Research Topics
Species | Hannu KalimoSummaryAffiliation: University of Turku Country: Finland Publications
| Collaborators
|
Detail Information
Publications
CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementiaHannu Kalimo
Department of Pathology, Turku University Hospital, Finland
Brain Pathol 12:371-84. 2002..It is as yet unclear which disturbance in the Notch signaling pathway leads to the characteristic vascular pathology of CADASIL...- Arterioles of the lenticular nucleus in CADASILQing Miao
Department of Pathology, University and University Hospital of Turku, Turku, Finland
Stroke 37:2242-7. 2006..The pathogenesis of lacunar infarcts in the WM and LN seem to be different, stenosis in the former and probably hemodynamic disturbances in the latter... - Mapping of tissue tropism determinants in coxsackievirus genomesHeli Harvala
Department of Virology and MediCity Research Laboratory, University of Turku, Kiinamyllynkatu 13, FIN 20520 Turku, Finland
J Gen Virol 83:1697-706. 2002..The presence of the 5'NCR of CAV9 clearly enhanced muscle tissue tropism... - Inhaled nitric oxide treatment inhibits neuronal injury after meconium aspiration in pigletsMinna Aaltonen
Research Centre of Applied and Preventive Cardiovascular Medicine CAPC, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
Early Hum Dev 83:77-85. 2007..Meconium aspiration-induced hypertensive lung injury is frequently associated with neuronal damage. Inhaled nitric oxide (iNO) is widely used in the treatment of pulmonary hypertension, but its effects on the brain are poorly known... - Meconium aspiration induces neuronal injury in pigletsMinna Aaltonen
Research Centre of Applied and Preventive Cardiovascular Medicine CAPC, University Hospital of Turku, Turku, Finland
Acta Paediatr 94:1468-75. 2005..We aimed to determine the neuronal injury induced by pulmonary meconium contamination alone and with concurrent asphyxia... - Chromogenic in situ hybridization-detected hotspot MYCN amplification associates with Ki-67 expression and inversely with nestin expression in neuroblastomasMiikka Korja
Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland
Mod Pathol 18:1599-605. 2005.... - Neuropathological examination in forensic contextHannu Kalimo
Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsingin yliopisto, Finland
Forensic Sci Int 146:73-81. 2004..Processing CNS for microscopy also requires special techniques and in addition to the routine stains both special histological and selected immunohistochemical stainings are often needed to reach the correct diagnosis... - Detection of the founder effect in Finnish CADASIL familiesKati Mykkänen
Department of Medical Genetics, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
Eur J Hum Genet 12:813-9. 2004..The age analysis of the founder mutation places the introduction of the mutation in the late 1600s or early 1700s... - [Nuclear lamins and their diseases]Pekka Taimen
Turun yliopisto, kliinis-teoreettinen laitos, , 4. kerros 20520 Turku
Duodecim 120:799-805. 2004 
Absence of polysialylated NCAM is an unfavorable prognostic phenotype for advanced stage neuroblastomaMiikka Korja
Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland
BMC Cancer 9:57. 2009....- Pathogenesis of coxsackievirus A9 in mice: role of the viral arginine-glycine-aspartic acid motifHeli Harvala
Department of Virology and MediCity Research Laboratory, University of Turku, Kiinamyllynkatu 13, FIN 20520 Turku, Finland
J Gen Virol 84:2375-9. 2003..These results suggest that the RGD motif has a significant role in the pathogenesis of CAV9 in mice but also that RGD-independent entry routes can be utilized in the infection of murine tissue... - Fibrosis and stenosis of the long penetrating cerebral arteries: the cause of the white matter pathology in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathyQing Miao
Department of Pathology, Turku University Hospital and University of Turku, Finland
Brain Pathol 14:358-64. 2004..This conforms to the abundance of infarcts and primary ischemic damage in CADASIL patients' white matter... - Mild eccentric stretch injury in skeletal muscle causes transient effects on tensile load and cell proliferationVille Aärimaa
Department of Surgery, Turku University Hospital, Turku, Finland
Scand J Med Sci Sports 14:367-72. 2004.... 
alpha-Synuclein pathology in the spinal cord autonomic nuclei associates with alpha-synuclein pathology in the brain: a population-based Vantaa 85+ studyMinna Oinas
Department of Pathology, Helsinki University Central Hospital, University of Helsinki, P O Box 21, Haartmaninkatu 3, 00014 Helsinki, Finland
Acta Neuropathol 119:715-22. 2010..alphaS pathology exclusively in the spinal cord was rare. Our study indicates that in general alphaS pathology in the spinal cord autonomic nuclei is associated with similar pathology in the brain...- Antioxidant enzymes in oligodendroglial brain tumors: association with proliferation, apoptotic activity and survivalSally Jarvela
Department of Pathology, Tampere University Hospital, Tampere, Finland
J Neurooncol 77:131-40. 2006..002). The results suggest that the expression of Trx has a correlation to patient outcome and that there may be some association between AOEs, like MnSOD and Trx, and clinicopathological features of oligodendrogliomas... - Transected myofibres may remain permanently divided in two partsSamuli Vaittinen
Department of Pathology, Turku University Hospital, Kiinanmyllynkatu 10, FIN-20520, Turku, Finland
Neuromuscul Disord 12:584-7. 2002..We conclude that transected myofibres probably remain permanently divided in two consecutive tendon-muscle-tendon units... - Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotypeJohan Lundkvist
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
Genesis 41:13-22. 2005..We discuss possible reasons for the different outcomes of the same germline CADASIL mutation in mice and humans... - Tissue tropism of recombinant coxsackieviruses in an adult mouse modelHeli Harvala
Department of Virology and MediCity Research Laboratory, University of Turku, FIN 20520 Turku, Finland
J Gen Virol 86:1897-907. 2005..These results demonstrate potential pathogenicity of intraspecies recombinant coxsackieviruses, and the complexity of the genetic determinants underlying tissue tropism... - Distal myopathy caused by homozygous missense mutations in the nebulin geneCarina Wallgren-Pettersson
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Brain 130:1465-76. 2007..We conclude that homozygous missense mutations in NEB cause a novel distal myopathy, predominantly involving lower leg extensor muscles, finger extensors and neck flexors... - Mitochondrial DNA sequence variation and mutation rate in patients with CADASILJohanna Annunen-Rasila
Department of Neurology, University of Oulu, Oulu, Finland
Neurogenetics 7:185-94. 2006..Our results show that mtDNA sequence variation is increased within CADASIL pedigrees. These findings suggest a relationship between NOTCH3 and mtDNA... - Cdk5 regulates the organization of Nestin and its association with p35Cecilia M Sahlgren
Department of Biology, Abo Akademi University, BioCity, Finland
Mol Cell Biol 23:5090-106. 2003..These results demonstrate that there is a continuous turnover of cdk5 and p35 activity on a scaffold formed by nestin. This association is likely to affect the organization and operation of both cdk5 and nestin during development... - Insidious cognitive decline in CADASILKaarina Amberla
Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden
Stroke 35:1598-602. 2004..CONCLUSIONS: A deterioration of working memory and executive function was already observed in the prestroke phase, which means that cognitive decline may start insidiously before the first onset of symptomatic ischemic episodes... - Restoration of myofiber continuity after transection injury in the rat soleusVille Aärimaa
Department of Surgery, Tampere University Hospital, Tampere, Finland
Neuromuscul Disord 14:421-8. 2004..More importantly our results indicate that fusion of the stumps and thus restoration of myofiber continuity, is possible after myofiber transection injury... - Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cellsShaobo Jin
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
Circ Res 102:1483-91. 2008..In sum, these data reveal a hierarchy for 2 important signaling systems, Notch and PDGF, in the vasculature and provide insights into how dysregulated Notch signaling perturbs VSMC differentiation and function... - Positron emission tomography examination of cerebral blood flow and glucose metabolism in young CADASIL patientsSusanna Tuominen
Department of Neurology, Turku University Hospital and University of Turku, Turku, Finland
Stroke 35:1063-7. 2004..These are obviously caused by the arteriopathy in long penetrating arteries and indicate early tissue damage, also expressed as impaired rCMR(gluc) in the WM... - Muscle injuries: optimising recoveryTero A H Järvinen
Institute of Medical Technology and Medical School, University of Tampere, Tampere, Finland
Best Pract Res Clin Rheumatol 21:317-31. 2007.... - Gene expression analyses of grade II gliomas and identification of rPTPbeta/zeta as a candidate oligodendroglioma markerDaniel Hägerstrand
Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, S 171 76 Stockholm, Sweden
Neuro Oncol 10:2-9. 2008..Furthermore, the results from the immunohistochemical analyses of rPTPbeta/zeta expression should prompt further evaluation of this protein as a novel oligodendroglioma marker... - Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumorsZhi Ping Ren
Department of Genetics and Pathology, Uppsala University, University Hospital, Uppsala, Sweden
J Neuropathol Exp Neurol 66:944-54. 2007..Our results are of importance for a further understanding of the molecular mechanisms behind failure to treat glioma patients... - Duchenne muscular dystrophy and idiopathic hyperCKemia in the same familyOrvar Eeg-Olofsson
Department of Women s and Children s Health Neuropaediatrics, University Children s Hospital, Uppsala, Sweden
Eur J Paediatr Neurol 12:404-7. 2008..We suggest that the occurrence of familial hyperCKemia may have triggered the early onset of symptoms in our patient... - Neurofibrillary tau pathology modulated by genetic variation of alpha-synucleinTerhi Peuralinna
Molecular Neurology Programme, Biomedicum, University of Helsinki, Helsinki, Finland
Ann Neurol 64:348-52. 2008..These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration... - Impaired endothelial function of forearm resistance arteries in CADASIL patientsAnna Stenborg
Department of Medical Sciences, University and University Hospital of Uppsala, Sweden
Stroke 38:2692-7. 2007..Mice expressing the mutated protein display early dysfunction in vasoreactivity in resistance arteries, but studies of patients have been inconclusive so far... - Proteome analysis of cultivated vascular smooth muscle cells from a CADASIL patientSaara Ihalainen
Protein Chemistry Unit, Institute of Biomedicine Anatomy, University of Helsinki, Helsinki, Finland
Mol Med 13:305-14. 2007..The accumulation of N3ECD on the cell surface possibly upregulates the angiotensin II regulatory feedback loop and thereby enhances the readiness of the cells to respond to angiotensin II stimulation... - Genetically distinct astrocytic and oligodendroglial components in oligoastrocytomasMingqi Qu
Department of Genetics and Pathology, University Hospital Uppsala, 751 85, Uppsala, Sweden
Acta Neuropathol 113:129-36. 2007.... - Ophthalmologic findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a cross-sectional studySusanna Roine
Department of Neurology, University and University Hospital of Turku, Turku, Finland
Ophthalmology 113:1411-7. 2006.... - Introduction: Non-atherosclerotic cerebrovascular disordersRaj N Kalaria
Wolfson Centre, Institute for Ageing and Health and Department of Psychiatry, Newcastle General Hospital, United Kingdom
Brain Pathol 12:337-42. 2002..The identification of novel genes associated with the hereditary forms of cerebrovascular disorders has been invaluable to understanding of the pathogenesis and management of sporadic disease... - Low expression of p27 indicates a poor prognosis in patients with high-grade astrocytomasRuut M Kirla
Department of Anesthesiology, University of Turku, Turku, Finland
Cancer 97:644-8. 2003..It appears that decreased levels of p21/p27 are associated with a poor prognosis and short survival... - Mechanical loading regulates the expression of tenascin-C in the myotendinous junction and tendon but does not induce de novo synthesis in the skeletal muscleTero A H Järvinen
Institute of Medical Technology and Medical School, University of Tampere, Tampere, Finland
J Cell Sci 116:857-66. 2003..Our results suggest that tenascin-C provides elasticity in mesenchymal tissues subjected to heavy tensile loading... - Does chronic brain edema explain the consequences of cerebral small-vessel disease?Hannu Kalimo
Stroke 34:806-12. 2003 - Expression of alpha7beta1 integrin splicing variants during skeletal muscle regenerationMinna Kääriäinen
Medical School and the Institute of Medical Technology, University of Tampere, Finland
Am J Pathol 161:1023-31. 2002..alpha7A and alpha7X1 appear to have a specific role during the dynamic phase of adhesion, whereas alpha7B, alpha7X2, and beta1D predominate during stable adhesion... - Neuropsychological functions in variant Alzheimer's disease with spastic paraparesisAuli Verkkoniemi
Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki FIN-00290, Finland
J Neurol Sci 218:29-37. 2004..However, all these early-onset patients (age range 43-63 years) with a deletion mutation of PS-1 gene showed prominent memory impairment and deficits in visuoconstructive and intellectual functions... - Scanning laser Doppler flowmetry shows reduced retinal capillary blood flow in CADASILMika Harju
Glaucoma Service, Department of Ophthalmology, Helsinki University Central Hospital, PL 220, 00029 HUS, Helsinki, Finland
Stroke 35:2449-52. 2004..A cross-sectional study was performed to examine the retinal vascular caliber and blood flow in CADASIL... - Muscle injuries: biology and treatmentTero A H Järvinen
Department of Orthopaedics, Tampere University Hospital and University of Tampere, PO Box 2000, FIN 33521 Tampere, Finland
Am J Sports Med 33:745-64. 2005..In the end, they extend these findings to clinical practice in an attempt to propose an evidence-based approach for the diagnosis and optimal treatment of skeletal muscle injuries... - The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperoneAnna Kaisa Anttonen
Folkhälsan Institute of Genetics and Neuroscience Center, University of Helsinki, PO Box 63, FI 00014 Helsinki, Finland
Nat Genet 37:1309-11. 2005..These data, together with the similar spatial and temporal patterns of tissue expression of Sil1 and Hspa5, suggest that disturbed SIL1-HSPA5 interaction and protein folding is the primary pathology in Marinesco-Sjögren syndrome... - The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic miceAnna Lord
Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Dag Hammarskjölds väg 20, SE 751 85 Uppsala, Sweden
Neurobiol Aging 27:67-77. 2006..We conclude that the Arctic mutation causes AD by facilitating amyloidosis through early accumulation of intracellular Abeta aggregates in association with a rapid onset of senile plaque deposition... - Electrophysiological findings in X-linked myopathy with excessive autophagySatu K Jääskeläinen
Department of Clinical Neurophysiology, University Central Hospital, Turku, Finland
Ann Neurol 51:648-52. 2002..Along with the clinicopathological features, these electrophysiological findings distinguish X-linked myopathy with excessive autophagy from other limb-girdle myopathies...