| Juulia JylhäväAffiliation: University of Tampere Country: Finland Jylhävä J. Determinants of longevity: genetics, biomarkers and therapeutic approaches. Curr Pharm Des. 2014;20:6058-70 pubmed Jylhävä J, Raitanen J, Marttila S, Hervonen A, Jylhä M, Hurme M. Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study. BMC Med Genomics. 2014;7:54 pubmed publisher Kananen L, Marttila S, Nevalainen T, Jylhävä J, Mononen N, Kähönen M, et al. Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. BMC Genomics. 2016;17:103 pubmed publisher ..We speculate that the a-CpGs identified here in a population with a narrow age-range represent clock-like changes, as they showed concordant methylation behavior in population spanning whole adulthood as well. .. Jylhävä J, Haarala A, Eklund C, Pertovaara M, Kahonen M, Hutri Kähönen N, et al. Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study. J Intern Med. 2009;266:286-95 pubmed publisher ..Further longitudinal studies will show whether SAA holds a prognostic value as a risk marker, analogously to CRP. .. Marttila S, Kananen L, Häyrynen S, Jylhävä J, Nevalainen T, Hervonen A, et al. Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics. 2015;16:179 pubmed publisher Jylhävä J, Eklund C, Jylha M, Hervonen A, Lehtimaki T, Karhunen P, et al. Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study. Exp Gerontol. 2009;44:297-9 pubmed publisher ..016). We propose that the increased mortality is inflammation-related and mediated by aberrant complement regulation by the CFH 402His variant. .. Jylhävä J, Eklund C, Pessi T, Raitakari O, Juonala M, Kahonen M, et al. Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study. Clin Exp Immunol. 2009;155:53-8 pubmed publisher ..We conclude that the combined presence of CRP haplotype ATGTG and CFH 402His allele may be disadvantageous to carotid artery elasticity in males. .. Jylhävä J, Eklund C, Jylha M, Hervonen A, Hurme M. Expression profiling of immune-associated genes in peripheral blood mononuclear cells reveals baseline differences in co-stimulatory signalling between nonagenarians and younger controls: the vitality 90+ study. Biogerontology. 2010;11:671-7 pubmed publisher ..Further research is, however, required to establish the relationship between these changes and the mechanisms of immunosenescence. .. Jylhävä J, Haarala A, Kahonen M, Lehtimaki T, Jula A, Moilanen L, et al. Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey. Clin Exp Immunol. 2011;164:211-7 pubmed publisher ..These results indicate that, in individuals at high risk of CVD, the PTX3 concentration is associated with cardiovascular risk factors but not with subclinical atherosclerosis. ..
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