Esko Kankuri

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine
    E Kankuri
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    J Pharmacol Exp Ther 298:1128-32. 2001
  2. ncbi request reprint Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis
    E Kankuri
    Institute of Biomedicine, Pharmacology, University of Helsinki, Biomedicum Helsinki, Finland
    Scand J Gastroenterol 38:186-92. 2003
  3. ncbi request reprint Fibroblast nemosis arrests growth and induces differentiation of human leukemia cells
    Esko Kankuri
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Int J Cancer 122:1243-52. 2008
  4. ncbi request reprint Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor cell invasiveness
    Esko Kankuri
    Institute of Biomedicine, Pharmacology, Haartman Institute, University of Helsinki, Finland
    Cancer Res 65:9914-22. 2005
  5. pmc hHGF overexpression in myoblast sheets enhances their angiogenic potential in rat chronic heart failure
    Antti Siltanen
    Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e19161. 2011
  6. doi request reprint Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide
    Antti J Väänänen
    Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, FIN 00014 University of Helsinki, Finland
    Free Radic Biol Med 45:749-55. 2008
  7. ncbi request reprint Cathepsin B is a differentiation-resistant target for nitroxyl (HNO) in THP-1 monocyte/macrophages
    Antti J Väänänen
    Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, University of Helsinki 00014, Finland
    Free Radic Biol Med 41:120-31. 2006
  8. doi request reprint Improved skin wound epithelialization by topical delivery of soluble factors from fibroblast aggregates
    Matti Peura
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Burns 38:541-50. 2012
  9. doi request reprint Paracrine factors from fibroblast aggregates in a fibrin-matrix carrier enhance keratinocyte viability and migration
    Matti Peura
    Institute of Biomedicine, Department of Pharmacology, Biomedicum, University of Helsinki, Finland
    J Biomed Mater Res A 95:658-64. 2010
  10. doi request reprint Gene expression profiling of negative-pressure-treated skin graft donor site wounds
    Kristo Nuutila
    Institute of Biomedicine, Pharmacology, Biomedicum, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland
    Burns 39:687-93. 2013

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine
    E Kankuri
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    J Pharmacol Exp Ther 298:1128-32. 2001
    ..In contrast, nonselective nitric-oxide synthase inhibition with L-NAME provided no benefit. These results support the idea that selective iNOS inhibitors have a promise in the treatment of colitis...
  2. ncbi request reprint Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis
    E Kankuri
    Institute of Biomedicine, Pharmacology, University of Helsinki, Biomedicum Helsinki, Finland
    Scand J Gastroenterol 38:186-92. 2003
    ..The aim of the present study was to investigate the effects of selective iNOS inhibition on the production of pro-inflammatory cytokines by the colon mucosa in UC...
  3. ncbi request reprint Fibroblast nemosis arrests growth and induces differentiation of human leukemia cells
    Esko Kankuri
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Int J Cancer 122:1243-52. 2008
    ..Our results emphasize the role of activated stromal fibroblasts in controlling progression of certain hematologic malignancies in a c-Met expression-dependent manner...
  4. ncbi request reprint Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor cell invasiveness
    Esko Kankuri
    Institute of Biomedicine, Pharmacology, Haartman Institute, University of Helsinki, Finland
    Cancer Res 65:9914-22. 2005
    ..Our results thus provide the first evidence that aggravated progression of tumors with necrotic foci may involve paracrine reciprocal signaling leading to stromal activation by direct cell-cell contact (i.e., nemosis)...
  5. pmc hHGF overexpression in myoblast sheets enhances their angiogenic potential in rat chronic heart failure
    Antti Siltanen
    Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e19161. 2011
    ..In conclusion, L6-HGF therapy effectively induced angiogenesis in the chronically failing heart. Cardiac function, however, was not further enhanced by hHGF expression...
  6. doi request reprint Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide
    Antti J Väänänen
    Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, FIN 00014 University of Helsinki, Finland
    Free Radic Biol Med 45:749-55. 2008
    ..Our results provide first evidence on a cellular level for the remarkably high sensitivity of active-site cysteines in cysteine proteases for modification by HNO...
  7. ncbi request reprint Cathepsin B is a differentiation-resistant target for nitroxyl (HNO) in THP-1 monocyte/macrophages
    Antti J Väänänen
    Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, University of Helsinki 00014, Finland
    Free Radic Biol Med 41:120-31. 2006
    ..Macrophage differentiation, associated with upregulation of antioxidant defenses such as increased cellular GSH, does not protect the lysosomal cysteine protease cathepsin B from inhibition...
  8. doi request reprint Improved skin wound epithelialization by topical delivery of soluble factors from fibroblast aggregates
    Matti Peura
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Burns 38:541-50. 2012
    ..Prompt healing is dependent on paracrine support from underlying dermal connective tissue fibroblasts...
  9. doi request reprint Paracrine factors from fibroblast aggregates in a fibrin-matrix carrier enhance keratinocyte viability and migration
    Matti Peura
    Institute of Biomedicine, Department of Pharmacology, Biomedicum, University of Helsinki, Finland
    J Biomed Mater Res A 95:658-64. 2010
    ..An inhibitor of EGFR/c-Met receptor tyrosine kinases abolished keratinocyte responses to fibrin-Finectra matrix. This matrix can thus deliver biologically relevant synergistic stimuli to keratinocytes and hasten re-epithelialization...
  10. doi request reprint Gene expression profiling of negative-pressure-treated skin graft donor site wounds
    Kristo Nuutila
    Institute of Biomedicine, Pharmacology, Biomedicum, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland
    Burns 39:687-93. 2013
    ..However, its continued use may inhibit epithelial differentiation...
  11. doi request reprint Bcl-2 improves myoblast sheet therapy in rat chronic heart failure
    Antti Siltanen
    Institute of Biomedicine, Pharmacology, Biomedicum, University of Helsinki, and Department of Cardiothoracic Surgery, Helsinki University Meilahti Hospital, Helsinki, Finland
    Tissue Eng Part A 17:115-25. 2011
    ..These effects were inhibited by SU5416 and were thus dependent on Flt1/Flk1 signaling. In conclusion, bcl2 improves efficacy of myoblast sheet transplantation and promotes proangiogenic paracrine signaling...
  12. doi request reprint Human skin transcriptome during superficial cutaneous wound healing
    Kristo Nuutila
    Institute of Biomedicine, Pharmacology, Biomedicum, University of Helsinki, Helsinki, Finland
    Wound Repair Regen 20:830-9. 2012
    ..The data not only reveal novel genes associated with epidermal wound healing but also provide a fundamental basis for the translational interpretation of data acquired from experimental models...
  13. doi request reprint Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction
    Pertteli Salmenperä
    Haartman Institute, POB 21, FIN 00014 University of Helsinki, Finland
    Exp Cell Res 314:3444-52. 2008
    ..Our results present a new mechanism of fibroblast activation, which is initiated by interaction of FN with its integrin receptors...
  14. doi request reprint Angiotensin receptors in the eyes of arterial hypertensive rats
    Anu Vaajanen
    Department of Pharmacology, Institute of Biomedicine, University of Helsinki, Finland
    Acta Ophthalmol 88:431-8. 2010
    ....
  15. doi request reprint Clustering of fibroblasts induces proinflammatory chemokine secretion promoting leukocyte migration
    Anna Enzerink
    Haartman Institute, University of Helsinki, P O Box 21, FIN 00014 Helsinki, Finland
    Mol Immunol 46:1787-95. 2009
    ....
  16. doi request reprint Bone marrow mesenchymal stem cells undergo nemosis and induce keratinocyte wound healing utilizing the HGF/c-Met/PI3K pathway
    Matti Peura
    Institute of Biomedicine, Pharmacology, Biomedicum, University of Helsinki, Helsinki, Finland
    Wound Repair Regen 17:569-77. 2009
    ..We conclude that nemosis of BMSCs can induce keratinocyte in vitro scratch-wound healing, and that in this effect signaling via HGF/c-Met is involved...
  17. ncbi request reprint Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases
    Vappu Sirén
    Haartman Institute, University of Helsinki, Finland
    Ann Med 38:212-20. 2006
    ..On the surface of the decomposing spheroids, activation of the major extracellular proteolytic cascade, plasminogen activation, associated with surface exposure of alpha-enolase, took place...
  18. ncbi request reprint Angeli's salt and spinal motor neuron injury
    Antti J Väänänen
    Institute of Biomedicine Pharmacology, Biomedicum Helsinki, P O Box 63, University of Helsinki 00014, Helsinki, Finland
    Free Radic Res 38:271-82. 2004
    ..The effect of intrathecal delivery of AS on the markers of the spinal cord injury and oxidative/nitrosative stress were further studied...
  19. ncbi request reprint Nitric oxide-related species-induced protein oxidation: reversible, irreversible, and protective effects on enzyme function of papain
    Antti J Väänänen
    Institute of Biomedicine Pharmacology, Biomedicum Helsinki, P O Box 63, University of Helsinki 00014, Finland
    Free Radic Biol Med 38:1102-11. 2005
    ..Furthermore, these results suggest that S-nitrosothiols may have a novel function in protecting critical thiols from irreversible oxidative damage...
  20. doi request reprint Heat shock enhances troponin expression and decreases differentiation-associated caspase-3 dependence in myoblasts under hypoxia
    Mona Augustin
    3rd Department of Surgery, Cell Therapy Research Consortium, HUS and Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
    J Surg Res 161:62-8. 2010
    ..The aim of this study was to demonstrate whether HS-pretreated cells would receive a differentiation benefit under hypoxic conditions...
  21. ncbi request reprint Interferon-gamma induces C/EBP beta expression and activity through MEK/ERK and p38 in T84 colon epithelial cells
    Pertteli Salmenperä
    Department of Pharmacology, Institute of Biomedicine, FIN 00014 University of Helsinki, Finland
    Am J Physiol Cell Physiol 284:C1133-9. 2003
    ..These results suggest a role for MEK2 and p38 in IFN-gamma-mediated signal transduction and induction of C/EBP beta expression and activity associated with interleukin-6 (IL-6) secretion in colon epithelial cells...
  22. ncbi request reprint Polyglycolic acid glue does not prevent intrapericardial adhesions in a short-term follow-up
    Tommi Pätilä
    Department of Cardiothoracic Surgery, Helsinki University Hospital, Helsinki, Finland
    J Surg Res 148:181-4. 2008
    ..In this study, we tested a novel, synthetic, sprayable, and resorbable polyglycolic acid glue (DuraSeal; Confluent Surgical, Inc., Waltham, MA) that has been approved by the United States Food and Drug Administration as a dural sealant...
  23. ncbi request reprint Ligation of ameroid-stenosed coronary artery leads to reproducible myocardial infarction--a pilot study in a porcine model
    Tuija S Ikonen
    Department of Vascular Surgery, University of Helsinki, Meilahti Hospital, Helsinki, Finland
    J Surg Res 142:195-201. 2007
    ..To produce a constant myocardial lesion after adaptation to ischemia, we surgically modified the ameroid-model by ligation. As a pilot study for further cell therapy research, the spontaneous myocardial response is described...
  24. ncbi request reprint Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD
    Marjo Volotinen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Invest Ophthalmol Vis Sci 50:3099-105. 2009
    ..However, mutations in the CYP1B1 gene have been linked to congenital glaucoma. The aim of the present study was to investigate the expression and regulation of cytochrome P450 enzymes in a human nonpigmented ciliary epithelial cell line...
  25. doi request reprint Effects of milk casein-derived tripeptides Ile-Pro-Pro, Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vasoactive precursors in vitro
    Risto Lehtinen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Arzneimittelforschung 60:182-5. 2010
    ..No inhibition of chymase and cathepsin G was observed by the tripeptides. The findings support the hypothesis that Ile-Pro-Pro, Val-Pro-Pro and Leu-Pro-Pro act favourably on blood pressure mainly by selective inhibition of ACE1...
  26. ncbi request reprint Incubation of porcine iris-ciliary bodies to study the mechanisms by which nitric oxide donors lower intraocular pressure
    Hanna Kotikoski
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Finland
    Med Sci Monit 9:BR1-7. 2003
    ..We previously reported that several nitric oxide (NO) donors, guanylate cyclase activators, and cyclic GMP lower intraocular pressure (IOP) in rabbits...
  27. ncbi request reprint Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients
    Aino Lepäntalo
    Department of Internal Medicine, Division of Hematology, Helsinki University Central Hospital, PO Box 340, FIN 00029 HUCH, Helsinki, Finland
    Thromb Haemost 95:253-9. 2006
    ..Evaluation of aspirin efficacy by AA-induced aggregation and PFA-100 detected different individuals, with different genotypic profiles, as being aspirin non-responders...
  28. ncbi request reprint Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro
    Esko Kankuri
    Institute of Biomedicine, Pharmacology, University of Helsinki, Biomedicum, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
    Thromb Res 110:299-303. 2003
    ..We suggest that the very potent inhibitory activity of p-phenetidine on PGE2 synthesis combined with the reduction of COX-2 expression could explain the renal papillary necrosis in phenacetin kidney...