Hannu Kalimo

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia
    Hannu Kalimo
    Department of Pathology, Turku University Hospital, Finland
    Brain Pathol 12:371-84. 2002
  2. ncbi request reprint Arterioles of the lenticular nucleus in CADASIL
    Qing Miao
    Department of Pathology, University and University Hospital of Turku, Turku, Finland
    Stroke 37:2242-7. 2006
  3. ncbi request reprint Mapping of tissue tropism determinants in coxsackievirus genomes
    Heli Harvala
    Department of Virology and MediCity Research Laboratory, University of Turku, Kiinamyllynkatu 13, FIN 20520 Turku, Finland
    J Gen Virol 83:1697-706. 2002
  4. ncbi request reprint Inhaled nitric oxide treatment inhibits neuronal injury after meconium aspiration in piglets
    Minna Aaltonen
    Research Centre of Applied and Preventive Cardiovascular Medicine CAPC, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Early Hum Dev 83:77-85. 2007
  5. ncbi request reprint Meconium aspiration induces neuronal injury in piglets
    Minna Aaltonen
    Research Centre of Applied and Preventive Cardiovascular Medicine CAPC, University Hospital of Turku, Turku, Finland
    Acta Paediatr 94:1468-75. 2005
  6. ncbi request reprint Chromogenic in situ hybridization-detected hotspot MYCN amplification associates with Ki-67 expression and inversely with nestin expression in neuroblastomas
    Miikka Korja
    Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland
    Mod Pathol 18:1599-605. 2005
  7. ncbi request reprint Neuropathological examination in forensic context
    Hannu Kalimo
    Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsingin yliopisto, Finland
    Forensic Sci Int 146:73-81. 2004
  8. ncbi request reprint Detection of the founder effect in Finnish CADASIL families
    Kati Mykkänen
    Department of Medical Genetics, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Eur J Hum Genet 12:813-9. 2004
  9. ncbi request reprint [Nuclear lamins and their diseases]
    Pekka Taimen
    Turun yliopisto, kliinis teoreettinen laitos, patologia MediCity tutkimuslaboratorio Tykistökatu 6 A, 4 kerros 20520 Turku
    Duodecim 120:799-805. 2004
  10. pmc Absence of polysialylated NCAM is an unfavorable prognostic phenotype for advanced stage neuroblastoma
    Miikka Korja
    Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland
    BMC Cancer 9:57. 2009

Collaborators

Detail Information

Publications45

  1. ncbi request reprint CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia
    Hannu Kalimo
    Department of Pathology, Turku University Hospital, Finland
    Brain Pathol 12:371-84. 2002
    ..It is as yet unclear which disturbance in the Notch signaling pathway leads to the characteristic vascular pathology of CADASIL...
  2. ncbi request reprint Arterioles of the lenticular nucleus in CADASIL
    Qing Miao
    Department of Pathology, University and University Hospital of Turku, Turku, Finland
    Stroke 37:2242-7. 2006
    ..To assess the pathogenesis of deep GM infarcts, we analyzed structural changes in arterioles of the lenticular nucleus (LN) in 6 CADASIL patients...
  3. ncbi request reprint Mapping of tissue tropism determinants in coxsackievirus genomes
    Heli Harvala
    Department of Virology and MediCity Research Laboratory, University of Turku, Kiinamyllynkatu 13, FIN 20520 Turku, Finland
    J Gen Virol 83:1697-706. 2002
    ..The presence of the 5'NCR of CAV9 clearly enhanced muscle tissue tropism...
  4. ncbi request reprint Inhaled nitric oxide treatment inhibits neuronal injury after meconium aspiration in piglets
    Minna Aaltonen
    Research Centre of Applied and Preventive Cardiovascular Medicine CAPC, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Early Hum Dev 83:77-85. 2007
    ..Meconium aspiration-induced hypertensive lung injury is frequently associated with neuronal damage. Inhaled nitric oxide (iNO) is widely used in the treatment of pulmonary hypertension, but its effects on the brain are poorly known...
  5. ncbi request reprint Meconium aspiration induces neuronal injury in piglets
    Minna Aaltonen
    Research Centre of Applied and Preventive Cardiovascular Medicine CAPC, University Hospital of Turku, Turku, Finland
    Acta Paediatr 94:1468-75. 2005
    ..We aimed to determine the neuronal injury induced by pulmonary meconium contamination alone and with concurrent asphyxia...
  6. ncbi request reprint Chromogenic in situ hybridization-detected hotspot MYCN amplification associates with Ki-67 expression and inversely with nestin expression in neuroblastomas
    Miikka Korja
    Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland
    Mod Pathol 18:1599-605. 2005
    ....
  7. ncbi request reprint Neuropathological examination in forensic context
    Hannu Kalimo
    Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsingin yliopisto, Finland
    Forensic Sci Int 146:73-81. 2004
    ..Processing CNS for microscopy also requires special techniques and in addition to the routine stains both special histological and selected immunohistochemical stainings are often needed to reach the correct diagnosis...
  8. ncbi request reprint Detection of the founder effect in Finnish CADASIL families
    Kati Mykkänen
    Department of Medical Genetics, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Eur J Hum Genet 12:813-9. 2004
    ..The age analysis of the founder mutation places the introduction of the mutation in the late 1600s or early 1700s...
  9. ncbi request reprint [Nuclear lamins and their diseases]
    Pekka Taimen
    Turun yliopisto, kliinis teoreettinen laitos, patologia MediCity tutkimuslaboratorio Tykistökatu 6 A, 4 kerros 20520 Turku
    Duodecim 120:799-805. 2004
  10. pmc Absence of polysialylated NCAM is an unfavorable prognostic phenotype for advanced stage neuroblastoma
    Miikka Korja
    Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland
    BMC Cancer 9:57. 2009
    ....
  11. ncbi request reprint Pathogenesis of coxsackievirus A9 in mice: role of the viral arginine-glycine-aspartic acid motif
    Heli Harvala
    Department of Virology and MediCity Research Laboratory, University of Turku, Kiinamyllynkatu 13, FIN 20520 Turku, Finland
    J Gen Virol 84:2375-9. 2003
    ..These results suggest that the RGD motif has a significant role in the pathogenesis of CAV9 in mice but also that RGD-independent entry routes can be utilized in the infection of murine tissue...
  12. ncbi request reprint Fibrosis and stenosis of the long penetrating cerebral arteries: the cause of the white matter pathology in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Qing Miao
    Department of Pathology, Turku University Hospital and University of Turku, Finland
    Brain Pathol 14:358-64. 2004
    ..This conforms to the abundance of infarcts and primary ischemic damage in CADASIL patients' white matter...
  13. ncbi request reprint Mild eccentric stretch injury in skeletal muscle causes transient effects on tensile load and cell proliferation
    Ville Aärimaa
    Department of Surgery, Turku University Hospital, Turku, Finland
    Scand J Med Sci Sports 14:367-72. 2004
    ....
  14. doi request reprint alpha-Synuclein pathology in the spinal cord autonomic nuclei associates with alpha-synuclein pathology in the brain: a population-based Vantaa 85+ study
    Minna Oinas
    Department of Pathology, Helsinki University Central Hospital, University of Helsinki, P O Box 21, Haartmaninkatu 3, 00014 Helsinki, Finland
    Acta Neuropathol 119:715-22. 2010
    ..alphaS pathology exclusively in the spinal cord was rare. Our study indicates that in general alphaS pathology in the spinal cord autonomic nuclei is associated with similar pathology in the brain...
  15. ncbi request reprint Antioxidant enzymes in oligodendroglial brain tumors: association with proliferation, apoptotic activity and survival
    Sally Jarvela
    Department of Pathology, Tampere University Hospital, Tampere, Finland
    J Neurooncol 77:131-40. 2006
    ..002). The results suggest that the expression of Trx has a correlation to patient outcome and that there may be some association between AOEs, like MnSOD and Trx, and clinicopathological features of oligodendrogliomas...
  16. ncbi request reprint Transected myofibres may remain permanently divided in two parts
    Samuli Vaittinen
    Department of Pathology, Turku University Hospital, Kiinanmyllynkatu 10, FIN 20520, Turku, Finland
    Neuromuscul Disord 12:584-7. 2002
    ..We conclude that transected myofibres probably remain permanently divided in two consecutive tendon-muscle-tendon units...
  17. ncbi request reprint Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype
    Johan Lundkvist
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Genesis 41:13-22. 2005
    ..We discuss possible reasons for the different outcomes of the same germline CADASIL mutation in mice and humans...
  18. ncbi request reprint Tissue tropism of recombinant coxsackieviruses in an adult mouse model
    Heli Harvala
    Department of Virology and MediCity Research Laboratory, University of Turku, FIN 20520 Turku, Finland
    J Gen Virol 86:1897-907. 2005
    ..These results demonstrate potential pathogenicity of intraspecies recombinant coxsackieviruses, and the complexity of the genetic determinants underlying tissue tropism...
  19. ncbi request reprint Distal myopathy caused by homozygous missense mutations in the nebulin gene
    Carina Wallgren-Pettersson
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Brain 130:1465-76. 2007
    ..We conclude that homozygous missense mutations in NEB cause a novel distal myopathy, predominantly involving lower leg extensor muscles, finger extensors and neck flexors...
  20. ncbi request reprint Mitochondrial DNA sequence variation and mutation rate in patients with CADASIL
    Johanna Annunen-Rasila
    Department of Neurology, University of Oulu, Oulu, Finland
    Neurogenetics 7:185-94. 2006
    ..Our results show that mtDNA sequence variation is increased within CADASIL pedigrees. These findings suggest a relationship between NOTCH3 and mtDNA...
  21. pmc Cdk5 regulates the organization of Nestin and its association with p35
    Cecilia M Sahlgren
    Department of Biology, Abo Akademi University, BioCity, Finland
    Mol Cell Biol 23:5090-106. 2003
    ..These results demonstrate that there is a continuous turnover of cdk5 and p35 activity on a scaffold formed by nestin. This association is likely to affect the organization and operation of both cdk5 and nestin during development...
  22. ncbi request reprint Insidious cognitive decline in CADASIL
    Kaarina Amberla
    Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden
    Stroke 35:1598-602. 2004
    ..The aim of this study was to characterize cognitive function in subjects with a C475T (R133C) mutation in the Notch3 gene, leading to CADASIL...
  23. ncbi request reprint Restoration of myofiber continuity after transection injury in the rat soleus
    Ville Aärimaa
    Department of Surgery, Tampere University Hospital, Tampere, Finland
    Neuromuscul Disord 14:421-8. 2004
    ..More importantly our results indicate that fusion of the stumps and thus restoration of myofiber continuity, is possible after myofiber transection injury...
  24. ncbi request reprint Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells
    Shaobo Jin
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Circ Res 102:1483-91. 2008
    ..In sum, these data reveal a hierarchy for 2 important signaling systems, Notch and PDGF, in the vasculature and provide insights into how dysregulated Notch signaling perturbs VSMC differentiation and function...
  25. ncbi request reprint Positron emission tomography examination of cerebral blood flow and glucose metabolism in young CADASIL patients
    Susanna Tuominen
    Department of Neurology, Turku University Hospital and University of Turku, Turku, Finland
    Stroke 35:1063-7. 2004
    ..The purpose of this study was to assess whether cerebral blood flow (CBF) and regional cerebral metabolic rates of glucose (rCMR(gluc)) in CADASIL patients are affected in early adulthood...
  26. ncbi request reprint Muscle injuries: optimising recovery
    Tero A H Järvinen
    Institute of Medical Technology and Medical School, University of Tampere, Tampere, Finland
    Best Pract Res Clin Rheumatol 21:317-31. 2007
    ....
  27. pmc Gene expression analyses of grade II gliomas and identification of rPTPbeta/zeta as a candidate oligodendroglioma marker
    Daniel Hägerstrand
    Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Neuro Oncol 10:2-9. 2008
    ..Furthermore, the results from the immunohistochemical analyses of rPTPbeta/zeta expression should prompt further evaluation of this protein as a novel oligodendroglioma marker...
  28. ncbi request reprint Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors
    Zhi Ping Ren
    Department of Genetics and Pathology, Uppsala University, University Hospital, Uppsala, Sweden
    J Neuropathol Exp Neurol 66:944-54. 2007
    ..Our results are of importance for a further understanding of the molecular mechanisms behind failure to treat glioma patients...
  29. ncbi request reprint Duchenne muscular dystrophy and idiopathic hyperCKemia in the same family
    Orvar Eeg-Olofsson
    Department of Women s and Children s Health Neuropaediatrics, University Children s Hospital, Uppsala, Sweden
    Eur J Paediatr Neurol 12:404-7. 2008
    ..We suggest that the occurrence of familial hyperCKemia may have triggered the early onset of symptoms in our patient...
  30. doi request reprint Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein
    Terhi Peuralinna
    Molecular Neurology Programme, Biomedicum, University of Helsinki, Helsinki, Finland
    Ann Neurol 64:348-52. 2008
    ..These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration...
  31. ncbi request reprint Impaired endothelial function of forearm resistance arteries in CADASIL patients
    Anna Stenborg
    Department of Medical Sciences, University and University Hospital of Uppsala, Sweden
    Stroke 38:2692-7. 2007
    ..Mice expressing the mutated protein display early dysfunction in vasoreactivity in resistance arteries, but studies of patients have been inconclusive so far...
  32. pmc Proteome analysis of cultivated vascular smooth muscle cells from a CADASIL patient
    Saara Ihalainen
    Protein Chemistry Unit, Institute of Biomedicine Anatomy, University of Helsinki, Helsinki, Finland
    Mol Med 13:305-14. 2007
    ..The accumulation of N3ECD on the cell surface possibly upregulates the angiotensin II regulatory feedback loop and thereby enhances the readiness of the cells to respond to angiotensin II stimulation...
  33. ncbi request reprint Genetically distinct astrocytic and oligodendroglial components in oligoastrocytomas
    Mingqi Qu
    Department of Genetics and Pathology, University Hospital Uppsala, 751 85, Uppsala, Sweden
    Acta Neuropathol 113:129-36. 2007
    ....
  34. ncbi request reprint Ophthalmologic findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a cross-sectional study
    Susanna Roine
    Department of Neurology, University and University Hospital of Turku, Turku, Finland
    Ophthalmology 113:1411-7. 2006
    ....
  35. ncbi request reprint Introduction: Non-atherosclerotic cerebrovascular disorders
    Raj N Kalaria
    Wolfson Centre, Institute for Ageing and Health and Department of Psychiatry, Newcastle General Hospital, United Kingdom
    Brain Pathol 12:337-42. 2002
    ..The identification of novel genes associated with the hereditary forms of cerebrovascular disorders has been invaluable to understanding of the pathogenesis and management of sporadic disease...
  36. ncbi request reprint Low expression of p27 indicates a poor prognosis in patients with high-grade astrocytomas
    Ruut M Kirla
    Department of Anesthesiology, University of Turku, Turku, Finland
    Cancer 97:644-8. 2003
    ..The authors studied the prognostic significance of p21 and p27 in patients with high-grade astrocytomas who were treated with radiotherapy...
  37. ncbi request reprint Mechanical loading regulates the expression of tenascin-C in the myotendinous junction and tendon but does not induce de novo synthesis in the skeletal muscle
    Tero A H Järvinen
    Institute of Medical Technology and Medical School, University of Tampere, Tampere, Finland
    J Cell Sci 116:857-66. 2003
    ..Our results suggest that tenascin-C provides elasticity in mesenchymal tissues subjected to heavy tensile loading...
  38. ncbi request reprint Does chronic brain edema explain the consequences of cerebral small-vessel disease?
    Hannu Kalimo
    Stroke 34:806-12. 2003
  39. pmc Expression of alpha7beta1 integrin splicing variants during skeletal muscle regeneration
    Minna Kääriäinen
    Medical School and the Institute of Medical Technology, University of Tampere, Finland
    Am J Pathol 161:1023-31. 2002
    ..alpha7A and alpha7X1 appear to have a specific role during the dynamic phase of adhesion, whereas alpha7B, alpha7X2, and beta1D predominate during stable adhesion...
  40. ncbi request reprint Neuropsychological functions in variant Alzheimer's disease with spastic paraparesis
    Auli Verkkoniemi
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki FIN 00290, Finland
    J Neurol Sci 218:29-37. 2004
    ..However, all these early-onset patients (age range 43-63 years) with a deletion mutation of PS-1 gene showed prominent memory impairment and deficits in visuoconstructive and intellectual functions...
  41. ncbi request reprint Scanning laser Doppler flowmetry shows reduced retinal capillary blood flow in CADASIL
    Mika Harju
    Glaucoma Service, Department of Ophthalmology, Helsinki University Central Hospital, PL 220, 00029 HUS, Helsinki, Finland
    Stroke 35:2449-52. 2004
    ..A cross-sectional study was performed to examine the retinal vascular caliber and blood flow in CADASIL...
  42. ncbi request reprint Muscle injuries: biology and treatment
    Tero A H Järvinen
    Department of Orthopaedics, Tampere University Hospital and University of Tampere, PO Box 2000, FIN 33521 Tampere, Finland
    Am J Sports Med 33:745-64. 2005
    ..In the end, they extend these findings to clinical practice in an attempt to propose an evidence-based approach for the diagnosis and optimal treatment of skeletal muscle injuries...
  43. ncbi request reprint The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone
    Anna Kaisa Anttonen
    Folkhälsan Institute of Genetics and Neuroscience Center, University of Helsinki, PO Box 63, FI 00014 Helsinki, Finland
    Nat Genet 37:1309-11. 2005
    ..These data, together with the similar spatial and temporal patterns of tissue expression of Sil1 and Hspa5, suggest that disturbed SIL1-HSPA5 interaction and protein folding is the primary pathology in Marinesco-Sjögren syndrome...
  44. ncbi request reprint The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice
    Anna Lord
    Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Dag Hammarskjölds väg 20, SE 751 85 Uppsala, Sweden
    Neurobiol Aging 27:67-77. 2006
    ..We conclude that the Arctic mutation causes AD by facilitating amyloidosis through early accumulation of intracellular Abeta aggregates in association with a rapid onset of senile plaque deposition...
  45. ncbi request reprint Electrophysiological findings in X-linked myopathy with excessive autophagy
    Satu K Jääskeläinen
    Department of Clinical Neurophysiology, University Central Hospital, Turku, Finland
    Ann Neurol 51:648-52. 2002
    ..Along with the clinicopathological features, these electrophysiological findings distinguish X-linked myopathy with excessive autophagy from other limb-girdle myopathies...