Anne Kallioniemi

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. pmc High-level amplification at 17q23 leads to coordinated overexpression of multiple adjacent genes in breast cancer
    J Pärssinen
    Laboratory of Cancer Genetics, Institute of Medical Technology, Tampere University Hospital, University of Tampere, FIN 33014, Finland
    Br J Cancer 96:1258-64. 2007
  2. pmc BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment
    Minna Ampuja
    Institute of Biomedical Technology, University of Tampere and BioMediTech, Tampere, Finland
    BMC Cancer 13:429. 2013
  3. doi request reprint Bone morphogenetic protein 4-a fascinating regulator of cancer cell behavior
    Anne Kallioniemi
    Institute of Biomedical Technology BioMediTech, University of Tampere and Fimlab Laboratories, Finland
    Cancer Genet 205:267-77. 2012
  4. pmc Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
    Guro E Lind
    Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    J Transl Med 6:13. 2008
  5. pmc Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
    Henna Heinonen
    Institute of Biomedicine and Biomedicum Biochip Center, Genome Scale Biology Research Program, University of Helsinki, Finland
    BMC Genomics 9:348. 2008
  6. pmc Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication
    Maija Wolf
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    BMC Cancer 10:181. 2010
  7. ncbi request reprint CGH microarrays and cancer
    Anne Kallioniemi
    Laboratory of Cancer Genetics, Tampere University Hospital and Institute of Medical Technology, University of Tampere, Biokatu 6, Tampere FI 33014, Finland
    Curr Opin Biotechnol 19:36-40. 2008
  8. doi request reprint DNA copy number analysis on tissue microarrays
    Anne Kallioniemi
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Methods Mol Biol 664:127-34. 2010
  9. doi request reprint BMP7 influences proliferation, migration, and invasion of breast cancer cells
    Emma Leena Alarmo
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, FIN 33014 Tampere, Finland
    Cancer Lett 275:35-43. 2009
  10. doi request reprint Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer
    Eeva Laurila
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Finland
    Genes Chromosomes Cancer 48:330-9. 2009

Collaborators

Detail Information

Publications50

  1. pmc High-level amplification at 17q23 leads to coordinated overexpression of multiple adjacent genes in breast cancer
    J Pärssinen
    Laboratory of Cancer Genetics, Institute of Medical Technology, Tampere University Hospital, University of Tampere, FIN 33014, Finland
    Br J Cancer 96:1258-64. 2007
    ..Moreover, our results highlight the fact that 17q23 amplicon carries multiple candidate genes and that this may be a more common event in gene amplification than previously thought...
  2. pmc BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment
    Minna Ampuja
    Institute of Biomedical Technology, University of Tampere and BioMediTech, Tampere, Finland
    BMC Cancer 13:429. 2013
    ..Here we examined the effects of BMP4 in a more physiological environment, in a 3D culture system...
  3. doi request reprint Bone morphogenetic protein 4-a fascinating regulator of cancer cell behavior
    Anne Kallioniemi
    Institute of Biomedical Technology BioMediTech, University of Tampere and Fimlab Laboratories, Finland
    Cancer Genet 205:267-77. 2012
    ..Improved knowledge of the downstream mediators of BMP4 effects in cancer cells may allow dissection of the different BMP4-induced phenotypes and thereby generation of specific targeted therapies...
  4. pmc Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
    Guro E Lind
    Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    J Transl Med 6:13. 2008
    ..The aim of the present study was to investigate the potential of the MAL (T-cell differentiation protein) gene as an early epigenetic diagnostic marker for colorectal tumors...
  5. pmc Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
    Henna Heinonen
    Institute of Biomedicine and Biomedicum Biochip Center, Genome Scale Biology Research Program, University of Helsinki, Finland
    BMC Genomics 9:348. 2008
    ..These profiles were further correlated with gene expression alterations caused by inhibition of PI3K/mTOR pathway with PI3K inhibitor Ly294002 or mTOR inhibitor rapamycin...
  6. pmc Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication
    Maija Wolf
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    BMC Cancer 10:181. 2010
    ..Here, we present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for neuroblastoma...
  7. ncbi request reprint CGH microarrays and cancer
    Anne Kallioniemi
    Laboratory of Cancer Genetics, Tampere University Hospital and Institute of Medical Technology, University of Tampere, Biokatu 6, Tampere FI 33014, Finland
    Curr Opin Biotechnol 19:36-40. 2008
    ..The genes involved in these aberrations are likely to contribute to cancer pathogenesis, and the high-resolution mapping by aCGH greatly facilitates the subsequent identification of these cancer-associated genes...
  8. doi request reprint DNA copy number analysis on tissue microarrays
    Anne Kallioniemi
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Methods Mol Biol 664:127-34. 2010
    ..Despite of the technical difficulties, FISH analysis on TMA has been successfully used not only to uncover genetic alterations in various malignancies but to also rapidly establish the clinical significance of such changes...
  9. doi request reprint BMP7 influences proliferation, migration, and invasion of breast cancer cells
    Emma Leena Alarmo
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, FIN 33014 Tampere, Finland
    Cancer Lett 275:35-43. 2009
    ..9-fold increase in cell invasion. In conclusion, BMP7 can promote and inhibit cell growth in breast cancer cell lines and, in a suitable environment, can also considerably induce breast cancer cell migration and invasion...
  10. doi request reprint Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer
    Eeva Laurila
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Finland
    Genes Chromosomes Cancer 48:330-9. 2009
    ..Taken together, our data implicate ARPC1A as a novel target for the 7q21-q22 amplification and a regulator of cell migration and invasion in pancreatic cancer, thus making it an interesting target for antimetastasis therapy...
  11. pmc MED29, a component of the mediator complex, possesses both oncogenic and tumor suppressive characteristics in pancreatic cancer
    Riina Kuuselo
    Institute of Medical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    Int J Cancer 129:2553-65. 2011
    ..Such a dualistic role appears to be more common than previously thought and is likely to depend on the genetic background of the cancer cells and their surrounding environment...
  12. ncbi request reprint Identification of differentially expressed genes after PPM1D silencing in breast cancer
    Jenita Pärssinen
    Laboratory of Cancer Genetics, Tampere University Hospital, FI 33014 University of Tampere, Finland
    Cancer Lett 259:61-70. 2008
    ..Overall, our findings suggest that PPM1D contributes to breast cancer associated phenotypic characteristics by directly or indirectly affecting several important cellular signaling pathways...
  13. pmc High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer
    Eija H Mahlamäki
    Laboratory of Cancer Genetics, University of Tampere and Tampere University Hospital, Tampere, Finland
    Neoplasia 6:432-9. 2004
    ..In conclusion, our results implicate a set of 105 genes that is likely to be actively involved in the development and progression of pancreatic cancer...
  14. ncbi request reprint Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer
    Emma Leena Alarmo
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Finland
    Genes Chromosomes Cancer 45:411-9. 2006
    ....
  15. doi request reprint PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53
    Jenita Pärssinen
    Institute of Medical Technology, University of Tampere, FIN 33014 University of Tampere, Finland
    Cancer Genet Cytogenet 182:33-9. 2008
    ....
  16. pmc Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes
    Alejandra Rodriguez-Martinez
    Laboratory of Cancer Genetics, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Finland
    BMC Med Genomics 4:80. 2011
    ..Data analysis included hierarchical clustering of differentially expressed genes, gene ontology enrichment analyses and model based clustering of temporal data...
  17. ncbi request reprint The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours
    Jenita Rauta
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Breast Cancer Res Treat 95:257-63. 2006
    ..Taken together, our findings substantiate an important role for PPM1D in breast cancer...
  18. doi request reprint Parallel inhibition of cell growth and induction of cell migration and invasion in breast cancer cells by bone morphogenetic protein 4
    Johanna M Ketolainen
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33014, Tampere, Finland
    Breast Cancer Res Treat 124:377-86. 2010
    ....
  19. pmc Amplification of a 280-kilobase core region at the ERBB2 locus leads to activation of two hypothetical proteins in breast cancer
    Paivikki Kauraniemi
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, FIN 33014 Finland
    Am J Pathol 163:1979-84. 2003
    ..These results support the recent findings on the influence of copy number on gene expression levels and highlight novel genes that might contribute to the clinical behavior of ERBB2-amplified breast tumors...
  20. ncbi request reprint Frequent amplification and overexpression of CCND1 in male breast cancer
    Maarit Bärlund
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Finland
    Int J Cancer 111:968-71. 2004
    ..Furthermore, the high frequency of hormone receptor positivity and the association between ER positivity and CCND1 overexpression supports the notion that hormonal regulation is likely to be essential for the development of MBC...
  21. doi request reprint Both inhibition and enhanced expression of miR-31 lead to reduced migration and invasion of pancreatic cancer cells
    Eeva M Laurila
    Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    Genes Chromosomes Cancer 51:557-68. 2012
    ..This study highlights a specific miRNA expression pattern in pancreatic cancer and reveals that manipulation of miR-31 expression leads to reduced cell migration and invasion in pancreatic cancer...
  22. ncbi request reprint Effects of Herceptin treatment on global gene expression patterns in HER2-amplified and nonamplified breast cancer cell lines
    Paivikki Kauraniemi
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, FIN 33520 Tampere, Finland
    Oncogene 23:1010-3. 2004
    ..These results provide additional clues to the downstream effects of blocking the HER2 pathway in breast cancer and may provide new targets for more effective treatment...
  23. pmc The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues
    Riikka Laurila
    Institute of Biomedical Technology, University of Tampere and BioMediTech, Tampere, Finland
    Int J Clin Exp Pathol 6:1400-8. 2013
    ..Even though gremlin 1 and noggin were not widely expressed in adult tissues, in a subset of organs their expression pattern indicated a potential role in normal tissue homeostasis as well as in malignancies. ..
  24. doi request reprint Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development
    Emma Leena Alarmo
    Institute of Biomedical Technology, University of Tampere and BioMediTech, Tampere, Finland
    Mod Pathol 26:10-21. 2013
    ..This role is biphasic in breast cancer as BMP4 expression is linked to reduced proliferation and increased recurrence, thus corroborating our previous in-vitro functional data...
  25. doi request reprint Bone morphogenetic protein -4 and -5 in pancreatic cancer--novel bidirectional players
    Siru Virtanen
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Finland
    Exp Cell Res 317:2136-46. 2011
    ....
  26. pmc Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions
    Szilvia Solyom
    Laboratory of Cancer Genetics, Department of Clinical Genetics, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu, Oulu University Hospital, Aapistie 5A, FI 90220 Oulu, Finland
    Sci Transl Med 4:122ra23. 2012
    ..1082G>A mutation connects to cancer predisposition. These findings contribute to the concept of a BRCA-centered tumor suppressor network and provide the identity of Abraxas as a new breast cancer susceptibility gene...
  27. ncbi request reprint Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification
    Riina Kuuselo
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Cancer Res 67:1943-9. 2007
    ..These findings implicate IXL as a novel amplification target gene in pancreatic cancer and suggest that IXL is required for cancer cell survival in 19q13-amplified tumors...
  28. ncbi request reprint Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer
    Eija H Mahlamäki
    Laboratory of Cancer Genetics, Tampere University Hospital and University of Tampere, Tampere, Finland
    Genes Chromosomes Cancer 35:353-8. 2002
    ..These results illustrate that amplification of genes from the 8q, 11q, 17q, and 20q chromosome arms is common in pancreatic cancer...
  29. pmc 19q13 amplification is associated with high grade and stage in pancreatic cancer
    Riina Kuuselo
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere, Finland
    Genes Chromosomes Cancer 49:569-75. 2010
    ..More importantly, the 19q13 amplifications were associated with poor tumor phenotype and showed a trend toward shorter survival...
  30. ncbi request reprint Pancreatic adenocarcinoma -- genetic portrait from chromosomes to microarrays
    Ritva Karhu
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Genes Chromosomes Cancer 45:721-30. 2006
    ....
  31. ncbi request reprint Large genomic BRCA2 rearrangements and male breast cancer
    Ritva Karhu
    Laboratory of Cancer Genetics, Tampere University Hospital and Institute of Medical Technology, University of Tampere, Teiskontie 35, FIN 33520 Tampere, Finland
    Cancer Detect Prev 30:530-4. 2006
    ..In recent literature, however, genomic alterations of BRCA2 have been linked especially to male breast cancer families. We wanted to screen large genomic deletions and duplications of BRCA2 among Finnish male breast cancer patients...
  32. ncbi request reprint KPNA7, a nuclear transport receptor, promotes malignant properties of pancreatic cancer cells in vitro
    Eeva Laurila
    Institute of Biomedical Technology, FIN 33014 University of Tampere and BioMediTech, Biokatu 6, 33520 Tampere, Finland Fimlab Laboratories, Biokatu 4, 33520 Tampere, Finland
    Exp Cell Res 322:159-67. 2014
    ..These data strongly demonstrate that KPNA7 silencing inhibits the malignant properties of pancreatic cancer cells in vitro and thereby provide the first evidence on the functional role for KPNA7 in human cancer. ..
  33. ncbi request reprint Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer
    Maarit Bärlund
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Genes Chromosomes Cancer 35:311-7. 2002
    ..2, undergo amplification, overexpression, and fusion in breast cancer and therefore may have a role in the frequent chromosomal alterations affecting these two loci...
  34. ncbi request reprint A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7
    Emma Leena Alarmo
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, Tampere, Finland
    Breast Cancer Res Treat 103:239-46. 2007
    ..Breast cancer cell lines and the data generated here serve as a good resource for further studies on BMP function in breast cancer...
  35. pmc Rare copy number variants observed in hereditary breast cancer cases disrupt genes in estrogen signaling and TP53 tumor suppression network
    Katri Pylkäs
    Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland
    PLoS Genet 8:e1002734. 2012
    ..These results suggest that rare CNVs represent an alternative source of genetic variation influencing hereditary risk for breast cancer...
  36. ncbi request reprint Search for large genomic alterations of the BRCA1 gene in a Finnish population
    Eeva Laurila
    Laboratory of Cancer Genetics and Institute of Medical Technology, University of Tampere, Teiskontie 35, Tampere FIN 33521, Finland
    Cancer Genet Cytogenet 163:57-61. 2005
    ..Our results are in agreement with the common hypothesis that there are still unknown breast cancer susceptibility gene(s) that are responsible for breast cancer predisposition...
  37. doi request reprint Penetrance analysis of the PALB2 c.1592delT founder mutation
    Hannele Erkko
    Laboratory of Cancer Genetics, Oulu University Hospital, Finland
    Clin Cancer Res 14:4667-71. 2008
    ..In the present study, we wanted to assess in more detail the increased risk (hazard ratio, HR) and the age-specific cumulative risk (penetrance) of c.1592delT with regard to susceptibility to breast and other forms of cancer...
  38. doi request reprint Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis?
    Emma Leena Alarmo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Finland
    Endocr Relat Cancer 17:R123-39. 2010
    ..In this review, we focus on the current knowledge of BMP expression, functional roles and involvement in bone metastasis in breast cancer...
  39. pmc Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins
    Heini Kallio
    Institute of Biomedical Technology, University of Tampere, Tampere, Finland
    PLoS ONE 6:e27152. 2011
    ..These studies provide ample evidence that the current name, "non-specific cytotoxic cell receptor protein 1," is not appropriate. We therefore propose that the gene name be changed to FBXO50...
  40. ncbi request reprint Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration
    Hanna E Rauhala
    Institute of Biomedical Technology, FIN_33014 University of Tampere, Finland
    Anticancer Res 33:45-52. 2013
    ..Actin-related protein 2/3 (ARP2/3) complex is an actin nucleator responsible for actin cytoskeleton branching which is essential for efficient cell migration...
  41. doi request reprint The diverse role of miR-31 in regulating cancer associated phenotypes
    Eeva M Laurila
    Institute of Biomedical Technology, University of Tampere and BioMediTech, Tampere, Finland
    Genes Chromosomes Cancer 52:1103-13. 2013
    ..This review summarizes the complex expression patterns of miR-31 in human cancers, describes the variable phenotypes caused by altered miR-31 expression, and highlights the current knowledge on the genes targeted by miR-31...
  42. ncbi request reprint Impact of DNA amplification on gene expression patterns in breast cancer
    Elizabeth Hyman
    Howard Hughes Medical Institute NIH Research Scholar, Bethesda, Maryland 20892, USA
    Cancer Res 62:6240-5. 2002
    ..These genes may provide insights to the clonal evolution and progression of breast cancer and highlight promising therapeutic targets...
  43. pmc High-throughput copy number analysis of 17q23 in 3520 tissue specimens by fluorescence in situ hybridization to tissue microarrays
    Claus L Andersen
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Pathol 161:73-9. 2002
    ..These results indicate that increased 17q23 copy number occurs frequently in several different tumor types suggesting that increased dosage of genes in this region might play a role in development and progression of many tumor types...
  44. pmc High-resolution analysis of gene copy number alterations in human prostate cancer using CGH on cDNA microarrays: impact of copy number on gene expression
    Maija Wolf
    Medical Biotechnology, VTT Technical Research Centre of Finland and University of Turku, Turku FIN 20520, Finland
    Neoplasia 6:240-7. 2004
    ....
  45. ncbi request reprint Mutations in the BRCA2 interacting DSS1 are not a risk factor for male breast cancer
    Kirsi Syrjakoski
    Int J Cancer 120:444-6. 2007
  46. ncbi request reprint CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer
    Harriet Wikman
    Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Genes Chromosomes Cancer 42:193-9. 2005
    ..Although CDK4 amplification seems to be a relatively rare event (4.3%) in lung tumors, it indicates the significance of the RB1-CCND1 pathway in lung tumorigenesis...
  47. ncbi request reprint Targets of gene amplification and overexpression at 17q in gastric cancer
    Asta Varis
    Department of Medical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki 00290, Finland
    Cancer Res 62:2625-9. 2002
    ..Additional studies will be initiated to understand the possible biological and clinical significance of these genes in gastric cancer development and progression...
  48. ncbi request reprint Clinical and functional target validation using tissue and cell microarrays
    Spyro Mousses
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 8000, USA
    Curr Opin Chem Biol 6:97-101. 2002
    ..New high-throughput techniques, such as tissue and cell microarrays, will facilitate clinical and functional analysis of molecular targets...
  49. ncbi request reprint New insights into testicular germ cell tumorigenesis from gene expression profiling
    Rolf I Skotheim
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Cancer Res 62:2359-64. 2002
    ....
  50. ncbi request reprint A recurrent mutation in PALB2 in Finnish cancer families
    Hannele Erkko
    Department of Clinical Genetics, University of Oulu and Oulu University Hospital, FIN 90029 OYS, Finland
    Nature 446:316-9. 2007
    ..1592delT truncation allele was observed. These results indicate that PALB2 is a breast cancer susceptibility gene that, in a suitably mutant form, may also contribute to familial prostate cancer development...