Mikko Käenmäki

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice
    M Käenmäki
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    Br J Pharmacol 158:1884-94. 2009
  2. doi Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice
    Mikko Käenmäki
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    J Neurochem 114:1745-55. 2010
  3. doi Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice
    Anne Tammimäki
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, P O Box 56, 00014, Helsinki, Finland
    Psychopharmacology (Berl) 211:389-401. 2010
  4. doi Discovery of dopamine glucuronide in rat and mouse brain microdialysis samples using liquid chromatography tandem mass spectrometry
    Päivi Uutela
    Division of Pharmaceutical Chemistry, FI 00014 University of Helsinki, Helsinki, Finland
    Anal Chem 81:427-34. 2009
  5. doi Nitecapone reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats
    Oleg Kambur
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Finland
    Eur J Pain 15:732-40. 2011

Detail Information

Publications5

  1. pmc Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice
    M Käenmäki
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    Br J Pharmacol 158:1884-94. 2009
    ..Here we report the generation of a mouse line that expresses MB-COMT but not S-COMT. We compared the effects of deleting S-COMT only or both COMT forms on the pharmacokinetics of oral L-DOPA...
  2. doi Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice
    Mikko Käenmäki
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    J Neurochem 114:1745-55. 2010
    ..Inhibition of DAT had no effect on DA levels in either genotype. Therefore, we conclude that in the mouse, PFC COMT contributes about one half of the total DA clearance...
  3. doi Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice
    Anne Tammimäki
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, P O Box 56, 00014, Helsinki, Finland
    Psychopharmacology (Berl) 211:389-401. 2010
    ..Our aims were to assess the behavioral phenotype of S-COMT mutant mice and to clarify the role of MB-COMT in dopamine metabolism in different brain areas...
  4. doi Discovery of dopamine glucuronide in rat and mouse brain microdialysis samples using liquid chromatography tandem mass spectrometry
    Päivi Uutela
    Division of Pharmaceutical Chemistry, FI 00014 University of Helsinki, Helsinki, Finland
    Anal Chem 81:427-34. 2009
    ..Dopamine sulfate was not detected in the microdialysates(limit of detection 0.8 nM). The main metabolites of dopamine were dihydroxyphenylacetic acid (DOPAC,1200 nM) and homovanillic acid (HVA, 700 nM)...
  5. doi Nitecapone reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats
    Oleg Kambur
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Finland
    Eur J Pain 15:732-40. 2011
    ..Nitecapone reduced the symptoms of neuropathic pain after the SNL, which is in line with the earlier study. Our results suggest that nitecapone and other COMT inhibitors should be studied further in the treatment of neuropathic pain...