Heikki Hyoty

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. ncbi request reprint Enterovirus infections and type 1 diabetes
    Heikki Hyoty
    JDRF Center for Prevention of Type 1 Diabetes, Tampere, Finland
    Ann Med 34:138-47. 2002
  2. doi request reprint Human rhinoviruses including group C are common in stool samples of young Finnish children
    Hanna Honkanen
    University of Tampere, School of Medicine, Tampere, Finland
    J Clin Virol 56:250-4. 2013
  3. ncbi request reprint Temporal relationship between human parechovirus 1 infection and otitis media in young children
    Sisko Tauriainen
    Dept of Virology, University of Tampere Medical School, 33014 University of Tampere, Tampere, Finland
    J Infect Dis 198:35-40. 2008
  4. doi request reprint Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes
    Olli H Laitinen
    Vactech Ltd, Tampere, Finland
    Diabetes 63:446-55. 2014
  5. pmc Maternal enterovirus infection as a risk factor for type 1 diabetes in the exposed offspring
    Hanna Viskari
    Department of Virology, University of Tampere, School of Medicine, Tampere, Finland
    Diabetes Care 35:1328-32. 2012
  6. doi request reprint Role of enterovirus infections in IgE sensitization
    Tapio Seiskari
    Department of Virology, University of Tampere, Tampere, Finland
    J Med Virol 84:268-71. 2012
  7. pmc Type 1 diabetes is associated with enterovirus infection in gut mucosa
    Maarit Oikarinen
    Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
    Diabetes 61:687-91. 2012
  8. ncbi request reprint Co-occurrence of allergic sensitization and type 1 diabetes
    Tapio Seiskari
    Department of Virology, University of Tampere, Tampere, Finland
    Ann Med 42:352-9. 2010
  9. doi request reprint Human parechoviruses are frequently detected in stool of healthy Finnish children
    Pekka Kolehmainen
    Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
    J Clin Virol 54:156-61. 2012
  10. ncbi request reprint Human parechovirus 1 infections in young children--no association with type 1 diabetes
    Sisko Tauriainen
    JDRF Center for Prevention of Type 1 Diabetes, Tampere, Finland
    J Med Virol 79:457-62. 2007

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Enterovirus infections and type 1 diabetes
    Heikki Hyoty
    JDRF Center for Prevention of Type 1 Diabetes, Tampere, Finland
    Ann Med 34:138-47. 2002
    ..Even if enterovirus infections were not associated with all diabetes cases but rather with a subgroup of them, this would offer attractive possibilities to prevent the disease or part of it, for example, by an enterovirus vaccine...
  2. doi request reprint Human rhinoviruses including group C are common in stool samples of young Finnish children
    Hanna Honkanen
    University of Tampere, School of Medicine, Tampere, Finland
    J Clin Virol 56:250-4. 2013
    ..They have been widely studied in respiratory samples in hospital patient series but only a few studies have been performed to assess their occurrence in other sample types and their circulation in healthy children background population...
  3. ncbi request reprint Temporal relationship between human parechovirus 1 infection and otitis media in young children
    Sisko Tauriainen
    Dept of Virology, University of Tampere Medical School, 33014 University of Tampere, Tampere, Finland
    J Infect Dis 198:35-40. 2008
    ..Because clinical symptoms are poorly documented, we evaluated the symptoms associated with HPeV1 infection in a cohort of children followed prospectively from birth at 3-month intervals...
  4. doi request reprint Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes
    Olli H Laitinen
    Vactech Ltd, Tampere, Finland
    Diabetes 63:446-55. 2014
    ..The clustering of the risk and protective viruses to this narrow phylogenetic lineage supports the biological plausibility of this phenomenon. ..
  5. pmc Maternal enterovirus infection as a risk factor for type 1 diabetes in the exposed offspring
    Hanna Viskari
    Department of Virology, University of Tampere, School of Medicine, Tampere, Finland
    Diabetes Care 35:1328-32. 2012
    ..The aim of this study was to evaluate this association in a unique series of pregnant mothers whose child progressed to clinical type 1 diabetes...
  6. doi request reprint Role of enterovirus infections in IgE sensitization
    Tapio Seiskari
    Department of Virology, University of Tampere, Tampere, Finland
    J Med Virol 84:268-71. 2012
    ..001; OR = 0.35, 95% CI: 0.18-0.67). The results support previous observations suggesting that infections by certain enterovirus types are associated with protection against IgE sensitization...
  7. pmc Type 1 diabetes is associated with enterovirus infection in gut mucosa
    Maarit Oikarinen
    Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
    Diabetes 61:687-91. 2012
    ..This finding opens new opportunities for studying the viral etiology of type 1 diabetes...
  8. ncbi request reprint Co-occurrence of allergic sensitization and type 1 diabetes
    Tapio Seiskari
    Department of Virology, University of Tampere, Tampere, Finland
    Ann Med 42:352-9. 2010
    ..If so, these diseases should co-occur more often than expected. We investigated this phenomenon in two contrasting socio-economic environments, Finland and Russian Karelia...
  9. doi request reprint Human parechoviruses are frequently detected in stool of healthy Finnish children
    Pekka Kolehmainen
    Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
    J Clin Virol 54:156-61. 2012
    ..Human parechoviruses (HPeVs) are common viruses mainly infecting young children. Most infections are mild, but HPeV3 causes severe CNS infections in new-born infants...
  10. ncbi request reprint Human parechovirus 1 infections in young children--no association with type 1 diabetes
    Sisko Tauriainen
    JDRF Center for Prevention of Type 1 Diabetes, Tampere, Finland
    J Med Virol 79:457-62. 2007
    ..No difference was found in infection frequency between boys and girls, nor between prediabetic, diabetic and control subjects. Most infections (87%) occurred during autumn, winter and spring...
  11. doi request reprint Lower economic status and inferior hygienic environment may protect against celiac disease
    Anita Kondrashova
    Department of Virology, University of Tampere, Medical School, Tampere, Finland
    Ann Med 40:223-31. 2008
    ..The populations in adjacent Russian Karelia and Finland are equally exposed to grain products and share partly the same ancestry, but live in completely different socioeconomic environments...
  12. doi request reprint The 'Hygiene hypothesis' and the sharp gradient in the incidence of autoimmune and allergic diseases between Russian Karelia and Finland
    Anita Kondrashova
    Department of Virology, University of Tampere, Tampere, Finland
    APMIS 121:478-93. 2013
    ..Infections, or lack of them, may indeed be strongly involved in the development of both autoimmune and allergic diseases...
  13. doi request reprint Human enterovirus 71 strains in the background population and in hospital patients in Finland
    Hanna Honkanen
    University of Tampere, Tampere, Finland
    J Clin Virol 56:348-53. 2013
    ..Human enterovirus 71 (HEV71) is a common cause of severe outbreaks of hand-foot- and mouth disease, aseptic meningitis and encephalitis in Asian populations but has not caused such epidemics in all populations...
  14. ncbi request reprint Maternal antibodies in breast milk protect the child from enterovirus infections
    Karita Sadeharju
    Department of Virology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Pediatrics 119:941-6. 2007
    ..We set out to assess whether breastfeeding can protect against these infections and whether such an effect is related to maternal antibodies in breast milk or in the peripheral circulation of the infant...
  15. doi request reprint Enteroviruses in the pathogenesis of type 1 diabetes
    Sisko Tauriainen
    Department of Virology, Medical School, University of Tampere, Biokatu 10, FIN 33520, Tampere, Finland
    Semin Immunopathol 33:45-55. 2011
    ..These findings open also new opportunities to explore the underlying mechanism and get closer to causal relationship...
  16. ncbi request reprint Can enteroviruses cause type 1 diabetes?
    Sisko Tauriainen
    JDRF Center for Prevention of Type 1 Diabetes in Finland, Department of Virology, University of Tampere, and University Hospital of Tampere, Tampere, Finland
    Ann N Y Acad Sci 1005:13-22. 2003
    ..This research field is becoming more and more important because it could open up possibilities to prevent type 1 diabetes by an enterovirus vaccine...
  17. doi request reprint Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media
    Elina Seppälä
    Department of Virology, University of Tampere, Tampere, Finland
    Vaccine 29:8615-8. 2011
    ..The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children...
  18. doi request reprint Time trends in allergic sensitisation and Helicobacter pylori prevalence in Finnish pregnant women
    Tapio Seiskari
    Department of Virology, University of Tampere, Tampere, Finland
    Int Arch Allergy Immunol 150:83-8. 2009
    ..We investigated whether the increase of allergic sensitisation still continues and correlates with the prevalence of H. pylori infections...
  19. doi request reprint Collecting high-quality pancreatic tissue for experimental study from organ donors with signs of β-cell autoimmunity
    Sisko Tauriainen
    Department of Virology, University of Tampere, Medical School, Tampere, Finland
    Diabetes Metab Res Rev 26:585-92. 2010
    ....
  20. doi request reprint Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes
    Sami Oikarinen
    Department of Virology, University of Tampere, Tampere, Finland
    Diabetes 63:655-62. 2014
    ..The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type. ..
  21. pmc Virus infections as potential targets of preventive treatments for type 1 diabetes
    Noora Nurminen
    Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
    Rev Diabet Stud 9:260-71. 2012
    ..Also, new sequencing technologies will provide additional information about the whole virome, which could enable the discovery of new candidate viruses. ..
  22. ncbi request reprint Signs of beta-cell autoimmunity in nondiabetic schoolchildren: a comparison between Russian Karelia with a low incidence of type 1 diabetes and Finland with a high incidence rate
    Anita Kondrashova
    Department of Virology, University of Tampere Medical School, Tampere, Finland
    Diabetes Care 30:95-100. 2007
    ..We sought to study the prevalence of autoantibodies to various islet cell antigens in the background population of two neighboring countries with a sixfold difference in the incidence of type 1 diabetes...
  23. doi request reprint Timing of infant feeding in relation to childhood asthma and allergic diseases
    Bright I Nwaru
    School of Health Sciences, University of Tampere, Tampere, Finland
    J Allergy Clin Immunol 131:78-86. 2013
    ..Emerging evidence questions current recommendations on the timing of infant feeding for the prevention of childhood allergies. The evidence for asthma is inconclusive...
  24. ncbi request reprint Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: results from the EPIVIR project
    Hanna Viskari
    JDRF Center for Prevention of Type 1 Diabetes, Finland
    J Med Virol 72:610-7. 2004
    ....
  25. doi request reprint Evaluation of immunohistochemistry and in situ hybridization methods for the detection of enteroviruses using infected cell culture samples
    Maarit Oikarinen
    Department of Virology, Medical School, University of Tampere, Tampere, Finland
    J Clin Virol 47:224-8. 2010
    ..Based on this there is an increasing need for the reliable detection of enteroviruses in different kinds of tissue samples...
  26. pmc Enterovirus RNA in blood is linked to the development of type 1 diabetes
    Sami Oikarinen
    Department of Virology, University of Tampere, Finland
    Diabetes 60:276-9. 2011
    ..Further, to study the role of enteroviruses in both the initiation of the process and the progression to type 1 diabetes...
  27. ncbi request reprint PCR inhibition in stool samples in relation to age of infants
    Sami Oikarinen
    JDRF Center for the Prevention of Type 1 Diabetes in Finland, Finland
    J Clin Virol 44:211-4. 2009
    ..PCR is rapidly replacing traditional methods in diagnostic virus laboratories. PCR inhibitors, which are often present in clinical samples, may lead to false negative test results...
  28. ncbi request reprint Rectal bleeding in infancy: clinical, allergological, and microbiological examination
    Taina Arvola
    Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Pediatrics 117:e760-8. 2006
    ..Because withdrawal of cow's milk antigens from the infants' diet is used as a first treatment without evidence of its efficacy, we also aimed to asses the effect of a cow's milk-elimination diet on the duration of rectal bleeding...
  29. ncbi request reprint Amplifying control RNA for RT-PCR applications by nucleic acid sequence based amplification (NASBA)
    Sisko Tauriainen
    Department of Virology, University of Tampere, Medical School, Biokatu 10, FIN 33520 Tampere, Finland
    J Virol Methods 132:222-6. 2006
    ..Generated RNA fragments were 195-714 bases long, of positive polarity and the amount of RNA was sufficient for thousands of RT-PCR reactions depending on the sensitivity of the RT-PCR...
  30. ncbi request reprint Coxsackievirus B1 reveals strain specific differences in plasmacytoid dendritic cell mediated immunogenicity
    Sanna Hämäläinen
    Immunoregulation, BioMediTech, University of Tampere, Tampere, Finland
    J Med Virol 86:1412-20. 2014
    ..J. Med. Virol. 86:1412-1420, 2014. © 2014 Wiley Periodicals, Inc. ..
  31. ncbi request reprint Environmental causes: viral causes
    Heikki Hyoty
    Juvenile Diabetes Research Foundation, Centre for Prevention of Type 1 Diabetes in Finland, Tampere, Finland
    Endocrinol Metab Clin North Am 33:27-44, viii. 2004
  32. ncbi request reprint Maternal first-trimester enterovirus infection and future risk of type 1 diabetes in the exposed fetus
    Hanna R Viskari
    Juvenile Diabetes Foundation International Center for the Prevention of type 1 diabetes in Finland and the Department of Virology, University of Tampere, Medical School, Tampere, Finland
    Diabetes 51:2568-71. 2002
    ..3%) of the subgroup of samples and in 5.7% of 70 IgM-positive women. The results suggest that enterovirus infection during the first trimester of pregnancy is not associated with increased risk for type 1 diabetes in the child...
  33. ncbi request reprint Role of viruses and other microbes in the pathogenesis of type 1 diabetes
    Anita Kondrashova
    School of Medicine, University of Tampere, Tampere, Finland
    Int Rev Immunol 33:284-95. 2014
    ..g. enterovirus vaccines) or use of protective microbes as probiotics. ..