DQB1*04 haplotype...
  80. ncbi Parental reactions to information about increased genetic risk of type 1 diabetes mellitus in infants
    Paula Simonen
    Department of Psychology, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland
    Arch Pediatr Adolesc Med 160:1131-6. 2006
    ..CONCLUSIONS: Learning about their infant's genetic diabetes mellitus risk induces only mild anxiety in most parents. Identifying the few parents with stronger anxiety helps focus intensified counseling...
  81. ncbi Time-resolved fluorescence imaging of islet cell autoantibodies
    Pauli Vuorinen
    The JDRF Center for the Prevention of Type I Diabetes in Finland, and University of Turku, Department of Pediatrics, Lemminkaisenkatu 14 18 A 5 krs, 20520 Turku, Finland
    Ann N Y Acad Sci 1079:226-8. 2006
    ..We now describe the TRFI as a method and its application for measurement of ICA...
  82. ncbi Signs of beta-cell autoimmunity in nondiabetic schoolchildren: a comparison between Russian Karelia with a low incidence of type 1 diabetes and Finland with a high incidence rate
    Anita Kondrashova
    Department of Virology, University of Tampere Medical School, Tampere, Finland
    Diabetes Care 30:95-100. 2007
    ..We sought to study the prevalence of autoantibodies to various islet cell antigens in the background population of two neighboring countries with a sixfold difference in the incidence of type 1 diabetes...
  83. ncbi Human parechovirus 1 infections in young children--no association with type 1 diabetes
    Sisko Tauriainen
    JDRF Center for Prevention of Type 1 Diabetes, Tampere, Finland
    J Med Virol 79:457-62. 2007
    ..No difference was found in infection frequency between boys and girls, nor between prediabetic, diabetic and control subjects. Most infections (87%) occurred during autumn, winter and spring...
  84. ncbi Ketoacidosis at diagnosis of type 1 diabetes in children in northern Finland: temporal changes over 20 years
    Anne Hekkala
    Department of Pediatrics, University of Oulu, Oulu University Hospital, Oulu, Finland
    Diabetes Care 30:861-6. 2007
    ..To study the frequency of diabetic ketoacidosis (DKA) over a 20-year period among children diagnosed with type 1 diabetes in northern Finland...
  85. ncbi Maternal antibodies in breast milk protect the child from enterovirus infections
    Karita Sadeharju
    Department of Virology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Pediatrics 119:941-6. 2007
    ..We set out to assess whether breastfeeding can protect against these infections and whether such an effect is related to maternal antibodies in breast milk or in the peripheral circulation of the infant...
  86. ncbi Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations
    Antti Pekka Laine
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Dis Markers 23:139-45. 2007
    ..These observations suggest that heterogeneity between the protective IDDM2 lineages could exist, and analyzing both -23HphI and -2221MspI would thus potentially enhance the sensitivity and specificity of type 1 diabetes risk estimation...
  87. ncbi Early epitope- and isotype-specific humoral immune responses to GAD65 in young children with genetic susceptibility to type 1 diabetes
    Matti S Ronkainen
    Department of Pediatrics, University of Oulu, Oulu, Finland
    Eur J Endocrinol 155:633-42. 2006
    ..A narrow initial IgG subclass response to GAD65 and the emergence of IgG4 antibodies were characteristic of those who remained non-diabetic over the first few years of GAD65 autoimmunity...
  88. ncbi Circulating antibodies to nephrin in patients with type 1 diabetes
    Petri Aaltonen
    Biomedicum, MolecularMedicine, PB 63, 00014 University of Helsinki, Finland
    Nephrol Dial Transplant 22:146-53. 2007
    ..Since circulating antibodies to nephrin have been shown to cause proteinuria, we wanted to test whether such autoantibodies can be detected in diabetic patients...
  89. ncbi IA-2 antibody epitopes and isotypes during the prediabetic process in siblings of children with type 1 diabetes
    Sanna Hoppu
    Pediatric Research Center, University of Tampere, and Tampere University Hospital, Tampere, Finland
    J Autoimmun 23:361-70. 2004
    ..This study demonstrates that JM-reactive IA-2 antibodies are associated with an increased risk of progression to overt T1D, whereas an IgE response to IA-2 confers relative protection against clinical disease...
  90. ncbi Absence of avidity maturation of autoantibodies to the protein tyrosine phosphatase-like IA-2 molecule and glutamic acid decarboxylase (GAD65) during progression to type 1 diabetes
    Annette Westerlund
    Department of Biochemistry and Pharmacy, Abo Akademi University, Tykistokatu 6, FIN 20520 Turku, Finland
    J Autoimmun 24:153-67. 2005
    ..Our results indicate that the analysis of the avidity index levels of IA-2A and GADA does not improve the accuracy of the prediction of type 1 diabetes based on autoantibody detection...
  91. ncbi A six-fold gradient in the incidence of type 1 diabetes at the eastern border of Finland
    Anita Kondrashova
    Juvenile Diabetes Research Foundation, Center for Prevention of Type 1 Diabetes, Finland
    Ann Med 37:67-72. 2005
    ..This suggests that environmental factors contribute to this steep difference in the incidence rate between these adjacent regions...
  92. ncbi Familial clustering of beta-cell autoimmunity in initially non-diabetic children
    Marika Kukko
    JDRF Centre for the Prevention of Type 1 Diabetes in Finland
    Diabetes Metab Res Rev 22:53-8. 2006
    ..The HLA-DQB1 genotypes are more often identical in siblings with autoantibodies than in other siblings...
  93. ncbi Lack of association of PAX4 gene with type 1 diabetes in the Finnish and Hungarian populations
    Robert Hermann
    Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN 20520 Turku, Finland
    Diabetes 54:2816-9. 2005
    ..The strong coherence between the datasets of the two ethnic groups studied with highly contrasting disease incidence, socioeconomic characteristics, and profoundly diverse environment emphasizes the impact of this finding...
  94. ncbi GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects
    Viveka Oling
    Department of Virology, University of Turku, MediCity, Biocity 4 krs, Tykistokatu 6 A, 20520 Turku, Finland
    J Autoimmun 25:235-43. 2005
    ..In conclusion, type 1 diabetes patients and at-risk subjects have a significantly higher prevalence of GAD65- and proinsulin-specific CD4(+) T-cells than the control subjects...
  95. ncbi Soluble adhesion molecules in young children with signs of beta-cell autoimmunity--prospective follow-up from birth
    Anna M Toivonen
    JDRF Centre for Prevention of Type 1 Diabetes in Finland, Finland
    Diabetes Metab Res Rev 22:176-83. 2006
    ....
  96. ncbi Serum alpha-tocopherol concentrations and risk of type 1 diabetes mellitus: a cohort study in siblings of affected children
    Liisa Uusitalo
    Tampere School of Public Health, University of Tampere, Finland
    J Pediatr Endocrinol Metab 18:1409-16. 2005
    ..08 and 0.09, respectively). Although the results did not reach statistical significance, they support the hypothesis that high alpha-tocopherol levels may protect against DM1...
  97. ncbi Age-specific levels of diabetes-related GAD and IA-2 antibodies in healthy children and adults
    Olga Kordonouri
    Children s Hospital, Otto Heubner Centrum, Charite, Humboldt University, Berlin, Germany
    J Pediatr Endocrinol Metab 15:47-52. 2002
    ..027 (at least one antibody elevated). These data emphasize the importance of establishing age-specific reference values for DM-related antibodies in the background population before applying them for screening and intervention studies...

Research Grants1

  1. Identification of Biomarkers of Autoimmunity in T1D by Novel Tools
    Mikael Knip; Fiscal Year: 2007
    ....