Timo Iirola

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. pmc Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients
    Timo Iirola
    Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, PO Box 52, FI 20521 Turku, Finland
    Crit Care 15:R257. 2011
  2. doi request reprint Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients
    T Iirola
    Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Br J Anaesth 108:460-8. 2012
  3. pmc Highly variable pharmacokinetics of dexmedetomidine during intensive care: a case report
    Timo Iirola
    Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, FIN 20521, Turku, Finland
    J Med Case Reports 4:73. 2010
  4. doi request reprint Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers
    T Iirola
    Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Br J Anaesth 106:522-7. 2011
  5. doi request reprint Bioavailability of dexmedetomidine after intranasal administration
    Timo Iirola
    Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, P O Box 52, FI 20521, Turku, Finland
    Eur J Clin Pharmacol 67:825-31. 2011

Detail Information

Publications5

  1. pmc Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients
    Timo Iirola
    Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, PO Box 52, FI 20521 Turku, Finland
    Crit Care 15:R257. 2011
    ..Additionally, we wanted to quantify for the first time in humans the concentrations of H-3, a practically inactive metabolite of dexmedetomidine...
  2. doi request reprint Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients
    T Iirola
    Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Br J Anaesth 108:460-8. 2012
    ..We characterized the pharmacokinetics of dexmedetomidine in critically ill patients during long-term sedation using a population pharmacokinetic approach...
  3. pmc Highly variable pharmacokinetics of dexmedetomidine during intensive care: a case report
    Timo Iirola
    Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, FIN 20521, Turku, Finland
    J Med Case Reports 4:73. 2010
    ..There are some previous reports on the use of long-term moderate to high-dose infusions of dexmedetomidine in patients in intensive care units, but none of these accounts have cited dexmedetomidine plasma concentrations...
  4. doi request reprint Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers
    T Iirola
    Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Br J Anaesth 106:522-7. 2011
    ..This study evaluated the effects of dexmedetomidine on gastric emptying and oro-caecal transit time in healthy volunteers...
  5. doi request reprint Bioavailability of dexmedetomidine after intranasal administration
    Timo Iirola
    Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, P O Box 52, FI 20521, Turku, Finland
    Eur J Clin Pharmacol 67:825-31. 2011
    ..The aim of this proof-of-concept study was to characterize the pharmacokinetics and pharmacodynamics of intranasal dexmedetomidine compared with its intravenous administration in a small number of healthy volunteers...