Elina Ikonen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. doi request reprint Amyloid precursor protein α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2
    Wei Wang
    2Institute of Biomedicine, Haartmaninkatu 8, FI 00014 University of Helsinki, Finland
    FASEB J 28:849-60. 2014
  2. ncbi request reprint Lipid microdomains and insulin resistance: is there a connection?
    Elina Ikonen
    Institute of Biotechnology, Viikinkaari 9, 00014 University of Helsinki, and National Public Health Institute, Helsinki, Finland
    Sci STKE 2005:pe3. 2005
  3. ncbi request reprint Mechanisms for cellular cholesterol transport: defects and human disease
    Elina Ikonen
    Institute of Biomedicine Anatomy, University of Helsinki, Helsinki, Finland
    Physiol Rev 86:1237-61. 2006
  4. ncbi request reprint Cellular pathology of Niemann-Pick type C disease
    Elina Ikonen
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Semin Cell Dev Biol 15:445-54. 2004
  5. doi request reprint Cellular cholesterol trafficking and compartmentalization
    Elina Ikonen
    Institute of Biomedicine Anatomy, University of Helsinki, Haartmaninkatu 8, University of Helsinki, Helsinki FI 00014, Finland
    Nat Rev Mol Cell Biol 9:125-38. 2008
  6. doi request reprint Cellular sterol trafficking and metabolism: spotlight on structure
    Elina Ikonen
    Institute of Biomedicine Anatomy, Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Curr Opin Cell Biol 20:371-7. 2008
  7. doi request reprint Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages
    Matts D Linder
    Institute of Biomedicine Anatomy, Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Arterioscler Thromb Vasc Biol 29:883-8. 2009
  8. doi request reprint Niemann-Pick C1 modulates hepatic triglyceride metabolism and its genetic variation contributes to serum triglyceride levels
    Riikka Liisa Uronen
    Institute of Biomedicine Anatomy, University of Helsinki, Finland
    Arterioscler Thromb Vasc Biol 30:1614-20. 2010
  9. pmc FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages
    Tomas Blom
    Institute of Biomedicine Anatomy, Haartmaninkatu 8, University of Helsinki, Finland
    Circ Res 106:720-9. 2010
  10. doi request reprint Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case
    Tomas Blom
    Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland
    Traffic 13:1234-43. 2012

Collaborators

Detail Information

Publications47

  1. doi request reprint Amyloid precursor protein α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2
    Wei Wang
    2Institute of Biomedicine, Haartmaninkatu 8, FI 00014 University of Helsinki, Finland
    FASEB J 28:849-60. 2014
    ..These results show that APP regulates cholesterol metabolism in cells relevant for whole-body cholesterol balance and reveal that APP α- and β-cleavages produce opposing paracrine regulators of SREBP2 signaling...
  2. ncbi request reprint Lipid microdomains and insulin resistance: is there a connection?
    Elina Ikonen
    Institute of Biotechnology, Viikinkaari 9, 00014 University of Helsinki, and National Public Health Institute, Helsinki, Finland
    Sci STKE 2005:pe3. 2005
    ..We put forward the idea that the dyslipidemic changes typically associated with insulin resistance and metabolic syndrome may impair the functionality of rafts in insulin target cells, thereby promoting insulin resistance...
  3. ncbi request reprint Mechanisms for cellular cholesterol transport: defects and human disease
    Elina Ikonen
    Institute of Biomedicine Anatomy, University of Helsinki, Helsinki, Finland
    Physiol Rev 86:1237-61. 2006
    ..Finally, because of the organizing potential of cholesterol in membranes, disturbances in cellular cholesterol transport have implications for a wide variety of human diseases, of which selected examples are given...
  4. ncbi request reprint Cellular pathology of Niemann-Pick type C disease
    Elina Ikonen
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Semin Cell Dev Biol 15:445-54. 2004
    ..The importance of NPC as a model for subcellular lipid imbalance in studying more common diseases, such as Alzheimer's and cardiovascular diseases, is discussed...
  5. doi request reprint Cellular cholesterol trafficking and compartmentalization
    Elina Ikonen
    Institute of Biomedicine Anatomy, University of Helsinki, Haartmaninkatu 8, University of Helsinki, Helsinki FI 00014, Finland
    Nat Rev Mol Cell Biol 9:125-38. 2008
    ..Increased understanding of these processes and their integration at the organ systems level provides fundamental insights into the physiology of cholesterol trafficking...
  6. doi request reprint Cellular sterol trafficking and metabolism: spotlight on structure
    Elina Ikonen
    Institute of Biomedicine Anatomy, Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Curr Opin Cell Biol 20:371-7. 2008
    ..This includes a novel, reversible modification of the sterol structure that affects the choice of transport route...
  7. doi request reprint Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages
    Matts D Linder
    Institute of Biomedicine Anatomy, Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Arterioscler Thromb Vasc Biol 29:883-8. 2009
    ..We have shown that Rab8 regulates endosomal cholesterol removal to apoA-I in human fibroblasts. Here, we investigated whether Rab8 plays a role in ABCA1 plasma membrane expression and cholesterol removal in primary human macrophages...
  8. doi request reprint Niemann-Pick C1 modulates hepatic triglyceride metabolism and its genetic variation contributes to serum triglyceride levels
    Riikka Liisa Uronen
    Institute of Biomedicine Anatomy, University of Helsinki, Finland
    Arterioscler Thromb Vasc Biol 30:1614-20. 2010
    ..To study how Niemann-Pick disease type C1 (NPC1) influences hepatic triacylglycerol (TG) metabolism and to determine whether this is reflected in circulating lipid levels...
  9. pmc FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages
    Tomas Blom
    Institute of Biomedicine Anatomy, Haartmaninkatu 8, University of Helsinki, Finland
    Circ Res 106:720-9. 2010
    ..Sphingolipid and cholesterol homeostasis are closely connected but whether FTY720 affects atherogenesis in humans is not known...
  10. doi request reprint Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case
    Tomas Blom
    Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland
    Traffic 13:1234-43. 2012
    ..Instead, NPC1-deficient cells displayed an increased affinity for sphingosine independently of protein-mediated lipid transport. This likely contributes to the increased sphingosine content of NPC1 cells...
  11. doi request reprint NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation
    Vilja Pietiäinen
    Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland
    J Cell Sci 126:3961-71. 2013
    ..These findings identify NDRG1 as a novel regulator of multivesicular body formation and endosomal LDLR trafficking. The deficiency of functional NDRG1 in CMT4D might impair lipid processing and differentiation of myelinating cells. ..
  12. ncbi request reprint Secretion of sterols and the NPC2 protein from primary astrocytes
    Aino Liisa Mutka
    Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00014 University of Helsinki, Finland
    J Biol Chem 279:48654-62. 2004
    ..In addition, the findings reveal a complexity of sterol species in astrocytes and bring up the possibility that some of the effects assigned to astrocyte cholesterol may be attributed to its penultimate precursors...
  13. pmc Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells
    Matts D Linder
    Institute of Biomedicine Anatomy, University of Helsinki, FI 00014 Helsinki, Finland
    Mol Biol Cell 18:47-56. 2007
    ..Our findings establish Rab8 as a key component of the regulatory machinery that leads to ABCA1-dependent removal of cholesterol from endocytic circuits...
  14. doi request reprint Endosomal actin remodeling by coronin-1A controls lipoprotein uptake and degradation in macrophages
    Maarit Hölttä-Vuori
    Institute of Biomedicine Anatomy, University of Helsinki, Finland
    Circ Res 110:450-5. 2012
    ..The actin cytoskeleton has been implicated in the processing of atherogenic lipoproteins in macrophages. However, the functional role of actin and the regulatory proteins involved are unknown...
  15. doi request reprint Sterol binding by OSBP-related protein 1L regulates late endosome motility and function
    Terhi Vihervaara
    Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Tukholmankatu 8, 00290 Helsinki, Finland
    Cell Mol Life Sci 68:537-51. 2011
    ..These data demonstrate that LE motility and functions in both protein and lipid transport are regulated by ORP1L...
  16. doi request reprint LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route
    Kristiina Kanerva
    Institute of Biomedicine, Anatomy, University of Helsinki, FI 00014 Helsinki, Finland Minerva Foundation Institute for Medical Research, FI 00290 Helsinki, Finland
    Dev Cell 27:249-62. 2013
    ..LDL increased the number and dynamics of FAs and stimulated cell migration in an acid lipase, NPC1, and Rab8a-dependent fashion, providing evidence that this cholesterol delivery route to the PM is important for cell movement. ..
  17. doi request reprint Role of ORPs in sterol transport from plasma membrane to ER and lipid droplets in mammalian cells
    Maurice Jansen
    Institute of Biomedicine, University of Helsinki, Finland
    Traffic 12:218-31. 2011
    ..This was accompanied by enhanced degradation of ORP2 and decreased levels of several FFAT motif-containing ORPs, suggesting a role for VAPs in sterol transport by stabilization of ORPs...
  18. pmc Defective insulin receptor activation and altered lipid rafts in Niemann-Pick type C disease hepatocytes
    Saara Vainio
    National Public Health Institute, Helsinki, Finland
    Biochem J 391:465-72. 2005
    ..Such a mechanism may participate in the pathogenesis of NPC disease and contribute to insulin resistance in other disorders of lipid metabolism...
  19. doi request reprint Cholesterol substitution increases the structural heterogeneity of caveolae
    Maurice Jansen
    Institute of Biomedicine Anatomy, University of Helsinki, Helsinki, Finland
    J Biol Chem 283:14610-8. 2008
    ....
  20. ncbi request reprint BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms
    Maarit Hölttä-Vuori
    Institute of Biomedicine Anatomy, Haartmaninkatu 8, University of Helsinki, Helsinki 00014, Finland
    Traffic 9:1839-49. 2008
    ..This is, to our knowledge, the first cholesterol probe that fulfills these prerequisites...
  21. doi request reprint ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion
    Eija Nissilä
    Institute of Biomedicine, Anatomy, PO Box 63, FI 00014 University of Helsinki, Finland
    Biochim Biophys Acta 1821:1472-84. 2012
    ..As a conclusion, the present study dissects the determinants of ORP10 association with MT and the Golgi complex and provides evidence for a specific role of this protein in β-lipoprotein secretion by human hepatocytes...
  22. pmc MLN64 is involved in actin-mediated dynamics of late endocytic organelles
    Maarit Hölttä-Vuori
    Institute of Biomedicine, University of Helsinki, 00014 Helsinki, Finland
    Mol Biol Cell 16:3873-86. 2005
    ..We propose that local sterol enrichment by MLN64 in the late endosomal membranes facilitates their association with actin, thereby governing actin-dependent fusion and degradative activity of late endocytic organelles...
  23. ncbi request reprint Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters?
    Terhi Vihervaara
    Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki, Finland
    Chem Phys Lipids 164:443-50. 2011
    ..In this review we discuss the current evidence for putative roles of ORPs as sterol sensors or transporters...
  24. pmc Endocytic trafficking of sphingomyelin depends on its acyl chain length
    Mirkka Koivusalo
    Institute of Biomedicine Anatomy and Institute of Biomedicine Biochemistry, University of Helsinki, FIN 00014, Helsinki, Finland
    Mol Biol Cell 18:5113-23. 2007
    ....
  25. ncbi request reprint Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts
    Saara Vainio
    Institute of Biomedicine Anatomy, University of Helsinki, Helsinki FI 00014, Finland
    J Biol Chem 281:348-55. 2006
    ..We suggest that the choice of cholesterol synthesis route may provide a physiological mechanism to modulate raft-dependent functions in cells...
  26. ncbi request reprint Alleviation of seipinopathy-related ER stress by triglyceride storage
    Maarit Hölttä-Vuori
    Institute of Biomedicine, Anatomy, University of Helsinki, 00014 Helsinki, Finland
    Hum Mol Genet 22:1157-66. 2013
    ..We propose that the decreased TG content contributes to the pathology induced by seipin N88S, and that rescuing TG levels may provide a novel therapeutic strategy in seipinopathy...
  27. doi request reprint Zebrafish: gaining popularity in lipid research
    Maarit Hölttä-Vuori
    Institute of Biomedicine Anatomy, Haartmaninkatu 8, 00140 University of Helsinki, Finland
    Biochem J 429:235-42. 2010
    ..As the insights into zebrafish lipid metabolism increase, it is likely that zebrafish as a model organism will become an increasingly powerful tool in lipid research...
  28. doi request reprint Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism
    Mia Lisa Schmiedt
    National Institute for Health and Welfare THL, Public Health Genomics Unit, Helsinki, Finland
    Neurobiol Dis 46:19-29. 2012
    ..Taken together, these data provide significant new information about events associated with Cln5-deficiency, revealing altered myelination and disturbances in lipid metabolism, together with an early neuroimmune response...
  29. pmc Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures
    Anette Pykäläinen
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Nat Struct Mol Biol 18:902-7. 2011
    ....
  30. doi request reprint What dictates the accumulation of desmosterol in the developing brain?
    Maurice Jansen
    Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland
    FASEB J 27:865-70. 2013
    ..This regulated accumulation of desmosterol by progesterone-induced suppression of DHCR24 may facilitate the rapid enrichment and distribution of membrane sterols in the developing brain...
  31. ncbi request reprint Fatty acyl esterification and deesterification of 17β-estradiol in human breast subcutaneous adipose tissue
    Feng Wang
    Folkhalsan Research Center, Biomedicum Helsinki C415, Haartmaninkatu 8, 00290 Helsinki, Finland
    J Clin Endocrinol Metab 97:3349-56. 2012
    ..Adipose tissue has an important role in peripheral estrogen synthesis. One of the metabolic pathways of estradiol (E(2)) is its conversion to lipophilic fatty acyl esters...
  32. ncbi request reprint The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes
    Inkeri Tiala
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    J Mol Med (Berl) 85:589-601. 2007
    ....
  33. ncbi request reprint Defective endocytic trafficking of NPC1 and NPC2 underlying infantile Niemann-Pick type C disease
    Titta S Blom
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 12:257-72. 2003
    ..These changes are accompanied by lysosomal accumulation of NPC2, suggesting that NPC1 governs the endocytic transport of NPC2...
  34. ncbi request reprint Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells
    Sari Lusa
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    J Biol Chem 278:19844-51. 2003
    ....
  35. pmc Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae
    Saara Vainio
    Department of Molecular Medicine, National Public Health Institute, Biomedicum Helsinki, PO Box 104, Haartmaninkatu 8, 00251 Helsinki, Finland
    EMBO Rep 3:95-100. 2002
    ..Rather, the dynamic recruitment of the ligand-bound IR into rafts may serve to regulate interactions in the initiation of the IR signalling cascade...
  36. ncbi request reprint Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain
    Aino Liisa Mutka
    Institute of Biomedicine Anatomy, Biomedicum, University of Helsinki, Helsinki, Finland
    J Neurochem 112:193-203. 2010
    ..These results provide evidence for dysmyelination and altered trafficking of cholesterol in brains of CTSD knockout mice, and warrant further studies on the role of lipid metabolism in the pathogenesis of CTSD deficiencies...
  37. ncbi request reprint Role of lysosomal acid lipase in the intracellular metabolism of LDL-transported dehydroepiandrosterone-fatty acyl esters
    Feng Wang
    Dept of Medicine, Helsinki Univ Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
    Am J Physiol Endocrinol Metab 295:E1455-61. 2008
    ..Although LAL contributed to the deesterification of DHEA-FAE, it was not solely responsible for the hydrolysis...
  38. ncbi request reprint Macrophage cholesterol transport: a critical player in foam cell formation
    Saara Vainio
    Department of Molecular Medicine, National Public Health Institute, Biomedicum Helsinki, Haartmaninkatu 8, Fl 00251 Helsinki, Finland
    Ann Med 35:146-55. 2003
    ..The importance of inflammatory cues, the cellular compartmentalization of cholesterol homeostatic responses and the increasing information on the transcriptional control of cholesterol balance are discussed...
  39. doi request reprint Cholesterol precursors: more than mere markers of biosynthesis
    Andrew J Brown
    aSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia bInstitute of Biomedicine, Anatomy, University of Helsinki cMinerva Foundation Institute for Medical Research, Helsinki, Finland
    Curr Opin Lipidol 25:133-9. 2014
    ..However, there is growing interest in their potential as markers of various disease states. The purpose of this review is to evaluate current literature on cholesterol precursors as disease markers...
  40. ncbi request reprint Cognitive deficit and development of motor impairment in a mouse model of Niemann-Pick type C disease
    Vootele Voikar
    Laboratory of Molecular Neurobiology, Institute of Biotechnology and Department of Biosciences, PO Box 56, Viikinkaari 5, FIN 00014 University of Helsinki, Helsinki, Finland
    Behav Brain Res 132:1-10. 2002
    ..The battery of behavioural tests employed here should be valuable in the assessment of effective approaches to treat NPC, for which no preventive or curative measures have so far been established...
  41. pmc Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis
    Riikka Hynynen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, Helsinki FI 00251, Finland
    Biochem J 390:273-83. 2005
    ..Our results suggest a function of ORP2 in both cholesterol trafficking and control of endocytic membrane transport...
  42. pmc Modulation of cellular cholesterol transport and homeostasis by Rab11
    Maarit Hölttä-Vuori
    Department of Molecular Medicine, National Public Health Institute, Biomedicum Helsinki, Finland
    Mol Biol Cell 13:3107-22. 2002
    ..The findings point to the importance of the recycling endosomes in regulating cholesterol and sphingolipid trafficking and cellular cholesterol homeostasis...
  43. ncbi request reprint Introduction: new aspects of cellular sterol metabolism and transport
    Elina Ikonen
    Semin Cell Dev Biol 16:151-3. 2005
  44. ncbi request reprint Genetics and molecular biology
    Elina Ikonen
    Curr Opin Lipidol 15:219-21. 2004
  45. ncbi request reprint Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction
    Laura Ahtiainen
    National Public Health Institute, Department of Molecular Medicine, Biomedicum Helsinki, PO Box 104, 00251 Helsinki, Finland
    Neurobiol Dis 28:52-64. 2007
    ..This study established that the neuronal deregulation in INCL is linked to neuronal maturation, lipid metabolism and calcium homeostasis...
  46. ncbi request reprint ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism
    Saara Laitinen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, Fin 00251 Helsinki, Finland
    J Lipid Res 43:245-55. 2002
    ..The results implicate ORP2 as a novel regulator of cellular sterol homeostasis and intracellular membrane trafficking...
  47. ncbi request reprint When intracellular logistics fails--genetic defects in membrane trafficking
    Vesa M Olkkonen
    Department of Molecular Medicine, National Public Health Institute KTL, Biomedicum, POBox 104, FI 00251 Helsinki, Finland
    J Cell Sci 119:5031-45. 2006
    ..Studies of the gene defects in trafficking disorders therefore not only open avenues for new therapeutic approaches but also significantly contribute to our knowledge of the fundamental mechanisms of intracellular membrane transport...