E Kajantie

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. doi Is very preterm birth a risk factor for adult cardiometabolic disease?
    Eero Kajantie
    National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland Children s Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland Department of Obstetrics and Gynaecology, Oulu University Central Hospital and University of Oulu, Oulu, Finland Electronic address
    Semin Fetal Neonatal Med 19:112-7. 2014
  2. pmc Lipoprotein subclass profiles in young adults born preterm at very low birth weight
    Petteri Hovi
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Mannerheimintie 166, PO Box 30, FI 00271 Helsinki, Finland
    Lipids Health Dis 12:57. 2013
  3. pmc Vasoactive agents for the prediction of early- and late-onset preeclampsia in a high-risk cohort
    Pia M Villa
    The Research Programs Unit, Women s Health, University of Helsinki, and Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    BMC Pregnancy Childbirth 13:110. 2013
  4. pmc Stroke is predicted by low visuospatial in relation to other intellectual abilities and coronary heart disease by low general intelligence
    Eero Kajantie
    National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 7:e46841. 2012
  5. doi No association between body size at birth and leucocyte telomere length in adult life--evidence from three cohort studies
    Eero Kajantie
    National Institute for Health and Welfare, Helsinki, Finland
    Int J Epidemiol 41:1400-8. 2012
  6. pmc Premenstrual symptoms in young adults born preterm at very low birth weight--from the Helsinki Study of Very Low Birth Weight Adults
    Sanna Mustaniemi
    Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    BMC Womens Health 11:25. 2011
  7. pmc Trajectories of growth and symptoms of attention-deficit/hyperactivity disorder in children: a longitudinal study
    Kati Heinonen
    Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland
    BMC Pediatr 11:84. 2011
  8. pmc Behavioural symptoms of attention deficit/hyperactivity disorder in preterm and term children born small and appropriate for gestational age: a longitudinal study
    Kati Heinonen
    Institute of Behavioral Science, P O Box 9, FI 00014 University of Helsinki, Helsinki, Finland
    BMC Pediatr 10:91. 2010
  9. ncbi Placental 11beta-HSD2 activity, early postnatal clinical course, and adrenal function in extremely low birth weight infants
    Eero Kajantie
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Pediatr Res 59:575-8. 2006
  10. ncbi The effects of sex and hormonal status on the physiological response to acute psychosocial stress
    Eero Kajantie
    Department of Epidemiology and Health Promotion, The National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Psychoneuroendocrinology 31:151-78. 2006

Detail Information

Publications100

  1. doi Is very preterm birth a risk factor for adult cardiometabolic disease?
    Eero Kajantie
    National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland Children s Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland Department of Obstetrics and Gynaecology, Oulu University Central Hospital and University of Oulu, Oulu, Finland Electronic address
    Semin Fetal Neonatal Med 19:112-7. 2014
    ..There are now enough data to warrant an expert evaluation of the level of evidence for cardiometabolic disease in individuals born very small or very preterm, which has possible public health implications. ..
  2. pmc Lipoprotein subclass profiles in young adults born preterm at very low birth weight
    Petteri Hovi
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Mannerheimintie 166, PO Box 30, FI 00271 Helsinki, Finland
    Lipids Health Dis 12:57. 2013
    ..Non-optimal lipoprotein profile is generally also likely to affect the increased cardiovascular risk, but lipoprotein subclass level data on adults born at VLBW are sparse...
  3. pmc Vasoactive agents for the prediction of early- and late-onset preeclampsia in a high-risk cohort
    Pia M Villa
    The Research Programs Unit, Women s Health, University of Helsinki, and Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    BMC Pregnancy Childbirth 13:110. 2013
    ..To evaluate the soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio for the prediction of early- and late-onset preeclampsia in a high-risk cohort...
  4. pmc Stroke is predicted by low visuospatial in relation to other intellectual abilities and coronary heart disease by low general intelligence
    Eero Kajantie
    National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 7:e46841. 2012
    ..Most studies have used a general intelligence score. We studied whether three different subscores of intellectual ability predict these disorders...
  5. doi No association between body size at birth and leucocyte telomere length in adult life--evidence from three cohort studies
    Eero Kajantie
    National Institute for Health and Welfare, Helsinki, Finland
    Int J Epidemiol 41:1400-8. 2012
    ..We studied whether body size at birth and underlying factors including severely preterm birth predict LTL in adult life...
  6. pmc Premenstrual symptoms in young adults born preterm at very low birth weight--from the Helsinki Study of Very Low Birth Weight Adults
    Sanna Mustaniemi
    Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    BMC Womens Health 11:25. 2011
    ..Preterm birth at very low birth weight (VLBW, < 1500g) has a multitude of consequences that extend to adult life, including altered stress responsiveness which could affect the prevalence of premenstrual symptoms...
  7. pmc Trajectories of growth and symptoms of attention-deficit/hyperactivity disorder in children: a longitudinal study
    Kati Heinonen
    Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland
    BMC Pediatr 11:84. 2011
    ..Data on the importance of postnatal growth is, however scanty. We studied whether pre- and postnatal growth up to 56 months is associated with symptoms of ADHD in children...
  8. pmc Behavioural symptoms of attention deficit/hyperactivity disorder in preterm and term children born small and appropriate for gestational age: a longitudinal study
    Kati Heinonen
    Institute of Behavioral Science, P O Box 9, FI 00014 University of Helsinki, Helsinki, Finland
    BMC Pediatr 10:91. 2010
    ..Thus, we tested whether preterm birth and small body size at birth adjusted for gestational age are independently associated with symptoms of ADHD in children...
  9. ncbi Placental 11beta-HSD2 activity, early postnatal clinical course, and adrenal function in extremely low birth weight infants
    Eero Kajantie
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Pediatr Res 59:575-8. 2006
    ..Although an association with baseline or ACTH-stimulated cortisol was not seen, possible relationships with other components of the hypothalamic-pituitary-adrenal axis remain to be determined...
  10. ncbi The effects of sex and hormonal status on the physiological response to acute psychosocial stress
    Eero Kajantie
    Department of Epidemiology and Health Promotion, The National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Psychoneuroendocrinology 31:151-78. 2006
    ..Studying this hypothesis may have a fundamental impact on our understanding about how adult health is set during early life and how adult disease could be prevented in men and women...
  11. ncbi Spontaneous hypothyroidism in adult women is predicted by small body size at birth and during childhood
    Eero Kajantie
    National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, 00300 Helsinki, Finland
    J Clin Endocrinol Metab 91:4953-6. 2006
    ..The relationships of early growth with coronary heart disease and type 2 diabetes have received considerable attention. It is not known whether fetal or childhood growth is linked with autoimmune disorders...
  12. ncbi Fetal origins of stress-related adult disease
    Eero Kajantie
    National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Ann N Y Acad Sci 1083:11-27. 2006
    ..This will be a crucial step when the associations that are currently emerging will be translated into disease prevention...
  13. ncbi Adiponectin concentrations in maternal serum: elevated in preeclampsia but unrelated to insulin sensitivity
    Eero Kajantie
    Hospital of Children and Adolescents and Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    J Soc Gynecol Investig 12:433-9. 2005
    ..We studied whether serum adiponectin is related to insulin sensitivity in preeclamptic and normotensive pregnant women...
  14. doi Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort study
    Eero Kajantie
    Department of Chronic Disease Prevention, Institute for Health and Welfare, Helsinki, Finland
    Stroke 40:1176-80. 2009
    ..We hypothesized that pre-eclampsia would lead to an increased risk of cardiovascular disease in the offspring...
  15. doi Young adults with very low birth weight: leaving the parental home and sexual relationships--Helsinki Study of Very Low Birth Weight Adults
    Eero Kajantie
    National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Pediatrics 122:e62-72. 2008
    ..We studied the tempo of first leaving the parental home and starting cohabitation with an intimate partner and sexual experience of young adults with very low birth weight (<1500 g)...
  16. pmc Childhood socioeconomic status modifies the association between intellectual abilities at age 20 and mortality in later life
    E Kajantie
    National Institute for Health and Welfare, PL 30, Helsinki 00271, Finland
    J Epidemiol Community Health 64:963-9. 2010
    ..People who score poorly in intellectual ability tests have shorter life expectancy. A study was undertaken to determine whether this association is different in people from different socioeconomic backgrounds...
  17. doi Early life predictors of the physiological stress response later in life
    Eero Kajantie
    National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland
    Neurosci Biobehav Rev 35:23-32. 2010
    ..We believe that important future directions include focusing on specific early life exposures as predictors and on stress response in everyday life as an outcome...
  18. pmc Preterm birth--a risk factor for type 2 diabetes? The Helsinki birth cohort study
    Eero Kajantie
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    Diabetes Care 33:2623-5. 2010
    ..The association between low birth weight and type 2 diabetes is well established. We studied whether preterm birth carries a similar risk...
  19. doi Growth before 2 years of age and serum lipids 60 years later: the Helsinki Birth Cohort study
    Eero Kajantie
    The National Public Health Institute, Helsinki, Finland
    Int J Epidemiol 37:280-9. 2008
    ..We tested the hypothesis that this path of growth is associated with an atherogenic lipid profile in later life...
  20. doi Adults born at very low birth weight exercise less than their peers born at term
    Eero Kajantie
    National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland
    J Pediatr 157:610-6, 616.e1. 2010
    ..To study the effects of very low birth weight (VLBW, <1500 g) birth on physical activity, an important protective and modifiable factor...
  21. ncbi Early-life events. Effects on aging
    Eero Kajantie
    National Public Health Institute, Helsinki, Finland
    Hormones (Athens) 7:101-13. 2008
    ..This review will discuss programming of the hypothalamic-pituitary-adrenal axis function as one of the best characterised examples of such mechanisms...
  22. ncbi Body size at birth predicts hypothalamic-pituitary-adrenal axis response to psychosocial stress at age 60 to 70 years
    Eero Kajantie
    National Public Health Institute, Department of Health Promotion and Chronic Disease Prevention, Mannerheimintie 166, 00300 Helsinki, Finland
    J Clin Endocrinol Metab 92:4094-100. 2007
    ..Studies in humans and animals have suggested intrauterine programming of hypothalamic-pituitary-adrenal axis (HPAA) function as an important mechanism in linking fetal life conditions with adult disease...
  23. ncbi Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-years
    Eero Kajantie
    National Public Health Institute, Helsinki, Finland
    Int J Epidemiol 34:655-63. 2005
    ..Our aim was to study the relationship between small size at birth and all-cause and non-cardiovascular mortality, which has been poorly documented...
  24. ncbi Size at birth, the metabolic syndrome and 24-h salivary cortisol profile
    Eero Kajantie
    National Public Health Institute, Helsinki, Finland
    Clin Endocrinol (Oxf) 60:201-7. 2004
    ..Our aim was to assess whether HPAA activity in everyday living circumstances is related to the metabolic syndrome and size at birth...
  25. ncbi [Are the diseases of adulthood determined already during fetal period and childhood?]
    Eero Kajantie
    Kansanterveyslaitos, epidemiologian ja terveyden edistämisen osasto Mannerheimintie 166, 00300 Helsinki
    Duodecim 119:1655-63. 2003
  26. ncbi A syndrome with multiple malformations, mental retardation, and ACTH deficiency
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    Am J Med Genet A 126:313-8. 2004
    ..Family history was negative. Adrenal insufficiency is an uncommon feature in multiple malformation syndromes and may thus serve as a diagnostic handle for recognizing other possible patients with a similar syndrome...
  27. ncbi Bilateral cleft lip and palate, hypertelorism and hypoplastic toes
    Eero Kajantie
    Clinical Genetics Unit, Helsinki University Central Hospital, Helsinki, Finland
    Clin Dysmorphol 13:195-6. 2004
    ..The mother used bisoprolol, naproxen and sumatriptan for migraine until the fifth postmenstrual week of pregnancy. We suggest that this patient's features represent a previously undescribed entity of as yet unknown aetiology...
  28. ncbi Insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1 and postnatal growth in very-low-birth-weight infants
    Eero Kajantie
    Helsinki University Central Hospital, Hospital for Children and Adolescents, Helsinki, Finland
    Horm Res 60:124-30. 2003
    ..Thus, IGF-I, IGFBP-3 and the phosphorylation status of IGFBP-1 in circulation are likely to be involved in growth regulation during the postnatal period in VLBW infants...
  29. ncbi Circulating glucocorticoid bioactivity in the preterm newborn after antenatal betamethasone treatment
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki, Finland
    J Clin Endocrinol Metab 89:3999-4003. 2004
    ....
  30. ncbi Cord plasma adiponectin: a 20-fold rise between 24 weeks gestation and term
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS Helsinki, Finland
    J Clin Endocrinol Metab 89:4031-6. 2004
    ..Adiponectin may play an important role in regulating fetal growth and explaining its links to the metabolic syndrome and its consequences during adult life...
  31. ncbi The effects of the ACE gene insertion/deletion polymorphism on glucose tolerance and insulin secretion in elderly people are modified by birth weight
    Eero Kajantie
    National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    J Clin Endocrinol Metab 89:5738-41. 2004
    ..We suggest that these findings reflect interactions between genotype and intrauterine environment with resulting changes in gene expression...
  32. doi Childhood growth and cardiovascular reactivity to psychological stressors in late adulthood
    K Feldt
    Departments of Psychology, University of Helsinki, Helsinki, Finland
    J Intern Med 264:72-82. 2008
    ..We studied whether CV reactivity, a predictor of CV disease risk, is associated with childhood growth trajectories...
  33. ncbi IGF-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1, and postnatal growth in very low birth weight infants
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 87:2171-9. 2002
    ..Finally, the regulation of IGFBP-1 by glucocorticoids may be divergent in situations with a high or low insulin concentration...
  34. ncbi Cardiovascular reactivity to psychological stressors in late adulthood is predicted by gestational age at birth
    K Feldt
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Hum Hypertens 21:401-10. 2007
    ....
  35. doi Role of childhood growth on the risk of metabolic syndrome in obese men and women
    M K Salonen
    Department of Chronic Disease Prevention, National Institute of Health and Welfare, Mannerheimintie 166, 00300 Helsinki, Finland
    Diabetes Metab 35:94-100. 2009
    ..Although obesity is the key characteristic of the metabolic syndrome, not all obese individuals develop the syndrome. Our aim was to identify characteristics of early growth that protect these individuals from the metabolic syndrome...
  36. doi Childhood growth and future risk of the metabolic syndrome in normal-weight men and women
    M K Salonen
    Department of Chronic Disease Prevention, National Institute of Health and Welfare, Mannerheimintie 166, 00300 Helsinki, Finland
    Diabetes Metab 35:143-50. 2009
    ..The aim of this study was to examine the effects of early growth on the risk of developing the metabolic syndrome in normal-weight individuals...
  37. doi Prenatal growth, postnatal growth and trait anxiety in late adulthood - the Helsinki Birth Cohort Study
    J Lahti
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Acta Psychiatr Scand 121:227-35. 2010
    ..Trait anxiety may predispose to anxiety disorders and cardiovascular events. We tested whether prenatal growth or postnatal growth from birth to 11 years of age and in adulthood predict trait anxiety in late adulthood...
  38. doi Body size at birth and cardiovascular response to and recovery from mental stress in children
    K Feldt
    Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
    J Hum Hypertens 25:231-40. 2011
    ..This phenomenon may be important in linking smaller body size at birth to adult CV disease...
  39. doi Depressive symptoms in adulthood and intrauterine exposure to pre-eclampsia: the Helsinki Birth Cohort Study
    S Tuovinen
    Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
    BJOG 117:1236-42. 2010
    ..We studied whether pre-eclampsia predicts depressive symptoms in offspring...
  40. ncbi Markers of type I and type III collagen turnover, insulin-like growth factors, and their binding proteins in cord plasma of small premature infants: relationships with fetal growth, gestational age, preeclampsia, and antenatal glucocorticoid treatment
    E Kajantie
    The Hospital for Children and Adolescents, Helsinki University Central Hospital, PL 280, FI 00029 HYKS, Helsinki, Finland
    Pediatr Res 49:481-9. 2001
    ..Cord blood PINP and ICTP reflect both fetal growth and maturity and deserve evaluation as potential indicators of postnatal growth velocity in preterm infants, whereas PIIINP reflects fetal maturity...
  41. ncbi Childhood growth and hypertension in later life
    Johan G Eriksson
    National Public Health Institute, Department of Health Promotion and Chronic Disease Prevention, Diabetes Unit, Helsinki, Finland
    Hypertension 49:1415-21. 2007
    ..28 to 1.57). We conclude that 2 different paths of childhood growth precede the development of hypertension. We suggest that they lead to hypertension through different biological mechanisms and may respond differently to medication...
  42. ncbi Birth size, adult body composition and muscle strength in later life
    H Ylihärsilä
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Int J Obes (Lond) 31:1392-9. 2007
    ..We examined how birth weight was related to adult body size, body composition and grip strength...
  43. ncbi Patterns of growth among children who later develop type 2 diabetes or its risk factors
    J G Eriksson
    National Public Health Institute, Helsinki, Finland
    Diabetologia 49:2853-8. 2006
    ..We studied fetal and childhood growth patterns that are associated with IGT and type 2 diabetes in adult life...
  44. doi Neurocognitive abilities in young adults with very low birth weight
    R Pyhälä
    Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland
    Neurology 77:2052-60. 2011
    ....
  45. doi Cardiovascular health of Finnish war evacuees 60 years later
    Hanna Alastalo
    National Public Health Institute, Helsinki, Finland
    Ann Med 41:66-72. 2009
    ..Early life experiences might have long-term effects on health...
  46. ncbi Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol/cortisone shuttle in small preterm infants
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 88:493-500. 2003
    ..Whether these conditions are associated with early postnatal adrenal insufficiency or long-term cardiovascular risk remains an important issue for further study...
  47. doi Early life stress and blood pressure levels in late adulthood
    H Alastalo
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    J Hum Hypertens 27:90-4. 2013
    ..This could be due to early hormonal and metabolic programming, during plastic periods in early life, influencing blood pressure levels in adult life...
  48. ncbi Size at birth, gestational age and cortisol secretion in adult life: foetal programming of both hyper- and hypocortisolism?
    Eero Kajantie
    The Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland
    Clin Endocrinol (Oxf) 57:635-41. 2002
    ..We set out to study reasons for this discrepancy by examining the relationship between adult HPA axis function and birthweight and body proportions at birth in a group of elderly subjects with detailed birth records...
  49. ncbi Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growth
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 88:1059-65. 2003
    ..Prospective studies should address whether this group is susceptible to type 2 diabetes, coronary heart disease, and osteoporosis...
  50. ncbi A syndrome with midface asymmetry, defective modelling of the skeleton, catch-up growth and truncal obesity
    E Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland
    Clin Dysmorphol 9:259-64. 2000
    ..We consider other differential diagnoses and suggest that the patient represents a hitherto undescribed syndrome...
  51. doi Childhood separation experience predicts HPA axis hormonal responses in late adulthood: a natural experiment of World War II
    Anu Katriina Pesonen
    Department of Clinical Medicine, Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Finland
    Psychoneuroendocrinology 35:758-67. 2010
    ....
  52. ncbi Fetal programming of temperamental negative affectivity among children born healthy at term
    Anu Katriina Pesonen
    Department of Psychology, University of Helsinki, P O Box 9, 00014, University of Helsinki, Helsinki, Finland
    Dev Psychobiol 48:633-43. 2006
    ....
  53. ncbi Markers of type I and III collagen turnover as indicators of growth velocity in very low birth weight infants
    E Kajantie
    The Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS Helsinki, Finland
    J Clin Endocrinol Metab 86:4299-306. 2001
    ..The most robust of these indicators is the ICTP/PINP ratio, which may thus serve as a clinical tool in assessing short-term growth of these infants...
  54. ncbi Body mass index during childhood and adult body composition in men and women aged 56-70 y
    Hilkka Ylihärsilä
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Am J Clin Nutr 87:1769-75. 2008
    ..The relation between the change in body mass index (BMI) through childhood and body composition in adult life is important because body composition is known to affect adult health...
  55. pmc Prenatal origins of poor sleep in children
    Anu Katriina Pesonen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Sleep 32:1086-92. 2009
    ..We examined whether small body size at birth and prenatal tobacco or alcohol exposure predict poor sleep and more sleep disturbances in children...
  56. ncbi Is early occupational therapy in extremely preterm infants of benefit in the long run?
    Teija Salokorpi
    Department of Child Neurology, Hospital for Children and Adolescents, Helsinki University Central Hospital, PL 280 HUCH, 00029 Helsinki, Finland
    Pediatr Rehabil 5:91-8. 2002
    ..It is concluded that this amount of occupational therapy in ELBW infants does not have any detectable effect on long-term neurological development...
  57. doi Leukocyte telomere length and its relation to food and nutrient intake in an elderly population
    A M K Tiainen
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    Eur J Clin Nutr 66:1290-4. 2012
    ..We hypothesized that intakes of fruits and vegetables would be positively associated with LTL and that intakes of fats, and especially saturated fatty acids (SFAs), would be negatively associated with LTL...
  58. doi Ambulatory blood pressure in young adults with very low birth weight
    Petteri Hovi
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    J Pediatr 156:54-59.e1. 2010
    ..We hypothesized that, as compared with a matched control group born at term, young adults with very low birth weight (VLBW <1.5 kg) would have higher 24-hour ambulatory blood pressure...
  59. doi Sleep duration and regularity are associated with behavioral problems in 8-year-old children
    Anu Katriina Pesonen
    Department of Psychology and Institute of Clinical Medicine, University of Helsinki, P O Box 9, Helsinki 00014, Finland
    Int J Behav Med 17:298-305. 2010
    ..Relatively little is known about the significance of normal variation in objectively assessed sleep duration and its regularity in children's psychological well-being...
  60. doi Maternal prenatal licorice consumption alters hypothalamic-pituitary-adrenocortical axis function in children
    Katri Raikkonen
    Department of Psychology, University of Helsinki, P O Box 9 Siltavuorenpenger 20 D, 00014 University of Helsinki, Finland
    Psychoneuroendocrinology 35:1587-93. 2010
    ..05). These effects appeared dose-related. Our findings lend support to prenatal 'programming' of HPAA function by overexposure to glucocorticoids...
  61. doi Slower reaction times and impaired learning in young adults with birth weight <1500 g
    Sonja Strang-Karlsson
    Institute of Clinical Medicine, Children s Hospital, Helsinki University Central Hospital, Helsinki, Finland
    Pediatrics 125:e74-82. 2010
    ..We assessed core neurocognitive abilities (processing speed, working memory, attention, and learning capacity) in young adults with VLBW and in term-born control subjects...
  62. ncbi Birthsize, gestational age and adrenal function in adult life: studies of dexamethasone suppression and ACTH1-24 stimulation
    Eero Kajantie
    National Public Health Institute, 00300 Helsinki, Finland
    Eur J Endocrinol 149:569-75. 2003
    ..We have now extended these findings by examining the relationship between birthweight, gestational age and tests of adrenal suppression and stimulation...
  63. doi Intima-media thickness and flow-mediated dilatation in the Helsinki study of very low birth weight adults
    Petteri Hovi
    Institute of Clinical Medicine, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Pediatrics 127:e304-11. 2011
    ..Adults born at a very low birth weight (VLBW) (< 1500 g), compared with those born at term, bear risk factors for cardiovascular disease, including higher blood pressure and insulin resistance...
  64. doi Advanced pubertal growth spurt in subjects born preterm: the Helsinki study of very low birth weight adults
    Karoliina Wehkalampi
    Department of Health Promotion and Chronic Disease Prevention, National Institute for Health and Welfare, P O Box 30, Mannerheimintie 164, 00271 Helsinki, Finland
    J Clin Endocrinol Metab 96:525-33. 2011
    ..Subjects born preterm with very low birth weight (VLBW; <1500 g) have as adults increased risk factors for cardiovascular disease. Little is known about their pubertal timing...
  65. doi Morningness propensity in young adults born prematurely: the Helsinki study of very low birth weight adults
    Sonja Strang-Karlsson
    Institute of Clinical Medicine, Children s Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
    Chronobiol Int 27:1829-42. 2010
    ..The finding is potentially important, since morningness is associated with beneficial health outcomes...
  66. pmc Distinct variants at LIN28B influence growth in height from birth to adulthood
    Elisabeth Widen
    Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    Am J Hum Genet 86:773-82. 2010
    ..These findings imply a critical role for LIN28B in the regulation of human growth...
  67. doi Reduced body size and shape-related symptoms in young adults born preterm with very low birth weight: Helsinki study of very low birth weight adults
    Karoliina Wehkalampi
    Department of Health Promotion and Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    J Pediatr 157:421-7, 427.e1. 2010
    ....
  68. doi Poor sleep and altered hypothalamic-pituitary-adrenocortical and sympatho-adrenal-medullary system activity in children
    Katri Raikkonen
    Department of Psychology, University of Helsinki, P O Box 9 Siltavuorenpenger 20 D, 00014 Helsinki, Finland
    J Clin Endocrinol Metab 95:2254-61. 2010
    ..Neuroendocrine alterations, with well-known links with health, may offer insight into why poor sleep is associated with poor health. Yet, studies testing associations between sleep and neuroendocrine activity in children are scarce...
  69. pmc Decreased bone mineral density in adults born with very low birth weight: a cohort study
    Petteri Hovi
    Hospital for Children and Adolescents, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland
    PLoS Med 6:e1000135. 2009
    ..We hypothesized that VLBW is associated with reduced bone mineral density (BMD) in adulthood...
  70. ncbi Self-perpetuating effects of birth size on blood pressure levels in elderly people
    Hilkka Ylihärsilä
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsink, Finland
    Hypertension 41:446-50. 2003
    ..Among elderly people with established hypertension, these processes have a strong effect on blood pressure levels, because they are processes that do not respond well to treatment...
  71. ncbi Effects of suppression of estrogen action by the p450 aromatase inhibitor letrozole on bone mineral density and bone turnover in pubertal boys
    Sanna Wickman
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, FIN 00029 HUS, Finland
    J Clin Endocrinol Metab 88:3785-93. 2003
    ....
  72. ncbi Glucose regulation in young adults with very low birth weight
    Petteri Hovi
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    N Engl J Med 356:2053-63. 2007
    ..We assessed glucose tolerance and insulin sensitivity and measured serum lipid levels and blood pressure in young adults with very low birth weight...
  73. ncbi Depression and its association with diabetes, cardiovascular disease, and birth weight
    Maria Paile-Hyvärinen
    National Public Health Institute, Department of Health Promotion and Chronic Disease Prevention, Diabetes Unit, Mannerheimintie 166, 00300 Helsinki, Finland
    Ann Med 39:634-40. 2007
    ..Diabetes increases the risk for depression...
  74. ncbi Depressive symptoms in adults separated from their parents as children: a natural experiment during World War II
    Anu Katriina Pesonen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Am J Epidemiol 166:1126-33. 2007
    ..Those separated from their father because of the father's military assignment (n = 744) did not differ from those who were not separated...
  75. ncbi Very low birth weight increases risk for sleep-disordered breathing in young adulthood: the Helsinki Study of Very Low Birth Weight Adults
    E Juulia Paavonen
    Department of Psychology, PO Box 9, 00014 University of Helsinki, Helsinki, Finland
    Pediatrics 120:778-84. 2007
    ..We investigated whether very low birth weight (<1500 g) is associated with the risk of sleep-disordered breathing in young adulthood...
  76. doi Depression in young adults with very low birth weight: the Helsinki study of very low-birth-weight adults
    Katri Raikkonen
    Department of Psychology, University of Helsinki, PO Box 9, FI 00014 Helsinki, Finland
    Arch Gen Psychiatry 65:290-6. 2008
    ..Little is known about the mental health outcomes of very low-birth-weight (VLBW) (< 1500 g) infants in young adulthood...
  77. doi Infant growth and hostility in adult life
    Katri Rikkönen
    Department of Psychology, University of Helsinki, P O Box 9 Siltavuorenpenger 20 D, 00014 University of Helsinki, Finland
    Psychosom Med 70:306-13. 2008
    ..A common origin in suboptimal fetal and early postnatal life may lie beneath. This study tested whether prenatal and postnatal growth predicts hostility in adult life...
  78. doi Prenatal and postnatal growth and cognitive abilities at 56 months of age: a longitudinal study of infants born at term
    Kati Heinonen
    Department of Psychology, PO Box 9, FI 00014 University of Helsinki, Helsinki, Finland
    Pediatrics 121:e1325-33. 2008
    ....
  79. doi Body size at birth and socio-economic status in childhood: implications for Cloninger's psychobiological model of temperament at age 60
    Jari Lahti
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Psychiatry Res 160:167-74. 2008
    ....
  80. doi Growth trajectories and intellectual abilities in young adulthood: The Helsinki Birth Cohort study
    Katri Raikkonen
    Department of Psychology, University of Helsinki, Finland
    Am J Epidemiol 170:447-55. 2009
    ..There is a second critical period, specific for verbal development, between ages 2 and 7 years and a third critical period for all 3 tested outcomes during adolescence...
  81. doi Free fatty acid profiles in preeclampsia
    Pia M Villa
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Prostaglandins Leukot Essent Fatty Acids 81:17-21. 2009
    ..009), was unrelated to total or any individual FFA concentration. We concluded that preeclamptic women have higher circulating FFA concentrations, which despite insulin resistance are suppressed by oral glucose loading...
  82. doi Activation of T cells in preterm infants with respiratory distress syndrome
    Riikka Turunen
    Department of Pediatrics, Kanta Hame Central Hospital, Hameenlinna, Finland
    Neonatology 96:248-58. 2009
    ..The role of lymphocytes in RDS is less studied. Activation of lymphocytes could mediate chronic inflammation and development of bronchopulmonary dysplasia (BPD)...
  83. doi Short sleep duration and behavioral symptoms of attention-deficit/hyperactivity disorder in healthy 7- to 8-year-old children
    E Juulia Paavonen
    Departments of Psychology, University of Helsinki, Helsinki, Finland
    Pediatrics 123:e857-64. 2009
    ..The objective of our study was to evaluate whether short sleep is associated with behavioral symptoms of attention-deficit/hyperactivity disorder in 7- to 8-year-old children...
  84. doi Endostatin concentration in cord plasma predicts the development of bronchopulmonary dysplasia in very low birth weight infants
    Joakim Janer
    Hospital for Children and Adolescents, University of Helsink, PO Box 281, 00029 HUS, Helsinki, Finland
    Pediatrics 123:1142-6. 2009
    ..Endostatin is an antiangiogenic growth factor. Together with proangiogenic growth factors it acts to shape the developing vasculature. Dysregulation of angiogenesis is a component in the pathogenesis of bronchopulmonary dysplasia...
  85. doi Intellectual ability in early adulthood and type 2 diabetes in later life
    Maria Paile-Hyvärinen
    Diabetes Prevention Unit, Department of Health Promotion and Chronic Disease Prevention, National Institute for Health and Welfare, Mannerheimintie 166, 00300, Helsinki, Finland
    Acta Diabetol 46:249-52. 2009
    ..50, 95% CI 0.28-0.91). While education seems to protect from type 2 diabetes, we could not detect a connection between early intellectual ability and impairment in glucose regulation in later adulthood...
  86. doi Very low birth weight and behavioral symptoms of attention deficit hyperactivity disorder in young adulthood: the Helsinki study of very-low-birth-weight adults
    Sonja Strang-Karlsson
    Hospital for Children and Adolescents, Biomedicum 2, Tukholmankatu 8C, Helsinki University Central Hospital, PO Box 705, FI 00029 Helsinki, Finland
    Am J Psychiatry 165:1345-53. 2008
    ....
  87. doi Small head circumference at birth and early age at adiposity rebound
    J G Eriksson
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland Vasa Central Hospital, Vasa, Finland Folkhalsan Research Centre, Helsingfors Universitet, Helsinki, Finland Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland
    Acta Physiol (Oxf) 210:154-60. 2014
    ..Here, we examine whether age at adiposity rebound is determined by influences during infancy or is a consequence of foetal growth. Our hypothesis was that measurements of body size at birth are related to age at adiposity rebound...
  88. doi Cardiovascular morbidity, mortality and pharmacotherapy in patients with schizophrenia
    M Lahti
    Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
    Psychol Med 42:2275-85. 2012
    ....
  89. doi Aspirin in the prevention of pre-eclampsia in high-risk women: a randomised placebo-controlled PREDO Trial and a meta-analysis of randomised trials
    P M Villa
    Research Programmes Unit, Women s Health, University of Helsinki, Helsinki, Finland
    BJOG 120:64-74. 2013
    ..To study the effect of aspirin in the prevention of pre-eclampsia in high-risk women...
  90. ncbi Familial asphyxiating thoracic dysplasia: clinical variability and impact of improved neonatal intensive care
    E Kajantie
    Hospital for Children and Adolescents and Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland
    J Pediatr 139:130-3. 2001
    ..The youngest sibling received aggressive modern respiratory intensive care, survived, and at 2 years showed no respiratory symptoms. Improved neonatal intensive care has implications for clinical decision making and genetic counseling...
  91. doi Personality of young adults born prematurely: the Helsinki study of very low birth weight adults
    Anu Katriina Pesonen
    Department of Psychology, University of Helsinki, Finland
    J Child Psychol Psychiatry 49:609-17. 2008
    ..Today, the first generations of very low birth weight (VLBW <or= 1500 g) infants are entering adulthood but very little is known of their personality traits, associated with both psychopathological vulnerability and resilience...
  92. ncbi Trajectories of growth among children who have coronary events as adults
    David J P Barker
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    N Engl J Med 353:1802-9. 2005
    ..Low birth weight is a risk factor for coronary heart disease. It is uncertain how postnatal growth affects disease risk...
  93. ncbi Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene
    Anna Rautanen
    Department of Medical Genetics, University of Helsinki, FIN 00014 Helsinki, Finland
    J Clin Endocrinol Metab 91:4544-51. 2006
    ..Small body size at birth is associated with cardiovascular disease and type 2 diabetes in adult life. This link may be in part mediated by early-life programming of the hypothalamic-pituitary-adrenal axis (HPAA) function...
  94. ncbi Infant growth and stroke in adult life: the Helsinki birth cohort study
    Clive Osmond
    MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
    Stroke 38:264-70. 2007
    ..People who had low birth weight are at increased risk of stroke. Little is known about the effects of early postnatal growth on stroke risk...
  95. doi Reproductive traits following a parent-child separation trauma during childhood: a natural experiment during World War II
    Anu Katriina Pesonen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Am J Hum Biol 20:345-51. 2008
    ..The implications are relevant to the 9.2 million child refugees living throughout the world today...
  96. ncbi Length of gestation and depressive symptoms at age 60 years
    Katri Raikkonen
    Department of Psychology, University of Helsinki, PO Box 9, 00014 University of Helsinki, Finland
    Br J Psychiatry 190:469-74. 2007
    ..A non-optimal foetal environment, reflected in smaller birth size and shorter duration of gestation, is a risk factor for compromised health later in life...
  97. ncbi Maternal and social origins of hypertension
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, USA
    Hypertension 50:565-71. 2007
    ....
  98. ncbi Sleep quality in young adults with very low birth weight--the Helsinki study of very low birth weight adults
    Sonja Strang-Karlsson
    Hospital for Children and Adolescents, Biomedicum 2, Tukholmankatu 8A, Helsinki University Central Hospital, PO Box 448, FI 00029, Helsinki, Finland
    J Pediatr Psychol 33:387-95. 2008
    ..To assess the relationship between very low birth weight (VLBW; <1,500 g) and quality and amount of sleep in young adults...
  99. ncbi A possible link between the pubertal growth of girls and breast cancer in their daughters
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, OR, USA
    Am J Hum Biol 20:127-31. 2008
    ....
  100. ncbi Clinical features and outcome of childhood minimal change nephrotic syndrome: is genetics involved?
    Anne Tiina Lahdenkari
    Hospital for Children and Adolescents and Biomedicum Helsinki, University of Helsinki, Finland
    Pediatr Nephrol 20:1073-80. 2005
    ..In conclusion, MCNS is a multifactorial disease, in which genetics play a minor role. Allelic variants of the podocyte proteins may, however, modify the phenotype in occasional individuals...