E Isolauri

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women
    Maria Carmen Collado
    Functional Foods Forum and Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Am J Clin Nutr 88:894-9. 2008
  2. pmc Microarray analysis reveals marked intestinal microbiota aberrancy in infants having eczema compared to healthy children in at-risk for atopic disease
    Lotta Nylund
    Functional Foods Forum, University of Turku, Turku, FI 20014, Finland
    BMC Microbiol 13:12. 2013
  3. doi request reprint Probiotics in the development and treatment of allergic disease
    Erika Isolauri
    Department of Paediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Gastroenterol Clin North Am 41:747-62. 2012
  4. ncbi request reprint Probiotics: effects on immunity
    E Isolauri
    Department of Pediatrics, The University of Turku, Turku, Finland
    Am J Clin Nutr 73:444S-450S. 2001
  5. ncbi request reprint Probiotics, gut inflammation and barrier function
    Erika Isolauri
    Department of Pediatrics, University of Turku, 20520 Turku, Finland
    Gastroenterol Clin North Am 34:437-50, viii. 2005
  6. ncbi request reprint Novel approaches to the nutritional management of the allergic infant
    Erika Isolauri
    Department of Paediatrics, University of Turku, Turku, Finland
    Acta Paediatr Suppl 94:110-4. 2005
  7. doi request reprint Obesity - extending the hygiene hypothesis
    Erika Isolauri
    Department of Pediatrics, Functional Foods Forum, and Department of Biochemistry and Food Chemistry, University of Turku, Turku University Central Hospital, Turku, Finland
    Nestle Nutr Workshop Ser Pediatr Program 64:75-85; discussion 85-9, 251-7. 2009
  8. ncbi request reprint Dietary modification of atopic disease: Use of probiotics in the prevention of atopic dermatitis
    Erika Isolauri
    Department of Paediatrics, Turku University Central Hospital, Finland
    Curr Allergy Asthma Rep 4:270-5. 2004
  9. pmc Food allergy in irritable bowel syndrome: new facts and old fallacies
    E Isolauri
    Department of Paediatrics, Turku University Central Hospital, 20520 Turku, Finland
    Gut 53:1391-3. 2004
  10. ncbi request reprint Role of probiotics in food hypersensitivity
    Erika Isolauri
    Department of Pediatrics, University of Turku, Finland
    Curr Opin Allergy Clin Immunol 2:263-71. 2002

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women
    Maria Carmen Collado
    Functional Foods Forum and Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    Am J Clin Nutr 88:894-9. 2008
    ..The mother influences the original inoculum and the development of infant microbiota, which in turn is associated with later weight gain...
  2. pmc Microarray analysis reveals marked intestinal microbiota aberrancy in infants having eczema compared to healthy children in at-risk for atopic disease
    Lotta Nylund
    Functional Foods Forum, University of Turku, Turku, FI 20014, Finland
    BMC Microbiol 13:12. 2013
    ..The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo...
  3. doi request reprint Probiotics in the development and treatment of allergic disease
    Erika Isolauri
    Department of Paediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Gastroenterol Clin North Am 41:747-62. 2012
    ..Probiotics also enhance gut-specific IgA responses, which are frequently defective in children with food allergy. In addition, probiotics have the potential to alleviate allergic inflammation locally and systemically...
  4. ncbi request reprint Probiotics: effects on immunity
    E Isolauri
    Department of Pediatrics, The University of Turku, Turku, Finland
    Am J Clin Nutr 73:444S-450S. 2001
    ..These results suggest that specific immunomodulatory properties of probiotic bacteria should be characterized when developing clinical applications for extended target populations...
  5. ncbi request reprint Probiotics, gut inflammation and barrier function
    Erika Isolauri
    Department of Pediatrics, University of Turku, 20520 Turku, Finland
    Gastroenterol Clin North Am 34:437-50, viii. 2005
  6. ncbi request reprint Novel approaches to the nutritional management of the allergic infant
    Erika Isolauri
    Department of Paediatrics, University of Turku, Turku, Finland
    Acta Paediatr Suppl 94:110-4. 2005
    ....
  7. doi request reprint Obesity - extending the hygiene hypothesis
    Erika Isolauri
    Department of Pediatrics, Functional Foods Forum, and Department of Biochemistry and Food Chemistry, University of Turku, Turku University Central Hospital, Turku, Finland
    Nestle Nutr Workshop Ser Pediatr Program 64:75-85; discussion 85-9, 251-7. 2009
    ....
  8. ncbi request reprint Dietary modification of atopic disease: Use of probiotics in the prevention of atopic dermatitis
    Erika Isolauri
    Department of Paediatrics, Turku University Central Hospital, Finland
    Curr Allergy Asthma Rep 4:270-5. 2004
    ....
  9. pmc Food allergy in irritable bowel syndrome: new facts and old fallacies
    E Isolauri
    Department of Paediatrics, Turku University Central Hospital, 20520 Turku, Finland
    Gut 53:1391-3. 2004
    ..These findings should encourage studies dissecting the mechanisms responsible for IgG production against dietary antigens and their putative role in IBS..
  10. ncbi request reprint Role of probiotics in food hypersensitivity
    Erika Isolauri
    Department of Pediatrics, University of Turku, Finland
    Curr Opin Allergy Clin Immunol 2:263-71. 2002
    ....
  11. ncbi request reprint Probiotics in human disease
    E Isolauri
    Department of Pediatrics, University of Turku, Finland
    Am J Clin Nutr 73:1142S-1146S. 2001
    ..Thus, modification of gut microflora by probiotic therapy may offer a therapeutic potential in clinical conditions associated with gut-barrier dysfunction and inflammatory response...
  12. pmc Probiotics: a role in the treatment of intestinal infection and inflammation?
    E Isolauri
    Department of Paediatrics, University of Turku, Finland
    Gut 50:III54-9. 2002
    ..Realisation of this has led to the introduction of novel modes of therapeutic and prophylactic intervention based on the consumption of mono and mixed cultures of beneficial live microorganisms as probiotics...
  13. ncbi request reprint The allergy epidemic extends beyond the past few decades
    E Isolauri
    Department of Paediatrics, University of Turku and Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 34:1007-10. 2004
    ..Increased prevalence of allergic diseases in western societies has been described as an epidemic. The precise turning point for the epidemic and the antigens responsible for it remain obscure...
  14. ncbi request reprint Modulation of the maturing gut barrier and microbiota: a novel target in allergic disease
    E Isolauri
    Department of Paediatrics, University of Turku, 20520 Turku, Finland
    Curr Pharm Des 14:1368-75. 2008
    ....
  15. pmc Probiotics for infectious diarrhoea
    E Isolauri
    Department of Paediatrics, University of Turku, 20520 Turku, Finland
    Gut 52:436-7. 2003
  16. ncbi request reprint Probiotics: use in allergic disorders: a Nutrition, Allergy, Mucosal Immunology, and Intestinal Microbiota (NAMI) Research Group Report
    Erika Isolauri
    Department of Paediatrics, University of Turku, Finland
    J Clin Gastroenterol 42:S91-6. 2008
    ....
  17. ncbi request reprint Microbial-gut interactions in health and disease. Probiotics
    Erika Isolauri
    Department of Paediatrics, Turku University Central Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Best Pract Res Clin Gastroenterol 18:299-313. 2004
    ..However, further rigorous scientific efforts are required to characterize the immunomodulatory potential of specific probiotic strains for these targets...
  18. ncbi request reprint Probiotics in preterm infants: a controversial issue
    Erika Isolauri
    Department of Paediatrics, University of Turku, Finland
    J Pediatr Gastroenterol Nutr 45:S188-9. 2007
    ..Consequently, research now focuses both on characterizing specific probiotic strains and on how the food matrix and the dietary content interact with the most efficient probiotic strains...
  19. ncbi request reprint New functional foods in the treatment of food allergy
    E Isolauri
    Department of Paediatrics, University of Turku, Finland
    Ann Med 31:299-302. 1999
    ..However, it represents an initial link in the development of more permanent sensitization to aeroallergens...
  20. pmc Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0-6 months
    M M Grönlund
    Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    Arch Dis Child Fetal Neonatal Ed 83:F186-92. 2000
    ..To evaluate the role of intestinal microflora and early formula feeding in the maturation of humoral immunity in healthy newborn infants...
  21. ncbi request reprint Early differences in fecal microbiota composition in children may predict overweight
    Marko Kalliomaki
    Functional Foods Forum and Program on Health Biosciences and the Department of Pediatrics, University of Turku, Turku, Finland
    Am J Clin Nutr 87:534-8. 2008
    ..Experimental studies suggest that gut microbiota deviations predispose toward energy storage and obesity...
  22. ncbi request reprint Proportions and concentrations of serum n-3 fatty acids can be increased by dietary counseling during pregnancy
    U Hautero
    1 Department of Paediatrics, Central Hospital of Vaasa, Vaasa, Finland 2 Functional Foods Forum, University of Turku, Turku, Finland 3 Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    Eur J Clin Nutr 67:1163-8. 2013
    ..We here aimed in a prospective study initiated in early pregnancy to establish whether serum fatty acid (FA) compositions and concentrations in the mother can be modified by dietary means emphasizing counseling on a recommended diet...
  23. ncbi request reprint Dietary fatty acids and allergy
    P Kankaanpaa
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Ann Med 31:282-7. 1999
    ..Therefore, it is concluded that careful manipulation of dietary PUFAs may play a key role in the successful management of inflammation associated with atopic diseases...
  24. ncbi request reprint Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study
    A Huurre
    Department of Pediatrics, Turku University Central Hospital and University of Turku, Turku, Finland
    Clin Exp Allergy 38:1342-8. 2008
    ..The effects of breastfeeding and probiotics on infant sensitization still remain discrepant...
  25. ncbi request reprint Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
    ..We assessed the effect on atopic disease of Lactobacillus GG (which is safe at an early age and effective in treatment of allergic inflammation and food allergy)...
  26. ncbi request reprint The ability of probiotic bacteria to bind to human intestinal mucus
    P V Kirjavainen
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    FEMS Microbiol Lett 167:185-9. 1998
    ..In conclusion, the age of the target group may be worthy of consideration when planning a schedule for probiotic or functional food therapy...
  27. ncbi request reprint Characterizing the composition of intestinal microflora as a prospective treatment target in infant allergic disease
    P V Kirjavainen
    Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    FEMS Immunol Med Microbiol 32:1-7. 2001
    ..In conclusion, the most prominent question raised by these data is whether Gram-positive bacteria may have distinctive importance in protection against atopic sensitization. Further studies aiming to answer this question are warranted...
  28. ncbi request reprint Polyunsaturated fatty acids in maternal diet, breast milk, and serum lipid fatty acids of infants in relation to atopy
    P Kankaanpaa
    Departments of Biochemistry and Food Chemistry, and Pediatrics, University of Turku, Turku, Finland
    Allergy 56:633-8. 2001
    ..We aimed to investigate whether maternal diet and atopic status influence the PUFA composition of breast milk and the serum lipid fatty acids of infants...
  29. pmc Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection
    M Juntunen
    Department of Pediatrics, Satakunta Central Hospital, Pori, FIN 25800 Pori, Finland
    Clin Diagn Lab Immunol 8:293-6. 2001
    ..Optimal clinical application of these interactions may offer novel therapeutic guidelines for the treatment and prevention of gastrointestinal infections...
  30. ncbi request reprint Diet and blood lipids in 1-4 year-old children
    U Hoppu
    Functional Foods Forum, 20014 University of Turku, Turku, Finland Electronic address
    Nutr Metab Cardiovasc Dis 23:980-6. 2013
    ..Further, the nutritional determinants of children's lipid profiles were assessed...
  31. ncbi request reprint Reshaping the gut microbiota at an early age: functional impact on obesity risk?
    R Luoto
    Department of Pediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland
    Ann Nutr Metab 63:17-26. 2013
    ..This would suggest a role for probiotic/prebiotic interventions in the search for preventive and therapeutic applications in weight management...
  32. ncbi request reprint Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG
    T Pessi
    Department of Paediatrics, University of Turku, Finland
    Clin Exp Allergy 30:1804-8. 2000
    ..The enhanced IL-10 generation in vivo substantiates the anti-inflammatory properties of specific probiotic bacteria strains, and provides an additional reason for considering such treatments for patients with intestinal inflammation...
  33. ncbi request reprint Adhesion of four Bifidobacterium strains to human intestinal mucus from subjects in different age groups
    A C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    FEMS Microbiol Lett 172:61-4. 1999
    ..The results suggest that reduced adhesion may be a factor involved in the decreasing colonisation of elderly subjects by bifidobacteria...
  34. ncbi request reprint Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant
    U Hoppu
    Department of Paediatrics, University of Turku, Turku, Finland
    Eur J Clin Nutr 54:702-5. 2000
    ..To investigate the impact of maternal diet during breastfeeding on atopic sensitization of infants at risk...
  35. pmc Mode of delivery directs the phagocyte functions of infants for the first 6 months of life
    M M Grönlund
    Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Immunol 116:521-6. 1999
    ....
  36. ncbi request reprint Impact of intrauterine and post-natal nutritional determinants on blood pressure at 4 years of age
    J Normia
    Department of Paediatrics, University of Turku and Turku University Hospital, Turku, Finland Functional Foods Forum, University of Turku, Turku, Finland Turku Health Centre, Turku, Finland
    J Hum Nutr Diet 26:544-52. 2013
    ..To prospectively study how the early nutritional environment can programme blood pressure in a well-nourished population of children...
  37. ncbi request reprint The mucus binding of Bifidobacterium lactis Bb12 is enhanced in the presence of Lactobacillus GG and Lact. delbrueckii subsp. bulgaricus
    A C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Lett Appl Microbiol 30:10-3. 2000
    ..The results suggest that combinations of probiotics strains may have synergistic adhesion effects. Such specific strain combinations should also be assessed in clinical studies...
  38. ncbi request reprint Rectal bleeding in infancy: clinical, allergological, and microbiological examination
    Taina Arvola
    Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Pediatrics 117:e760-8. 2006
    ..Because withdrawal of cow's milk antigens from the infants' diet is used as a first treatment without evidence of its efficacy, we also aimed to asses the effect of a cow's milk-elimination diet on the duration of rectal bleeding...
  39. pmc Antiproliferative effects of homogenates derived from five strains of candidate probiotic bacteria
    T Pessi
    Department of Pediatrics, University of Turku, Turku, Finland
    Appl Environ Microbiol 65:4725-8. 1999
    ..These bacteria may be used to generate microbiologically nonviable yet immunologically active probiotic food products that are easier to store and have a longer shelf life...
  40. pmc Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning?
    P V Kirjavainen
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Gut 51:51-5. 2002
    ..Recent data have outlined a relationship between the composition of the intestinal microflora and allergic inflammation, and demonstrated the competence of probiotics in downregulation of such inflammation...
  41. ncbi request reprint Maternal breast-milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease
    M M Grönlund
    Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 37:1764-72. 2007
    ..The sources and the impact of maternal bacteria on the initial inoculum of the intestinal microflora of newborn infants remain elusive...
  42. ncbi request reprint Probiotics: on-going research on atopic individuals
    K Laiho
    Department of Paediatrics, University of Turku, 20520, Finland
    Br J Nutr 88:S19-27. 2002
    ..Future research will clarify the mechanisms to control specific physiological processes in the evolution of atopic disease in at-risk populations or in the management of allergic diseases...
  43. ncbi request reprint Impact of dietary counselling on nutrient intake during pregnancy: a prospective cohort study
    T Piirainen
    Department of Paediatrics, University of Turku, Turku, Finland
    Br J Nutr 96:1095-104. 2006
    ..Dietary counselling combined with the provision of food products during pregnancy is of importance in modifying food and nutrient intake, with potential health benefits...
  44. ncbi request reprint Differences in composition and mucosal adhesion of bifidobacteria isolated from healthy adults and healthy seniors
    F He
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Curr Microbiol 43:351-4. 2001
    ..This shift to a Bifidobacterium flora with reduced adhesive abilities may explain the decrease in bifidobacteria levels in the intestinal microflora of aging people...
  45. doi request reprint The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years
    R Luoto
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Int J Obes (Lond) 34:1531-7. 2010
    ..The recently discovered instrumental role of the gut microbiota in host metabolism may offer a novel target in the prevention and management of obesity...
  46. ncbi request reprint Adhesion of Bifidobacterium spp. to human intestinal mucus
    F He
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Microbiol Immunol 45:259-62. 2001
    ..animalis and B. lactis was not preferential. These results suggest that the mucosal adhesive properties of bifidobacteria may be a strain dependent feature, and the mucosal binding of the human bifidobacteria may be more host specific...
  47. ncbi request reprint Mode of delivery and asthma -- is there a connection?
    Jukka Kero
    Department of Paediatrics, Turku University Central Hospital, FIN 20520, Turku, Finland
    Pediatr Res 52:6-11. 2002
    ..31 (0.65-2.65), p = 0.11. In conclusion, these results suggest that caesarean section delivery may be associated with an increased prevalence of atopic asthma...
  48. ncbi request reprint Safety of barley starch syrup in patients with allergy to cereals
    Merja Nermes
    Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    Br J Nutr 101:165-8. 2009
    ..This study confirmed with 98% confidence that at least 90% of the patients with verified allergy to cereals will not react with allergic symptoms to barley starch syrup...
  49. ncbi request reprint Breast milk--immunomodulatory signals against allergic diseases
    U Hoppu
    Department of Paediatrics, University of Turku, Turku, Finland
    Allergy 56:23-6. 2001
    ..In future, an improved understanding of the mechanisms of this programming may offer specific therapeutic modalities for the prevention of allergic disease...
  50. ncbi request reprint Impact of national fortification of fluid milks and margarines with vitamin D on dietary intake and serum 25-hydroxyvitamin D concentration in 4-year-old children
    T Piirainen
    Department of Biochemistry and Food Chemistry, Turku University Central Hospital, Turku, Finland
    Eur J Clin Nutr 61:123-8. 2007
    ..To assess the impact of national fortification of fluid milks and margarines with vitamin D on dietary intake and on serum 25-hydroxyvitamin D concentration in Finnish 4-year-old children...
  51. pmc Influence of mode of delivery on gut microbiota composition in seven year old children
    S Salminen
    Functional Foods Forum, University of Turku, 20014 Turku, Finland
    Gut 53:1388-9. 2004
  52. pmc Effects of polyunsaturated fatty acids in growth medium on lipid composition and on physicochemical surface properties of lactobacilli
    P Kankaanpaa
    Department of Biochemistry and Food Chemistry, Turku University Central Hospital, University of Turku, Turku, Finland
    Appl Environ Microbiol 70:129-36. 2004
    ..The potential role of lactobacilli as regulators of PUFA absorption may represent another means by which probiotics could redirect the delicate balance of inflammatory mediators derived from PUFA within the inflamed intestine...
  53. ncbi request reprint The influence of polyunsaturated fatty acids on probiotic growth and adhesion
    P E Kankaanpää
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    FEMS Microbiol Lett 194:149-53. 2001
    ..As the adhesion to mucosal surfaces is pivotal in health promoting effects by probiotics, our results indicate that the action of probiotics in the gut may be modulated by dietary PUFA...
  54. ncbi request reprint Concerns and expectations of parents with atopic infants
    T Arvola
    Department of Paediatrics, University of Tampere, Finland
    Pediatr Allergy Immunol 11:183-8. 2000
    ..The present data support a comprehensive team approach to the care of atopic infants and their parents...
  55. doi request reprint Interaction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis
    M Nermes
    Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 41:370-7. 2011
    ..The maturational events in the gut parallel its step-wise colonization. Atopic dermatitis (AD) is associated with aberrant barrier functions of the skin epithelium and, in a subgroup of patients, of the gut mucosa...
  56. doi request reprint Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study
    J Aaltonen
    Functional Foods Forum, University of Turku, Turku, Finland
    Eur J Clin Nutr 65:10-9. 2011
    ..To evaluate the impact of maternal diet and intensive dietary counselling during pregnancy and breastfeeding on the infant's metabolic status...
  57. ncbi request reprint Pandemic of atopic diseases--a lack of microbial exposure in early infancy?
    M Kalliomaki
    Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
    Curr Drug Targets Infect Disord 2:193-9. 2002
    ..The actual preventive role of natural and genetically constructed supplementary microbes in the development of immunological diseases, like allergy, remains to be elucidated...
  58. doi request reprint Bifidobacterium and Lactobacillus DNA in the human placenta
    R Satokari
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, Turun yliopisto, Finland
    Lett Appl Microbiol 48:8-12. 2009
    ..Although the newborn infant is considered immunologically immature, exposure by bacterial DNA may programme the infant's immune development during foetal life earlier than previously considered...
  59. ncbi request reprint Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant
    Samuli Rautava
    Department of Paediatrics, University of Turku, Finland
    J Allergy Clin Immunol 109:119-21. 2002
    ....
  60. ncbi request reprint Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema
    K Laitinen
    Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 36:166-73. 2006
    ..The major theory implicating diet with allergic diseases is associated with altered food consumption and subsequent changes in fatty acid composition...
  61. doi request reprint Incidence of necrotizing enterocolitis in very-low-birth-weight infants related to the use of Lactobacillus GG
    R Luoto
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Acta Paediatr 99:1135-8. 2010
    ..One of the five level III neonatal intensive care units (NICU) in Finland has used prophylactic Lactobacillus GG (LGG) for very-low-birth-weight (VLBW) infants since 1997...
  62. pmc Extent of fussing and colic type crying preceding atopic disease
    M Kalliomaki
    Department of Paediatrics, Turku University Hospital, PO Box 52, FI 20521 Turku, Finland
    Arch Dis Child 84:349-50. 2001
    ..Of children who manifested atopic disease at 2 years, 44/116 (38%), had shown significantly more fussing during the seventh, and colic type cry during the twelfth week than those who remained healthy (72/116, 62%)...
  63. ncbi request reprint Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
    M Kalliomaki
    Department of Pediatrics, University of Turku, Turku
    J Allergy Clin Immunol 107:129-34. 2001
    ..On the basis of both intensity and timing of stimulus, it has been hypothesized that exposure to commensal microflora may represent another key protective modulator of immunity against atopy and subsequent atopic diseases...
  64. ncbi request reprint Vitamin C in breast milk may reduce the risk of atopy in the infant
    U Hoppu
    Department of Paediatrics, University of Turku, Turku, Finland
    Eur J Clin Nutr 59:123-8. 2005
    ....
  65. ncbi request reprint Mode of delivery - effects on gut microbiota and humoral immunity
    Anu Huurre
    Department of Pediatrics, Turku University Central Hospital and University of Turku, Turku, Finland
    Neonatology 93:236-40. 2008
    ..The rate of caesarean deliveries has increased 10-fold worldwide during the past decades...
  66. ncbi request reprint Evidence of infant blood pressure programming by maternal nutrition during pregnancy: a prospective randomized controlled intervention study
    Jonna Aaltonen
    Functional Foods Forum, Department of Pediatrics, University of Turku, Turku, Finland
    J Pediatr 152:79-84, 84.e1-2. 2008
    ..To evaluate the impact of maternal nutrition during pregnancy on infant blood pressure...
  67. ncbi request reprint The hygiene hypothesis of atopic disease--an extended version
    Samuli Rautava
    Department of Pediatrics, Turku University Central Hospital, Finland
    J Pediatr Gastroenterol Nutr 38:378-88. 2004
    ..Third, in addition to protection against atopy, protection against infectious, inflammatory, and autoimmune diseases may also depend upon healthy host-microbe interactions implicated in the hygiene hypothesis...
  68. pmc Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly
    M Carmen Collado
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, 5th Floor, FI 20520 Turku, Finland
    Appl Environ Microbiol 73:7767-70. 2007
    ..05) in the elderly...
  69. doi request reprint Microbial-host interactions: selecting the right probiotics and prebiotics for infants
    Seppo Salminen
    Functional Foods Forum, University of Turku, Turku, Finland
    Nestle Nutr Workshop Ser Pediatr Program 64:201-13; discussion 213-7, 251-7. 2009
    ..Continuous control of probiotic strains or strain combinations is a must as small changes in production process or growth media may significantly affect the properties of a strain or strain combination...
  70. doi request reprint Specific probiotic strains and their combinations counteract adhesion of Enterobacter sakazakii to intestinal mucus
    Maria Carmen Collado
    Functional Foods Forum, University of Turku, Turku, Finland
    FEMS Microbiol Lett 285:58-64. 2008
    ..This approach may also allow the development of new probiotic combinations to counteract the risks associated with other pathogens by improving the intestinal barrier against pathogens...
  71. ncbi request reprint Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial
    Marko Kalliomaki
    Department of Paediatrics, University of Turku, Finland
    Lancet 361:1869-71. 2003
    ..Our results suggest that the preventive effect of lactobacillus GG on atopic eczema extends beyond infancy...
  72. ncbi request reprint Breast milk fatty acids, eicosanoids, and cytokines in mothers with and without allergic disease
    Kirsi Laiho
    Department of Pediatrics, University of Turku, Finland
    Pediatr Res 53:642-7. 2003
    ..The observed associations between nutritional and inflammatory factors in breast milk suggest that it may be possible to influence the immunologic properties of breast milk by dietary intervention of the mother...
  73. doi request reprint Specific probiotics in reducing the risk of acute infections in infancy--a randomised, double-blind, placebo-controlled study
    Samuli Rautava
    Department of Paediatrics, University of Turku, Turku, Finland
    Br J Nutr 101:1722-6. 2009
    ..Further clinical trials are warranted...
  74. doi request reprint Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial
    Kirsi Laitinen
    Department of Biochemistry and Food Chemistry, University of Turku, 20014 Turku, Finland
    Br J Nutr 101:1679-87. 2009
    ....
  75. ncbi request reprint The development of gut immune responses and gut microbiota: effects of probiotics in prevention and treatment of allergic disease
    Samuli Rautava
    Department of Paediatrics, University of Turku, Finland
    Curr Issues Intest Microbiol 3:15-22. 2002
    ..Thus probiotics may prove beneficial in the prevention and alleviation of allergic disease...
  76. ncbi request reprint Probiotics: an overview of beneficial effects
    Arthur C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    Antonie Van Leeuwenhoek 82:279-89. 2002
    ..Results from well conducted clinical studies will expand and increase the acceptance of probiotics for the treatment and prevention of selected diseases...
  77. doi request reprint Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy
    Maria Carmen Collado
    Functional Foods Forum, University of Turku, Turku, Finland
    Am J Clin Nutr 92:1023-30. 2010
    ..Alterations in microbiota compositions of mothers may be transferred to infants and lead to an increased risk of overweight...
  78. ncbi request reprint The role of the intestinal microflora for the development of the immune system in early childhood
    Arthur Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, Finland
    Eur J Nutr 41:I32-7. 2002
    ..The precise mechanisms behind these immune modulatory activities are not well understood and require further investigation...
  79. ncbi request reprint Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study
    Raakel Luoto
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Br J Nutr 103:1792-9. 2010
    ..In view of the fact that birth size is a risk marker for later obesity, the present results are of significance for public health in demonstrating that this risk is modifiable...
  80. doi request reprint Dietary sucrose intake is related to serum leptin concentration in overweight pregnant women
    Sanna Vähämiko
    Functional Foods Forum, University of Turku, Turku, Finland
    Eur J Nutr 49:83-90. 2010
    ..Overweight, characterized by low-degree systemic inflammation, predisposes women to impaired glucose metabolism during pregnancy. Adipokine leptin participates in the regulation of energy balance and immune action...
  81. ncbi request reprint Serum alpha- and gamma-tocopherol levels in atopic mothers and their infants are correlated
    Ulla Hoppu
    Department of Pediatrics, University of Turku, Finland
    Biol Neonate 88:24-6. 2005
    ..Vitamin E may have immunomodulatory properties beyond its antioxidant function. The objective here was to assess the alpha- and gamma-tocopherol status and its correlation between atopic mothers and their infants...
  82. ncbi request reprint Probiotic bacteria in the management of atopic disease: underscoring the importance of viability
    Pirkka V Kirjavainen
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    J Pediatr Gastroenterol Nutr 36:223-7. 2003
    ..The aim of this study was to assess the efficacy of oral supplementation of viable and heat-inactivated probiotic bacteria in the management of atopic disease and to observe their effects on the composition of the gut microbiota...
  83. ncbi request reprint Role of intestinal flora in the development of allergy
    Marko Kalliomaki
    Department of Pediatrics, University of Turku, Finland
    Curr Opin Allergy Clin Immunol 3:15-20. 2003
    ..The gastrointestinal system, which comprises the largest lymphoid tissue and microbial reservoir of the body, has received more attention during the last few years as a potential determiner in the development of atopic disease...
  84. doi request reprint Positive interactions with the microbiota: probiotics
    Marko Kalliomaki
    Department of Paediatrics, University of Turku, Turku, Finland
    Adv Exp Med Biol 635:57-66. 2008
    ..Introduction of genetic engineering has provided advanced tools to amend probiotics' properties in the fight against different inflammatory conditions...
  85. ncbi request reprint Cow's milk allergy in infants with atopic eczema is associated with aberrant production of interleukin-4 during oral cow's milk challenge
    Samuli Rautava
    Department of Paediatrics, University of Turku, Turku, Finland
    J Pediatr Gastroenterol Nutr 39:529-35. 2004
    ....
  86. ncbi request reprint Effect of probiotics and breastfeeding on the bifidobacterium and lactobacillus/enterococcus microbiota and humoral immune responses
    Minna Rinne
    University of Turku, Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    J Pediatr 147:186-91. 2005
    ..To assess impact of probiotics and breastfeeding on gut microecology...
  87. ncbi request reprint Probiotic intervention in neonates--will permanent colonization ensue?
    Miguel Gueimonde
    Functional Foods Forum and Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    J Pediatr Gastroenterol Nutr 42:604-6. 2006
    ..The presence of the strain at the end of the administration period was correlated with a reduced prevalence of atopic eczema later in life...
  88. ncbi request reprint Breast milk fatty acid composition is associated with development of atopic dermatitis in the infant
    Ulla Hoppu
    Department of Pediatrics, University of Turku, Finland
    J Pediatr Gastroenterol Nutr 41:335-8. 2005
    ..The aim of this study was to assess the impact of the breast milk fatty acid composition on the development of atopic dermatitis (AD) in high-risk infants...
  89. ncbi request reprint Breast milk fatty acids may link innate and adaptive immune regulation: analysis of soluble CD14, prostaglandin E2, and fatty acids
    Kirsi Laitinen
    Department of Paediatrics, Turku University Central Hospital, 20521 Turku, Finland
    Pediatr Res 59:723-7. 2006
    ..These results suggest that fatty acids contribute to the regulation of innate and adaptive immune responses and link intraluminal exposures, mother's diet, and microbes...
  90. ncbi request reprint Probiotics and down-regulation of the allergic response
    Marko A Kalliomäki
    Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Immunol Allergy Clin North Am 24:739-52, viii. 2004
    ....
  91. ncbi request reprint Effect of maternal consumption of lactobacillus GG on transfer and establishment of fecal bifidobacterial microbiota in neonates
    Miguel Gueimonde
    Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A 5th Floor, FIN 20014 Turku, Finland
    J Pediatr Gastroenterol Nutr 42:166-70. 2006
    ..Deviations in this process precede the development of specific diseases providing the rationale for the use of probiotics to counteract them...
  92. ncbi request reprint Evaluation of diet and growth in children with and without atopic eczema: follow-up study from birth to 4 years
    Kirsi Laitinen
    Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    Br J Nutr 94:565-74. 2005
    ..1 % (95 % CI -8.9, -1.2 %) lower compared with children without (P=0.010). The joint effects of nutrients and probiotics need to be considered in active prevention and management schemes for allergic diseases...
  93. ncbi request reprint Characterization of breast milk received by infants with gross blood in stools
    Kirsi Laitinen
    Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    Biol Neonate 87:66-72. 2005
    ..The aim of this study was to ascertain factors that might be protective of the appearance of gross blood in the stools of breast-fed infants...
  94. ncbi request reprint Management of food allergy: vitamins, fatty acids or probiotics?
    Kirsi Laitinen
    Department of Paediatrics, University of Turku and Turku University Central Hospital, Finland
    Eur J Gastroenterol Hepatol 17:1305-11. 2005
    ..To meet these targets, rigorous scientific effort is required to elucidate how the food matrix and the dietary content impacts on the complex cascade of interrelated immunological mechanisms in food allergy...
  95. ncbi request reprint Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota
    Minna M Rinne
    The University of Turku, 20014 Turku, Finland Department of Pediatrics, Turku University Central Hospital, 20520 Turku, Finland
    FEMS Immunol Med Microbiol 43:59-65. 2005
    ..This would suggest that early gut Bifidobacterium microbiota can be modified by special diets up to the age of 6 months...
  96. ncbi request reprint Specific probiotics in enhancing maturation of IgA responses in formula-fed infants
    Samuli Rautava
    Department of Pediatrics, University of Turku, Finland
    Pediatr Res 60:221-4. 2006
    ....
  97. ncbi request reprint Breast milk: a source of bifidobacteria for infant gut development and maturation?
    Miguel Gueimonde
    Functional Foods Forum and Departments, University of Turku, Turku, Finland
    Neonatology 92:64-6. 2007
    ..Aberrant gut microbiota at an early age may predispose to disease later in life. Breast-fed infants harbor a characteristic intestinal microbiota dominated by bifidobacteria...
  98. ncbi request reprint Unique cytokine secretion profile in children with both type I diabetes and asthma distinct from that of solely diabetic or asthmatic children
    Essi Kainonen
    Department of Paediatrics, University of Turku, Turku, Finland
    Cytokine 34:198-205. 2006
    ..In particular, these children appear to have a defect in regulation of IL-10 secretion...
  99. ncbi request reprint Probiotics that modify disease risk
    Seppo J Salminen
    Functional Foods Forum and Department of Biochemistry and Food Chemistry, University of Turku, Finland
    J Nutr 135:1294-8. 2005
    ..Most recently, a reduction in risk of atopic diseases followed early administration of specific probiotics...
  100. ncbi request reprint Microbiota composition of the intestinal mucosa: association with fecal microbiota?
    Arthur C Ouwehand
    Department of Biochemistry and Food Chemistry, University of Turku, 20014 Turku, Finland
    Microbiol Immunol 48:497-500. 2004
    ..This indicates that the unidentified part of the microbiota, especially on the mucosa, deserves more attention...
  101. ncbi request reprint How practice meets guidelines: evaluation of nutrition counselling in Finnish well-women and well-baby clinics
    Anu Huurre
    Department of Paediatrics, Turku University Central Hospital and University of Turku, Turku, Finland
    Acta Paediatr 95:1353-9. 2006
    ..To assess the current practices of nutrition counselling given by nurses in well-women (WW) and well-baby (WB) clinics in Finland...