Peeter Karihtala

Summary

Affiliation: University of Oulu
Country: Finland

Publications

  1. doi request reprint Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis
    Peeter Karihtala
    Departments of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Histopathology 58:854-62. 2011
  2. doi request reprint Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype
    Peeter Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital, PO Box 22, 90029 Oulu, Finland
    Breast Cancer Res Treat 138:81-90. 2013
  3. pmc Oxidative stress and redox state-regulating enzymes have prognostic relevance in diffuse large B-cell lymphoma
    Pekka Peroja
    Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Oulu, Finland
    Exp Hematol Oncol 1:2. 2012
  4. pmc Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype
    P Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, PO Box 22, FIN 90029, Oulu, Finland
    Br J Cancer 106:344-7. 2012
  5. doi request reprint Long-term observational follow-up study of breast cancer diagnosed in women ≤40 years old
    Peeter Karihtala
    Department of Oncology and Radiotherapy, University of Oulu, PO Box 22, FIN 90029, Oulu University Hospital, Finland
    Breast 19:456-61. 2010
  6. ncbi request reprint Front-line bevacizumab in serous epithelial ovarian cancer: biomarker analysis of the FINAVAST trial
    Peeter Karihtala
    Department of Oncology and Radiotherapy, P O Box 22, FIN 90029 Oulu University Hospital, Finland
    Anticancer Res 30:1001-6. 2010
  7. ncbi request reprint Hyaluronan in breast cancer: correlations with nitric oxide synthases and tyrosine nitrosylation
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, PO Box 5000, FIN 90014, University of Oulu, Oulu, Finland
    J Histochem Cytochem 55:1191-8. 2007
  8. ncbi request reprint Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, PO Box 5000, FIN 90014 University of Oulu, Finland
    Eur J Cancer 42:2653-9. 2006
  9. doi request reprint DNA adduct 8-hydroxydeoxyguanosine, a novel putative marker of prognostic significance in ovarian carcinoma
    Peeter Karihtala
    Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Oulo, Finland
    Int J Gynecol Cancer 19:1047-51. 2009
  10. pmc Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas
    Peeter Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    BMC Cancer 11:262. 2011

Collaborators

Detail Information

Publications21

  1. doi request reprint Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis
    Peeter Karihtala
    Departments of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Histopathology 58:854-62. 2011
    ....
  2. doi request reprint Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype
    Peeter Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital, PO Box 22, 90029 Oulu, Finland
    Breast Cancer Res Treat 138:81-90. 2013
    ..002) in the whole cohort. The current results emphasize the increased role of EMT in TNBC and especially in basal-like breast cancers. These observations also support the role of studied parameters in tumour progression...
  3. pmc Oxidative stress and redox state-regulating enzymes have prognostic relevance in diffuse large B-cell lymphoma
    Pekka Peroja
    Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Oulu, Finland
    Exp Hematol Oncol 1:2. 2012
    ..abstract:..
  4. pmc Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype
    P Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, PO Box 22, FIN 90029, Oulu, Finland
    Br J Cancer 106:344-7. 2012
    ..8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most abundant marker of DNA damage and it reflects oxidative stress. Human 8-oxoguanine glycosylase (hOGG1) is a DNA-repair enzyme that participates in 8-oxodG removal...
  5. doi request reprint Long-term observational follow-up study of breast cancer diagnosed in women ≤40 years old
    Peeter Karihtala
    Department of Oncology and Radiotherapy, University of Oulu, PO Box 22, FIN 90029, Oulu University Hospital, Finland
    Breast 19:456-61. 2010
    ..This study revealed a high relapse rate in the youngest women as early as during the first few years after diagnosis, although their prognosis as a whole was surprisingly good...
  6. ncbi request reprint Front-line bevacizumab in serous epithelial ovarian cancer: biomarker analysis of the FINAVAST trial
    Peeter Karihtala
    Department of Oncology and Radiotherapy, P O Box 22, FIN 90029 Oulu University Hospital, Finland
    Anticancer Res 30:1001-6. 2010
    ..Potential tissue and serum biomarkers were assessed for predicting efficacy of bevacizumab in ovarian cancer (OC)...
  7. ncbi request reprint Hyaluronan in breast cancer: correlations with nitric oxide synthases and tyrosine nitrosylation
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, PO Box 5000, FIN 90014, University of Oulu, Oulu, Finland
    J Histochem Cytochem 55:1191-8. 2007
    ....
  8. ncbi request reprint Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, PO Box 5000, FIN 90014 University of Oulu, Finland
    Eur J Cancer 42:2653-9. 2006
    ..On the other hand, a significant reduction in expression of mismatch repair proteins occurs during the progression of in situ lesions to invasive tumours...
  9. doi request reprint DNA adduct 8-hydroxydeoxyguanosine, a novel putative marker of prognostic significance in ovarian carcinoma
    Peeter Karihtala
    Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Oulo, Finland
    Int J Gynecol Cancer 19:1047-51. 2009
    ..The purpose of the current study was to identify the role of oxidative stress and major antioxidant enzymes in ovarian carcinomas...
  10. pmc Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas
    Peeter Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    BMC Cancer 11:262. 2011
    ..This is the first study to assess oxidative stress and or cell redox state-regulating enzymes in TNBC and BLBC...
  11. ncbi request reprint Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, Oulu, Finland
    APMIS 115:81-103. 2007
    ..The present review aims to clarify the significance of oxidative stress and the role of cell redox state modulating systems in human malignancies in light of the current literature...
  12. doi request reprint Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma
    Siria Lemma
    Department of Radiotherapy and Oncology, Oulu University Hospital, Oulu, Finland
    Histopathology 62:326-33. 2013
    ..EMT has been shown to enhance solid tumour metastasis, invasion, and proliferation...
  13. doi request reprint Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis
    Marjo Pylväs
    Department of Obstetrics and Gynecology, University of Oulu and Oulu University Hospital, Finland
    Eur J Cancer 46:1661-7. 2010
    ..This difference could also offer a potential tool for differential diagnosis between benign and borderline epithelial ovarian tumours...
  14. doi request reprint Expression and prognostic evaluation of oxidative stress markers in an immunohistochemical study of B-cell derived lymphomas
    Anna Kaisa Pasanen
    Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Oulu, Finland
    Leuk Lymphoma 53:624-31. 2012
    ..These markers seem to have strong prognostic value, but this has to be verified in larger studies...
  15. ncbi request reprint Antioxidative response for nitric oxide production in breast carcinoma
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, FIN 90014 Oulu, Finland
    Oncol Rep 12:755-9. 2004
    ..The current results also imply the attempt of cells to hedge against effects of NO by increasing their MnSOD and catalase expression...
  16. ncbi request reprint Elevated serum 8-OHdG is associated with poor prognosis in epithelial ovarian cancer
    Marjo Pylväs
    Department of Obstetrics, University of Oulu, Finland
    Anticancer Res 31:1411-5. 2011
    ..8-Hydroxydeoxyguanosine (8-OHdG) is a marker of oxidative stress in DNA. This study was undertaken to reveal whether serum 8-OHdG could be a prognostic factor in epithelial ovarian carcinoma (EOC)...
  17. ncbi request reprint Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma
    Nina Turunen
    Department of Pathology, Oulu University Hospital, Oulu, Finland
    APMIS 112:123-32. 2004
    ....
  18. ncbi request reprint Peroxiredoxins in breast carcinoma
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, 90014 Oulu, Finland
    Clin Cancer Res 9:3418-24. 2003
    ..The mammalian Prx family has six distinct members located in various subcellular locations, including peroxisomes and mitochondria, places where oxidative stress is most evident...
  19. doi request reprint Metformin decreases serum 8-hydroxy-2'-deoxyguanosine levels in polycystic ovary syndrome
    Henri Sova
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Fertil Steril 99:593-8. 2013
    ..To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG)...
  20. ncbi request reprint Down-regulation of 8-hydroxydeoxyguanosine and peroxiredoxin II in the pathogenesis of endometriosis-associated ovarian cancer
    Henri Sova
    Department of Oncology and Radiotherapy, P O Box 22, FIN 90029 Oulu University Hospital, Finland
    Anticancer Res 32:3037-44. 2012
    ..To evaluate the roles of oxidative stress marker 8-hydroxydeoxyguanosine (8-OHdG) and peroxiredoxin (PRX) antioxidants in the development of endometriosis and endometriosis-associated ovarian cancer (EAC)...
  21. doi request reprint Distinctively low levels of serum 8-hydroxydeoxyguanosine in women with polycystic ovary syndrome
    Henri Sova
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Fertil Steril 94:2670-3. 2010
    ..To investigate oxidative stress and angiogenetic factors in polycystic ovary syndrome (PCOS)...