Markus Juonala

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 110:2918-23. 2004
  2. doi request reprint Parental smoking produces long-term damage to vascular function in their children
    Markus Juonala
    Cardiovascular Research Center, University of Turku and Turku University Hospital, Turku, Finland
    Curr Opin Cardiol 28:569-74. 2013
  3. doi request reprint Higher maternal body mass index is associated with an increased risk for later type 2 diabetes in offspring
    Markus Juonala
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    J Pediatr 162:918-23.e1. 2013
  4. doi request reprint Main findings from the prospective Cardiovascular Risk in Young Finns Study
    Markus Juonala
    University of Turku and Turku University Hospital, Cardiovascular Research Center, Turku, Finland
    Curr Opin Lipidol 24:57-64. 2013
  5. pmc Early atherosclerosis and cardiac autonomic responses to mental stress: a population-based study of the moderating influence of impaired endothelial function
    Nadja Chumaeva
    Institute of Behavioural Sciences, University of Helsinki, PO Box 9, FIN 00014 Helsinki, Finland
    BMC Cardiovasc Disord 10:16. 2010
  6. pmc Sex differences in the combined effect of chronic stress with impaired vascular endothelium functioning and the development of early atherosclerosis: the Cardiovascular Risk in Young Finns study
    Nadja Chumaeva
    Institute of Behavioral Sciences, University of Helsinki, PO Box 9, 00014 Helsinki, Finland
    BMC Cardiovasc Disord 10:34. 2010
  7. doi request reprint Alcohol consumption is directly associated with carotid intima-media thickness in Finnish young adults: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    University of Turku, Department of Medicine, Finland
    Atherosclerosis 204:e93-8. 2009
  8. doi request reprint Childhood levels of serum apolipoproteins B and A-I predict carotid intima-media thickness and brachial endothelial function in adulthood: the cardiovascular risk in young Finns study
    Markus Juonala
    Department of Medicine, University of Turku, Turku, Finland
    J Am Coll Cardiol 52:293-9. 2008
  9. pmc Childhood environmental and genetic predictors of adulthood obesity: the cardiovascular risk in young Finns study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, FIN 20520 Finland
    J Clin Endocrinol Metab 96:E1542-9. 2011
  10. doi request reprint Metabolic syndrome and carotid intima-media thickness in young adults: roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: the cardiovascular risk in young Finns study
    Noora Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Finland
    Arterioscler Thromb Vasc Biol 30:1861-6. 2010

Detail Information

Publications88

  1. ncbi request reprint Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 110:2918-23. 2004
    ..We examined their correlation and interaction with risk factors in a large, community-based cohort of young adults...
  2. doi request reprint Parental smoking produces long-term damage to vascular function in their children
    Markus Juonala
    Cardiovascular Research Center, University of Turku and Turku University Hospital, Turku, Finland
    Curr Opin Cardiol 28:569-74. 2013
    ..This review provides an overview of recent findings concerning the cardiovascular effects of childhood exposure to environmental tobacco smoke (ETS)...
  3. doi request reprint Higher maternal body mass index is associated with an increased risk for later type 2 diabetes in offspring
    Markus Juonala
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    J Pediatr 162:918-23.e1. 2013
    ..To investigate whether the body mass index (BMI) of a child's mother is associated with an increased future risk of type 2 diabetes, independent of genetic risk or childhood metabolic, behavioral, and environmental factors...
  4. doi request reprint Main findings from the prospective Cardiovascular Risk in Young Finns Study
    Markus Juonala
    University of Turku and Turku University Hospital, Cardiovascular Research Center, Turku, Finland
    Curr Opin Lipidol 24:57-64. 2013
    ..This prospective multicenter study initiated in 1980 (N = 3596, baseline age 3-18 years) has followed up study participants over 30 years to investigate childhood risk factors for cardiometabolic outcomes in adulthood...
  5. pmc Early atherosclerosis and cardiac autonomic responses to mental stress: a population-based study of the moderating influence of impaired endothelial function
    Nadja Chumaeva
    Institute of Behavioural Sciences, University of Helsinki, PO Box 9, FIN 00014 Helsinki, Finland
    BMC Cardiovasc Disord 10:16. 2010
    ..The present study aims to examine the interactive effect of acute mental stress-induced cardiac reactivity/recovery and endothelial function on the prevalence of carotid atherosclerosis...
  6. pmc Sex differences in the combined effect of chronic stress with impaired vascular endothelium functioning and the development of early atherosclerosis: the Cardiovascular Risk in Young Finns study
    Nadja Chumaeva
    Institute of Behavioral Sciences, University of Helsinki, PO Box 9, 00014 Helsinki, Finland
    BMC Cardiovasc Disord 10:34. 2010
    ....
  7. doi request reprint Alcohol consumption is directly associated with carotid intima-media thickness in Finnish young adults: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    University of Turku, Department of Medicine, Finland
    Atherosclerosis 204:e93-8. 2009
    ..Therefore, our aim was to study whether alcohol consumption is associated with carotid intima-media thickness (IMT), marker of subclinical atherosclerosis, in young, healthy adults...
  8. doi request reprint Childhood levels of serum apolipoproteins B and A-I predict carotid intima-media thickness and brachial endothelial function in adulthood: the cardiovascular risk in young Finns study
    Markus Juonala
    Department of Medicine, University of Turku, Turku, Finland
    J Am Coll Cardiol 52:293-9. 2008
    ..The aim of this study was to determine whether apolipoproteins (apo) B and A-I measured in childhood and adolescence predict atherosclerosis in adulthood...
  9. pmc Childhood environmental and genetic predictors of adulthood obesity: the cardiovascular risk in young Finns study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, FIN 20520 Finland
    J Clin Endocrinol Metab 96:E1542-9. 2011
    ..Increased youth BMI is a risk factor for later obesity, but it is unknown whether identification of other risk factors, including recently discovered genetic markers, would help to identify children at risk of developing adult obesity...
  10. doi request reprint Metabolic syndrome and carotid intima-media thickness in young adults: roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: the cardiovascular risk in young Finns study
    Noora Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Finland
    Arterioscler Thromb Vasc Biol 30:1861-6. 2010
    ..We examined whether the association between carotid atherosclerosis and MetS in a population of young adults is mediated by apoB and apoA-I and/or by inflammatory markers C-reactive protein and type II secretory phospholipase A2...
  11. ncbi request reprint Geographic origin as a determinant of carotid artery intima-media thickness and brachial artery flow-mediated dilation: the Cardiovascular Risk in Young Finns study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 25:392-8. 2005
    ..Whether this is because of genetic or environmental factors is unknown. We examined the effect of geographic family origin on subclinical atherosclerosis among young Finns...
  12. doi request reprint Effect of age, gender and cardiovascular risk factors on carotid distensibility during 6-year follow-up. The cardiovascular risk in Young Finns study
    Juha Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Atherosclerosis 224:474-9. 2012
    ..Arterial elasticity decreases with aging. We evaluated the role of conventional cardiovascular risk factors in this process and studied the modifying effect of gender in a population of young adults...
  13. doi request reprint Association of fitness with vascular intima-media thickness and elasticity in adolescence
    Katja Pahkala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Pediatrics 132:e77-84. 2013
    ..Data on the effect of cardiorespiratory fitness on these measures of vascular health in adolescence are scarce. The aim was to examine the association of fitness with aortic and carotid artery IMT and elasticity in adolescents...
  14. doi request reprint Arterial structure and function after recovery from the metabolic syndrome: the cardiovascular risk in Young Finns Study
    Juha Koskinen
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI 20520, Finland
    Circulation 121:392-400. 2010
    ..We examined whether spontaneous recovery from MetS (according to the International Diabetes Federation definition) has a favorable effect on vascular properties and evaluated the associations between lifestyle factors and MetS recovery...
  15. ncbi request reprint Effect of age and sex on carotid intima-media thickness, elasticity and brachial endothelial function in healthy adults: the cardiovascular risk in Young Finns Study
    Markus Juonala
    Department of Medicine, University of Turku, PO Box 52, 20521 Turku, Finland
    Eur Heart J 29:1198-206. 2008
    ..The objective was to produce reference values and to analyse the associations of age and sex with carotid intima-media thickness (IMT), carotid compliance (CAC), and brachial flow-mediated dilatation (FMD) in young healthy adults...
  16. doi request reprint Parental smoking in childhood and brachial artery flow-mediated dilatation in young adults: the Cardiovascular Risk in Young Finns study and the Childhood Determinants of Adult Health study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 32:1024-31. 2012
    ..Passive smoking has been associated with increased cardiovascular morbidity. The present study aimed to examine the long-term effects of childhood exposure to tobacco smoke on endothelium-dependent vasodilation in adults...
  17. pmc Cardiovascular risk scores in the prediction of subclinical atherosclerosis in young adults: evidence from the cardiovascular risk in a young Finns study
    Juho R H Raiko
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital dFinnish Institute of Occupational Health, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 17:549-55. 2010
    ..To study the utility of risk scores in the prediction of subclinical atherosclerosis in young adults...
  18. doi request reprint Conventional cardiovascular risk factors and metabolic syndrome in predicting carotid intima-media thickness progression in young adults: the cardiovascular risk in young Finns study
    Juha Koskinen
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 120:229-36. 2009
    ..We evaluated the relations of conventional risk factors and MetS to the 6-year progression of carotid intima-media thickness (IMT) in a population of young adults...
  19. doi request reprint Childhood adiposity, adult adiposity, and cardiovascular risk factors
    Markus Juonala
    Research Center of Applied and Preventive Cardiovascular Medicine Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
    N Engl J Med 365:1876-85. 2011
    ..Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults...
  20. pmc Pediatric metabolic syndrome predicts adulthood metabolic syndrome, subclinical atherosclerosis, and type 2 diabetes mellitus but is no better than body mass index alone: the Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study
    Costan G Magnussen
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Circulation 122:1604-11. 2010
    ....
  21. doi request reprint Childhood physical, environmental, and genetic predictors of adult hypertension: the cardiovascular risk in young Finns study
    Jonna Juhola
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Circulation 126:402-9. 2012
    ....
  22. doi request reprint Associations between serum uric acid and markers of subclinical atherosclerosis in young adults. The cardiovascular risk in Young Finns study
    Mervi Oikonen
    The Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, P O Box 52, FI 20520 Turku, Finland
    Atherosclerosis 223:497-503. 2012
    ..In addition to ordinary regression, we used Mendelian randomization techniques to infer causal associations...
  23. doi request reprint Socioeconomic status, cardiovascular risk factors, and subclinical atherosclerosis in young adults: the cardiovascular risk in Young Finns Study
    Paula Kestilä
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, and Department of Medicine, Turku University Hospital, Turku, Finland
    Arterioscler Thromb Vasc Biol 32:815-21. 2012
    ....
  24. doi request reprint Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study
    Jonna Juhola
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Central Hospital, Turku, Finland
    J Pediatr 159:584-90. 2011
    ..To examine tracking and predictiveness of childhood lipid levels, blood pressure, and body mass index for risk profile in adulthood and the best age to measure the childhood risk factor levels...
  25. ncbi request reprint Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study
    Markus Juonala
    Department of Medicine, University of Turku, 20521 Turku, Finland
    Circulation 116:1367-73. 2007
    ..To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachial artery flow-mediated dilation (FMD) in a large population of young adults...
  26. doi request reprint Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study
    Markus Juonala
    Department of Medicine, University of Turku and Turku University Central Hospital, PO Box 52, 20500 Turku, Finland
    Eur Heart J 31:1745-51. 2010
    ..The aim of this study is to evaluate whether childhood risk factors are associated with a 6-year change in carotid intima-media thickness (IMT) in young adulthood independent of the current risk factors...
  27. doi request reprint Childhood serum fatty acid quality is associated with adult carotid artery intima media thickness in women but not in men
    Jari E Kaikkonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    J Nutr 143:682-9. 2013
    ..05) after controlling for confounders. These longitudinal data suggest that fat quality as reflected in the serum cholesterol ester fraction in childhood is associated with adult cIMT in women...
  28. doi request reprint Association of liver enzymes with metabolic syndrome and carotid atherosclerosis in young adults. The Cardiovascular Risk in Young Finns Study
    Juha Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Ann Med 44:187-95. 2012
    ....
  29. doi request reprint Associations of dyslipidemias from childhood to adulthood with carotid intima-media thickness, elasticity, and brachial flow-mediated dilatation in adulthood: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 28:1012-7. 2008
    ..In the present study, we examined the effects of dyslipidemias from childhood to adulthood and their interaction with nonlipid risk factors on markers of subclinical atherosclerosis...
  30. pmc Combined effects of child and adult elevated blood pressure on subclinical atherosclerosis: the International Childhood Cardiovascular Cohort Consortium
    Jonna Juhola
    Research Centre of Applied and Preventive Cardiovascular Medicine and the Departments of Clinical Physiology and Nuclear Medicine and Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Circulation 128:217-24. 2013
    ..However, it is uncertain whether this risk is attenuated in individuals who acquire normal BP by adulthood. The present study examined the effect of child and adult BP levels on carotid artery intima-media thickness (IMT) in adulthood...
  31. doi request reprint A longitudinal analysis on associations of adiponectin levels with metabolic syndrome and carotid artery intima-media thickness. The Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Atherosclerosis 217:234-9. 2011
    ..To gain insight on the interrelations between MetS, adiponectin and cardiovascular risk, we also examined the associations of adiponectin and carotid atherosclerosis according to MetS status...
  32. ncbi request reprint Elevated blood pressure in adolescent boys predicts endothelial dysfunction: the cardiovascular risk in young Finns study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Hypertension 48:424-30. 2006
    ....
  33. ncbi request reprint Arterial structure and function in young adults with the metabolic syndrome: the Cardiovascular Risk in Young Finns Study
    Noora Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Eur Heart J 29:784-91. 2008
    ..To study the relations between the metabolic syndrome (MS) and subclinical atherosclerosis in young adults...
  34. doi request reprint Ideal cardiovascular health in adolescence: effect of lifestyle intervention and association with vascular intima-media thickness and elasticity (the Special Turku Coronary Risk Factor Intervention Project for Children [STRIP] study)
    Katja Pahkala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Circulation 127:2088-96. 2013
    ..Additionally, we investigated the association between the concept and vascular intima-media thickness and elasticity in adolescence...
  35. doi request reprint Apolipoprotein B, oxidized low-density lipoprotein, and LDL particle size in predicting the incidence of metabolic syndrome: the Cardiovascular Risk in Young Finns study
    Juha Koskinen
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Eur J Prev Cardiol 19:1296-303. 2012
    ..To test whether serum apolipoprotein B (apoB) and low-density lipoprotein (LDL) particle characteristics (oxidation and mean particle size) predict the incidence of metabolic syndrome (MetS)...
  36. doi request reprint Tissue inhibitor of matrix metalloproteinases 4 (TIMP4) in a population of young adults: relations to cardiovascular risk markers and carotid artery intima-media thickness. The Cardiovascular Risk in Young Finns Study
    Mervi Oikonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland
    Scand J Clin Lab Invest 72:540-6. 2012
    ....
  37. doi request reprint Ideal cardiovascular health in childhood and cardiometabolic outcomes in adulthood: the Cardiovascular Risk in Young Finns Study
    Tomi T Laitinen
    BM, Research Centre of Applied and Preventive Cardiovascular Medicine, Turku, Finland
    Circulation 125:1971-8. 2012
    ..The applicability of this concept to a cohort of children and its relationship with cardiometabolic outcomes in adulthood has not been reported...
  38. doi request reprint Pulse pressure in youth and carotid intima-media thickness in adulthood: the cardiovascular risk in young Finns study
    Olli T Raitakari
    Departments of Clinical Physiology, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Stroke 40:1519-21. 2009
    ..We examined whether exposure to large pulse pressure in childhood predicts carotid artery intima-media thickness in adulthood...
  39. pmc Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study
    Mervi Oikonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, PO Box 52, FI 20521 Turku, Finland
    Hypertension 58:1079-85. 2011
    ..5-mm Hg higher blood pressure, and this trajectory continues from childhood to adulthood...
  40. ncbi request reprint Childhood C-reactive protein in predicting CRP and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    The Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 26:1883-8. 2006
    ..The value of measuring inflammatory markers in the pediatric risk assessment, however, is uncertain. We examined whether childhood C-reactive protein (CRP) levels predict CRP and carotid intima-media thickness (IMT) in adulthood...
  41. ncbi request reprint Young adults with family history of coronary heart disease have increased arterial vulnerability to metabolic risk factors: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 26:1376-82. 2006
    ..We investigated the occurrence of subclinical atherosclerosis in young adults with family history of CHD and tested the hypothesis that their arteries are more vulnerable to the proatherogenic effects of metabolic risk factors...
  42. ncbi request reprint Relation of apolipoprotein E polymorphism to markers of early atherosclerotic changes in young adults--the Cardiovascular Risk in Young Finns Study
    Paula Grönroos
    Department of Clinical Chemistry, University of Turku, Turku, Finland
    Circ J 72:29-34. 2008
    ..Also brachial flow-mediated dilatation (FMD) and carotid artery compliance (CAC) were determined to clarify their relation to this genetic factor...
  43. pmc Childhood nutrition in predicting metabolic syndrome in adults: the cardiovascular risk in Young Finns Study
    Paula Jääskeläinen
    University of Turku, Turku, Finland
    Diabetes Care 35:1937-43. 2012
    ..Our aim was to study the associations of childhood lifestyle factors (the frequency of consumption of vegetables, fruit, fish, and meat, butter use on bread, and physical activity) with the metabolic syndrome (MetS) in adulthood...
  44. doi request reprint Cross-sectional associations between physical activity and selected coronary heart disease risk factors in young adults. The Cardiovascular Risk in Young Finns Study
    Kristiina Mansikkaniemi
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Ann Med 44:733-44. 2012
    ..Physical activity (PA) may reduce the risk of coronary heart disease (CHD) by inducing beneficial changes in several risk factors. We studied the associations between PA and a range of risk markers of CHD in young adults...
  45. doi request reprint A diagnosis of the metabolic syndrome in youth that resolves by adult life is associated with a normalization of high carotid intima-media thickness and type 2 diabetes mellitus risk: the Bogalusa heart and cardiovascular risk in young Finns studies
    Costan G Magnussen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    J Am Coll Cardiol 60:1631-9. 2012
    ..The aim of this study was to examine the effect of resolution from metabolic syndrome (MetS) between youth and adulthood on carotid artery intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM)...
  46. ncbi request reprint Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study
    Olli T Raitakari
    Department of Clinical Physiology and PET Centre, University of Turku, Turku
    JAMA 290:2277-83. 2003
    ..Exposure to cardiovascular risk factors during childhood and adolescence may be associated with the development of atherosclerosis later in life...
  47. doi request reprint Tracking of noninvasive ultrasound measurements of subclinical atherosclerosis in adulthood: findings from the Cardiovascular Risk in Young Finns Study
    Juho R H Raiko
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Ultrasound Med Biol 36:1237-44. 2010
    ..36; r = 0.19, p = 0.01). In conclusion, ultrasound measurements tracked low to moderate over 6-years and was influenced by cardiovascular disease (CVD) risk factor status...
  48. doi request reprint Plasminogen activator inhitor-1 associates with cardiovascular risk factors in healthy young adults in the Cardiovascular Risk in Young Finns Study
    Juho R H Raiko
    The Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Atherosclerosis 224:208-12. 2012
    ..We examined associations between serum PAI-1, ultrasound markers of atherosclerosis and CVD risk factors and whether PAI-1 improves prediction of atherosclerosis over known risk factors in a cohort of asymptomatic adults...
  49. doi request reprint Relation of total and free testosterone and sex hormone-binding globulin with cardiovascular risk factors in men aged 24-45 years. The Cardiovascular Risk in Young Finns Study
    Sonja Firtser
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Finland
    Atherosclerosis 222:257-62. 2012
    ..We studied the levels of total testosterone, calculated free testosterone and sex hormone-binding globulin (SHBG), and their relations with cardiovascular risk factors in young Finnish men...
  50. doi request reprint Plasma osteopontin is not associated with vascular markers of subclinical atherosclerosis in a population of young adults without symptoms of cardiovascular disease. The Cardiovascular Risk in Young Finns Study
    Maria Wendelin-Saarenhovi
    Department of Clinical Physiology, Turku University Hospital, Turku, Finland
    Scand J Clin Lab Invest 71:683-9. 2011
    ..Osteopontin is used as a biomarker for measuring the severity of atherosclerosis, but the role of osteopontin in the pathogenesis of atherosclerosis is not clear...
  51. ncbi request reprint Obesity in youth is not an independent predictor of carotid IMT in adulthood. The Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Atherosclerosis 185:388-93. 2006
    ..610 mm versus 0.627 mm, respectively. We conclude that being obese in youth is associated with increased carotid IMT in adulthood, but this relationship is explained by significant tracking of body mass from youth to adulthood...
  52. ncbi request reprint Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 112:1486-93. 2005
    ..Exposure to risk factors in childhood may have long-term influences on vascular function. We examined the relationship between risk factors identified in childhood and arterial elasticity assessed in adulthood...
  53. doi request reprint Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine St
    Markus Juonala
    Department of Medicine, Turku University Hospital, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Circulation 122:2514-20. 2010
    ..The aim of this study was to investigate the influence of age on the associations between childhood risk factors and carotid artery intima-media thickness, a marker of subclinical atherosclerosis...
  54. doi request reprint Childhood predictors of the metabolic syndrome in adulthood. The Cardiovascular Risk in Young Finns Study
    Noora Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Ann Med 40:542-52. 2008
    ..Obese youths may be susceptible to develop the metabolic syndrome (MS) later in life...
  55. doi request reprint Adiponectin is related with carotid artery intima-media thickness and brachial flow-mediated dilatation in young adults--the Cardiovascular Risk in Young Finns Study
    Liisa A Saarikoski
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Ann Med 42:603-11. 2010
    ..We investigated the relation of adiponectin on early functional and structural markers of subclinical atherosclerosis in a large population-based cohort of young men and women...
  56. pmc Ideal cardiovascular health in young adult populations from the United States, Finland, and Australia and its association with cIMT: the International Childhood Cardiovascular Cohort Consortium
    Mervi Oikonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    J Am Heart Assoc 2:e000244. 2013
    ..We studied the prevalence of ideal CV health and its associations with ultrasonographically measured carotid intima-media thickness (cIMT) cross-sectionally in 5 international populations...
  57. pmc Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study
    Sebastian Okser
    Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland
    PLoS Genet 6:e1001146. 2010
    ..043). These results demonstrate that the modeling framework can utilize the "gray zone" of genetic variation in the classification of subjects with different degrees of risk of developing atherosclerosis...
  58. doi request reprint Relations between carotid artery distensibility and heart rate variability The Cardiovascular Risk in Young Finns Study
    Tuomas Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Auton Neurosci 161:75-80. 2011
    ..We studied at the population level the relations between carotid-artery-distensibility (Cdist) and vagal modulation of heart rate...
  59. doi request reprint Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: the Cardiovascular Risk in Young Finns Study
    Tatu A Miettinen
    Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland
    Atherosclerosis 209:592-7. 2010
    ..The aim of the present study was to evaluate the role of cholesterol metabolism in the development of atheromatous artery disease...
  60. pmc Childhood lifestyle and clinical determinants of adult ideal cardiovascular health: The Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Princeton Follow-up Study
    Tomi T Laitinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland Electronic address
    Int J Cardiol 169:126-32. 2013
    ..Our aim was thus to comprehensively explore childhood determinants of adult ideal cardiovascular health in population based cohorts from three continents...
  61. doi request reprint Does childhood nutrition influence adult cardiovascular disease risk?--insights from the Young Finns Study
    Jari E Kaikkonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Ann Med 45:120-8. 2013
    ..Our findings and the current literature suggest that childhood nutrition has a significant role in the progression of CVD...
  62. doi request reprint Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk
    Olli T Raitakari
    Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Atherosclerosis 226:245-51. 2013
    ..We used computational methods to estimate apoB and apoA1 from serum total cholesterol, HDL-cholesterol and triglycerides and tested their clinical value in comparison to measured apoB and apoA1 values...
  63. doi request reprint When and how to start prevention of atherosclerosis? Lessons from the Cardiovascular Risk in the Young Finns Study and the Special Turku Coronary Risk Factor Intervention Project
    Costan G Magnussen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520, Finland, Finland
    Pediatr Nephrol 27:1441-52. 2012
    ....
  64. ncbi request reprint Assessment of inflammatory markers and endothelial function
    Mikko J Jarvisalo
    The Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology, University of Turku, Turku, and Department of Internal Medicine, Satakunta Central Hospital, Pori, Finland
    Curr Opin Clin Nutr Metab Care 9:547-52. 2006
    ..To describe the background and assessment of inflammatory markers and endothelial function in atherosclerosis...
  65. ncbi request reprint Use of B-mode ultrasound to examine preclinical markers of atherosclerosis: image quality may bias associations between adiposity and measures of vascular structure and function
    Costan G Magnussen
    Menzies Reserach Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia Research Center of Applied and Preventive Cardiovascualr Medicine, University of Turku and Turku University Hospital, Turku, Finland and Murdoch Children s Research Institute, Melbourne, Victoria, Australia
    J Ultrasound Med 30:363-9. 2011
    ..The purpose of this study was to examine the association between adiposity measures, ultrasound image quality, and preclinical markers of atherosclerosis in young adults...
  66. doi request reprint Adolescence risk factors are predictive of coronary artery calcification at middle age: the cardiovascular risk in young Finns study
    Olli Hartiala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, and Turku PET Center, Turku University Hospital, Turku, Finland
    J Am Coll Cardiol 60:1364-70. 2012
    ..The purpose of this study was to examine the roles of adolescence risk factors in predicting coronary artery calcium (CAC)...
  67. ncbi request reprint [Why coronary heart disease is still more problem in Eastern than Western Finland?]
    Markus Juonala
    Loimaan aluesairaala
    Duodecim 122:55-61. 2006
  68. doi request reprint Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, UK
    Arterioscler Thromb Vasc Biol 28:1679-83. 2008
    ..The effect of the locus on early markers of atherosclerosis is unknown. We examined its association with carotid intima-media thickness (CIMT) and brachial flow-mediated dilatation (FMD)...
  69. ncbi request reprint Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms and their association with carotid artery intima-media thickness in the Finnish population. The Cardiovascular Risk in Young Finns Study
    Md Shaheenul Islam
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Medical School, Tampere University Hospital, The University of Tampere, Tampere, Finland
    Atherosclerosis 180:79-86. 2005
    ..However, serum total and LDL cholesterol and apoB concentrations were significantly different among apoB genotype groups (p<0.001 for all traits). The apoA-I/C-III/A-IV SstI polymorphism is associated with carotid IMT in young Finns...
  70. ncbi request reprint [Risk factors of coronary artery syndrome are significant all the way from childhood]
    Markus Juonala
    Duodecim 121:1137-9. 2005
  71. ncbi request reprint Depressive symptoms and carotid artery intima-media thickness in young adults: the Cardiovascular Risk in Young Finns Study
    Marko Elovainio
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Psychosom Med 67:561-7. 2005
    ..We tested the hypothesis that a high level of depressive symptoms in healthy young adults would be related to more prevalent preclinical atherosclerosis...
  72. ncbi request reprint Lifecourse socioeconomic position, C-reactive protein, and carotid intima-media thickness in young adults: the cardiovascular risk in Young Finns Study
    Mika Kivimaki
    Department of Psychology, University of Helsinki, Finland
    Arterioscler Thromb Vasc Biol 25:2197-202. 2005
    ..We examined associations between socioeconomic position in childhood and adulthood, adult CRP, and carotid intima-media thickness (IMT), a presymptomatic predictor of coronary heart disease, in a population of young adults...
  73. ncbi request reprint Job strain and early atherosclerosis: the Cardiovascular Risk in Young Finns study
    Mirka Hintsanen
    Department of Psychology, PUniversity of Helsinki, Helsinki, Finland
    Psychosom Med 67:740-7. 2005
    ..The purpose of this study was to determine whether job strain and social support are associated with early atherosclerosis measured by carotid intima-media thickness (IMT) in young adults...
  74. ncbi request reprint Polymorphism of the angiotensin-converting enzyme (ACE) and angiotesinogen (AGT) genes and their associations with blood pressure and carotid artery intima media thickness among healthy Finnish young adults--the Cardiovascular Risk in Young Finns Study
    Md Shaheenul Islam
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the University of Tampere, Medical School, Finland
    Atherosclerosis 188:316-22. 2006
    ..01 mm (95% CI: -0.04 to 0.02, p=0.59) lower mean IMT, respectively, compared to the MM genotype group. We conclude that ACE I/D and AGT m235t polymorphisms are not associated with carotid IMT in healthy young Finnish adults...
  75. ncbi request reprint Associations between connexin37 gene polymorphism and markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns study
    Auni Collings
    Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital, Tampere University Medical School, Finland
    Atherosclerosis 195:379-84. 2007
    ..e., early ultrasound markers of subclinical atherosclerosis - in a clinically healthy population of young Finnish adults...
  76. ncbi request reprint Neuregulin-1 genotype moderates the association between job strain and early atherosclerosis in young men
    Mirka Hintsanen
    Department of Psychology, University of Helsinki, Finland
    Ann Behav Med 33:148-55. 2007
    ..Neuregulin-1 (NRG-1) has various roles in the development and function of the heart and autonomic nervous system...
  77. doi request reprint The influence of smoking and homocysteine on subclinical atherosclerosis is modified by the connexin37 C1019T polymorphism - The Cardiovascular Risk in Young Finns Study
    Auni Collings
    Centre for Laboratory Medicine, Tampere University Hospital, and Tampere University Medical School, Tampere, Finland
    Clin Chem Lab Med 46:1102-8. 2008
    ....
  78. ncbi request reprint Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms do not affect early functional and structural changes in atherosclerosis: the Cardiovascular Risk in Young Finns study
    Tuomo Nieminen
    Department of Pharmacological Sciences, Medical School, University of Tampere, Tampere, Finland
    Circ J 71:741-5. 2007
    ....
  79. ncbi request reprint Association of age at menarche with cardiovascular risk factors, vascular structure, and function in adulthood: the Cardiovascular Risk in Young Finns study
    Mika Kivimaki
    Department of Epidemiology and Public Health, University College London, London, United Kingdom
    Am J Clin Nutr 87:1876-82. 2008
    ..It is unclear whether age at menarche is an independent determinant of future cardiovascular risk...
  80. ncbi request reprint Subtle changes in ADMA and l-arginine concentrations in normal pregnancies are unlikely to account for pregnancy-related increased flow-mediated dilatation
    Heli Saarelainen
    Department of Ob Gyn, Kuopio University Hospital, University of Kuopio, Kuopio, Finland
    Clin Physiol Funct Imaging 28:120-4. 2008
    ..Our objective was to investigate whether serum concentrations of asymmetric dimethylarginine (ADMA) or l-arginine correlate to hyperlipidemia or endothelial function in normal pregnancy compared with the non-pregnant subjects...
  81. ncbi request reprint Utility of currently recommended pediatric dyslipidemia classifications in predicting dyslipidemia in adulthood: evidence from the Childhood Determinants of Adult Health (CDAH) study, Cardiovascular Risk in Young Finns Study, and Bogalusa Heart Study
    Costan G Magnussen
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
    Circulation 117:32-42. 2008
    ..The aim of this study was to determine which of the NHANES or NCEP adolescent lipoprotein classifications was most effective for predicting abnormal levels in adulthood...
  82. ncbi request reprint Toll-like receptor 4 gene (Asp299Gly) polymorphism associates with carotid artery elasticity. The cardiovascular risk in young Finns study
    Jussi A Hernesniemi
    Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Finland
    Atherosclerosis 198:152-9. 2008
    ..We wanted to examine the association of this polymorphism with carotid IMT and compliance in a population of young Finnish Caucasian adults...
  83. pmc Association of Pathobiologic Determinants of Atherosclerosis in Youth risk score and 15-year change in risk score with carotid artery intima-media thickness in young adults (from the Cardiovascular Risk in Young Finns Study)
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Am J Cardiol 100:1124-9. 2007
    ..997 for a 1-point decrease). In conclusion, the change in risk score over time (decrease or increase) during adolescence and young adulthood, as well as the risk score early in life, are important predictors of atherosclerosis...
  84. ncbi request reprint CYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study
    Meng Fan
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Finland
    J Hypertens 25:1381-7. 2007
    ..We examined the relationship of the C242T polymorphism with endothelial-dependent brachial artery flow-mediated vasodilatation (FMD) in a population-based sample of young healthy adults...
  85. ncbi request reprint Type A eagerness-energy across developmental periods predicts adulthood carotid intima-media thickness: the Cardiovascular Risk in Young Finns Study
    Liisa Keltikangas-Jarvinen
    Department of Psychology, University of Helsinki, P O Box 9, Finland
    Arterioscler Thromb Vasc Biol 27:1638-44. 2007
    ..We examined the Type A behavior across developmental periods as a predictor of adult carotid artery intima-media thickness (IMT)...
  86. ncbi request reprint Allelic variants of upstream transcription factor 1 associate with carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns study
    Auni Collings
    Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, PO Box 2000, 33521 Tampere, Finland
    Circ J 72:1158-64. 2008
    ....
  87. ncbi request reprint Relations of APOE promoter polymorphisms to LDL cholesterol and markers of subclinical atherosclerosis in young adults
    Leena E Viiri
    Department of Forensic Medicine, University of Tampere Medical School, and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    J Lipid Res 47:1298-306. 2006
    ....
  88. ncbi request reprint Pregnancy-related hyperlipidemia and endothelial function in healthy women
    Heli Saarelainen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, University of Kuopio, Finland
    Circ J 70:768-72. 2006
    ..The purpose of the present study was to investigate pregnancy-related changes in the maternal serum lipid profile and endothelial function...