Juulia Jylhävä

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. Jylhävä J. Determinants of longevity: genetics, biomarkers and therapeutic approaches. Curr Pharm Des. 2014;20:6058-70 pubmed
  2. Jylhävä J, Raitanen J, Marttila S, Hervonen A, Jylhä M, Hurme M. Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study. BMC Med Genomics. 2014;7:54 pubmed publisher
  3. Kananen L, Marttila S, Nevalainen T, Jylhävä J, Mononen N, Kähönen M, et al. Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. BMC Genomics. 2016;17:103 pubmed publisher
    ..We speculate that the a-CpGs identified here in a population with a narrow age-range represent clock-like changes, as they showed concordant methylation behavior in population spanning whole adulthood as well. ..
  4. Jylhävä J, Haarala A, Eklund C, Pertovaara M, Kahonen M, Hutri Kähönen N, et al. Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study. J Intern Med. 2009;266:286-95 pubmed publisher
    ..Further longitudinal studies will show whether SAA holds a prognostic value as a risk marker, analogously to CRP. ..
  5. Marttila S, Kananen L, Häyrynen S, Jylhävä J, Nevalainen T, Hervonen A, et al. Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics. 2015;16:179 pubmed publisher
  6. Jylhävä J, Eklund C, Jylha M, Hervonen A, Lehtimaki T, Karhunen P, et al. Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study. Exp Gerontol. 2009;44:297-9 pubmed publisher
    ..016). We propose that the increased mortality is inflammation-related and mediated by aberrant complement regulation by the CFH 402His variant. ..
  7. Jylhävä J, Eklund C, Pessi T, Raitakari O, Juonala M, Kahonen M, et al. Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study. Clin Exp Immunol. 2009;155:53-8 pubmed publisher
    ..We conclude that the combined presence of CRP haplotype ATGTG and CFH 402His allele may be disadvantageous to carotid artery elasticity in males. ..
  8. Jylhävä J, Eklund C, Jylha M, Hervonen A, Hurme M. Expression profiling of immune-associated genes in peripheral blood mononuclear cells reveals baseline differences in co-stimulatory signalling between nonagenarians and younger controls: the vitality 90+ study. Biogerontology. 2010;11:671-7 pubmed publisher
    ..Further research is, however, required to establish the relationship between these changes and the mechanisms of immunosenescence. ..
  9. Jylhävä J, Haarala A, Kahonen M, Lehtimaki T, Jula A, Moilanen L, et al. Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey. Clin Exp Immunol. 2011;164:211-7 pubmed publisher
    ..These results indicate that, in individuals at high risk of CVD, the PTX3 concentration is associated with cardiovascular risk factors but not with subclinical atherosclerosis. ..

More Information

Publications12

  1. Jylhävä J, Lyytikäinen L, Kahonen M, Hutri Kähönen N, Kettunen J, Viikari J, et al. A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study. PLoS ONE. 2012;7:e35426 pubmed publisher
    ..These data indicate that UGT1A1-associated processes are also involved in the regulation of serum cf-DNA concentrations. ..
  2. Jylhävä J, Nevalainen T, Marttila S, Jylha M, Hervonen A, Hurme M. Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty. Aging Cell. 2013;12:388-97 pubmed publisher
    ..In addition, we suggest that circulating self-DNA, assessed as total or unmethylated cf-DNA, might aggravate immunoinflammatory reactivity in very old individuals. ..
  3. Kananen L, Nevalainen T, Jylhävä J, Marttila S, Hervonen A, Jylhä M, et al. Cytomegalovirus infection accelerates epigenetic aging. Exp Gerontol. 2015;72:227-9 pubmed publisher
    ..5 vs. 24.0 (p < 0.02,Mann–Whitney U-test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes. ..