Valtteri Kaasinen

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease
    V Kaasinen
    Department of Neurology, University of Turku, Finland
    Neurology 54:1482-7. 2000
  2. ncbi request reprint Extrastriatal dopamine D(2) receptors in Parkinson's disease: a longitudinal study
    V Kaasinen
    Department of Neurology, Turku PES Centre, Turku, Finland
    J Neural Transm 110:591-601. 2003
  3. ncbi request reprint Age-related loss of extrastriatal dopamine D(2) -like receptors in women
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Turku, Finland
    J Neurochem 81:1005-10. 2002
  4. ncbi request reprint Expectation of caffeine induces dopaminergic responses in humans
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Eur J Neurosci 19:2352-6. 2004
  5. ncbi request reprint Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Finland
    Mov Disord 19:1348-51. 2004
  6. ncbi request reprint Increased frontal [(18)F]fluorodopa uptake in early Parkinson's disease: sex differences in the prefrontal cortex
    V Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    Brain 124:1125-30. 2001
  7. ncbi request reprint Mapping brain structure and personality in late adulthood
    V Kaasinen
    Department of Neurology, University of Turku, FIN 20521 Turku, Finland Turku PET Centre, FIN 20521 Turku, Finland
    Neuroimage 24:315-22. 2005
  8. ncbi request reprint Sex differences in extrastriatal dopamine d(2)-like receptors in the human brain
    V Kaasinen
    Department of Neurology and Psychiatry, University of Turku, Finland
    Am J Psychiatry 158:308-11. 2001
  9. ncbi request reprint Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
    V Kaasinen
    Department of Neurology, University of Turku, Finland
    Neurobiol Aging 21:683-8. 2000
  10. ncbi request reprint Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Neurosci Biobehav Rev 26:785-93. 2002

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease
    V Kaasinen
    Department of Neurology, University of Turku, Finland
    Neurology 54:1482-7. 2000
    ..To investigate whether dopamine D2 and D3 receptor subtypes (D2/3Rs) outside the caudate-putamen are affected in PD...
  2. ncbi request reprint Extrastriatal dopamine D(2) receptors in Parkinson's disease: a longitudinal study
    V Kaasinen
    Department of Neurology, Turku PES Centre, Turku, Finland
    J Neural Transm 110:591-601. 2003
    ..Our longitudinal study shows first evidence concerning cortical D(2) receptor loss in the progression of PD, although it is not possible to distinguish between the effects of the therapy and the disease...
  3. ncbi request reprint Age-related loss of extrastriatal dopamine D(2) -like receptors in women
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Turku, Finland
    J Neurochem 81:1005-10. 2002
    ..The results may prove to be important in studies where the biochemical basis of clinical sex differences is examined in patients with dopamine-related neuropsychiatric disorders...
  4. ncbi request reprint Expectation of caffeine induces dopaminergic responses in humans
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Eur J Neurosci 19:2352-6. 2004
    ..The results therefore suggest that caffeine and placebo caffeine may share some dopaminergic mechanisms of action...
  5. ncbi request reprint Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Finland
    Mov Disord 19:1348-51. 2004
    ..The results provide further support for a relationship between novelty seeking and insular D2 receptors. They indicate that the association is cross-cultural, independent of age, and unaffected by dopaminergic degeneration...
  6. ncbi request reprint Increased frontal [(18)F]fluorodopa uptake in early Parkinson's disease: sex differences in the prefrontal cortex
    V Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    Brain 124:1125-30. 2001
    ..The reported sex difference may be linked to clinical sex differences in the symptoms and treatment response in Parkinson's disease...
  7. ncbi request reprint Mapping brain structure and personality in late adulthood
    V Kaasinen
    Department of Neurology, University of Turku, FIN 20521 Turku, Finland Turku PET Centre, FIN 20521 Turku, Finland
    Neuroimage 24:315-22. 2005
    ..The results suggest that high self-transcendence, which has adaptive advantages in the later part of life, is associated with relatively greater temporal cortical GM volumes...
  8. ncbi request reprint Sex differences in extrastriatal dopamine d(2)-like receptors in the human brain
    V Kaasinen
    Department of Neurology and Psychiatry, University of Turku, Finland
    Am J Psychiatry 158:308-11. 2001
    ..The study examined gender differences in extrastriatal dopamine D2-like receptor levels in the human brain in vivo...
  9. ncbi request reprint Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
    V Kaasinen
    Department of Neurology, University of Turku, Finland
    Neurobiol Aging 21:683-8. 2000
    ..Further, the rate of D2/3R decline may be faster in the frontal cortex as compared to the temporal and thalamic regions...
  10. ncbi request reprint Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Neurosci Biobehav Rev 26:785-93. 2002
    ..In particular, the focus is on describing and discussing the relationships between aging, cognition and the dopaminergic system in healthy subjects and in patients with Parkinson's disease...
  11. doi request reprint Effects of intravenous placebo with glucose expectation on human basal ganglia dopaminergic function
    Lauri T Haltia
    Department of Neurology, University of Turku, Turku, Finland
    Synapse 62:682-8. 2008
    ..g., amphetamine and glucose). Also, they suggest that the DA release in the ventral striatum mediates placebo responses in the context of glucose expectation...
  12. ncbi request reprint Dopaminergic effects of caffeine in the human striatum and thalamus
    Valtteri Kaasinen
    Department of Neurology, University of Turku, PO Box 52, FIN 20521, Turku, Finland
    Neuroreport 15:281-5. 2004
    ..81, p = 0.03). The findings indicate that caffeine has effects on dopaminergic neurotransmission in the human brain, which may be differential in the striatum and the thalamus...
  13. doi request reprint The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects
    Sargo Aalto
    Turku PET Centre, University of Turku, 20014 Turku, Finland
    Eur J Nucl Med Mol Imaging 36:475-83. 2009
    ..The dopamine D(2)/D(3) receptor ligand [(11)C]FLB 457 and PET enable quantification of low-density extrastriatal D(2)/D(3) receptors, but it is uncertain whether [(11)C]FLB 457 can be used for measuring extrastriatal dopamine release...
  14. ncbi request reprint Effects of intravenous glucose on dopaminergic function in the human brain in vivo
    Lauri T Haltia
    Department of Neurology, University of Turku, Turku, Finland
    Synapse 61:748-56. 2007
    ....
  15. doi request reprint Seasonality of striatal dopamine synthesis capacity in Parkinson's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
    Neurosci Lett 530:80-4. 2012
    ..Findings concerning season of birth further suggest that there may be gestational or perinatal seasonal factors, which influence dopaminergic function in adulthood...
  16. doi request reprint Mesolimbic dopamine release is linked to symptom severity in pathological gambling
    Juho Joutsa
    Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
    Neuroimage 60:1992-9. 2012
    ..Human reward-seeking gambling behavior, and especially pathological gambling, has been presumed to be modulated by brain dopamine...
  17. ncbi request reprint Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease
    N Kemppainen
    Department of Neurology, PO Box 52, University of Turku, FIN 20521 Turku, Finland
    Eur J Neurosci 18:149-54. 2003
    ..002). Our findings suggest a role for temporal lobe D2 receptors in the memory and naming performance in AD, and suggest that studies to evaluate the efficiency of dopaminergic medication on patients with early AD might be warranted...
  18. doi request reprint Effects of dopamine agonist dose and gender on the prognosis of impulse control disorders in Parkinson's disease
    Juho Joutsa
    Department of Neurology, University of Turku and Turku University Hospital, Finland
    Parkinsonism Relat Disord 18:1079-83. 2012
    ..There have been no previous large-scale prospective studies investigating predictive and prognostic factors of these disorders...
  19. doi request reprint Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders
    Juho Joutsa
    Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
    Mov Disord 27:778-82. 2012
    ..Impulse control disorders (ICDs) occur frequently in PD patients...
  20. ncbi request reprint Substantial thalamostriatal dopaminergic defect in Unverricht-Lundborg disease
    Miikka Korja
    Department of Neurology, Turku University Hospital, Turku, Finland
    Epilepsia 48:1768-73. 2007
    ..Myoclonus, the characteristic symptom in ULD, suggests that dopamine neurotransmission may be involved in the pathophysiology of ULD. Our purpose was to examine brain dopaminergic function in ULD patients...
  21. doi request reprint Acute hormonal changes following intravenous glucose challenge in lean and obese human subjects
    Lauri T Haltia
    Department of Neurology, University of Turku, Finland
    Scand J Clin Lab Invest 70:275-80. 2010
    ..v. glucose bolus on insulin, leptin, ghrelin, peptide YY (PYY), free fatty acids (FFA), glucagon and glucagon-like peptide-1 (GLP-1) concentrations together with self-reported satiety ratings in lean and obese human subjects...
  22. ncbi request reprint Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease
    Valtteri Kaasinen
    Department of Neurology, University of Turku, Turku, Finland
    J Clin Psychopharmacol 22:615-20. 2002
    ..We hypothesize that the clinical improvement in behavioral and attentional symptoms of AD due to AChE inhibitors is associated with the frontal AChE inhibition...
  23. doi request reprint Impulse control disorders and depression in Finnish patients with Parkinson's disease
    Juho Joutsa
    Department of Neurology, University of Turku and Turku University Hospital, Finland
    Parkinsonism Relat Disord 18:155-60. 2012
    ..However, the frequencies have been investigated mainly in patients from secondary or tertiary care centers, and thus, the prevalence rates in general community are not known...
  24. ncbi request reprint Personality traits and striatal 6-[18F]fluoro-L-dopa uptake in healthy elderly subjects
    Valtteri Kaasinen
    Department of Neurology, University of Turku, P O Box 52, FIN 20521 Turku, Finland
    Neurosci Lett 332:61-4. 2002
    ..The results indicate that the previous positive findings concerning harm avoidance and (18)F-dopa uptake in Parkinson's disease are disease-related, and that they can not be generalized to healthy individuals...
  25. ncbi request reprint Naming multiple objects: neural correlates as measured by positron emission tomography
    Kati Renvall
    Department of Psychology, University of Turku, Finland
    Appl Neuropsychol 10:224-33. 2003
    ..These findings thus provide independent evidence for the claim that CP is a valid paradigm for the study of word production proper...
  26. ncbi request reprint Brain white matter expansion in human obesity and the recovering effect of dieting
    Lauri T Haltia
    Department of Neurology, University of Turku, P O Box 52, FIN 20521 Turku, Finland
    J Clin Endocrinol Metab 92:3278-84. 2007
    ..We hypothesized that possible differences seen in the brains of obese subjects would disappear or diminish after an intensive dieting period...
  27. ncbi request reprint The translating brain: cerebral activation patterns during simultaneous interpreting
    J O Rinne
    Turku PET Center, University of Turku, P O Box 52, FIN 20521, Turku, Finland
    Neurosci Lett 294:85-8. 2000
    ..Brain activation patterns were clearly modulated by direction of translation, with more extensive activation during translation into the non-native language which is often considered to a be more demanding task...
  28. pmc Hippocampal and prefrontal atrophy in patients with early non-demented Parkinson's disease is related to cognitive impairment
    A Bruck
    Turku PET Centre, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    J Neurol Neurosurg Psychiatry 75:1467-9. 2004
    ..Early stage patients with Parkinson's disease (PD) show cognitive impairment in frontal lobe functions and memory tests. Hippocampal atrophy is seen in medicated patients with advanced PD...
  29. pmc Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease
    J O Rinne
    Department of Neurology, University of Turku, FIN 20521 Turku, Finland
    J Neurol Neurosurg Psychiatry 74:113-5. 2003
    ..Brain acetylcholinesterase activity was determined in healthy controls and in patients with mild cognitive impairment and early Alzheimer's disease...
  30. ncbi request reprint Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia
    J O Rinne
    Turku PET Centre, University of Turku, Finland
    Neurology 58:1489-93. 2002
    ..To evaluate dopaminergic function in patients with frontotemporal dementia (FTD)...
  31. ncbi request reprint Role of the dopaminergic system in chronic pain -- a fluorodopa-PET study
    S K Jääskeläinen
    Department of Clinical Neurophysiology, Turku University Central Hospital, PL 52, FI 20 521 Turku, Finland
    Pain 90:257-60. 2001
    ..The present result provides direct evidence of the involvement of the nigrostriatal dopaminergic system in pain for the first time in a clinical pain condition...
  32. doi request reprint Reduced Striatal Dopamine Synthesis Capacity is Associated with Symptoms of Depression in Patients with de novo Unmedicated Parkinson's Disease
    Juho Joutsa
    Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland
    J Parkinsons Dis 3:325-9. 2013
    ....
  33. pmc Personality traits and brain dopaminergic function in Parkinson's disease
    V Kaasinen
    Departments of Neurology and Radiology, University of Turku, and Turku PET Centre, P.O. Box 52, FIN-20521, Turku, Finland
    Proc Natl Acad Sci U S A 98:13272-7. 2001
    ..The correlation between the personality trait of harm avoidance and (18)F-dopa may reflect a specific feedback circuitry of neurotransmitters that is associated with negative emotionality in Parkinson's disease...
  34. pmc Parallel appearance of compulsive behaviors and artistic creativity in Parkinson's disease
    Juho Joutsa
    Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
    Case Rep Neurol 4:77-83. 2012
    ....
  35. doi request reprint Extensive abnormality of brain white matter integrity in pathological gambling
    Juho Joutsa
    Department of Neurology, University of Turku, Turku, Finland Turku PET Centre, University of Turku, Finland
    Psychiatry Res 194:340-6. 2011
    ..The results suggest that pathological gambling is associated with extensive lower integrity of several brain white matter tracts. The diffusion abnormality closely resembles previous findings in individuals with substance addictions...
  36. ncbi request reprint Different brain activation patterns during production of animals versus artefacts: a PET activation study on category-specific processing
    Matti Laine
    Department of Psychology, Abo Akademi University, FIN 20500 Turku, Finland
    Brain Res Cogn Brain Res 13:95-9. 2002
    ..In our study, it may represent an involvement of visual imagery in generation of animal names. In contrast, production of artefact names elicited increased rCBF in frontoparietal regions previously related to attention and mental effort...
  37. ncbi request reprint Brain function during multi-trial learning in mild cognitive impairment: a PET activation study
    Chris J A Moulin
    Institute of Psychological Sciences, University of Leeds, UK
    Brain Res 1136:132-41. 2007
    ..Subtle functional changes occur in the pre-Alzheimer brain before there are marked structural or behavioural abnormalities...
  38. doi request reprint Striatal FDOPA uptake and cognition in advanced non-demented Parkinson's disease: a clinical and FDOPA-PET study
    Marije van Beilen
    Department of Neurology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    Parkinsonism Relat Disord 14:224-8. 2008
    ..Interestingly, the caudate may be more important in the mental components of executive functioning, while the putamen may be more important in the motor components of executive functioning...