M Kivipelto

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. pmc Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
    M Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    BMJ 322:1447-51. 2001
  2. ncbi Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study
    M Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, Finland
    Neurology 56:1683-9. 2001
  3. ncbi Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: potential for pharmacological intervention
    Miia Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    CNS Drugs 16:435-44. 2002
  4. ncbi Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
    Miia Kivipelto
    University of Kuopio, Department of Neuroscience and Neurology, PO Box 1627, 70211 Kuopio, Finland
    Ann Intern Med 137:149-55. 2002
  5. doi Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study
    M Rusanen
    Department of Neurology, University of Eastern Finland, Kuopio, Finland
    Dement Geriatr Cogn Disord 30:277-84. 2010
  6. pmc A voxel based morphometry study on mild cognitive impairment
    C Pennanen
    Department of Neurology, Bldg 5, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland
    J Neurol Neurosurg Psychiatry 76:11-4. 2005
  7. doi Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study
    A Hämäläinen
    Department of Neuroscience and Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio, Finland
    Neurodegener Dis 5:186-9. 2008
  8. ncbi Midlife income, occupation, APOE status, and dementia: a population-based study
    T Anttila
    Department of Public Health and General Practice, University of Kuopio, Kuopio, Japan
    Neurology 59:887-93. 2002
  9. doi Lipid-lowering treatment is related to decreased risk of dementia: a population-based study (FINRISK)
    A Solomon
    Department of Neurology, University of Kuopio, PO Box 1627, FI 70211 Kuopio, Finland
    Neurodegener Dis 7:180-2. 2010
  10. ncbi Usefulness of repeated presentation of Mini-Mental State Examination as a diagnostic procedure--a population-based study
    E L Helkala
    Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    Acta Neurol Scand 106:341-6. 2002

Detail Information

Publications47

  1. pmc Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
    M Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    BMJ 322:1447-51. 2001
    ..To examine the relation of midlife raised blood pressure and serum cholesterol concentrations to Alzheimer's disease in later life...
  2. ncbi Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study
    M Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, Finland
    Neurology 56:1683-9. 2001
    ....
  3. ncbi Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: potential for pharmacological intervention
    Miia Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    CNS Drugs 16:435-44. 2002
    ..Based on these data, we propose that proper, early interventions aimed at reducing these cardiovascular risk factors may have an impact on the future incidence and prevalence of Alzheimer's disease...
  4. ncbi Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
    Miia Kivipelto
    University of Kuopio, Department of Neuroscience and Neurology, PO Box 1627, 70211 Kuopio, Finland
    Ann Intern Med 137:149-55. 2002
    ..Elevated midlife values for total cholesterol level and blood pressure have been implicated recently as risk factors for Alzheimer disease...
  5. doi Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study
    M Rusanen
    Department of Neurology, University of Eastern Finland, Kuopio, Finland
    Dement Geriatr Cogn Disord 30:277-84. 2010
    ..To elucidate the effect of midlife smoking on the risk of dementia and Alzheimer's disease (AD), and the possible modification of this relation by the apolipoprotein E (APOE) ε4...
  6. pmc A voxel based morphometry study on mild cognitive impairment
    C Pennanen
    Department of Neurology, Bldg 5, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland
    J Neurol Neurosurg Psychiatry 76:11-4. 2005
    ..A number of volumetric magnetic resonance imaging (MRI) studies have detected atrophy of the medial temporal lobe in subjects with MCI, but for the other cerebral regions the results have been inconsistent...
  7. doi Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study
    A Hämäläinen
    Department of Neuroscience and Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio, Finland
    Neurodegener Dis 5:186-9. 2008
    ..The apolipoprotein E (APOE) epsilon4 allele is a risk factor for Alzheimer's disease. Earlier studies have shown differences in brain structure according to the APOE epsilon4 status...
  8. ncbi Midlife income, occupation, APOE status, and dementia: a population-based study
    T Anttila
    Department of Public Health and General Practice, University of Kuopio, Kuopio, Japan
    Neurology 59:887-93. 2002
    ..To examine the relationship between socioeconomic factors and APOE carrier status on the development of dementia...
  9. doi Lipid-lowering treatment is related to decreased risk of dementia: a population-based study (FINRISK)
    A Solomon
    Department of Neurology, University of Kuopio, PO Box 1627, FI 70211 Kuopio, Finland
    Neurodegener Dis 7:180-2. 2010
    ..Several lines of evidence have linked cholesterol to dementia...
  10. ncbi Usefulness of repeated presentation of Mini-Mental State Examination as a diagnostic procedure--a population-based study
    E L Helkala
    Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    Acta Neurol Scand 106:341-6. 2002
    ..The MMSE was presented again...
  11. ncbi Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study
    A Solomon
    Department of Neuroscience and Neurology, University of Kuopio, Finland
    Neurology 68:751-6. 2007
    ..Longitudinal studies have shown that high serum total cholesterol (TC) at midlife is a risk factor for dementia/Alzheimer disease. The significance of TC later in life is unclear...
  12. ncbi Serum total cholesterol, statins and cognition in non-demented elderly
    A Solomon
    Department of Neurology, University of Kuopio, P O Box 1627 FIN 70211, Kuopio, Finland
    Neurobiol Aging 30:1006-9. 2009
    ..The association between serum total cholesterol (TC), lipid-lowering drugs and cognition in the elderly is currently controversial...
  13. ncbi Decreased brain creatine levels in elderly apolipoprotein E epsilon 4 carriers
    M P Laakso
    Department of Neurology, Clinical Radiology, Kuopio University Hospital, Kuopio, Finland
    J Neural Transm 110:267-75. 2003
    ..These findings may be of significant clinical interest as potential indicator of incipient AD, and also from therapeutical point of view given the potential neuroprotective effects of creatine...
  14. doi Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study
    B Hooshmand
    Aging Research Center, KarolinskaInstitutet, Stockholm, Sweden
    J Intern Med 271:204-12. 2012
    ....
  15. ncbi Advances in the prevention of Alzheimer's disease and dementia
    A Solomon
    Karolinska Institutet Alzheimer Disease Research Center KI ADRC, Stockholm, Sweden Department of Neurology, University of Eastern Finland, Kuopio, Finland
    J Intern Med 275:229-50. 2014
    ..The shift towards presymptomatic and pre-dementia stages of AD has brought prevention and treatment trials much closer to each other than before...
  16. ncbi Serum testosterone levels in males with Alzheimer's disease
    C Pennanen
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    J Neuroendocrinol 16:95-8. 2004
    ..These data provide no support for hypotheses of (disproportionally) decreased levels of serum testosterone in AD. These data also show that all cognitively normal controls had an FAI below the normal range...
  17. ncbi Carotid intima-media thickness and cognitive function in elderly women: a population-based study
    Pirjo Komulainen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Neuroepidemiology 28:207-13. 2007
    ..We investigated whether carotid intima-media thickness (IMT) predicts the risk of cognitive impairment and whether the putative impairment is specific for some cognitive domains...
  18. ncbi Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women
    Pirjo Komulainen
    Kuopio Research Institute of Exercise Medicine, Department of Physiology, University of Kuopio, Kuopio, Finland
    Dement Geriatr Cogn Disord 23:29-34. 2007
    ..To test the hypothesis that metabolic syndrome predicts cognitive impairment, and to examine the association of single metabolic risk factors with cognitive functioning...
  19. ncbi MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study
    Tero Tapiola
    Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
    Neurobiol Aging 29:31-8. 2008
    ..The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD...
  20. ncbi Alcohol drinking and cognitive functions: findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) Study
    Tiia Ngandu
    Aging Research Center ARC, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 23:140-9. 2007
    ..Little is known about the effects of midlife alcohol drinking on the cognitive functions later in life...
  21. ncbi Serum high sensitivity C-reactive protein and cognitive function in elderly women
    Pirjo Komulainen
    Kuopio Research Institute of Exercise Medicine, Finland
    Age Ageing 36:443-8. 2007
    ..Inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function...
  22. ncbi Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment
    Anne Hämäläinen
    Department of Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, and Kuopio University Hospital, Finland
    Neuroimage 37:1122-31. 2007
    ..We conclude that widespread cortical atrophy is present already two and a half years before a clinical diagnosis of dementia can be set...
  23. ncbi Work-related physical activity and the risk of dementia and Alzheimer's disease
    Suvi Rovio
    Aging Research Center, NVS, Karolinska Institutet, Stockholm, Sweden
    Int J Geriatr Psychiatry 22:874-82. 2007
    ..This study aimed to clarify the association between work-related physical activity and dementia/AD...
  24. ncbi Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders
    Marjan Shafaati
    Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Neurosci Lett 425:78-82. 2007
    ..The levels of apoE in cerebrospinal fluid were also correlated to the levels of Tau and the possibility is discussed that the level of apoE in cerebrospinal fluid may be used as a marker of neurodegeneration...
  25. doi A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease
    Taru Tukiainen
    Computational Medicine Research Group, Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, P O Box 9203, FI 02015 HUT, Finland
    Biochem Biophys Res Commun 375:356-61. 2008
    ..The analyses also feature the role of elevated glycoproteins in the risk for AD, supporting the view that coexistence of inflammation and the MetS forms a high risk condition for cognitive decline...
  26. ncbi Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study
    Miia Kivipelto
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 5:735-41. 2006
    ..Several vascular risk factors are associated with dementia. We sought to develop a simple method for the prediction of the risk of late-life dementia in people of middle age on the basis of their risk profiles...
  27. ncbi Rethinking the dementia diagnoses in a population-based study: what is Alzheimer's disease and what is vascular dementia?. A study from the kungsholmen project
    Hedda Aguero-Torres
    Aging Research Center ARC, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 22:244-9. 2006
    ..To explore the hypothesis that older adults often are affected by more than one disease, making the differential diagnosis between Alzheimer's disease (AD) and vascular dementia (VaD) difficult...
  28. pmc Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study
    Tiia Anttila
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Box 6401, 11382 Stockholm, Sweden
    BMJ 329:539. 2004
    ..To evaluate the relation between midlife alcohol consumption and mild cognitive impairment and dementia in old age, and the possible modification of this relation by apolipoprotein E...
  29. ncbi Utilization of cognitive support in episodic free recall as a function of apolipoprotein E and vitamin B12 or folate among adults aged 75 years and older
    David Bunce
    Department of Psychology, Goldsmiths College, University of London, London, United Kingdom
    Neuropsychology 18:362-70. 2004
    ..A similar, but nonsignificant, trend was evident in relation to folate. The research is discussed with reference to vulnerability models and genetic influences on brain reserves...
  30. ncbi Incidence and risk factors for mild cognitive impairment: a population-based three-year follow-up study of cognitively healthy elderly subjects
    Susanna Tervo
    Department of Neuroscience and Neurology, Brain Research Unit, Clinical Research Centre, Mediteknia, University of Kuopio, Kuopio, Finland
    Dement Geriatr Cogn Disord 17:196-203. 2004
    ..Both the apolipoprotein E (ApoE) epsilon4 allele and vascular factors have been associated with a higher risk for AD, recently they have also been linked to the risk of MCI...
  31. ncbi Serum lipids and hippocampal volume: the link to Alzheimer's disease?
    Henrike Wolf
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Ann Neurol 56:745-8. 2004
    ..This is compatible with protective effects of high-density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease...
  32. ncbi [Genetics of Alzheimer's disease]
    Mikko Hiltunen
    Kuopion yliopisto, Neurologian klinikka, Mediteknia
    Duodecim 120:2425-31. 2004
  33. ncbi Apolipoprotein E, B vitamins, and cognitive function in older adults
    David Bunce
    Department of Psychology, Goldsmiths College, University of London, London, SE14 6NW, UK
    J Gerontol B Psychol Sci Soc Sci 60:P41-8. 2005
    ..This finding was unrelated to incipient dementia up to 6 years following testing. The results are discussed with reference to the neuroanatomical reserves that epsilon4 carriers may possess...
  34. ncbi Statin therapy in Alzheimer's disease
    Miia Kivipelto
    Lancet Neurol 4:521-2. 2005
  35. ncbi Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
    Miia Kivipelto
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 62:1556-60. 2005
    ..Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascular risk factors on the development of dementia...
  36. ncbi Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
    Suvi Rovio
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 4:705-11. 2005
    ..The aim of our study was to investigate the association between leisure-time physical activity at midlife and the subsequent development of dementia and Alzheimer's disease (AD)...
  37. ncbi Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment?
    Valerio Leoni
    Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital in Huddinge, Stockholm, Sweden
    Neurosci Lett 397:83-7. 2006
    ..In patients with AD, the percentages of those with increased levels of 24OHC, tau and phospho tau were similar (55-67%). In this pilot study, we discuss the possibility that 24OHC may be a sensitive test for MCI...
  38. ncbi The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study
    Corina Pennanen
    Department of Neuroscience and Neurology, University of Kuopio, Canthia, Kuopio, Finland
    Dement Geriatr Cogn Disord 22:60-6. 2006
    ..In cases homozygous for the epsilon4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus...
  39. ncbi Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
    Corina Pennanen
    Department of Neuroscience and Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, P O Box 1627, FIN 70 211 Kuopio, Finland
    Neurobiol Aging 25:303-10. 2004
    ..Our results suggest that the ERC atrophy precedes hippocampal atrophy in AD. The ERC volume loss is dominant over the hippocampal volume loss in MCI, whereas more pronounced hippocampal volume loss appears in mild AD...
  40. ncbi Hypertension and white matter lesions of the brain
    Miia Kivipelto
    J Hypertens 20:387-9. 2002
  41. ncbi Memantine offers new possibilities for the treatment of VaD
    Bengt Winblad
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine and Geriatric Epidemiology, Huddinge University Hospital, 141 86 Stockholm, Sweden
    Lancet Neurol 1:469. 2002
  42. doi The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics
    Roy W Jones
    RICE The Research Institute for the Care of Older People, Royal United Hospital, Bath, United Kingdom
    Alzheimers Dement 4:145-53. 2008
    ....
  43. ncbi Acetylcholinesterase and its inhibition in Alzheimer disease
    Roger M Lane
    Novartis Neuroscience, Novartis Pharmaceuticals Corp, East Hanover, NJ 07936 1080, USA
    Clin Neuropharmacol 27:141-9. 2004
    ..If such differences between ChE-Is are shown to have clinical correlates, this may prompt reconsideration of the rationale and expectations of some agents in the long-term management of AD...
  44. doi The International Network on Public Health and Aging (INOPA): introducing a life course perspective to the public health agenda
    Ake Wahlin
    Department of Psychology, Stockholm University, 106 91, Stockholm, Sweden
    J Cross Cult Gerontol 23:97-105. 2008
    ....
  45. pmc Cerebral embolism and Alzheimer's disease
    Miia Kivipelto
    BMJ 332:1104-5. 2006
  46. ncbi High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice
    Atiqur Rahman
    Karolinska Institutet, Neurotec Department, Division of Experimental Geriatrics, Novum, Karolinska University Hospital, SE 14186 Huddinge, Sweden
    FEBS Lett 579:6411-6. 2005
    ..Our results suggest an interaction between dietary and genetic factors in the development of tauopathies, which can be relevant in humans, where the apoE4 isoform could have a lack of function as compared to other isoforms...
  47. pmc Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 7:812-26. 2008
    ..Dementia costs in developing countries are estimated to be US$73 billion yearly, but care demands social protection, which seems scarce in these regions...