Research Topics
Species | E KalsoSummaryAffiliation: University of Helsinki Country: Finland Publications
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Detail Information
Publications
Epidural and subcutaneous morphine in the management of cancer pain: a double-blind cross-over studyE Kalso
Department of Anaesthesia, Helsinki University Central Hospital, Finland
Pain 67:443-9. 1996..Both treatments provided better pain relief with less adverse effects compared with the prestudy oral morphine treatment...- Opioids in chronic non-cancer pain: systematic review of efficacy and safetyEija Kalso
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS, Finland
Pain 112:372-80. 2004..The small number of selected patients and the short follow-ups do not allow conclusions concerning problems such as tolerance and addiction... - Sodium channel blockers in neuropathic painEija Kalso
University of Helsinki, Institute of Clinical Medicine, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS, Finland
Curr Pharm Des 11:3005-11. 2005..An oral local anesthetic type sodium channel blocker, mexiletine is an antiarrhythmic agent that is effective in neuropathic pain. However, effective doses may be difficult to achieve because of adverse effects... - Improving opioid effectiveness: from ideas to evidenceEija Kalso
Department of Anaesthesia and Intensive Care Medicine, Pain Clinic, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS, Finland
Eur J Pain 9:131-5. 2005..The theoretical background and the clinical evidence of these combinations will be discussed... - No pain, no gain: clinical excellence and scientific rigour--lessons learned from IA morphineEija Kalso
Pain Clinic, Department of Anaesthesia and Intensive Care, Helsinki University Hospital, P O Box 340, Helsinki, FIN 00029 HUS, Finland
Pain 98:269-75. 2002..A minimum of 30% of the maximum possible pain intensity is needed for an analgesic effect to be detected in a study... - Chronic post-sternotomy painE Kalso
Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
Acta Anaesthesiol Scand 45:935-9. 2001..The aim of this paper was to study the incidence and possible risk factors of chronic pain following sternotomy operations performed for coronary bypass grafting or thymectomy... - Five easy pieces on evidence based medicine (5). Trading benefit against harm--pain relief vs. adverse effectsEija Kalso
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
Eur J Pain 6:409-12. 2002 - Endogenous noradrenergic tone controls symptoms of allodynia in the spinal nerve ligation model of neuropathic painM Xu
Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, Finland
Eur J Pharmacol 366:41-5. 1999..t. or 1 mg/kg s.c.) had no effect on the neuropathic symptoms. These results indicate that mechanical and cold allodynia are under endogenous noradrenergic rather than opioidergic control in this model of neuropathic pain... - Effects of (1DMe)NPYF, a synthetic neuropeptide FF analogue, in different pain modelsM Xu
Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, Finland
Peptides 20:1071-7. 1999..In the neuropathic pain model, the lowest dose tested (0.5 nmol) showed antiallodynic effects against cold allodynia. The results suggest a potential role for (1DMe)NPYF in the treatment of pain including neuropathic pain... - Itraconazole, a potent inhibitor of P-glycoprotein, moderately increases plasma concentrations of oral morphineT Heiskanen
Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
Acta Anaesthesiol Scand 52:1319-26. 2008..The aim of this study was to evaluate whether itraconazole, which is a potent inhibitor of P-glycoprotein and CYP3A4, would change the pharmacokinetics or the pharmacodynamics of oral morphine... - The effects of the alpha2-adrenergic agonist, dexmedetomidine, in the spinal nerve ligation model of neuropathic pain in ratsV K Kontinen
Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, Finland
Anesth Analg 86:355-60. 1998..At tolerable doses, systemic dexmedetomidine neither prevented nor attenuated neuropathic pain behavior... - Analgesic effects of dextromethorphan and morphine in patients with chronic painTarja Heiskanen
Pain Clinic, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
Pain 96:261-7. 2002..There were no significant differences in either the incidence or severity of adverse effects. In conclusion, oral dextromethorphan 100 mg had no effect on pain relief by intravenous morphine 15 mg in patients with chronic pain... - Post-thoracotomy pain after thoracic epidural analgesia: a prospective follow-up studyE Tiippana
Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
Acta Anaesthesiol Scand 47:433-8. 2003..The patients had significant pain and needed regular pain medication and instructions during the first week after discharge. Extended postoperative analgesia up to the first week at home is warranted... - Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review)R F Bell
Pain Clinic, Department of Anaesthesia and Intensive Care, Haukeland University Hospital and Department of Surgical Sciences, University of Bergen, Norway
Acta Anaesthesiol Scand 49:1405-28. 2005..The objective of this systematic review was to evaluate the effectiveness and tolerability of ketamine administered peri-operatively in the treatment of acute post-operative pain in adults... - Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodoneT Heiskanen
Department of Anaesthesia, Helsinki University Central Hospital, Finland
Clin Pharmacol Ther 64:603-11. 1998..The aim of this study was to evaluate the role of oxymorphone in mediating the opioid effects of oxycodone by means of blocking CYP2D6 with quinidine... - Inhibitors of catechol-O-methyltransferase sensitize mice to painO Kambur
Primary laboratory of origin Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Br J Pharmacol 161:1553-65. 2010..Here, we have assessed the effects of acute and repeated administrations of COMT inhibitors on mechanical, thermal and carrageenan-induced nociception in male mice... - Pain and other symptoms during the first year after radical and conservative surgery for breast cancerT Tasmuth
Department of Anaesthesia, Helsinki University Central Hospital, Finland
Br J Cancer 74:2024-31. 1996..Both the anxiety and depression scores were highest before surgery, decreasing with time, and were significantly correlated with preoperative stressful events... - Effects of radolmidine, a novel alpha2 -adrenergic agonist compared with dexmedetomidine in different pain models in the ratM Xu
Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, Helsinki University Hospital, Finland
Anesthesiology 93:473-81. 2000..This study determined the antinociceptive and sedative effects of radolmidine in different models of acute and chronic pain. Dexmedetomidine and saline served as controls... - Widespread unilateral pain associated with herpes simplex virus infectionsKatariina Kallio-Laine
Pain Clinic, Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, HUS, Helsinki, Finland
J Pain 9:658-65. 2008..HSV reactivations and the accompanying inflammatory process cause dysfunction of the central nervous system that manifests as neuropathic pain. Studies using functional brain imaging are needed to clarify this syndrome... - Treatment-related factors predisposing to chronic pain in patients with breast cancer--a multivariate approachT Tasmuth
Department of Anaesthesia, Helsinki University Central Hospital, Finland
Acta Oncol 36:625-30. 1997..The most important factors included in the models of chronic pain were: intensity of the acute postoperative pain, the type of operation, involvement of regional lymph nodes and radiotherapy... - Disodium clodronate in the treatment of diffuse sclerosing osteomyelitis (DSO) of the mandibleM Montonen
Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital, Finland
Int J Oral Maxillofac Surg 30:313-7. 2001..However, 6 months after treatment there was a statistically significant difference in pain intensity between the groups, with the disodium clodronate group experiencing significantly less pain... - Effect of paracetamol and coxib with or without dexamethasone after laparoscopic cholecystectomyE Tiippana
Department of Anaesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Medicine, Helsinki University Hospital, Helsinki, Finland
Acta Anaesthesiol Scand 52:673-80. 2008..Effective post-operative pain control is necessary in LCC performed as day-case surgery. We studied the efficacy of paracetamol or valdecoxib with or without dexamethasone after LCC... - Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the ratKim Lemberg
Department of Pharmacology, Institute of Biomedicine, University of Helsinki, Finland
Anesth Analg 102:1768-74. 2006..Opioids seem to have different profiles in different pain models. l-methadone should be studied for neuropathic pain in humans... - Stress-induced analgesia and morphine responses are changed in catechol-O-methyltransferase-deficient male miceOleg Kambur
Department of Pharmacology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Basic Clin Pharmacol Toxicol 103:367-73. 2008..COMT activity seems to take part in the modulation of nociception not only in the brain, as suggested earlier, but also at the spinal/peripheral level... - Clustering of symptoms associated with fibromyalgia in a Finnish Twin CohortRitva Markkula
Helsinki University Central Hospital, Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, 00029 HUS Helsinki, Finland
Eur J Pain 13:744-50. 2009..The symptoms known to be associated with fibromyalgia seem to have a strong genetic background... - HLA-DRB1*01 allele and low plasma immunoglobulin G1 concentration may predispose to herpes-associated recurrent lymphocytic meningitisKatariina Kallio-Laine
Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
Hum Immunol 71:179-81. 2010..05). HLA-DRB1*01 (p = 0.009) and -B*27 (p = 0.050) were more common among patients than controls. We conclude that HLA-DRB1*01 and -B*27 alleles and low plasma IgG1 levels may be significant risk factors for RLM... - Recurrent lymphocytic meningitis positive for herpes simplex virus type 2Katariina Kallio-Laine
Helsinki University Central Hospital, Helsinki, Finland
Emerg Infect Dis 15:1119-22. 2009..2/100,000 population in Finland during 1996-2006, higher than previous estimates. PCR was most sensitive in detecting HSV-2 DNA from cerebrospinal fluid if the sample was taken 2-5 days after symptom onset... - Medical undergraduate students' beliefs and attitudes toward pain: how do they mature?Leila Niemi-Murola
Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Finland
Eur J Pain 11:700-6. 2007..Attitudes towards treating the pain of cancer patients and elderly patients are positive. Attention should be paid to helping students to cope with their emotions and to reducing their anxiety about meeting patients with chronic pain... - Do strong opioids have a role in the early management of back pain? Recommendations from a European expert panelEija Kalso
Pain Clinic, Helsinki University Central Hospital, Helsinki, Finland
Curr Med Res Opin 21:1819-28. 2005..Given the prevalence of CLBP, and the complex nature of this multifactorial condition, it was felt that specific, evidence-based recommendations, with a focus on primary-care treatment, would be helpful... - A systematic review of trial methodology, using the placebo groups of randomized controlled trials in paediatric postoperative painKatri Hamunen
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 140, FIN 00029 HUS, Finland
Pain 116:146-58. 2005..In conclusion, analysis of the methodology showed several aspects of trial design that can be improved in future studies. Placebo control groups can be used in paediatric analgesic studies to demonstrate internal sensitivity... - Placebo and opioid analgesia-- imaging a shared neuronal networkPredrag Petrovic
Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
Science 295:1737-40. 2002..These findings indicate a related neural mechanism in placebo and opioid analgesia... - Development of a screening instrument for risk factors of persistent pain after breast cancer surgeryR Sipilä
Department of Anaesthesia and Intensive Care, Pain Clinic, Helsinki University Central Hospital, PO Box 140, 00029 HUS, Helsinki, Finland
Br J Cancer 107:1459-66. 2012..Identification of risk factors may lead to prevention of persistent postsurgery pain. This tool could be used for target prevention to those who are at the highest risk of developing persistent postsurgery pain... - Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteersK Hamunen
Pain Clinic, Department of Anaesthesia and Intensive Care, Helsinki University Central Hospital, PO Box 140, Helsinki FIN 00029 HUS, Finland
Br J Anaesth 108:838-44. 2012..The aim of our study was to correlate the intensity of experimental pain to changes in physiological variables reflecting the autonomic nervous system response to pain... - Transdermal fentanyl in cachectic cancer patientsTarja Heiskanen
Pain Clinic, Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 140, 00029 HUS Helsinki, Finland
Pain 144:218-22. 2009..Absorption of transdermal fentanyl is impaired in cachectic patients compared with that of normal weight cancer pain patients... - Pain intensity influences the relationship between anger management style and depressionAnn Mari Estlander
Helsinki University Central Hospital, Pain Clinic, Mannerheimvagen 110 A 4, 00250 Helsinki, Finland
Pain 140:387-92. 2008..However, analysing separately the two subscales of the BDI, negative view and physical function, significant positive relationships between pain intensity and both subscales appeared... - Venlafaxine in neuropathic pain following treatment of breast cancerTiina Tasmuth
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, FIN-00029 HUS, Helsinki, Finland
Eur J Pain 6:17-24. 2002..The two poor responders had low venlafaxine concentrations whereas the two slow hydroxylizers had high venlafaxine concentrations and excellent pain relief. Thus, higher doses could be used in order to improve pain relief... - Predicting long-term response to strong opioids in patients with low back pain: findings from a randomized, controlled trial of transdermal fentanyl and morphineEija Kalso
Pain Clinic, Helsinki University Central Hospital, Helsinki, Finland
BMC Med 5:39. 2007..We assessed data from a large-scale randomized comparison of transdermal fentanyl (TDF) and sustained-release oral morphine (slow-release morphine; SRM) to determine characteristics of treatment responders... - Recommendations for using opioids in chronic non-cancer painEija Kalso
Helsinki University Central Hospital, Finland
Eur J Pain 7:381-6. 2003..6. Treatment should be monitored. 7. A contract setting out the patient's rights and responsibilities may help to emphasize the importance of patient involvement. 8. Opioid treatment should not be considered a lifelong treatment... - The outcome of pain related undergraduate teaching in Finnish medical facultiesR Poyhia
Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS Helsinki, Finland
Pain 115:234-7. 2005..The clinical problems were excellently solved. In conclusion, the IASP curriculum is well covered in the present programmes in the Finnish medical faculties. However, the quality and the methods of teaching still need improvement... - Role of the delta-opioid receptor in (1DMe)NPYF mediated antinociceptionM Xu
Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, Finland
Peptides 22:33-8. 2001..01-0.001). These data suggest that activation of spinal delta-opioid receptors plays an important role in mediating the spinal antinociceptive effects of (1DMe)NPYF... - Trends in opioid consumption in the Nordic countries 2002-2006Katri Hamunen
Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Meilahti Hospital, Helsinki, HUS, Finland
Eur J Pain 13:954-62. 2009..The purpose of the study was to examine the trends in opioid consumption in the five Nordic countries between 2002 and 2006 and to explore possible explanations for changes in the quality and quantity of opioids consumed... - Amitriptyline in the treatment of chemotherapy-induced neuropathic symptomsAnna Liisa Kautio
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
J Pain Symptom Manage 35:31-9. 2008..No statistical significance was reached, probably due to the small number of patients and too low dose of amitriptyline. Amitriptyline was well tolerated... - Amitriptyline in the prevention of chemotherapy-induced neuropathic symptomsAnna Liisa Kautio
Department of Oncology, Helsinki University Central Hospital, 00029 HUS, Finland
Anticancer Res 29:2601-6. 2009..This double-blind, randomized placebo-controlled trial assessed the efficacy of amitriptyline to prevent chemotherapy-induced neuropathic symptoms... - Five easy pieces on evidence-based medicine (4)Eija Kalso
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
Eur J Pain 6:89-93. 2002 - OxycodoneEija Kalso
University of Helsinki, and Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
J Pain Symptom Manage 29:S47-56. 2005..Oxycodone closely resembles morphine but it has some distinct differences, particularly in its pharmacokinetic profile. Being an old drug, the basic pharmacology of oxycodone has been a neglected field of research... - Acute opioid effects on human brain as revealed by functional magnetic resonance imagingMika Leppä
Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS, Finland
Neuroimage 31:661-9. 2006..These areas belong to a circuitry that modulates the affective experience of sensory stimuli... - What do different databases tell about the use of opioids in seven European countries in 2002?Katri Hamunen
Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 140, FIN 00029 HUS, Finland
Eur J Pain 12:705-15. 2008..The objective of this paper was to analyse opioid consumption in a number European countries using different sources of data... - Radiofrequency denervation for neck and back pain: a systematic review within the framework of the cochrane collaboration back review groupLeena Niemistö
ORTON Orthopaedic Hospital, Invalid Foundation, Helsinki, Finland
Spine (Phila Pa 1976) 28:1877-88. 2003..Systematic review... - Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safetyElina M Tiippana
Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
Anesth Analg 104:1545-56, table of contents. 2007..These properties may also be beneficial in acute postoperative pain. In this study we evaluated randomized, controlled trials examining the analgesic efficacy, adverse effects, and clinical value of gabapentinoids in postoperative pain... - Is intranasal ketamine an appropriate treatment for chronic non-cancer breakthrough pain?Rae F Bell
Pain 108:1-2. 2004 - Of mice and men: what can we predict from the effects of morphine in a mouse model of bone cancer?Vesa K Kontinen
Pain 132:5-7. 2007 - Venlafaxine in the treatment of atypical facial pain: a randomized controlled trialHeli Forssell
Department of Oral Diseases Pain Clinic, Turku University Central Hospital Turku, Finland
J Orofac Pain 18:131-7. 2004..To study in a randomized placebo-controlled design the efficacy of the antidepressant venlafaxine, a serotonin and a weak noradrenaline reuptake inhibitor, in the treatment of atypical facial pain (AFP)... - Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic reviewRae F Bell
Pain Clinic, Department of Anesthesia and Intensive Care, Haukeland University Hospital, 5021 Bergen, Norway
J Pain Symptom Manage 26:867-75. 2003..High quality, randomized, controlled trials with larger numbers of patients and standardized, clinically relevant routes of administration of ketamine are needed... - [Opioids in the treatment of pain--efficient weapon in the expert's hand]Eija Kalso
HYKS, anestesiologia ja tehohoito, kipuklinikka PL 340, 00029 HUS
Duodecim 120:195-6. 2004 - [Only placebo?]Eija Kalso
Duodecim 118:1733-4. 2002 - Biomarkers for painEija Kalso
Pain 107:199-201. 2004 - Opioids for persistent non-cancer painEija Kalso
BMJ 330:156-7. 2005 - Pain- and morphine-associated transcriptional regulation of neuropeptide FF and the G-protein-coupled NPFF2 receptor geneJohanna M Nystedt
Department of Biology, Abo Akademi University, Turku, Finland
Neurobiol Dis 16:254-62. 2004..Acute, but not chronic, morphine activated the genes supraspinally. The results give further evidence for the involvement of the NPFF system in pain modulation and may provide new therapeutic opportunities for pathologic pain... - Successful and unsuccessful outcomes with long-term opioid therapy: a survey of physicians' opinionsMina Nishimori
The MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts 02114, USA
J Palliat Med 9:50-6. 2006..The attitudes, beliefs, and experience of physicians will influence how they view the use of opioids for chronic nonterminal pain... - The compassionate brain: humans detect intensity of pain from another's faceMiiamaaria V Saarela
Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, Espoo, Finland
Cereb Cortex 17:230-7. 2007..These findings imply that the intersubjective representation of pain in the human brain is more detailed than has been previously thought... - How palliative care of cancer patients is organised between a university hospital and primary care in FinlandTiina Tasmuth
Cancer Society of Finland
Acta Oncol 45:325-31. 2006..Every third patient reported of poor quality of palliative care in the primary care. Also the physicians reported a need for training in palliative care... - Subanesthetic ketamine for cancer pain and scientific rigor in cancer pain trials. A reply to Jackson et alRae Frances Bell
J Pain Symptom Manage 31:386. 2006 - Application of principles of evidence-based medicine to occlusal treatment for temporomandibular disorders: are there lessons to be learned?Heli Forssell
Department of Oral Diseases Pain Clinic, Turku University Central Hospital, Turku, Finland
J Orofac Pain 18:9-22; discussion 23-32. 2004..None of the occlusal adjustment studies provided evidence supporting the use of this treatment method. The clinical implications of the findings and future perspectives are discussed... - Prolactin-releasing peptide affects pain, allodynia and autonomic reflexes through medullary mechanismsMaija Liisa Kalliomäki
Department of Biology, Abo Akademi University, Biocity Artillerigatan 6A, 20520 Turku, SF, Finland
Neuropharmacology 46:412-24. 2004..The results show that PrRP modulates nociception due to supraspinal rather than spinal action, and that its antinociceptive mechanism differs from that previously characterized for NPFF... - How different is oxycodone from morphine?Eija Kalso
Pain 132:227-8. 2007 - Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanismsKristina B Svendsen
Danish Pain Research Center, University Hospital of Aarhus, Noerrebrogade 44, Building 1A, 8000 Aarhus, Denmark
Eur J Pain 9:195-206. 2005..It is suggested that sensitization could be the common denominator of BTP in malignant and non-malignant pain...