J Kaprio

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. pmc Body mass index and subjective well-being in young adults: a twin population study
    Milla S Linna
    Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland
    BMC Public Health 13:231. 2013
  2. pmc Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes
    Blake E Haas
    Department of Human Genetics, Gonda Center, Los Angeles, California, 90095 7088, USA
    BMC Med Genomics 5:61. 2012
  3. doi The Finnish Twin Cohort Study: an update
    Jaakko Kaprio
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Twin Res Hum Genet 16:157-62. 2013
  4. doi Twins and the mystery of missing heritability: the contribution of gene-environment interactions
    J Kaprio
    Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
    J Intern Med 272:440-8. 2012
  5. pmc Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, Espoo, FI 02044 VTT, Finland
    Genome Med 4:1. 2012
  6. pmc Vitamin E supplementation and pneumonia risk in males who initiated smoking at an early age: effect modification by body weight and dietary vitamin C
    Harri Hemilä
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Nutr J 7:33. 2008
  7. pmc Are computer and cell phone use associated with body mass index and overweight? A population study among twin adolescents
    Hanna Reetta Lajunen
    Dept of Public Health, University of Helsinki, Helsinki, Finland
    BMC Public Health 7:24. 2007
  8. pmc Serotonin transporter binding of [123I]ADAM in bulimic women, their healthy twin sisters, and healthy women: a SPET study
    Anu K Koskela
    Department of Clinical Physiology and Nuclear Medicine, HUSLAB Helsinki University Central Hospital, Helsinki, Finland
    BMC Psychiatry 7:19. 2007
  9. pmc Seasonal changes, sleep length and circadian preference among twins with bipolar disorder
    Reeta Hakkarainen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 3:6. 2003
  10. pmc The stability of life satisfaction in a 15-year follow-up of adult Finns healthy at baseline
    Heli Koivumaa-Honkanen
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    BMC Psychiatry 5:4. 2005

Detail Information

Publications191 found, 100 shown here

  1. pmc Body mass index and subjective well-being in young adults: a twin population study
    Milla S Linna
    Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland
    BMC Public Health 13:231. 2013
    ..However, the association may not be linear. Therefore, we investigated whether a nonlinear (U-shaped) trend would better describe this relationship, and whether eating disorders might account for the association in young adults...
  2. pmc Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes
    Blake E Haas
    Department of Human Genetics, Gonda Center, Los Angeles, California, 90095 7088, USA
    BMC Med Genomics 5:61. 2012
    ..Fat is stored in the form of TGs in human adipose tissue. We hypothesized that gene co-expression networks in human adipose tissue may be correlated with serum TG levels and help reveal novel genes involved in TG regulation...
  3. doi The Finnish Twin Cohort Study: an update
    Jaakko Kaprio
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Twin Res Hum Genet 16:157-62. 2013
    ..Based on the cohorts, many sub-studies with more detailed phenotyping and collection of omics data have been conducted or are in progress. We also contribute to numerous national and international collaborations...
  4. doi Twins and the mystery of missing heritability: the contribution of gene-environment interactions
    J Kaprio
    Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
    J Intern Med 272:440-8. 2012
    ..Here, the progress in accounting for a greater proportion of the variance is reviewed. In particular, gene-environment interactions can, for some traits and in certain circumstances, explain part of this missing heritability...
  5. pmc Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, Espoo, FI 02044 VTT, Finland
    Genome Med 4:1. 2012
    ..The 'prostaglandin deficiency' hypothesis postulates that defective enzyme systems converting essential fatty acids to prostaglandins lead to diminished levels of prostaglandins, which in turn affect synaptic transmission...
  6. pmc Vitamin E supplementation and pneumonia risk in males who initiated smoking at an early age: effect modification by body weight and dietary vitamin C
    Harri Hemilä
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Nutr J 7:33. 2008
    ..In this study, we explored the modification of vitamin E effect by body weight, because the same dose could lead to a greater effect in participants with low body weight...
  7. pmc Are computer and cell phone use associated with body mass index and overweight? A population study among twin adolescents
    Hanna Reetta Lajunen
    Dept of Public Health, University of Helsinki, Helsinki, Finland
    BMC Public Health 7:24. 2007
    ..Overweight in children and adolescents has reached dimensions of a global epidemic during recent years. Simultaneously, information and communication technology use has rapidly increased...
  8. pmc Serotonin transporter binding of [123I]ADAM in bulimic women, their healthy twin sisters, and healthy women: a SPET study
    Anu K Koskela
    Department of Clinical Physiology and Nuclear Medicine, HUSLAB Helsinki University Central Hospital, Helsinki, Finland
    BMC Psychiatry 7:19. 2007
    ..We hypothesized clearly reduced SERT binding in BN women as opposed to healthy women, and intermediate SERT binding in unaffected co-twins...
  9. pmc Seasonal changes, sleep length and circadian preference among twins with bipolar disorder
    Reeta Hakkarainen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 3:6. 2003
    ..We aimed at studying the seasonal changes in mood and behaviour, the distribution of hospital admissions by season, and the persistence of the circadian type in twins with bipolar disorder and their healthy co-twins...
  10. pmc The stability of life satisfaction in a 15-year follow-up of adult Finns healthy at baseline
    Heli Koivumaa-Honkanen
    Department of Psychiatry, University of Kuopio, Kuopio, Finland
    BMC Psychiatry 5:4. 2005
    ..However, we lack long-term data on the natural course of subjective well-being in the general population. The aim of this study was to investigate the long-term course of self-reported life satisfaction...
  11. pmc Prevalence and correlates of alcohol and other substance use disorders in young adulthood: A population-based study
    Antti Latvala
    Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
    BMC Psychiatry 9:73. 2009
    ..The incidence of SUDs peaks by young adulthood making epidemiological studies of SUDs in young adults informative...
  12. pmc Allelic variants of IL1R1 gene associate with severe hand osteoarthritis
    Annu Näkki
    Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    BMC Med Genet 11:50. 2010
    ..In this study we targeted a 470 kb region on 2q11.2 presenting the locus with most evidence for linkage to severe OA of distal interphalangeal joints (DIP) in our genome wide scan families...
  13. pmc Gene expression profiles in Finnish twins with multiple sclerosis
    Silja Särkijärvi
    Neuroimmunology Unit, Department of Neurology, Tampere University Hospital, Teiskontie, 35, 33520 Tampere, Finland
    BMC Med Genet 7:11. 2006
    ....
  14. ncbi Genetic and environmental factors in health-related behaviors: studies on Finnish twins and twin families
    Jaakko Kaprio
    Dept of Public Health, University of Helsinki, National Public Health Institute, Helsinki, Finland
    Twin Res 5:366-71. 2002
    ..Twin and twin-family studies with multiple measurements of risk factors and morbidity over time can permit a much more detailed assessment of the developmental dynamics of disease risk and the unfolding of behavioral risk factors...
  15. ncbi Genetic and environmental factors in complex diseases: the older Finnish Twin Cohort
    Jaakko Kaprio
    Dept of Public Health, University of Helsinki, National Public Health Institute, Helsinki, Finland
    Twin Res 5:358-65. 2002
    ..Finally, the inclusion of DNA-based genetic information in a phenotypically rich family data base will offer a unique resource for research in genetic epidemiology and behavioral medicine...
  16. ncbi Heritability of leptin levels and the shared genetic effects on body mass index and leptin in adult Finnish twins
    J Kaprio
    University of Helsinki, Department of Public Health, The Finnish Twin Cohort Study, Helsinki, Finland
    Int J Obes Relat Metab Disord 25:132-7. 2001
    ..Leptin is involved in the regulation of body weight, but the relative role of genetic and environmental influences on inter-individual variation in leptin levels is unknown...
  17. ncbi Genetic epidemiology of smoking behavior and nicotine dependence
    Jaakko Kaprio
    Department of Public Health, University of Helsinki, Finland
    COPD 6:304-6. 2009
    ..Further studies with more sophisticated phenotypes, larger sample sizes and better measures of the environment are needed...
  18. ncbi Physical activity and other risk factors in male twin-pairs discordant for coronary heart disease
    J Kaprio
    Department of Public Health, University of Helsinki, P O Box 41, Mannerheimintie 172, FIN 00014, Helsinki, Finland
    Atherosclerosis 150:193-200. 2000
    ....
  19. pmc Chromosome 20 shows linkage with DSM-IV nicotine dependence in Finnish adult smokers
    Kaisu Keskitalo-Vuokko
    Corresponding Author Jaakko Kaprio, M D, Ph D, Department of Public Health, University of Helsinki, PO Box 41 Mannerheimintie 172, Helsinki 00014, Finland
    Nicotine Tob Res 14:153-60. 2012
    ..Chromosome 20 has previously been associated with nicotine dependence (ND) and smoking cessation. Our aim was to replicate and extend these findings...
  20. ncbi Twin studies in Finland 2006
    Jaakko Kaprio
    Department of Public Health, University of Helsinki, FIN 00014 Helsinki, Finland
    Twin Res Hum Genet 9:772-7. 2006
    ..This article describes current, ongoing data collection and analyses...
  21. ncbi Genetic epidemiology of cannabis use, abuse and dependence: a comment on Agrawal and Lynskey (2006)
    Jaakko Kaprio
    Department of Public Health, PO Box 41, University of Helskinki, Finland
    Addiction 101:779-80; author reply 781-2. 2006
  22. ncbi Differences in smoking habits of MZ and DZ twins: a commentary on Tishler and Carey
    Jaakko Kaprio
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Twin Res Hum Genet 10:718-20. 2007
    ..Even if the Tisher/Carey finding holds up in further analyses, it pertains only to the observed trait, the effect is small in size, and the mechanism underlying it needs to be explored...
  23. doi Does dieting make you fat? A twin study
    K H Pietiläinen
    Obesity Research Unit, Department of Medicine, Division of Internal Medicine and Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    Int J Obes (Lond) 36:456-64. 2012
    ..To investigate whether the paradoxical weight gain associated with dieting is better related to genetic propensity to weight gain than to the weight loss episodes themselves...
  24. ncbi Hypertension in master endurance athletes
    M Hernelahti
    Unit for Sports and Exercise Medicine, Institute of Biomedicine, University of Helsinki, Finland
    J Hypertens 16:1573-7. 1998
    ..To determine whether long-term very vigorous endurance training prevents hypertension...
  25. ncbi Tracking of body size from birth to late adolescence: contributions of birth length, birth weight, duration of gestation, parents' body size, and twinship
    K H Pietiläinen
    Department of Public Health, University of Helsinki, PO Box 41, FIN 00014 Helsinki, Finland
    Am J Epidemiol 154:21-9. 2001
    ..These findings suggest that the intrauterine period has enduring effects on later body size but leave unresolved whether these effects are genetic or environmental...
  26. pmc Bruxism is associated with nicotine dependence: a nationwide Finnish twin cohort study
    K Rintakoski
    Institute of Dentistry, University of Helsinki, PL 41, Helsinki 00014, Finland
    Nicotine Tob Res 12:1254-60. 2010
    ..To investigate the association of smoking with bruxism while controlling for genetic and environmental factors using a co-twin-control design. Especially, the role of nicotine dependence was studied in this context...
  27. ncbi Subsequent primary cancers after basal-cell carcinoma: A nationwide study in Finland from 1953 to 1995
    T Milan
    Department of Public Health, University of Turku, Turku, Finland
    Int J Cancer 87:283-8. 2000
    ..However, the increases in the risk of several non-cutaneous cancers suggest a generalized carcinogenic role of some factors in the BCC pathogenic pathways...
  28. ncbi Weight cycling of athletes and subsequent weight gain in middleage
    S E Saarni
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Int J Obes (Lond) 30:1639-44. 2006
    ..To study the effects of repeated cycles of weight loss and regain as young adults on long-term weight development...
  29. ncbi Breast cancer risk in monozygotic and dizygotic female twins: a 20-year population-based cohort study in Finland from 1976 to 1995
    P K Verkasalo
    Department of Public Health, University of Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 8:271-4. 1999
    ..Our results, which are in line with earlier studies on the same topic, suggest that prenatal influences or postnatal behavioral factors may protect MZ female twins from breast cancer...
  30. ncbi Influence of physical activity on depression and anxiety of former elite athletes
    H Bäckmand
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Int J Sports Med 24:609-19. 2003
    ..Very high physical activity has a significant protective effect against depression...
  31. doi Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: a follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study
    M Lehtovirta
    Department of Public Health, University of Helsinki, P O Box 41, FIN 00014, Helsinki, Finland
    Diabetologia 53:1314-21. 2010
    ..We investigated whether BMI predicts type 2 diabetes in twins and to what extent that is explained by common genetic factors...
  32. ncbi Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings
    M Perola
    National Public Health Institute, Department of Human Molecular Genetics, Helsinki, Finland
    J Hypertens 18:1579-85. 2000
    ..To review, on a genome-wide scale, a linkage result obtained in an earlier candidate gene analysis in this same study sample, and to look for other possible contributing genetic loci predisposing to hypertension in this population...
  33. ncbi Genetic predisposition, environment and cancer incidence: a nationwide twin study in Finland, 1976-1995
    P K Verkasalo
    Department of Public Health, University of Helsinki, Finland
    Int J Cancer 83:743-9. 1999
    ..Our results appear to exclude a contribution greater than one-third for genetic predisposition in the development of cancer in the general population, thus pointing to the earlier confirmed substantial role of environment...
  34. pmc Cigarette smoking, alcohol intoxication and major depressive episode in a representative population sample
    J Hämäläinen
    National Public Health Institute, Department of Mental Health and Alcohol Research, Mannerheimintie 166, 00300, Helsinki, Finland
    J Epidemiol Community Health 55:573-6. 2001
    ..This study investigated the associations of cigarette smoking and alcohol intoxication with major depressive episode...
  35. pmc Hereditary factors in basal cell carcinoma of the skin: a population-based cohort study in twins
    T Milan
    Department of Public Health, University of Turku, Finland
    Br J Cancer 78:1516-20. 1998
    ..Model fitting indicated that genetic factors were not needed to account for the distribution of basal cell carcinoma in twin pairs. These results confirm the major role of environmental factors in the aetiology of basal cell carcinoma...
  36. ncbi Familial aggregation of leisure-time physical activity -- a three generation study
    M Aarnio
    Department of Public Health, University of Helsinki, Finland
    Int J Sports Med 18:549-56. 1997
    ..Because physical activity patterns do not appear to be transmitted from one generation to the next, it is probable that by constant training and education we can obtain the benefits of physical activity...
  37. pmc Evening types are more often current smokers and nicotine-dependent-a study of Finnish adult twins
    U Broms
    Department of Public Health, Hjelt Institute, University of Helsinki, Finland
    Addiction 106:170-7. 2011
    ..To examine the association between diurnal type and smoking status and nicotine dependence (ND)...
  38. pmc Relative effect of genetic and environmental factors on body height: differences across birth cohorts among Finnish men and women
    K Silventoinen
    Department of Public Health, University of Helsinki, Finland
    Am J Public Health 90:627-30. 2000
    ..This study examined the change in heritability of adult body height across birth cohorts in Finland...
  39. pmc Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins
    H R Lajunen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Int J Obes (Lond) 33:559-67. 2009
    ..To study genetic and environmental factors affecting body mass index (BMI) and BMI phenotypic correlations across adolescence...
  40. ncbi Nightmares: familial aggregation and association with psychiatric disorders in a nationwide twin cohort
    C Hublin
    The Finnish Twin Cohort, Department of Public Health, University of Helsinki, Finland
    Am J Med Genet 88:329-36. 1999
    ..Nightmares are quite a stable trait from childhood to middle age. There are persistent genetic effects on the disposition to nightmares both in childhood and adulthood. Nightmares are significantly associated with psychiatric disorders...
  41. pmc Prospective relationships of ADHD symptoms with developing substance use in a population-derived sample
    E Sihvola
    Department of Public Health, University of Helsinki, Finland
    Psychol Med 41:2615-23. 2011
    ..Clinically ascertained reports suggest that boys and girls with attention deficit hyperactivity disorder (ADHD) may differ from each other in their vulnerability to substance use problems...
  42. ncbi Predictors of weight change in middle-aged and old men
    M Fogelholm
    Palmenia Centre for Research and Continuing Education, University of Helsinki, Finland
    Obes Res 8:367-73. 2000
    ..Studies on weight change and mortality have yielded inconclusive results. This 10-year prospective study was undertaken to improve understanding of factors affecting weight change...
  43. pmc Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q
    J Leppävuori
    Department of Human Molecular Genetics, National Public Health Institute, University of Helsinki, Finland
    Am J Hum Genet 65:1060-7. 1999
    ..Three additional chromosomal regions-4q26-q27, 7p15-p21, and Xcen-also provided some evidence for linkage, and further analyses would be justified to clarify their potential involvement in the genetic predisposition to DIP OA...
  44. ncbi Sex differences in genetic and environmental factors contributing to body-height
    K Silventoinen
    Department of Public Health, PO Box 41, 00014 University of Helsinki, Finland
    Twin Res 4:25-9. 2001
    ..The stronger contribution of environmental factors to body-height among women questions the hypothesis that women are better buffered against environmental stress, at least for this phenotype...
  45. ncbi Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension
    K Kainulainen
    Department of Medicine, University of Helsinki, Finland
    Hypertension 33:844-9. 1999
    ..The data provide evidence that a common genetic variant of the AT1 gene locus influences the risk of essential hypertension in the Finnish population...
  46. ncbi High concordance of bipolar I disorder in a nationwide sample of twins
    Tuula Kieseppä
    Department of Mental Health and Alcohol Research, National Public Health Institute, 00300 Helsinki 30, Finland
    Am J Psychiatry 161:1814-21. 2004
    ..The authors report what appears to be the first twin study of bipolar I disorder involving a population-based twin sample, in which the diagnoses were made by using structured, personal interviews...
  47. doi Incidence and outcomes of bulimia nervosa: a nationwide population-based study
    A Keski-Rahkonen
    Department of Public Health, University of Helsinki, Finland
    Psychol Med 39:823-31. 2009
    ..Little is known about the epidemiology of bulimia nervosa outside clinical settings. We report the incidence, prevalence and outcomes of bulimia nervosa using for the first time a nationwide study design...
  48. ncbi Genetic and environmental factors in relative weight from birth to age 18: the Swedish young male twins study
    K Silventoinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Int J Obes (Lond) 31:615-21. 2007
    ..To investigate the contributions of genetic and environmental factors to the development of relative weight during the growth period...
  49. ncbi Lifestyle differences in twin pairs discordant for basal cell carcinoma of the skin
    T Milan
    Department of Public Health, University of Turku, Lemminkäisenkatu 1, FIN 20520 Turku, Finland
    Br J Dermatol 149:115-23. 2003
    ..Case-control studies in disease-discordant twin pairs adjust for familial factors and improve the power of conventional case-control studies...
  50. pmc Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups
    M Perola
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 69:117-23. 2001
    ..61). Encouragingly, the locus on chromosome 7 is supported by the data reported by Hirschhorn et al. (in this issue), who used a similar method. We found no evidence for QTLs affecting BMI...
  51. doi Associations between sports participation, cardiorespiratory fitness, and adiposity in young adult twins
    L Mustelin
    Hjelt Institute, Dept of Public Health, Twin Research Unit, PB 41, 00014 Univ of Helsinki, Finland
    J Appl Physiol (1985) 110:681-6. 2011
    ..Our results suggest that genetic factors explain a considerable part of the associations between sports participation, cardiorespiratory fitness, and obesity...
  52. ncbi Personality and mood of former elite male athletes--a descriptive study
    H Bäckmand
    Department of Public Health, University of Helsinki, Finland
    Int J Sports Med 22:215-21. 2001
    ..Bearing in mind the limitations of the study subjects, it is concluded that former athletes differ from nonathletes in some personality characteristics and depression...
  53. ncbi Parasomnias: co-occurrence and genetics
    C Hublin
    The Finnish Twin Cohort, Department of Public Health, University of Helsinki
    Psychiatr Genet 11:65-70. 2001
    ..The estimated proportions of shared genetic effects were 50, 30, and 26%, respectively. The present results indicate that parasomnias share some common genetic background...
  54. pmc Social predictors of adult asthma: a co-twin case-control study
    E Huovinen
    Department of Public Health, University of Helsinki, Finland
    Thorax 56:234-6. 2001
    ..A co-twin case-control study was undertaken to examine possible social risk factors for asthma...
  55. doi Genetic influences on adult body mass index followed over 29 years and their effects on late-life mobility: a study of twin sisters
    A Ortega-Alonso
    Department of Public Health, University of Helsinki, FIN 00014 Helsinki, Finland
    J Epidemiol Community Health 63:651-8. 2009
    ..This twin study examined prospectively whether genetic and environmental influences on women's BMI also account for mobility 29 years later...
  56. ncbi Coffee consumption, serum gamma-glutamyltransferase and risk of type II diabetes
    S Bidel
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Eur J Clin Nutr 62:178-85. 2008
    ..To study the joint association of coffee consumption and serum gamma-glutamyltransferase (GGT) levels on the risk of developing type II diabetes...
  57. pmc Genetic association study of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura
    P Tikka-Kleemola
    Institute of Molecular Medicine in Finland, University of Helsinki, 00014 Helsinki, Finland
    Cephalalgia 29:1224-31. 2009
    ..The trait age of onset < 20 years was also associated with rs2048894 (OR 1.69, 95% CI 1.13-2.54, P = 0.011) in the pooled sample. To confirm this finding studies on even larger samples are required...
  58. doi The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies
    K Silventoinen
    Department of Sociology, Population Research Unit, University of Helsinki, Helsinki, Finland
    Int J Obes (Lond) 34:29-40. 2010
    ..More studies of genetic architecture in non-Caucasian populations, of gene-environment interactions, and of body composition and body fat distribution are needed...
  59. ncbi Epidemiology of narcolepsy
    C Hublin
    Department of Neurology, University of Helsinki, Finland
    Sleep 17:S7-12. 1994
    ..In three subjects the narcolepsy diagnosis was verified (all dizygotic, nonfamilial and human leukocyte antigen DR2/DQB-0602 positive), giving a prevalence of 0.026% in the adult Finnish (Caucasian) population...
  60. ncbi Sleeptalking in twins: epidemiology and psychiatric comorbidity
    C Hublin
    Department of Public Health, University of Helsinki, Finland
    Behav Genet 28:289-98. 1998
    ..In adults psychiatric comorbidity is about twice as common in those with frequent sleeptalking, compared to those with infrequent or no sleeptalking, but most cases of sleeptalking are not associated with serious psychopathology...
  61. ncbi Relationship of leisure-time physical activity and mortality: the Finnish twin cohort
    U M Kujala
    Unit for Sports and Exercise Medicine, Institute of Biomedicine, Helsinki, Finland
    JAMA 279:440-4. 1998
    ..Physical activity and fitness are believed to reduce premature mortality, but whether genetic factors modify this effect is not known...
  62. ncbi Genetic and environmental contributions to the association between body height and educational attainment: a study of adult Finnish twins
    K Silventoinen
    Department of Public Health, University of Helsinki, Finland
    Behav Genet 30:477-85. 2000
    ..The correlation of genetic factors between these two characteristics was not statistically significant. The results suggest that the association between body height and education is due mainly to nongenetic family factors...
  63. doi Smoking reduction predicts cessation: longitudinal evidence from the Finnish adult twin cohort
    Ulla Broms
    Department of Public Health, University of Helsinki, Finland
    Nicotine Tob Res 10:423-7. 2008
    ..We conclude that smokers who are able to decrease the number of cigarettes smoked per day by at least 25% are more likely to quit later...
  64. doi Longitudinal study on poor sleep and life dissatisfaction in a nationwide cohort of twins
    Tiina Paunio
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 169:206-13. 2009
    ..21 for men and 0.27 for women in a multivariate genetic model. This finding is consistent with the hypothesis that poor sleep may have direct effects on the brain, emotions, and mood...
  65. ncbi No association of migraine to the GABA-A receptor complex on chromosome 15
    G Oswell
    The Finnish Genome Center, University of Helsinki, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 147:33-6. 2008
    ..No association to MA was detected, suggesting that common variants of the GABA cluster are unlikely to be major contributors of MA susceptibility...
  66. ncbi Intentional weight loss and smoking in young adults
    S E Saarni
    Department of Public Health, University of Helsinki, Finland
    Int J Obes Relat Metab Disord 28:796-802. 2004
    ..To investigate whether current smoking and lifetime snuff use are associated with a lifetime history of major (>/=5 kg) intentional weight loss in young adults, and to examine the dependence of this association on familial factors...
  67. ncbi Joint-specific twin and familial aggregation of recalled physician diagnosed osteoarthritis
    U M Kujala
    Unit for Sports and Exercise Medicine, Institute of Biomedicine, University of Helsinki, Finland
    Twin Res 2:196-202. 1999
    ..Based on our joint-specific data finger and knee joints are the most optimal targets for studies of genetic factors predisposing to the development of OA...
  68. pmc Future hospital care in a population-based series of twin pairs discordant for physical activity behavior
    U M Kujala
    University of Helsinki, Finland
    Am J Public Health 89:1869-72. 1999
    ..This study investigated the association between physical activity behavior and morbidity, taking into account genetic selection...
  69. ncbi Migraine and concomitant symptoms among 8167 adult twin pairs
    M L Honkasalo
    University of Helsinki, Department of Public Health, Finland
    Headache 35:70-8. 1995
    ..Our results emphasize a multifactorial and higher than previously reported genetic pattern in the etiology of migraine. Also unshared environmental factors play an important role...
  70. pmc Associations of health related behaviour, social relationships, and health status with persistent physical activity and inactivity: a study of Finnish adolescent twins
    M Aarnio
    Department of Public Health, University of Helsinki, Finland
    Br J Sports Med 36:360-4. 2002
    ..To examine the association between leisure time physical activity over a three year period and health related behaviour, social relationships, and health status in late adolescence as part of a nationwide longitudinal study...
  71. ncbi A descriptive study of weight loss maintenance: 6 and 15 year follow-up of initially overweight adults
    S Sarlio-Lähteenkorva
    Department of Public Health, University of Helsinki, Helsinki
    Int J Obes Relat Metab Disord 24:116-25. 2000
    ..To describe factors associated with long-term maintenance of weight loss...
  72. ncbi A population-based survey of headache and migraine in 22,809 adults
    M L Honkasalo
    Department of Public Health, University of Helsinki, Finland
    Headache 33:403-12. 1993
    ..5% of all headache occasions among women and for 60.8% among men. Thus, from the public health view-point, studies of "non-clinical" headache, e.g. headache without migrainous features should be emphasized...
  73. pmc Natural selection to sports, later physical activity habits, and coronary heart disease
    U M Kujala
    Unit for Sports and Exercise Medicine, Institute of Clinical Medicine, University of Helsinki, Finland
    Br J Sports Med 34:445-9. 2000
    ..To investigate the associations between natural selection to sports at a young age, continuity of physical activity, and occurrence of coronary heart disease...
  74. doi Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins
    L Mustelin
    Department of Public Health, Twin Research Unit, University of Helsinki, Helsinki, Finland
    Int J Obes (Lond) 33:29-36. 2009
    ..We therefore analyzed these complex relationships, and also examined whether physical activity modifies the degree of genetic influence on body mass index (BMI) and waist circumference (WC)...
  75. pmc Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    PLoS Med 5:e51. 2008
    ..The goal of this study was to investigate this important acquired component and expose obesity-induced changes in biological pathways in an identical genetic background...
  76. doi Characteristics and consistency of light smoking: long-term follow-up among Finnish adults
    Maria Hukkinen
    Department of Public Health, University of Helsinki, and the National Institute for Health and Welfare, Helsinki FIN 00014, Finland
    Nicotine Tob Res 11:797-805. 2009
    ..The main body of smoking behavior research has targeted primarily moderate and heavy smoking. This study aimed to define characteristics of daily light smoking and to examine the consistency of this smoking pattern...
  77. doi Adolescent risk factors for excessive alcohol use at age 32 years. A 16-year prospective follow-up study
    Taina Huurre
    Department of Mental Health and Substance Abuse Services, Child and Adolescent Mental Health Unit, National Institute for Health and Welfare, P O Box 30, 00271, Helsinki, Finland
    Soc Psychiatry Psychiatr Epidemiol 45:125-34. 2010
    ..To examine which socioeconomic, family, personal and lifestyle risk factors in adolescence were the strongest independent predictors of excessive alcohol use in adulthood...
  78. ncbi Physical activity and the risk of pneumonia in male smokers administered vitamin E and beta-carotene
    H Hemilä
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Int J Sports Med 27:336-41. 2006
    ..The finding that vitamin E reduced the risk of pneumonia in persons carrying out leisure-time exercise warrants further study...
  79. ncbi Narcolepsy-like symptoms among adult twins
    J Kaprio
    Department of Public Health, University of Helsinki, Finland
    J Sleep Res 5:55-60. 1996
    ..Further investigation of the complex genetic architecture of narcolepsy and its symptoms is warranted...
  80. doi Smoking strongly predicts disability retirement due to COPD: the Finnish Twin Cohort Study
    K Koskenvuo
    Social Insurance Institution of Finland, Research Dept, Helsinki, Finland
    Eur Respir J 37:26-31. 2011
    ..70, 95% CI 1.08-2.68). Smoking strongly predicts disability retirement due to COPD. Preventive measures against disability retirement and other harmful consequences of tobacco smoking should receive greater emphasis...
  81. doi Cumulative incidence of shoulder region tendon injuries in male former elite athletes
    J A Kettunen
    ORTON Orthopaedic Hospital ORTON Foundation ARCADA University of Applied Sciences, Helsinki, Finland
    Int J Sports Med 32:451-4. 2011
    ....
  82. ncbi The 12-month prevalence and characteristics of major depressive episode in a representative nationwide sample of adolescents and young adults
    L Haarasilta
    National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
    Psychol Med 31:1169-79. 2001
    ..CONCLUSIONS: Episodes of major depression among adolescents and young adults in the general population are short but often associated with psychosocial impairment, especially if frequent drunkenness coexists...
  83. ncbi Twin studies in narcolepsy
    M Partinen
    Department of Neurology, Finnish Twin Cohort, University of Helsinki, Finland
    Sleep 17:S13-6. 1994
    ..Not a single case suggestive of narcolepsy was found. Narcolepsy in monozygotic twins is very rare. These facts support the hypothesis of a multifactorial etiology with a strong influence of nongenetic environmental factors...
  84. ncbi Clinical characteristics of migraine in a population-based twin sample: similarities and differences between migraine with and without aura
    M Kallela
    Department of Neurology, University of Helsinki, Finland
    Cephalalgia 19:151-8. 1999
    ..To look into clinical differences between migraine with and without aura in a population-based sample of migraineurs...
  85. pmc Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects--a monozygotic twin study
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    PLoS ONE 2:e218. 2007
    ..Our results show that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance...
  86. pmc Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity
    Linda Mustelin
    Department of Laboratory Medicine, Division of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Am J Physiol Endocrinol Metab 295:E148-54. 2008
    ..8 +/- 0.5 vs. 3.3 +/- 0.6, P < 0.01). This implies that acquired poor physical fitness is associated with defective expression of the oxidative pathway components in adipose tissue mitochondria...
  87. ncbi Major depressive episode and physical health in adolescents and young adults: results from a population-based interview survey
    Linnea Haarasilta
    National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
    Eur J Public Health 15:489-93. 2005
    ..This paper aimed to investigate associations between major depressive episode (MDE) and chronic illness, disability, self-perceived health and number of sick-days among adolescents and young adults in the general population...
  88. ncbi Stressful life events and risk of breast cancer in 10,808 women: a cohort study
    Kirsi Lillberg
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Am J Epidemiol 157:415-23. 2003
    ..36, 95% CI: 1.00, 1.86) were all associated with increased risk of breast cancer. The findings suggest a role for life events in breast cancer etiology through hormonal or other mechanisms...
  89. ncbi Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study
    Valma Hyttinen
    National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
    Diabetes 52:1052-5. 2003
    ..In conclusion, these nationwide twin data demonstrated high genetic liability for type 1 diabetes. Early-onset diabetes increases the risk in cotwins. However, the majority of affected MZ twin pairs remain discordant for type 1 diabetes...
  90. ncbi Malignant skin cancers in the Finnish Twin Cohort: a population-based study, 1976-97
    T Milan
    Department of Public Health, University of Turku, Lemminkäisenkatu 1, FIN 20520 Turku, Finland
    Br J Dermatol 147:509-12. 2002
    ..Both hereditary and environmental factors are implicated in the aetiology of cutaneous neoplasms. Studies of twins make it possible to estimate the contribution of inherited genes to the development of disease...
  91. ncbi Stability of leisure-time physical activity during adolescence--a longitudinal study among 16-, 17- and 18-year-old Finnish youth
    M Aarnio
    Department of Public Health, University of Helsinki, Finland
    Scand J Med Sci Sports 12:179-85. 2002
    ..2-10.2) and 10.4 for girls (CI 6.4-16.9). Adolescents are recommended to participate in and try different types of sports, and especially for girls ball games would appear to favour long-term maintenance of leisure-time physical activity...
  92. pmc Sleep and mortality: a population-based 22-year follow-up study
    Christer Hublin
    Research Center, Finnish Institute of Occupational Health, Helsinki, Finland
    Sleep 30:1245-53. 2007
    ..Long and short sleep have been associated with increased mortality. We assessed mortality and 3 aspects of sleep behavior in a large cohort with 22-year follow-up...
  93. doi Minor change in the diagnostic threshold leads into major alteration in the prevalence estimate of depression
    Linnea Karlsson
    National Institute for Health and Welfare, Department for Mental Health and Services for Substance Abuse, Helsinki, Finland
    J Affect Disord 122:96-101. 2010
    ..General population data on this topic are scarce...
  94. ncbi Co-twin dependence modifies heritability of abstinence and alcohol use: a population-based study of Finnish twins
    Varpu Penninkilampi-Kerola
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Twin Res Hum Genet 8:232-44. 2005
    ..An interdependent sibling relationship is an important modifier of drinking habits, and it appears to reduce the impact of inherited liabilities on alcohol-related behavior especially in adolescence...
  95. doi BMI, weight stability and mortality among adults without clinical co-morbidities: a 22-year mortality follow-up in the Finnish twin cohort
    Maarit Korkeila
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Obes Facts 2:344-51. 2009
    ..Deaths and cause of death were ascertained from national registries. Associations with mortality were estimated by Cox proportional hazards model for all individuals and conditional logistic regression analysis for pairwise analyses...
  96. doi Heritability of body size and muscle strength in young adulthood: a study of one million Swedish men
    Karri Silventoinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Genet Epidemiol 32:341-9. 2008
    ..This may have inflated heritability estimates in previous twin studies. Nonetheless, we showed that genetic factors affect muscle strength and part of these genes are common to different strength indicators and body size...
  97. pmc The effect of alcohol consumption on later obesity in early adulthood--a population-based longitudinal study
    Matti Pajari
    Department of Public Health, University of Helsinki, PO Box 14, 00014 Helsinki, Finland
    Alcohol Alcohol 45:173-9. 2010
    ..The study aimed to determine whether alcohol use during late adolescence contributes to the weight gain from adolescence to young adulthood or risk of obesity or waist circumference at young adulthood...
  98. ncbi Genetic and environmental effects on fasting and postchallenge plasma glucose and serum insulin values in Finnish twins
    Shuichi Katoh
    Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
    J Clin Endocrinol Metab 90:2642-7. 2005
    ..81). In conclusion, additive genetic effects are important for the insulin secretion, whereas nonshared environmental effects contribute strongly to peripheral insulin resistance...
  99. ncbi Physical and psychological functioning of daily living in relation to physical activity. A longitudinal study among former elite male athletes and controls
    Heli Bäckmand
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Aging Clin Exp Res 18:40-9. 2006
    ....
  100. ncbi Heritability of adult body height: a comparative study of twin cohorts in eight countries
    Karri Silventoinen
    Department of Public Health, University of Helsinki, Finland
    Twin Res 6:399-408. 2003
    ..Our results indicate that, in general, there are only minor differences in the genetic architecture of height between affluent Caucasian populations, especially among men...