Affiliation: University of Tampere
Kananen L, Marttila S, Nevalainen T, Kummola L, Junttila I, Mononen N, et al
. The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies. Age (Dordr). 2016;38:65 pubmed publisher
..Overall, these observations contribute to the understanding of the longitudinal aspects of the DNAmAge estimate. ..
Kananen L, Nevalainen T, JylhÃ¤vÃ¤ J, Marttila S, Hervonen A, JylhÃ¤ M, et al
. Cytomegalovirus infection accelerates epigenetic aging. Exp Gerontol. 2015;72:227-9 pubmed publisher
..5 vs. 24.0 (p < 0.02,Mannâ€“Whitney U-test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes. ..
Kananen L, Marttila S, Nevalainen T, JylhÃ¤vÃ¤ J, Mononen N, KÃ¤hÃ¶nen M, et al
. Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. BMC Genomics. 2016;17:103 pubmed publisher
..We speculate that the a-CpGs identified here in a population with a narrow age-range represent clock-like changes, as they showed concordant methylation behavior in population spanning whole adulthood as well. ..
Marttila S, Kananen L, HÃ¤yrynen S, JylhÃ¤vÃ¤ J, Nevalainen T, Hervonen A, et al
. Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics. 2015;16:179 pubmed publisher