Markus Juonala

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. pmc No association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study
    Kati Lähteelä
    Department of Medical Biochemistry, University of Tampere Medical School, Tampere, Finland
    BMC Med Genet 13:32. 2012
  2. doi request reprint Parental smoking in childhood and brachial artery flow-mediated dilatation in young adults: the Cardiovascular Risk in Young Finns study and the Childhood Determinants of Adult Health study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 32:1024-31. 2012
  3. doi request reprint Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine St
    Markus Juonala
    Department of Medicine, Turku University Hospital, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Circulation 122:2514-20. 2010
  4. ncbi request reprint [Why coronary heart disease is still more problem in Eastern than Western Finland?]
    Markus Juonala
    Loimaan aluesairaala
    Duodecim 122:55-61. 2006
  5. ncbi request reprint Effect of age and sex on carotid intima-media thickness, elasticity and brachial endothelial function in healthy adults: the cardiovascular risk in Young Finns Study
    Markus Juonala
    Department of Medicine, University of Turku, PO Box 52, 20521 Turku, Finland
    Eur Heart J 29:1198-206. 2008
  6. doi request reprint Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study
    Markus Juonala
    Department of Medicine, University of Turku and Turku University Central Hospital, PO Box 52, 20500 Turku, Finland
    Eur Heart J 31:1745-51. 2010
  7. doi request reprint A longitudinal analysis on associations of adiponectin levels with metabolic syndrome and carotid artery intima-media thickness. The Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Atherosclerosis 217:234-9. 2011
  8. doi request reprint Effect of age, gender and cardiovascular risk factors on carotid distensibility during 6-year follow-up. The cardiovascular risk in Young Finns study
    Juha Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Atherosclerosis 224:474-9. 2012
  9. ncbi request reprint Geographic origin as a determinant of carotid artery intima-media thickness and brachial artery flow-mediated dilation: the Cardiovascular Risk in Young Finns study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 25:392-8. 2005
  10. doi request reprint Alcohol consumption is directly associated with carotid intima-media thickness in Finnish young adults: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    University of Turku, Department of Medicine, Finland
    Atherosclerosis 204:e93-8. 2009

Detail Information

Publications81

  1. pmc No association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study
    Kati Lähteelä
    Department of Medical Biochemistry, University of Tampere Medical School, Tampere, Finland
    BMC Med Genet 13:32. 2012
    ....
  2. doi request reprint Parental smoking in childhood and brachial artery flow-mediated dilatation in young adults: the Cardiovascular Risk in Young Finns study and the Childhood Determinants of Adult Health study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 32:1024-31. 2012
    ..Passive smoking has been associated with increased cardiovascular morbidity. The present study aimed to examine the long-term effects of childhood exposure to tobacco smoke on endothelium-dependent vasodilation in adults...
  3. doi request reprint Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine St
    Markus Juonala
    Department of Medicine, Turku University Hospital, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Circulation 122:2514-20. 2010
    ..The aim of this study was to investigate the influence of age on the associations between childhood risk factors and carotid artery intima-media thickness, a marker of subclinical atherosclerosis...
  4. ncbi request reprint [Why coronary heart disease is still more problem in Eastern than Western Finland?]
    Markus Juonala
    Loimaan aluesairaala
    Duodecim 122:55-61. 2006
  5. ncbi request reprint Effect of age and sex on carotid intima-media thickness, elasticity and brachial endothelial function in healthy adults: the cardiovascular risk in Young Finns Study
    Markus Juonala
    Department of Medicine, University of Turku, PO Box 52, 20521 Turku, Finland
    Eur Heart J 29:1198-206. 2008
    ..The objective was to produce reference values and to analyse the associations of age and sex with carotid intima-media thickness (IMT), carotid compliance (CAC), and brachial flow-mediated dilatation (FMD) in young healthy adults...
  6. doi request reprint Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study
    Markus Juonala
    Department of Medicine, University of Turku and Turku University Central Hospital, PO Box 52, 20500 Turku, Finland
    Eur Heart J 31:1745-51. 2010
    ..The aim of this study is to evaluate whether childhood risk factors are associated with a 6-year change in carotid intima-media thickness (IMT) in young adulthood independent of the current risk factors...
  7. doi request reprint A longitudinal analysis on associations of adiponectin levels with metabolic syndrome and carotid artery intima-media thickness. The Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Atherosclerosis 217:234-9. 2011
    ..To gain insight on the interrelations between MetS, adiponectin and cardiovascular risk, we also examined the associations of adiponectin and carotid atherosclerosis according to MetS status...
  8. doi request reprint Effect of age, gender and cardiovascular risk factors on carotid distensibility during 6-year follow-up. The cardiovascular risk in Young Finns study
    Juha Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Atherosclerosis 224:474-9. 2012
    ..Arterial elasticity decreases with aging. We evaluated the role of conventional cardiovascular risk factors in this process and studied the modifying effect of gender in a population of young adults...
  9. ncbi request reprint Geographic origin as a determinant of carotid artery intima-media thickness and brachial artery flow-mediated dilation: the Cardiovascular Risk in Young Finns study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 25:392-8. 2005
    ..Whether this is because of genetic or environmental factors is unknown. We examined the effect of geographic family origin on subclinical atherosclerosis among young Finns...
  10. doi request reprint Alcohol consumption is directly associated with carotid intima-media thickness in Finnish young adults: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    University of Turku, Department of Medicine, Finland
    Atherosclerosis 204:e93-8. 2009
    ..Therefore, our aim was to study whether alcohol consumption is associated with carotid intima-media thickness (IMT), marker of subclinical atherosclerosis, in young, healthy adults...
  11. ncbi request reprint Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 110:2918-23. 2004
    ..We examined their correlation and interaction with risk factors in a large, community-based cohort of young adults...
  12. ncbi request reprint Association of fitness with vascular intima-media thickness and elasticity in adolescence
    Katja Pahkala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Pediatrics 132:e77-84. 2013
    ..Data on the effect of cardiorespiratory fitness on these measures of vascular health in adolescence are scarce. The aim was to examine the association of fitness with aortic and carotid artery IMT and elasticity in adolescents...
  13. ncbi request reprint Arterial structure and function after recovery from the metabolic syndrome: the cardiovascular risk in Young Finns Study
    Juha Koskinen
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI 20520, Finland
    Circulation 121:392-400. 2010
    ..We examined whether spontaneous recovery from MetS (according to the International Diabetes Federation definition) has a favorable effect on vascular properties and evaluated the associations between lifestyle factors and MetS recovery...
  14. doi request reprint Conventional cardiovascular risk factors and metabolic syndrome in predicting carotid intima-media thickness progression in young adults: the cardiovascular risk in young Finns study
    Juha Koskinen
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 120:229-36. 2009
    ..We evaluated the relations of conventional risk factors and MetS to the 6-year progression of carotid intima-media thickness (IMT) in a population of young adults...
  15. doi request reprint Childhood levels of serum apolipoproteins B and A-I predict carotid intima-media thickness and brachial endothelial function in adulthood: the cardiovascular risk in young Finns study
    Markus Juonala
    Department of Medicine, University of Turku, Turku, Finland
    J Am Coll Cardiol 52:293-9. 2008
    ..The aim of this study was to determine whether apolipoproteins (apo) B and A-I measured in childhood and adolescence predict atherosclerosis in adulthood...
  16. doi request reprint Associations between serum uric acid and markers of subclinical atherosclerosis in young adults. The cardiovascular risk in Young Finns study
    Mervi Oikonen
    The Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, P O Box 52, FI 20520 Turku, Finland
    Atherosclerosis 223:497-503. 2012
    ..In addition to ordinary regression, we used Mendelian randomization techniques to infer causal associations...
  17. doi request reprint Socioeconomic status, cardiovascular risk factors, and subclinical atherosclerosis in young adults: the cardiovascular risk in Young Finns Study
    Paula Kestilä
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, and Department of Medicine, Turku University Hospital, Turku, Finland
    Arterioscler Thromb Vasc Biol 32:815-21. 2012
    ....
  18. ncbi request reprint Young adults with family history of coronary heart disease have increased arterial vulnerability to metabolic risk factors: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 26:1376-82. 2006
    ..We investigated the occurrence of subclinical atherosclerosis in young adults with family history of CHD and tested the hypothesis that their arteries are more vulnerable to the proatherogenic effects of metabolic risk factors...
  19. doi request reprint Childhood serum fatty acid quality is associated with adult carotid artery intima media thickness in women but not in men
    Jari E Kaikkonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    J Nutr 143:682-9. 2013
    ..05) after controlling for confounders. These longitudinal data suggest that fat quality as reflected in the serum cholesterol ester fraction in childhood is associated with adult cIMT in women...
  20. doi request reprint Childhood physical, environmental, and genetic predictors of adult hypertension: the cardiovascular risk in young Finns study
    Jonna Juhola
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Circulation 126:402-9. 2012
    ....
  21. doi request reprint Association of liver enzymes with metabolic syndrome and carotid atherosclerosis in young adults. The Cardiovascular Risk in Young Finns Study
    Juha Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Ann Med 44:187-95. 2012
    ....
  22. doi request reprint Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study
    Jonna Juhola
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Central Hospital, Turku, Finland
    J Pediatr 159:584-90. 2011
    ..To examine tracking and predictiveness of childhood lipid levels, blood pressure, and body mass index for risk profile in adulthood and the best age to measure the childhood risk factor levels...
  23. ncbi request reprint Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study
    Markus Juonala
    Department of Medicine, University of Turku, 20521 Turku, Finland
    Circulation 116:1367-73. 2007
    ..To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachial artery flow-mediated dilation (FMD) in a large population of young adults...
  24. pmc Combined effects of child and adult elevated blood pressure on subclinical atherosclerosis: the International Childhood Cardiovascular Cohort Consortium
    Jonna Juhola
    Research Centre of Applied and Preventive Cardiovascular Medicine and the Departments of Clinical Physiology and Nuclear Medicine and Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Circulation 128:217-24. 2013
    ..However, it is uncertain whether this risk is attenuated in individuals who acquire normal BP by adulthood. The present study examined the effect of child and adult BP levels on carotid artery intima-media thickness (IMT) in adulthood...
  25. ncbi request reprint Childhood C-reactive protein in predicting CRP and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    The Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 26:1883-8. 2006
    ..The value of measuring inflammatory markers in the pediatric risk assessment, however, is uncertain. We examined whether childhood C-reactive protein (CRP) levels predict CRP and carotid intima-media thickness (IMT) in adulthood...
  26. doi request reprint Pulse pressure in youth and carotid intima-media thickness in adulthood: the cardiovascular risk in young Finns study
    Olli T Raitakari
    Departments of Clinical Physiology, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Stroke 40:1519-21. 2009
    ..We examined whether exposure to large pulse pressure in childhood predicts carotid artery intima-media thickness in adulthood...
  27. ncbi request reprint Elevated blood pressure in adolescent boys predicts endothelial dysfunction: the cardiovascular risk in young Finns study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Hypertension 48:424-30. 2006
    ....
  28. ncbi request reprint Arterial structure and function in young adults with the metabolic syndrome: the Cardiovascular Risk in Young Finns Study
    Noora Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Eur Heart J 29:784-91. 2008
    ..To study the relations between the metabolic syndrome (MS) and subclinical atherosclerosis in young adults...
  29. doi request reprint Childhood adiposity, adult adiposity, and cardiovascular risk factors
    Markus Juonala
    Research Center of Applied and Preventive Cardiovascular Medicine Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
    N Engl J Med 365:1876-85. 2011
    ..Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults...
  30. pmc Pediatric metabolic syndrome predicts adulthood metabolic syndrome, subclinical atherosclerosis, and type 2 diabetes mellitus but is no better than body mass index alone: the Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study
    Costan G Magnussen
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Circulation 122:1604-11. 2010
    ....
  31. doi request reprint Associations of dyslipidemias from childhood to adulthood with carotid intima-media thickness, elasticity, and brachial flow-mediated dilatation in adulthood: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 28:1012-7. 2008
    ..In the present study, we examined the effects of dyslipidemias from childhood to adulthood and their interaction with nonlipid risk factors on markers of subclinical atherosclerosis...
  32. pmc Childhood lifestyle and clinical determinants of adult ideal cardiovascular health: The Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Princeton Follow-up Study
    Tomi T Laitinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland Electronic address
    Int J Cardiol 169:126-32. 2013
    ..Our aim was thus to comprehensively explore childhood determinants of adult ideal cardiovascular health in population based cohorts from three continents...
  33. doi request reprint Ideal cardiovascular health in adolescence: effect of lifestyle intervention and association with vascular intima-media thickness and elasticity (the Special Turku Coronary Risk Factor Intervention Project for Children [STRIP] study)
    Katja Pahkala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Circulation 127:2088-96. 2013
    ..Additionally, we investigated the association between the concept and vascular intima-media thickness and elasticity in adolescence...
  34. doi request reprint Tissue inhibitor of matrix metalloproteinases 4 (TIMP4) in a population of young adults: relations to cardiovascular risk markers and carotid artery intima-media thickness. The Cardiovascular Risk in Young Finns Study
    Mervi Oikonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland
    Scand J Clin Lab Invest 72:540-6. 2012
    ....
  35. doi request reprint Ideal cardiovascular health in childhood and cardiometabolic outcomes in adulthood: the Cardiovascular Risk in Young Finns Study
    Tomi T Laitinen
    BM, Research Centre of Applied and Preventive Cardiovascular Medicine, Turku, Finland
    Circulation 125:1971-8. 2012
    ..The applicability of this concept to a cohort of children and its relationship with cardiometabolic outcomes in adulthood has not been reported...
  36. doi request reprint Effect of repeated dietary counseling on serum lipoproteins from infancy to adulthood
    Harri Niinikoski
    Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
    Pediatrics 129:e704-13. 2012
    ..Our aim was to study the influences of repeated low saturated fat dietary counseling on dietary intakes and lipoprotein measures from infancy to adulthood...
  37. doi request reprint Blood pressure is lower in children and adolescents with a low-saturated-fat diet since infancy: the special turku coronary risk factor intervention project
    Harri Niinikoski
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Hypertension 53:918-24. 2009
    ..The importance of childhood lifestyle counseling and primary prevention of hypertension should be emphasized, especially in those children with a family history of hypertension or atherosclerotic vascular disease...
  38. ncbi request reprint Relation of apolipoprotein E polymorphism to markers of early atherosclerotic changes in young adults--the Cardiovascular Risk in Young Finns Study
    Paula Grönroos
    Department of Clinical Chemistry, University of Turku, Turku, Finland
    Circ J 72:29-34. 2008
    ..Also brachial flow-mediated dilatation (FMD) and carotid artery compliance (CAC) were determined to clarify their relation to this genetic factor...
  39. doi request reprint Apolipoprotein B, oxidized low-density lipoprotein, and LDL particle size in predicting the incidence of metabolic syndrome: the Cardiovascular Risk in Young Finns study
    Juha Koskinen
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Eur J Prev Cardiol 19:1296-303. 2012
    ..To test whether serum apolipoprotein B (apoB) and low-density lipoprotein (LDL) particle characteristics (oxidation and mean particle size) predict the incidence of metabolic syndrome (MetS)...
  40. doi request reprint A diagnosis of the metabolic syndrome in youth that resolves by adult life is associated with a normalization of high carotid intima-media thickness and type 2 diabetes mellitus risk: the Bogalusa heart and cardiovascular risk in young Finns studies
    Costan G Magnussen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    J Am Coll Cardiol 60:1631-9. 2012
    ..The aim of this study was to examine the effect of resolution from metabolic syndrome (MetS) between youth and adulthood on carotid artery intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM)...
  41. pmc Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study
    Mervi Oikonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, PO Box 52, FI 20521 Turku, Finland
    Hypertension 58:1079-85. 2011
    ..5-mm Hg higher blood pressure, and this trajectory continues from childhood to adulthood...
  42. ncbi request reprint Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 112:1486-93. 2005
    ..Exposure to risk factors in childhood may have long-term influences on vascular function. We examined the relationship between risk factors identified in childhood and arterial elasticity assessed in adulthood...
  43. doi request reprint Higher maternal body mass index is associated with an increased risk for later type 2 diabetes in offspring
    Markus Juonala
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    J Pediatr 162:918-23.e1. 2013
    ..To investigate whether the body mass index (BMI) of a child's mother is associated with an increased future risk of type 2 diabetes, independent of genetic risk or childhood metabolic, behavioral, and environmental factors...
  44. ncbi request reprint Plasminogen activator inhitor-1 associates with cardiovascular risk factors in healthy young adults in the Cardiovascular Risk in Young Finns Study
    Juho R H Raiko
    The Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Atherosclerosis 224:208-12. 2012
    ..We examined associations between serum PAI-1, ultrasound markers of atherosclerosis and CVD risk factors and whether PAI-1 improves prediction of atherosclerosis over known risk factors in a cohort of asymptomatic adults...
  45. pmc Childhood nutrition in predicting metabolic syndrome in adults: the cardiovascular risk in Young Finns Study
    Paula Jääskeläinen
    University of Turku, Turku, Finland
    Diabetes Care 35:1937-43. 2012
    ..Our aim was to study the associations of childhood lifestyle factors (the frequency of consumption of vegetables, fruit, fish, and meat, butter use on bread, and physical activity) with the metabolic syndrome (MetS) in adulthood...
  46. ncbi request reprint Relation of total and free testosterone and sex hormone-binding globulin with cardiovascular risk factors in men aged 24-45 years. The Cardiovascular Risk in Young Finns Study
    Sonja Firtser
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Finland
    Atherosclerosis 222:257-62. 2012
    ..We studied the levels of total testosterone, calculated free testosterone and sex hormone-binding globulin (SHBG), and their relations with cardiovascular risk factors in young Finnish men...
  47. doi request reprint Plasma osteopontin is not associated with vascular markers of subclinical atherosclerosis in a population of young adults without symptoms of cardiovascular disease. The Cardiovascular Risk in Young Finns Study
    Maria Wendelin-Saarenhovi
    Department of Clinical Physiology, Turku University Hospital, Turku, Finland
    Scand J Clin Lab Invest 71:683-9. 2011
    ..Osteopontin is used as a biomarker for measuring the severity of atherosclerosis, but the role of osteopontin in the pathogenesis of atherosclerosis is not clear...
  48. doi request reprint Cross-sectional associations between physical activity and selected coronary heart disease risk factors in young adults. The Cardiovascular Risk in Young Finns Study
    Kristiina Mansikkaniemi
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Ann Med 44:733-44. 2012
    ..Physical activity (PA) may reduce the risk of coronary heart disease (CHD) by inducing beneficial changes in several risk factors. We studied the associations between PA and a range of risk markers of CHD in young adults...
  49. ncbi request reprint Obesity in youth is not an independent predictor of carotid IMT in adulthood. The Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Atherosclerosis 185:388-93. 2006
    ..610 mm versus 0.627 mm, respectively. We conclude that being obese in youth is associated with increased carotid IMT in adulthood, but this relationship is explained by significant tracking of body mass from youth to adulthood...
  50. ncbi request reprint Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study
    Olli T Raitakari
    Department of Clinical Physiology and PET Centre, University of Turku, Turku
    JAMA 290:2277-83. 2003
    ..Exposure to cardiovascular risk factors during childhood and adolescence may be associated with the development of atherosclerosis later in life...
  51. doi request reprint Tracking of noninvasive ultrasound measurements of subclinical atherosclerosis in adulthood: findings from the Cardiovascular Risk in Young Finns Study
    Juho R H Raiko
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Ultrasound Med Biol 36:1237-44. 2010
    ..36; r = 0.19, p = 0.01). In conclusion, ultrasound measurements tracked low to moderate over 6-years and was influenced by cardiovascular disease (CVD) risk factor status...
  52. ncbi request reprint Adiponectin is related with carotid artery intima-media thickness and brachial flow-mediated dilatation in young adults--the Cardiovascular Risk in Young Finns Study
    Liisa A Saarikoski
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Ann Med 42:603-11. 2010
    ..We investigated the relation of adiponectin on early functional and structural markers of subclinical atherosclerosis in a large population-based cohort of young men and women...
  53. ncbi request reprint Youth overweight and metabolic disturbances in predicting carotid intima-media thickness, type 2 diabetes, and metabolic syndrome in adulthood: the Cardiovascular Risk in Young Finns study
    Juha Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FinlandDepartment of Medicine, Kymenlaakso Central Hospital, Kotka, Finland
    Diabetes Care 37:1870-7. 2014
    ..e., elevated blood pressure, glucose, triglycerides, low HDL cholesterol, and high LDL cholesterol) and their combinations as youth...
  54. doi request reprint Main findings from the prospective Cardiovascular Risk in Young Finns Study
    Markus Juonala
    University of Turku and Turku University Hospital, Cardiovascular Research Center, Turku, Finland
    Curr Opin Lipidol 24:57-64. 2013
    ..This prospective multicenter study initiated in 1980 (N = 3596, baseline age 3-18 years) has followed up study participants over 30 years to investigate childhood risk factors for cardiometabolic outcomes in adulthood...
  55. doi request reprint Childhood predictors of the metabolic syndrome in adulthood. The Cardiovascular Risk in Young Finns Study
    Noora Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Ann Med 40:542-52. 2008
    ..Obese youths may be susceptible to develop the metabolic syndrome (MS) later in life...
  56. pmc Ideal cardiovascular health in young adult populations from the United States, Finland, and Australia and its association with cIMT: the International Childhood Cardiovascular Cohort Consortium
    Mervi Oikonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    J Am Heart Assoc 2:e000244. 2013
    ..We studied the prevalence of ideal CV health and its associations with ultrasonographically measured carotid intima-media thickness (cIMT) cross-sectionally in 5 international populations...
  57. pmc Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study
    Sebastian Okser
    Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland
    PLoS Genet 6:e1001146. 2010
    ..043). These results demonstrate that the modeling framework can utilize the "gray zone" of genetic variation in the classification of subjects with different degrees of risk of developing atherosclerosis...
  58. doi request reprint Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: the Cardiovascular Risk in Young Finns Study
    Tatu A Miettinen
    Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland
    Atherosclerosis 209:592-7. 2010
    ..The aim of the present study was to evaluate the role of cholesterol metabolism in the development of atheromatous artery disease...
  59. doi request reprint Relations between carotid artery distensibility and heart rate variability The Cardiovascular Risk in Young Finns Study
    Tuomas Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Auton Neurosci 161:75-80. 2011
    ..We studied at the population level the relations between carotid-artery-distensibility (Cdist) and vagal modulation of heart rate...
  60. doi request reprint Short-term heart rate variability in healthy young adults: the Cardiovascular Risk in Young Finns Study
    Tuomas Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Auton Neurosci 145:81-8. 2009
    ..Because of good reproducibility the short-term indices of HRV and deep breathing test can be used in clinical work...
  61. doi request reprint Association of physical activity in childhood and early adulthood with carotid artery elasticity 21 years later: the cardiovascular risk in young Finns study
    Kristiina S Pälve
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    J Am Heart Assoc 3:e000594. 2014
    ..The aim of this study was to determine the long-term effects of physical activity in children and young adults on carotid artery elasticity after 21 years of follow-up...
  62. doi request reprint Parental smoking produces long-term damage to vascular function in their children
    Markus Juonala
    Cardiovascular Research Center, University of Turku and Turku University Hospital, Turku, Finland
    Curr Opin Cardiol 28:569-74. 2013
    ..This review provides an overview of recent findings concerning the cardiovascular effects of childhood exposure to environmental tobacco smoke (ETS)...
  63. ncbi request reprint Beat-to-beat oscillations in pulse pressure
    Raine Virtanen
    Department of Medicine, Turku University Central Hospital, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Clin Physiol Funct Imaging 24:304-9. 2004
    ..18, P = 0.031) and serum triglycerides (0.16, P = 0.048). Our findings suggest that increased beat-to-beat oscillation of PP reflects arterial stiffening and impaired baroreflex function...
  64. ncbi request reprint Impact of repeated dietary counseling between infancy and 14 years of age on dietary intakes and serum lipids and lipoproteins: the STRIP study
    Harri Niinikoski
    Department of Pediatrics, University of Turku, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Circulation 116:1032-40. 2007
    ..The aims of the present study were to evaluate the effect of low-saturated-fat, low-cholesterol dietary counseling on fat intakes, growth, serum cholesterol values, and pubertal development in children and adolescents...
  65. doi request reprint Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk
    Olli T Raitakari
    Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Atherosclerosis 226:245-51. 2013
    ..We used computational methods to estimate apoB and apoA1 from serum total cholesterol, HDL-cholesterol and triglycerides and tested their clinical value in comparison to measured apoB and apoA1 values...
  66. doi request reprint Does childhood nutrition influence adult cardiovascular disease risk?--insights from the Young Finns Study
    Jari E Kaikkonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Ann Med 45:120-8. 2013
    ..Our findings and the current literature suggest that childhood nutrition has a significant role in the progression of CVD...
  67. doi request reprint When and how to start prevention of atherosclerosis? Lessons from the Cardiovascular Risk in the Young Finns Study and the Special Turku Coronary Risk Factor Intervention Project
    Costan G Magnussen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520, Finland, Finland
    Pediatr Nephrol 27:1441-52. 2012
    ....
  68. ncbi request reprint Assessment of inflammatory markers and endothelial function
    Mikko J Jarvisalo
    The Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology, University of Turku, Turku, and Department of Internal Medicine, Satakunta Central Hospital, Pori, Finland
    Curr Opin Clin Nutr Metab Care 9:547-52. 2006
    ..To describe the background and assessment of inflammatory markers and endothelial function in atherosclerosis...
  69. doi request reprint Adolescence risk factors are predictive of coronary artery calcification at middle age: the cardiovascular risk in young Finns study
    Olli Hartiala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, and Turku PET Center, Turku University Hospital, Turku, Finland
    J Am Coll Cardiol 60:1364-70. 2012
    ..The purpose of this study was to examine the roles of adolescence risk factors in predicting coronary artery calcium (CAC)...
  70. doi request reprint Childhood serum cholesterol ester fatty acids are associated with blood pressure 27 y later in the Cardiovascular Risk in Young Finns Study
    Jari E Kaikkonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Am J Clin Nutr 95:1422-31. 2012
    ..In adults, dietary fatty acids (FAs) modify blood pressure (BP), but it is not known whether childhood FA quality is associated with adulthood BP...
  71. ncbi request reprint The effects of a 6-month sodium restriction on cardiac autonomic function in patients with mild to moderate essential hypertension
    Petri Mäkelä
    Department of Medicine, Turku University Hospital, Turku, Finland
    Am J Hypertens 21:1183-7. 2008
    ..The blood pressure-lowering mechanism of low-sodium diet is not fully understood...
  72. doi request reprint Metabolic syndrome and carotid intima-media thickness in young adults: roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: the cardiovascular risk in young Finns study
    Noora Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Finland
    Arterioscler Thromb Vasc Biol 30:1861-6. 2010
    ..We examined whether the association between carotid atherosclerosis and MetS in a population of young adults is mediated by apoB and apoA-I and/or by inflammatory markers C-reactive protein and type II secretory phospholipase A2...
  73. pmc Cardiovascular risk scores in the prediction of subclinical atherosclerosis in young adults: evidence from the cardiovascular risk in a young Finns study
    Juho R H Raiko
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital dFinnish Institute of Occupational Health, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 17:549-55. 2010
    ..To study the utility of risk scores in the prediction of subclinical atherosclerosis in young adults...
  74. ncbi request reprint Home-measured blood pressure is more strongly associated with atherosclerosis than clinic blood pressure: the Finn-HOME Study
    Teemu Niiranen
    Department of Health and Functional Capacity, National Public Health Institute, Helsinki, Finland
    J Hypertens 25:1225-31. 2007
    ..Other risk factors associated with carotid atherosclerosis were also investigated...
  75. pmc Statin adherence and the risk of major coronary events in patients with diabetes: a nested case-control study
    Päivi Ruokoniemi
    Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland
    Br J Clin Pharmacol 71:766-76. 2011
    ..To evaluate whether good statin adherence is associated with a reduced incidence of major coronary events (MCEs) among diabetic patients with and without coronary heart disease (CHD)...
  76. doi request reprint Evaluation of multiplex immunoassays, used for determination of adiponectin, resistin, leptin, and ghrelin from human blood samples, in comparison to ELISA assays
    Britt Marie Loo
    National Institute for Health and Welfare, Department of Chronic Disease Prevention, Turku, Finland
    Scand J Clin Lab Invest 71:221-6. 2011
    ..We have evaluated the performance of two multiplex immunoassays for determination of adiponectin, resistin, ghrelin and leptin in comparison to corresponding, conventional ELISA assays...
  77. doi request reprint When to prevent cardiovascular disease? As early as possible: lessons from prospective cohorts beginning in childhood
    Costan G Magnussen
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    Curr Opin Cardiol 28:561-8. 2013
    ....
  78. doi request reprint Genetic variation of the interleukin-1 family and nongenetic factors determining the interleukin-1 receptor antagonist phenotypes
    Kari Luotola
    Department of Medicine, HUCH Helsinki University Central Hospital, Box 340 HUS, FI 00029 Helsinki, Finland
    Metabolism 59:1520-7. 2010
    ..The proportion of phenotypic variation in IL-1Ra explained by the genetic variants was, however, modest compared with the proportion explained by the body mass index...
  79. doi request reprint Vitamin D status and common risk factors for bone fragility as determinants of quantitative ultrasound variables in a nationally representative population sample
    Maarit Kauppi
    Department of Health and Functional Capacity, National Public Health Institute, Turku, Finland
    Bone 45:119-24. 2009
    ..Obesity should be taken into account in future assessments of vitamin D status in Finland as in other countries...
  80. ncbi request reprint Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial
    Antti Jula
    Department of Health and Functional Capacity, National Public Health Institute of Finland, Turku, Finland
    Arterioscler Thromb Vasc Biol 25:1952-9. 2005
    ..To explore the separate and combined effects of simvastatin and a low-saturated diet rich in alpha-linolenic acid on serum fatty acids...
  81. ncbi request reprint Anxiety and hostility are associated with reduced baroreflex sensitivity and increased beat-to-beat blood pressure variability
    Raine Virtanen
    Department of Medicine, Turku University Central Hospital, Finland
    Psychosom Med 65:751-6. 2003
    ..The purpose of this study was to determine whether psychological factors are associated with heart rate variability (HRV), blood pressure variability (BPV), and baroreflex sensitivity (BRS) among healthy middle-aged men and women...