Marja Jylha

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. pmc Dementia as a determinant of social and health service use in the last two years of life 1996-2003
    Leena Forma
    School of Health Sciences, FI 33014 University of Tampere, Finland
    BMC Geriatr 11:14. 2011
  2. ncbi request reprint Old age and loneliness: cross-sectional and longitudinal analyses in the Tampere Longitudinal Study on Aging
    Marja Jylha
    School of Public Health, University of Tampere, Finland
    Can J Aging 23:157-68. 2004
  3. ncbi request reprint Self-rated health showed a graded association with frequently used biomarkers in a large population sample
    Marja Jylha
    University of Tampere, School of Public Health, Medisiinarinkatu 3, Tampere, FIN 33014, Finland
    J Clin Epidemiol 59:465-71. 2006
  4. ncbi request reprint [Good and bad aspects of the medicalisation of aging]
    Marja Jylha
    Tampereen yliopiston terveystieteen laitos, 33014 Tampereen yliopisto
    Duodecim 119:1886-92. 2003
  5. ncbi request reprint Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study
    Marja Jylha
    Tampere School of Public Health, FIN 33014 University of Tampere, Finland
    J Gerontol A Biol Sci Med Sci 62:1016-21. 2007
  6. ncbi request reprint What is self-rated health and why does it predict mortality? Towards a unified conceptual model
    Marja Jylha
    School of Public Health, University of Tampere, Finland
    Soc Sci Med 69:307-16. 2009
  7. pmc Inflammation, adiposity, and mortality in the oldest old
    Inna Lisko
    Gerontology Research Center, School of Health Sciences, University of Tampere, Finland
    Rejuvenation Res 15:445-52. 2012
  8. ncbi request reprint Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians
    Riikka Rontu
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Centre for Laboratory Medicine and Department of Clinical Chemistry, University of Tampere, Medical School, Finland
    Clin Endocrinol (Oxf) 64:265-70. 2006
  9. doi request reprint Predictors of mortality in men and women aged 90 and older: a nine-year follow-up study in the Vitality 90+ study
    Kristina Tiainen
    Gerontology Research Center and School of Health Sciences, University of Tampere, Finland
    Age Ageing 42:468-75. 2013
  10. doi request reprint Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: the Vitality 90+ Study
    Juulia Jylhävä
    Department of Microbiology and Immunology, School of Medicine, University of Tampere, Finland
    Exp Gerontol 47:372-8. 2012

Detail Information

Publications41

  1. pmc Dementia as a determinant of social and health service use in the last two years of life 1996-2003
    Leena Forma
    School of Health Sciences, FI 33014 University of Tampere, Finland
    BMC Geriatr 11:14. 2011
    ..The aim of this study was to assess the effects of dementia and year of death (1998-2003) on health and social service use in the last two years of life among old people...
  2. ncbi request reprint Old age and loneliness: cross-sectional and longitudinal analyses in the Tampere Longitudinal Study on Aging
    Marja Jylha
    School of Public Health, University of Tampere, Finland
    Can J Aging 23:157-68. 2004
    ..In conclusion, only a minority of older people continuously suffer from loneliness. Loneliness does increase with age, not because of age per se, but because of increasing disability and decreasing social integration...
  3. ncbi request reprint Self-rated health showed a graded association with frequently used biomarkers in a large population sample
    Marja Jylha
    University of Tampere, School of Public Health, Medisiinarinkatu 3, Tampere, FIN 33014, Finland
    J Clin Epidemiol 59:465-71. 2006
    ..We investigated the association of frequently used biomarkers with self-rated health, and the role of these biomarkers in the association of self-rated health with mortality...
  4. ncbi request reprint [Good and bad aspects of the medicalisation of aging]
    Marja Jylha
    Tampereen yliopiston terveystieteen laitos, 33014 Tampereen yliopisto
    Duodecim 119:1886-92. 2003
  5. ncbi request reprint Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study
    Marja Jylha
    Tampere School of Public Health, FIN 33014 University of Tampere, Finland
    J Gerontol A Biol Sci Med Sci 62:1016-21. 2007
    ..We investigated blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra), and their combinations as predictors of mortality in nonagenarians...
  6. ncbi request reprint What is self-rated health and why does it predict mortality? Towards a unified conceptual model
    Marja Jylha
    School of Public Health, University of Tampere, Finland
    Soc Sci Med 69:307-16. 2009
    ..Self-rated health lies at the cross-roads of culture and biology, therefore a collaborative effort between different disciplines can only improve our understanding of this key measure of health status...
  7. pmc Inflammation, adiposity, and mortality in the oldest old
    Inna Lisko
    Gerontology Research Center, School of Health Sciences, University of Tampere, Finland
    Rejuvenation Res 15:445-52. 2012
    ..We investigated the association of inflammatory markers with body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) in nonagenarians, and the combined effects of BMI, WC, WHR, and inflammatory status on mortality...
  8. ncbi request reprint Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians
    Riikka Rontu
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Centre for Laboratory Medicine and Department of Clinical Chemistry, University of Tampere, Medical School, Finland
    Clin Endocrinol (Oxf) 64:265-70. 2006
    ..The aim of the present study was to establish whether APOE genotype is related to plasma concentrations of CRP and lipids, or longevity among nonagenarians...
  9. doi request reprint Predictors of mortality in men and women aged 90 and older: a nine-year follow-up study in the Vitality 90+ study
    Kristina Tiainen
    Gerontology Research Center and School of Health Sciences, University of Tampere, Finland
    Age Ageing 42:468-75. 2013
    ..information about the predictors of mortality among the oldest-old is limited. Also possible gender differences are poorly known...
  10. doi request reprint Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: the Vitality 90+ Study
    Juulia Jylhävä
    Department of Microbiology and Immunology, School of Medicine, University of Tampere, Finland
    Exp Gerontol 47:372-8. 2012
    ..The cf-DNA concentration could thus represent a novel biomarker for systemic inflammation and mortality in the elderly...
  11. pmc Transcriptional analysis reveals gender-specific changes in the aging of the human immune system
    Saara Marttila
    Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland Gerontology Research Center, Tampere, Finland
    PLoS ONE 8:e66229. 2013
    ..In males significantly fewer pathways were affected, two of which are known to be regulated by estrogen. These data show that the effects of aging on the human immune system are significantly different in males and females...
  12. doi request reprint Effects of municipality factors on care transitions
    Mari Aaltonen
    Gerontology Research Center and School of Health Sciences, University of Tampere, Tampere, Finland
    Scand J Public Health 41:604-15. 2013
    ..To analyse whether transitions between care settings differ between municipalities in the last 2 years of life among older people in Finland...
  13. doi request reprint Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty
    Juulia Jylhävä
    Department of Microbiology and Immunology, The School of Medicine, University of Tampere, Tampere, Finland
    Aging Cell 12:388-97. 2013
    ..In addition, we suggest that circulating self-DNA, assessed as total or unmethylated cf-DNA, might aggravate immunoinflammatory reactivity in very old individuals...
  14. ncbi request reprint Vascular cell adhesion molecule 1, soluble Fas and hepatocyte growth factor as predictors of mortality in nonagenarians: the Vitality 90+ study
    Niko Kämppä
    Department of Clinical Chemistry, School of Medicine, University of Tampere, Tampere, Finland Fimlab Laboratories, Tampere, Finland Electronic address
    Exp Gerontol 48:1167-72. 2013
    ..We analysed the associations of the plasma levels of vascular cell adhesion molecule-1 (VCAM-1), hepatocyte growth factor (HGF) and soluble Fas (sFAS), and their combinations, with 4-year mortality to identify new biomarkers...
  15. doi request reprint Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis
    Taru Kuparinen
    Department of Microbiology and Immunology, School of Medicine, 33014 University of Tampere, Tampere, Finland
    Exp Gerontol 48:305-12. 2013
    ..Taken together, these results indicate that the CMV-dependent and CMV-independent changes in the aging of the immune system are fundamentally different...
  16. doi request reprint Among nonagenarians, congruence between self-rated and proxy-rated health was low but both predicted mortality
    Merja Vuorisalmi
    Tampere School of Health Sciences, University of Tampere, Medisiinarinkatu 3, Tampere 33014, Finland
    J Clin Epidemiol 65:553-9. 2012
    ....
  17. doi request reprint Inflammatory markers and physical performance among nonagenarians
    Kristina Tiainen
    Tampere School of Public Health, University of Tampere, FI 33014 University of Tampere, Finland
    J Gerontol A Biol Sci Med Sci 65:658-63. 2010
    ..This study examined associations between inflammatory markers and physical performance among nonagenarians...
  18. doi request reprint Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study
    Juulia Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, FIN 33014 Tampere, Finland
    Exp Gerontol 44:297-9. 2009
    ..016). We propose that the increased mortality is inflammation-related and mediated by aberrant complement regulation by the CFH 402His variant...
  19. ncbi request reprint Interleukin-6 modulates plasma cholesterol and C-reactive protein concentrations in nonagenarians
    Terho Lehtimaki
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Tampere, Finland
    J Am Geriatr Soc 53:1552-8. 2005
    ..To establish whether the relationship between interleukin-6 (IL-6) and plasma lipid and C-reactive protein (CRP) concentrations is different in Finnish nonagenarians than in middle-aged subjects with lower inflammatory status...
  20. doi request reprint Municipal variation in health and social service use in the last 2 years of life among old people
    Leena Forma
    School of Health Sciences, University of Tampere, Finland
    Scand J Public Health 39:361-70. 2011
    ..To describe and analyse municipal differences in health and social service use among old people in the last 2 years of life...
  21. ncbi request reprint Global self-rated health data from a longitudinal study predicted mortality better than comparative self-rated health in old age
    Merja Vuorisalmi
    Tampere School of Public Health and Centre of Advanced Study, University of Tampere, Finland
    J Clin Epidemiol 58:680-7. 2005
    ..Two SRH measures are examined, an age group comparative question and a global question with no explicit point of reference...
  22. doi request reprint IL-7 concentration is increased in nonagenarians but is not associated with markers of T cell immunosenescence
    Saara Marttila
    Department of Microbiology and Immunology, School of Medicine, University of Tampere, Finland
    Exp Gerontol 46:1000-2. 2011
    ..These results suggest that the IL-7 levels in nonagenarians do not have an inhibitory effect on the development of immunosenescence; rather they are associated with increased inflammation...
  23. doi request reprint The impact of dementia on care transitions during the last two years of life
    Mari Aaltonen
    School of Health Sciences, University of Tampere, Tampere FIN 33014, Finland
    Age Ageing 41:52-7. 2012
    ..Dementia is one of the main challenges to our health and social care. This study compares the number and timing of transitions between care settings in the last 2 years of life among older people with and without dementia...
  24. doi request reprint Expression profiling of immune-associated genes in peripheral blood mononuclear cells reveals baseline differences in co-stimulatory signalling between nonagenarians and younger controls: the vitality 90+ study
    Juulia Jylhävä
    Department of Microbiology and Immunology, University of Tampere, Finland
    Biogerontology 11:671-7. 2010
    ..Further research is, however, required to establish the relationship between these changes and the mechanisms of immunosenescence...
  25. ncbi request reprint Old people, alcohol use and mortality. A ten-year prospective study
    Eija Tolvanen
    Tampere School of Public Health, University of Tampere, Finland
    Aging Clin Exp Res 17:426-33. 2005
    ..The aim of this study was to examine the association of drinking frequencies and beverage types with all-cause mortality among old people...
  26. doi request reprint Body mass index, waist circumference, and waist-to-hip ratio as predictors of mortality in nonagenarians: the Vitality 90+ Study
    Inna Lisko
    School of Health Sciences, University of Tampere, Finland
    J Gerontol A Biol Sci Med Sci 66:1244-50. 2011
    ..The purpose of this study was to investigate the association of BMI, waist circumference (WC), and waist-to-hip ratio with mortality in nonagenarians...
  27. ncbi request reprint Comparative vs global self-rated health: associations with age and functional ability
    Merja Vuorisalmi
    School of Public Health, University of Tampere, 33014 Tampere, Finland
    Aging Clin Exp Res 18:211-7. 2006
    ..The focus is on differences between these questions and on the consequences which these differences have in research...
  28. pmc Associations between inflammatory markers, candidate polymorphisms and physical performance in older Danish twins
    Kristina Tiainen
    School of Health Sciences, University of Tampere, FI 33014 Tampere, Finland
    Exp Gerontol 47:109-15. 2012
    ..However, other gene variations than the candidate gene polymorphisms studied here seem to explain the major part of the genetic proportion of this association...
  29. pmc Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells
    Saara Marttila
    Department of Microbiology and Immunology, The School of Medicine, University of Tampere, Finland
    Immun Ageing 8:9. 2011
    ..abstract:..
  30. ncbi request reprint Always one step behind: husbands' narratives about taking care of their demented wives
    Tapio Kirsi
    University of Tampere, Finland
    Health (London) 8:159-81. 2004
    ....
  31. ncbi request reprint Use of hospitals at age 90. A population-based study
    Sirkka Goebeler
    Department of Forensic Medicine, Medical School, University of Tampere, Bldg B, FIN 33014 Tampere, Finland
    Arch Gerontol Geriatr 39:93-102. 2004
    ..2%. People aged 90 are an important group of hospital users. In the future, hospitals need to be prepared to provide adequate care for the most common diseases affecting the growing population of the oldest-old...
  32. doi request reprint Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: the Vitality 90+ study
    Juulia Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, Biokatu 6, FIN Medi 33014, Finland
    Mech Ageing Dev 132:20-6. 2011
    ..In nonagenarians, the quality of cf-DNA appeared similar in the original and follow-up samples. We propose that some, as yet uncharacterized, aspects of aging are reflected in the appearance of cf-DNA...
  33. ncbi request reprint IgA levels are predictors of mortality in Finnish nonagenarians
    Mikko Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School and Tampere University Hospital, Finland
    Mech Ageing Dev 126:829-31. 2005
    ..These data imply that elevated serum IgA level, i.e. indicator of intestinal inflammation and/or defect in mucosal defence, is a strong mortality predicting factor...
  34. ncbi request reprint Medical history, cognitive status and mobility at the age of 90. A population-based study in Tampere, Finland
    Sirkka Goebeler
    School of Public Health, University of Tampere, Tampere, Finland
    Aging Clin Exp Res 15:154-61. 2003
    ..We studied the population of people born in 1907-1910 and living in the city of Tampere (Finland) at the age 90 (N=916, 79.4% women, 20.6% men); 71.7% of the population lived in the community and 28.3% in institutions...
  35. ncbi request reprint Circadian activity rhythm in demented and non-demented nursing-home residents measured by telemetric actigraphy
    Paula Paavilainen
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    J Sleep Res 14:61-8. 2005
    ....
  36. ncbi request reprint Are IADLs comparable across countries? Sociodemographic associates of harmonized IADL measures
    Suvi Nikula
    University of Tampere, School of Public Health, Tampere, Finland
    Aging Clin Exp Res 15:451-9. 2003
    ..The focus of this report is to examine the comparability of IADLs across countries and to study the association of IADLs with age, gender and socioeconomic status, and the scalability of the measure...
  37. doi request reprint Age and closeness of death as determinants of health and social care utilization: a case-control study
    Leena Forma
    Tampere School of Public Health, University of Tampere, Finland
    Eur J Public Health 19:313-8. 2009
    ..We used case-control design to compare utilization of health and social services between older decedents and survivors, and to identify the respective impact of age and closeness of death on the utilization of services...
  38. pmc Is there successful aging for nonagenarians? The vitality 90+ study
    Lily Nosraty
    Gerontology Research Center and School of Health Sciences, 33014 University of Tampere, Tampere, Finland
    J Aging Res 2012:868797. 2012
    ..Age-sensitive approaches would help us better understand the potential of successful aging among individuals who already have success in longevity...
  39. ncbi request reprint Urinary incontinence in a Finnish population aged 70 and over. Prevalence of types, associated factors and self-reported treatments
    Maria Nuotio
    Vaasa City Hospital, University of Tampere, Finland
    Scand J Prim Health Care 21:182-7. 2003
    ..To describe the prevalence, associated factors and self-reported treatments of different types of incontinence in a random older population...
  40. ncbi request reprint Self-reported medical history and self-rated health at age 90. Agreement with medical records
    Sirkka Goebeler
    School of Public Health, University of Tampere, Tampere, Finland
    Aging Clin Exp Res 19:213-9. 2007
    ..We ascertained whether the self-reported medical history and self-rated health of 90-year-olds would be in agreement with their medical records...